• Disease
  • Flecainide
  • Flecainide Acetate
  • Kevin J Hellestrand

    Prominent publications by KEVIN J HELLESTRAND

    KOL Index score: 12499

    Intravenous flecainide acetate was administered to 33 patients undergoing routine electrophysiologic study: 18 patients had a direct accessory atrioventricular (AV) pathway and 15 patients had functional longitudinal A-H dissociation (dual A-H pathways). Flecainide was given to 14 patients during sustained AV reentrant tachycardia and to 9 patients during sustained intra-AV nodal reentrant tachycardia. AV reentrant tachycardia was successfully terminated in 12 of 14 patients. Tachycardia ...

    Also Ranks for: Flecainide Acetate |  accessory pathway |  patients tachycardia |  electrophysiologic effects |  anterograde retrograde
    KOL Index score: 8707

    The electrophysiological effects of flecainide acetate (2 mg/kg as an intravenous infusion over five minutes) were assessed in 47 patients undergoing electrophysiological study. Seven patients had normal electrophysiology, 16 had a direct accessory atrioventricular pathway, 12 had dual atrioventricular nodal (AH) pathways, five had paroxysmal ventricular tachycardia, six had conduction system disease, and one patient had a left atrial tachycardia. No significant change occurred in sinus ...

    Also Ranks for: Flecainide Acetate |  electrophysiological effects |  cardiac conduction |  qt interval |  ventricular arrhythmias
    KOL Index score: 8024

    Thirteen patients suffering from reentrant supraventricular tachycardia have undergone implantation of a scanning extrastimulus pacemaker. This pacemaker is fully implanted and automatic, and it requires no external control device to activate or control it. The pacemaker is activated when tachycardia occurs. After four cycles an extrastimulus is induced with a preset coupling time from a sensed intracardiac potential, and every four cycles thereafter a further extrastimulus occurs, but ...

    Also Ranks for: Termination Tachycardia |  scanning pacemaker |  implantation patients |  implantable automatic |  coupling intervals
    KOL Index score: 7843

    The function of both the denervated donor and innervated recipient sinus nodes of 14 asymptomatic cardiac transplant recipients was assessed. Tests of sinoatrial function were performed in 14 donor and 10 recipient atria. The mean spontaneous cycle length of the recipient atria was significantly longer than that of the donor atria (944 +/- 246 versus 663 +/- 158 ms, p less than 0.01). Donor sinus node recovery time was prolonged in four patients (greater than 2,500 ms in two) and ...

    Also Ranks for: Cardiac Transplantation |  recipient atria |  recovery time |  sinus node |  heart rate
    KOL Index score: 7089

    Flecainide acetate, a new potent class I antiarrhythmic agent, was given to 152 patients (46 orally and 106 intravenously) over a period of 22 months. Seven patients developed proarrhythmic effects. The only conduction abnormalities induced were PR interval prolongation and QRS complex widening, and no patient developed significant sinus bradyarrhythmias; patients with known serious abnormalities of impulse generation or conduction were excluded from this study. Five patients developed ...

    Also Ranks for: Proarrhythmic Effects |  flecainide acetate |  antiarrhythmic agent |  patients ventricular tachycardia |  ventricular arrhythmias
    KOL Index score: 6911

    Intravenous flecainide acetate (2 mg/kg) was administered to 40 patients undergoing routine electrophysiological evaluation for the investigation of recurrent paroxysmal tachycardias. Ten patients had recurrent atrial flutter, 11 patients had recurrent atrial fibrillation, one of whom also had paroxysmal left atrial tachycardia, and 19 patients had recurrent ventricular tachyarrhythmias (17 with recurrent ventricular tachycardia and 2 with recurrent fascicular tachycardia). Flecainide ...

    Also Ranks for: Flecainide Acetate |  atrial fibrillation |  sinus rhythm |  ventricular tachycardia |  40 patients
    KOL Index score: 6909

    The electrophysiological effects of intravenous sotalol hydrochloride (0.4 mg/kg) were assessed in 24 patients, including 13 with the Wolff-Parkinson-White syndrome, undergoing routine electrophysiological study. Fifteen to 30 minutes after sotalol administration there was a significant increase in sinus cycle length and in sinus node recovery time. There was a small increase in the AH interval, but the HV interval was unchanged. The QT and JT intervals, measured during sinus rhythm, ...

    Also Ranks for: Electrophysiological Effects |  beta blocker |  patients sotalol |  accessory pathway |  sinus rhythm
    KOL Index score: 6371

    The acute electrophysiologic effects of i.v. flecainide acetate (2 mg/kg body weight) were assessed in 71 patients undergoing electrophysiologic study. Ten patients underwent investigation for sinus node dysfunction. Sinus cycle length shortened slightly, from 980 +/- 292 to 931 +/- 276 ms (p less than 0.01). Uncorrected or corrected sinus node recovery times or sinoatrial conduction time (according to the methods of Strauss and Narula) did not change in 6 patients with normal sinus node ...

    Also Ranks for: Flecainide Acetate |  electrophysiologic effects |  sinus node function |  acute termination |  accessory pathway
    KOL Index score: 5328

    Flecainide acetate depresses both the upstroke of the intracellular action potential and the rate of diastolic depolarisation in isolated tissue preparations of atrial myocardium. It produces no consistent effect on action potential duration. Predictably, in the human heart, studied by clinical cardiac electrophysiological techniques, conduction velocity through atrial myocardium, the atrioventricular (AV) node and anomalous tissue is depressed following flecainide administration. ...

