Kevin J. Hellestrand

Kevin J. Hellestrand

From The Deparlment Of Cardiology, St. Bartholomew's Hospital, West Smithfield, London, England

Direct Impact

Concepts for which Kevin J Hellestrand has direct influence:

flecainide acetate
proarrhythmic effects
tachycardia termination
sinus node
atrioventricular conduction
cardiac transplantation
cycle length

External impact

Concepts related to the work of other authors for which Kevin J Hellestrand has influence:

electrophysiological effects
accessory pathway
retrograde conduction
wolff-parkinson-white syndrome
oral flecainide acetate
paroxysmal supraventricular tachycardia
atrioventricular node

Prominent publications by Kevin J. Hellestrand

KOL-Index: 27 The function of both the denervated donor and innervated recipient sinus nodes of 14 asymptomatic cardiac transplant recipients was assessed. Tests of sinoatrial function were performed in 14 donor and 10 recipient atria. The mean spontaneous cycle length of the recipient atria was significantly longer than that of the donor atria (944 +/- 246 versus 663 +/- 158 ms, p less than 0.01). Donor ...
Known for
14 Donor | Function Cardiac | Atria Occurred | 188
KOL-Index: 24 A 67-year-old mand in whom mitral and tricuspid Bjork-Shiley tilting disc prostheses had been implanted 68 months previously presented with thrombotic obstruction of his tricuspid prosthesis. Initial cardiac catheterization demonstrated a significant transprosthetic tricuspid diastolic gradient (9.5 mmHg) with a calculated prosthetic valve orifice area (0.62 cm2) indicating a critical degree ...
Known for
Gradient Tricuspid | Transprosthetic | Valve Orifice | Area Cm2
KOL-Index: 23 Flecainide acetate, a new potent class I antiarrhythmic agent, was administered to 152 patients (orally to 46, intravenously to 106) over a period of 22 months. Seven patients developed proarrhythmic effects. The only conduction abnormalities induced were PR interval prolongation and QRS complex widening, and no patient developed significant sinus bradyarrhythmias; patients with known ...
Known for
Atrioventricular Tachycardia | Induced Prolongation | Arrhythmias Developed | Series Proarrhythmic
KOL-Index: 18 Flecainide acetate depresses both the upstroke of the intracellular action potential and the rate of diastolic depolarisation in isolated tissue preparations of atrial myocardium. It produces no consistent effect on action potential duration. Predictably, in the human heart, studied by clinical cardiac electrophysiological techniques, conduction velocity through atrial myocardium, the ...
Known for
Arrhythmias Flecainide | Terminated Atrial | Myocardium Atrioventricular | Nodal Tachycardia
KOL-Index: 17 It is usual to record independent activity from both the innervated recipient and the denervated donor atria in cardiac transplant recipients except for occasional, short-lived periods of entrainment that may occur during exercise. In this report a case is described in which, following orthotopic cardiac transplantation, the recipient and donor atria remained synchronized during a variety of ...
Known for
Physiological Non-Physiological Situations | Recipient Donor | Orthotopic Cardiac Transplantation | Atria Cardiac
KOL-Index: 16 Fourteen relatively long term survivors of cardiac transplantation underwent systematic electrophysiological evaluation and ambulatory electrocardiographic monitoring. Six patients had prolonged conduction intervals during sinus rhythm. Sinus node function could be assessed in all donor atria and in 10 recipient atria. Sinus node recovery times were prolonged in four of the donor atria and ...
Known for
Abnormal Sinus Node Recovery | Donor Sinus Node Function | 10 Recipient Atria | Atrioventricular Nodal Conduction
KOL-Index: 16 The acute electrophysiologic effects of i.v. flecainide acetate (2 mg/kg body weight) were assessed in 71 patients undergoing electrophysiologic study. Ten patients underwent investigation for sinus node dysfunction. Sinus cycle length shortened slightly, from 980 +/- 292 to 931 +/- 276 ms (p less than 0.01). Uncorrected or corrected sinus node recovery times or sinoatrial conduction time ...
Known for
276 | Tachycardias Flecainide | Normal Sinus Node Function | Refractoriness
KOL-Index: 15 To evaluate the direct electrophysiologic effects of i.v. disopyramide phosphate and to differentiate these effects from its autonomically mediated actions, we administered the drug (2 mg/kg over 5 minutes) during electrophysiologic study to eight cardiac transplant recipients who had documented functional cardiac denervation. After disopyramide, the cycle length of the denervated donor ...
Known for
Autonomically Mediated Actions | Effective Refractory Period | Innervated Normal Heart | 17 Msec
KOL-Index: 14 The electrophysiological effects of flecainide acetate (2 mg/kg as an intravenous infusion over five minutes) were assessed in 47 patients undergoing electrophysiological study. Seven patients had normal electrophysiology, 16 had a direct accessory atrioventricular pathway, 12 had dual atrioventricular nodal (AH) pathways, five had paroxysmal ventricular tachycardia, six had conduction ...
KOL-Index: 12 Twenty consecutive patients with paroxysmal intra A-V nodal or atrio-ventricular tachycardia had a new tachycardia reversion pacing modality evaluated during routine electrophysiological study. The pacing was controlled by a micropressor interfaced with a stimulator connected to a right atrial pacing electrode. On detection of tachycardia the first pacing cycle interval is equal to the ...
Known for
Cycle Tachycardia | Safe Successful Termination | Paroxysmal Intra A-V Nodal | Competitive Constant Rate Overdrive

From the Deparlment of Cardiology, St. Bartholomew's Hospital, West Smithfield, London, England

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