 | James Buxbaum |
Prominent publications by James Buxbaum
Cathepsins regulate premature trypsinogen activation within acinar cells, a key initial step in pancreatitis. The identity, origin, and causative roles of activated cathepsins in pancreatic inflammation and pain are not defined. By using a near infrared-labeled activity-based probe (GB123) that covalently modifies active cathepsins, we localized and identified activated cathepsins in mice with cerulein-induced pancreatitis and in pancreatic juice from patients with chronic pancreatitis. ...
| Also Ranks for: Active Cathepsins | chronic pancreatitis | acinar cells | based probe | animals cathepsin |
BACKGROUND & AIMS: The prevalence and significance of digestive manifestations in coronavirus disease 2019 (COVID-19) remain uncertain. We aimed to assess the prevalence, spectrum, severity, and significance of digestive manifestations in patients hospitalized with COVID-19.
METHODS: Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in North America. Data pertaining to baseline characteristics, symptomatology, ...
| Also Ranks for: Patients Hospitalized | gastrointestinal symptoms | covid19 prevalence | north america | medical centers |
Safety and efficacy of digital single-operator pancreatoscopy for obstructing pancreatic ductal stones
[ PUBLICATION ]
Abstract
Background and study aims The role of the digital single-operator pancreatoscopy (D-SOP) with electrohydraulic (EHL) or laser lithotripsy (LL) in treating pancreatic ductal stones is unclear. We investigated the safety and efficacy of D-SOP with EHL or LL in patients with obstructing pancreatic duct stones.
Patients and methods Retrospective analysis of 109 patients who underwent D-SOP for pancreatic stones at 17 tertiary centers in the United ...
| Also Ranks for: Pancreatic Stones | operator pancreatoscopy | digital single | laser lithotripsy | procedure time |
BACKGROUND AND AIMS: EUS-guided FNA or biopsy sampling is widely practiced. Optimal sonographic visualization of the needle is critical for image-guided interventions. Of the several commercially available needles, bench-top testing and direct comparison of these needles have not been done to reveal their inherent echogenicity. The aims are to provide bench-top data that can be used to guide clinical applications and to promote future device research and development.
METHODS: Descriptive ...
| Also Ranks for: Clinical Applications | eus fna | 22 gauge | endoscopic ultrasound | needle aspiration |
Lactated Ringers vs. Normal Saline Resuscitation for Mild Acute Pancreatitis: A Randomized Trial
[ PUBLICATION ]
| Also Ranks for: Lactated Ringers | acute pancreatitis | normal saline | fluid therapy | inflammatory response |
Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19
[ PUBLICATION ]
| Also Ranks for: Histamine Antagonists | proton pump | inhibitors retrospective | cov2 severity |
The role of endoscopy and findings in COVID-19 patients, an early North American Cohort
[ PUBLICATION ]
BACKGROUND AND AIMS: Gastrointestinal manifestations in patients with COVID-19 are common but the role of endoscopy in this patient population remains unclear. We investigated the need for endoscopic procedures, their findings, and impact on patient care in a systematic and geographically diverse sample of patients hospitalized with COVID-19.
METHODS: As part of the North American Alliance for the Study of Digestive Manifestations of COVID-19, we identified consecutive patients ...
| Also Ranks for: Endoscopic Findings | gastrointestinal bleeding |
An Unsuccessful Randomized Trial of Percutaneous vs Endoscopic Drainage of Suspected Malignant Hilar Obstruction
[ PUBLICATION ]
Percutaneous transhepatic biliary drainage (PTBD) and endoscopic retrograde cholangiopancreatography (ERCP) are widely accepted but competing approaches for the management of malignant obstruction at the hilum of the liver. ERCP is favored in the United States on the basis of high success rates for non-hilar indications, the perceived safety and superior tissue sampling capability of ERCP relative to PTBD, and the avoidance of external drains that are undesirable to patients. A recent ...
| Also Ranks for: Percutaneous Endoscopic | biliary drainage |
Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19
[ PUBLICATION ]
BACKGROUND AND AIMS: The most common symptoms of Covid-19 are respiratory; however, gastrointestinal symptoms are present in up to 50% of patients. We aimed to determine characteristics associated with the development of gastrointestinal symptoms in patients with Covid-19.
METHODS: A case-control study of adults hospitalized for Covid-19 was conducted across a geographically diverse alliance of 36 US and Canadian medical centers. Data were manually abstracted from electronic health ...
James Buxbaum: Influence Statistics
| Concept | World rank |
|---|---|
| 540 38 | #32 |
| gastrointestinal symptom diarrhea | #32 |
| characteristics gastrointestinal symptoms | #33 |
| inflammatory disease pancreas | #48 |
| development gastrointestinal symptoms | #69 |
| operator pancreatoscopy | #70 |
| gastrointestinal symptoms diarrhea | #71 |
| symptom diarrhea | #81 |
| active cathepsins | #88 |
| dsop | #99 |
Key People For Chronic Pancreatitis
James Buxbaum:Expert Impact
Concepts for whichJames Buxbaumhas direct influence:Chronic pancreatitis, Gastrointestinal symptoms, Acute pancreatitis, Patients chronic pancreatitis, Covid19 gastrointestinal symptoms, Pancreatitis chronic, Gastrointestinal symptoms patients, Gastrointestinal symptom.
James Buxbaum:KOL impact
Concepts related to the work of other authors for whichfor which James Buxbaum has influence:Chronic pancreatitis, Gastrointestinal symptoms, Normal saline, Severe outcomes, Endoscopic ultrasonography, Intraductal lithotripsy, Pancreas divisum.
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