    Also Ranks for: Flecainide Acetate |  atrial tachycardia |  supraventricular arrhythmias |  small proportion |  atrioventricular node
    KOL Index score: 4958

    To evaluate the direct electrophysiologic effects of i.v. disopyramide phosphate and to differentiate these effects from its autonomically mediated actions, we administered the drug (2 mg/kg over 5 minutes) during electrophysiologic study to eight cardiac transplant recipients who had documented functional cardiac denervation. After disopyramide, the cycle length of the denervated donor right atrium increased from 626 +/- 129 to 716 +/- 148 msec (mean +/- SD, p less than 0.001), whereas ...

    Also Ranks for: Transplanted Human Heart |  electrophysiologic effects |  qt interval |  cycle length |  qrs duration
    KOL Index score: 4501

    A fully implantable automatic scanning pacemaker designed for tachycardia termination has been used in three patients with regular paroxysmal supraventricular tachycardia. The pacemaker recognizes tachycardia and delivers one or two extrastimuli which automatically scan inwards if tachycardia continues. A memory is incorporated to retain and immediately reuse a successful pacing sequence if tachycardia recurs. Ventricular pacing has been used in two patients and atrial stimulation in ...

    Also Ranks for: Tachycardia Termination |  frequent attacks |  aged pacemaker |  implantable scanning |  white syndrome
    KOL Index score: 4241

    Twenty consecutive patients with paroxysmal intra A-V nodal or atrio-ventricular tachycardia had a new tachycardia reversion pacing modality evaluated during routine electrophysiological study. The pacing was controlled by a micropressor interfaced with a stimulator connected to a right atrial pacing electrode. On detection of tachycardia the first pacing cycle interval is equal to the tachycardia cycle length minus a decrement value D. Each subsequent pacing cycle is further reduced by ...

    Also Ranks for: Atrial Pacing |  artificial tachycardia |  unwanted arrhythmias |  heart ventricles |  evaluation studies
    KOL Index score: 3762

    It is usual to record independent activity from both the innervated recipient and the denervated donor atria in cardiac transplant recipients except for occasional, short-lived periods of entrainment that may occur during exercise. In this report a case is described in which, following orthotopic cardiac transplantation, the recipient and donor atria remained synchronized during a variety of physiological and non-physiological situations. Under no circumstances did the two sets of atria ...

    Also Ranks for: Recipient Atria |  cardiac transplant |  rate heart |  node adult |  denervated donor


    KEVIN J HELLESTRAND: Influence Statistics

    Sample of concepts for which KEVIN J HELLESTRAND is among the top experts in the world.
    Concept World rank
    inwards tachycardia #2
    tachycardia memory #2
    implantation sustained episodes #2
    ventricular revert tachycardia #2
    incorporated retain #2
    successful pacing sequence #2
    effective versatile form #2
    initial experience scanning #2
    extrastimuli inwards #2
    termination fully #2
    scanning extrastimulus pacemaker #2
    tachycardia extrastimuli #2
    acetate sinus #3
    series proarrhythmic #3
    flecainide acute threshold #3
    flecainide acetate review #3
    developed proarrhythmic #3
    292 931 276 #3
    narula method #3
    patient sinoatrial #3
    flecainide atrial tachycardia #3
    pacemaker thresholds #3
    acute threshold maximum #3
    reentrant tachycardias flecainide #3
    recurrent fascicular tachycardia #3
    methods strauss #3
    tachycardias flecainide #3
    sustained episodes tachycardia #3
    flecainide administration increase #3
    normal flecainide #3
    159 strauss method #3
    flecainide acute termination #3
    1398 1455 #3
    152 patients period #3
    administered tachycardia #3
    cardiac cycle extrastimuli #4
    tachycardia trigger rate #4
    coupling time stimuli #4
    patients normal electrophysiology #4
    reinitiation intra #4
    sensed intracardiac potential #4
    preset coupling #4
    reentrant junctional #4
    flecainide fast pathway #4
    cycles extrastimulus #4
    delay flecainide #4
    extrastimulus occurs #4
    scanned extrastimuli #4
    scanned coupling #4
    administration reinitiation #4

    Key People For Flecainide Acetate

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    Concepts for whichKEVIN J HELLESTRANDhas direct influence:Flecainide acetate,  Intravenous flecainide,  Proarrhythmic effects,  Tachycardia termination,  Electrophysiological effects,  Intravenous flecainide acetate,  Electrophysiologic effects,  Cardiac transplantation.


    Concepts related to the work of other authors for whichfor which KEVIN J HELLESTRAND has influence:Atrial fibrillation,  Ventricular tachycardia,  Flecainide acetate,  Sinus rhythm,  Heart transplantation,  Electrophysiologic effects,  Cardiac pacing.



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    From the Department of Cardiology, St. Bartholomew's Hospital, London, England, and the Department of Cardiology, Royal North Shore Hospital, Sydney, Australia | Department of Cardiology, St. Bartholomew’s Hospital, West Smith-field, EC1A 7BE, London