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    • Jean Francois Regnard
    • Jean Francois Regnard

      Jean Francois Regnard

      Department of Thoracic Surgery, Hôpitaux Universitaire Paris Centre, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. | Department of Thoracic Surgery, ...



      KOL Resume for Jean Francois Regnard


      Department of Thoracic Surgery, Hôpitaux Universitaire Paris Centre, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.


      Thoracic surgery department, Paris center hospitals, University Paris Descartes, APHP, Paris, France, View further author information

      Service de Chirurgie Thoracique, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris Descartes University, Paris, France


      Department of Thoracic Surgery, Cochin hospital, APHP, Paris Descartes University, Paris, France.

      University Paris Descartes, Paris, France


      Paris Descartes-Paris 5 University, Paris, France; Thoracic Surgery Department, Cochin hospital, AP-HP, Paris, France

      5 Service de Chirurgie Thoracique, Hôpital Cochin, and.


      Faculty of Medicine, Paris Descartes University, Chest Surgery Department, AP-HP, Cochin University Hospital

      Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France

      Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.


      Department of Thoracic Surgerym, Cochin University Hospital Group, AP-HP, Paris Descartes University, Paris, France


      Authors' Affiliations: 1Institut National de la Santé et de la Recherche Médicale (INSERM), U872, Centre de Recherche des Cordeliers; 2Université Pierre et Marie Curie-Paris 6, UMRS 872; 3Université Paris Descartes-Paris 5, UMRS 872; 4Université Denis Diderot-Paris 7; 5Services d'anatomie-pathologique et de chirurgie thoracique, Hôpital Hôtel Dieu; 6Services d'anatomie-pathologique, oncologie et de chirurgie thoracique; 7Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou; 8Service d'anatomie-pathologique, Hôpital Saint-Antoine; 9Service d'anatomie-pathologique, Hôpital Cochin; and 10Service d'anatomie-pathologique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France


      Departments of Thoracic Surgery and Pathology, Hôtel-Dieu University Hospital, Paris, France


      Department of Thoracic Surgery, Hôtel Dieu Hospital, AP-HP, 1, Place du Parvis Notre-Dame, 75181 Paris Cedex, France


      Department of Thoracic Surgery, Hôtel-Dieu Hospital and University Paris V, 1, place du Parvis de Notre-Dame, 75005 Paris, France


      Department of Thoracic Surgery, Hôtel Dieu Hospital, AP-HP, Paris, France


      Faculty of Medicine Paris-Descartes, Paris, France


      Unité de Chirurgie Thoracique, Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Université Paris V, Paris, 1 place du Parvis Notre Dame, 75181, Paris, Cedex 04, France


      Department of Thoracic Surgery, Hotel-Dieu, AP-HP, Paris, France

      Hôpital de la Timone, Hôpital Sainte-Marguerite, Marseille.« Ce texte, qui fait le point sur la place actuelle de la chirurgie d’exérèse dans la prise en charge médico-chirurgicale du mésothéliome pleural malin, tient compte des résultats de la conférence d’experts qui s’est tenue à Nice le 27/01/2006 lors du congrès de la SPLF. »


      Service de Chirurgie Thoracique, Hôtel Dieu, Paris, France

      Hôtel-Dieu, Paris


      Service de Chirurgie Thoracique, Hôtel Dieu, 1 Place du parvis Notre Dame, 75001, Paris, France


      Unité de Chirurgie Thoracique, Hôtel-Dieu, AP-HP, 1, Place du Parvis Nôtre-Dame, 75181 Paris Cedex 04, France


      Service de Chirurgie Thoracique, Hôtel-Dieu, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France


      Unit of Thoracic Surgery, Hôtel-Dieu Hospital, Paris, France


      Department of Thoracic Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France


      From the Departments of Medicine (A.U., J.N.M.) and Pathology (P.T.), Institut Gustave-Roussy, Villejuif; and Departments of Thoracic and Vascular Surgery (J.F.R.) and Pathology (V.M.), Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France.

      Hôpital Marie Lannelongue, Le Plessis-Robinson.

      Service de Chirurgie Thoracique et Vasculaire, Centre Chirurgical Marie Lannelongue, 133 Avenue de la résistance, Le Plessis, Robinson, 92350, France



      Jean Francois Regnard: Influence Statistics

      Sample of concepts for which Jean Francois Regnard is among the top experts in the world.
      Concept World rank
      diaphragmatic holes #1
      t3n1 female humans #1
      latissimus transposition #1
      sleeve resection stage #1
      nsclc bronchogenic carcinoma #1
      existing scoliosis #1
      thoracotomy scar recurrence #1
      postpneumonectomy syndrome 75yearold #1
      75yearold lung cancer #1
      brachiocephalic vein origin #1
      primary sarcoma lung #1
      initial masaoka staging #1
      89 stages #1
      thoracotomy completion pneumonectomy #1
      tumeurs neuroendocrines exérèse #1
      extrinsic compression bronchus #1
      9 wedge resections #1
      preexisting thoracic scoliosis #1
      commonly myasthenia #1
      bronchus lobe bronchus #1
      treatment postpneumonectomy cavity #1
      bronchial stump cavity #1
      57 stage iib #1
      complete tumoral resection #1
      case postpneumonectomy syndrome #1
      fistula cough #1
      26 recurrent cancers #1
      flagstaff lung neoplasms #1
      empyema pulmonary #1
      bronchial stump closure #1
      tracheal cancers #1
      abstractthymic tumours #1
      resection copd #1
      local recurrences resection #1
      existing thoracic #1
      completion pneumonectomy latissimus #1
      masses résiduelles #1
      nephrectomy pneumonectomy #1
      depth parietal invasion #1
      tumeurs tumeurs thymus #1


      Prominent publications by Jean Francois Regnard

      KOL-Index: 22005

      Alterations in the signaling pathways of epidermal growth factor receptors (HERs) are associated with tumor aggressiveness. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 60% of lung cancers. In a previous clinical study, NTSR1 overexpression was shown to predict a poor prognosis for 5 year overall survival in a selected population of stage I lung adenocarcinomas treated by surgery alone. In a second study, shown here, the frequent and high expression of ...

      Known for Nts Ntsr1 | Egfr Her2 | Affinity Receptor | Tumor Aggressiveness | Lung Adenocarcinoma
      KOL-Index: 12332

      PURPOSE: If immune cells are involved in tumor surveillance and have a prognostic impact in most primary tumors, little is known about their significance in metastases. Because patients' survival is heterogeneous, even at metastatic stages, we hypothesized that immune cells may be involved in the control of metastases. We therefore characterized the tumor immune microenvironment and its prognostic value in colorectal and renal cell carcinoma (RCC) metastases, and compared it to primary ...

      Known for Cell Carcinoma | Lung Metastases | Tumor Origin | Immune Environment | Prognostic Impact
      KOL-Index: 11306

      Epidemiological studies have shown that asbestos fibers constitute the major occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data are available on the role of asbestos fibers. P16/CDKN2A is an important tumor suppressor gene that is frequently altered in lung cancer via promoter 5'-CpG island hypermethylation and homozygous deletion, and ...

      Known for Lung Cancer | Asbestos Exposure | Tobacco Smoking | Homozygous Deletion | Small Cell
      KOL-Index: 10491

      Three hundred seven cases of patients who underwent operation for thymoma (196 of whom had myasthenia gravis) were analyzed to assess the prognostic values of Masaoka clinical staging, completeness of resection, histologic classification, history of myasthenia gravis, and postoperative radiotherapy. According to the Masaoka staging system, 135 thymomas were stage I, 70 were stage II, 83 were stage III, and 19 were stage IV. According to the Verley and Hollmann histologic classification ...

      Known for Thymoma Resection | Postoperative Radiotherapy | Myasthenia Gravis | Histologic Classification | Masaoka Staging
      KOL-Index: 10425

      OBJECTIVE: The research was designed to evaluate the results of surgical resection of renal lung metastases.

      METHODS: Between 1960 and 1994, 50 consecutive patients underwent resection for pulmonary metastases from renal cell carcinoma. Mean age was 59 years (range: 40-78 years). Mean time between nephrectomy and pulmonary resection was 3 years (range: 0-18 years). Nineteen patients had solitary metastase, 13 multiple unilateral, and 18 bilateral. Wedge excision was performed in 28 ...

      Known for Renal Cell | Lung Metastases | Surgical Resection | 3 Years | Fiveyear Survival
      KOL-Index: 10411

      OBJECTIVES: Superior vena cava (SVC) resection with prosthetic replacement for non-small cell lung cancer (NSCLC) is infrequently performed and oncological results are unclear. To establish a historical benchmark for this extended surgery, we have updated and reviewed data from four international centers.

      METHODS: Data were obtained through retrospective chart review. Prognostic factors were analyzed using first univariate techniques and subsequently multiple regression (logistic ...

      Known for Prosthetic Replacement | Vena Cava | Small Cell | Svc Resection | Lung Cancer
      KOL-Index: 10370

      OBJECTIVE: Successful treatment of postoperative empyema remains a challenge for thoracic surgeons. We report herein our 12-year experience in the management of this condition by means of open window thoracostomy.

      METHODS: Open window thoracostomy was used in the treatment of 46 patients with empyema complicating pulmonary resection. A bronchopleural fistula was associated in 39 of 46 cases. Previous operations included pneumonectomy (n = 30), bilobectomy (n = 5), lobectomy (n = 9), and ...

      Known for Window Thoracostomy | Pulmonary Resection | Flap Transposition | Bronchopleural Fistula | Empyema Complicating
      KOL-Index: 10354

      Thyroid transcription factor-1 (TTF-1) is considered as a reliable marker for differential diagnosis in distinguishing primary adenocarcinomas of the lung from extrathoracic origins. We previously reported the first case of lung metastasis of colorectal origin, with nuclear expression of TTF-1. As most previous studies were performed on series of extrathoracic primary tumors, we raised the question of a possible role of lung microenviroment in TTF-1 expression. We investigated the rate ...

      Known for Colorectal Origin | Ttf1 Expression | Nuclear Staining | Differential Diagnosis | Primary Adenocarcinomas
      KOL-Index: 10283

      BACKGROUND: Hypothesizing that nutritional status, systemic inflammation and tumoral immune microenvironment play a role as determinants of lung cancer evolution, the purpose of this study was to assess their respective impact on long-term survival in resected non-small cell lung cancers (NSCLC).

      METHODS AND FINDINGS: Clinical, pathological and laboratory data of 303 patients surgically treated for NSCLC were retrospectively analyzed. C-reactive protein (CRP) and prealbumin levels were ...

      Known for Nutritional Status | Systemic Inflammation | Cell Lung | Immune Microenvironment | Creactive Protein
      KOL-Index: 10112

      BACKGROUND: Postoperative pneumonia (POP) is a life-threatening complication of lung resection. The incidence, causative bacteria, predisposing factors, and outcome are poorly understood.

      DESIGN: Prospective observational study.

      METHODS: A prospective study of all patients undergoing major lung resections for noninfectious disease was performed over a 6-mo period. Culture of intraoperative bronchial aspirates was systematically performed. All patients with suspicion of pneumonia ...

      Known for Postoperative Pneumonia | Patients Pop | Lung Resection | Bronchial Colonization | Noninfectious Disease
      KOL-Index: 10081

      OBJECTIVE: The aim of this paper is to study clinical characteristics, surgical treatment and outcome of patients with solitary fibrous tumor of the pleura operated in our institutions in a 20-year period.

      METHODS: Clinical records of all patients operated for solitary fibrous tumors of the pleura between 1981 and 2000 were reviewed retrospectively. Tumors were classified as malignant in the presence of at least one of the following criteria: (1) high mitotic activity; (2) high ...

      Known for Clinical Characteristics | Solitary Fibrous Tumors | Surgical Treatment | Cases Malignant | Patients Benign
      KOL-Index: 9991

      PURPOSE: This study aimed to investigate the role of the neurotensin/neurotensin receptor I (NTSR1) complex in non-small cell lung cancer (NSCLC) progression.

      EXPERIMENTAL DESIGN: The expression of neurotensin and NTSR1 was studied by transcriptome analysis and immunohistochemistry in two series of 74 and 139 consecutive patients with pathologic stage I NSCLC adenocarcinoma. The findings were correlated with clinic-pathologic features. Experimental tumors were generated from the ...

      Known for Cell Lung | Neurotensin Receptor | Ntsr1 Expression | Tumor Growth | Carcinoma Small
      KOL-Index: 9828

      BACKGROUND: Extended resection of non-small-cell lung cancer (NSCLC) involving the superior vena cava (SVC) system is infrequently performed and oncologic benefits are still uncertain.

      METHODS: From 1983 to 1996, 25 patients underwent resection of the SVC system for T4, NSCLC.

      RESULTS: A total of 12 pneumonectomies (48%), ten lobectomies (40%), and three wedge resections (12%) were performed. Seven patients had complete resection of the SVC with graft interposition, 12 patients underwent ...

      Known for Vena Cava | Extended Resections | Bronchogenic Carcinoma | Nsclc Svc | Lung Neoplasms
      KOL-Index: 9446

      BACKGROUND: Hypothesizing that morphometric measurements are reliable markers of fitness in patients with lung cancer requiring aggressive surgical intervention, the purpose of this study was to assess their impact on postoperative outcome and long-term survival in patients with non-small cell lung cancer (NSCLC) requiring pneumonectomy.

      METHODS: Height, weight, and body mass index (BMI), as well as usual clinical, laboratory (including C-reactive protein [CRP] concentrations), and ...

      Known for Total Psoas Area | Patients Pneumonectomy | Body Mass Bmi | 33rd Percentile | Lung Cancer
      KOL-Index: 9307

      To determine long-term survival and prognostic factors, 208 patients with primary tracheal tumors were evaluated in a retrospective multicenter study including 26 centers. Ninety-four patients had squamous cell carcinoma, four had adenocarcinoma, 65 had adenoid cystic carcinoma, and 45 patients had miscellaneous tumors. The following resections were performed: tracheal resection with primary anastomosis, 165; carinal resection, 24; and laryngotracheal resection, 19. Postoperative ...

      Known for Primary Tracheal | Postoperative Radiotherapy | Adenoid Cystic Carcinomas | Carinal Resection | Histologic Type

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      Jean Francois Regnard:Expert Impact

      Concepts for whichJean Francois Regnardhas direct influence:Lung cancer,  Vena cava,  Lung resection,  Surgical treatment,  Catamenial pneumothorax,  Cell lung,  Window thoracostomy,  Bronchogenic carcinoma.

      Jean Francois Regnard:KOL impact

      Concepts related to the work of other authors for whichfor which Jean Francois Regnard has influence:Lung cancer,  Nk cells,  Small cell,  Surgical resection,  Spontaneous pneumothorax,  Thoracic surgery,  Pulmonary metastases.



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      Department of Thoracic Surgery, Hôpitaux Universitaire Paris Centre, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. | Department of Thoracic Surgery, Paris-Center University-Hospital, Assistance Publique-Hôpitaux de Paris, Par

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