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    • David A Lynch

      David A Lynch

      National Jewish Health, Radiology, Denver, Colorado, United States; lynchd@njhealth.org. | Department of Radiology, National Jewish Health, Denver, CO, USA | Department of ...



      KOL Resume for David A Lynch


      National Jewish Health, Radiology, Denver, Colorado, United States;

      School of Medicine, University of Colorado, Aurora, CO, USA

      Department of Radiology,


      From the Division of Pulmonary Diseases and Critical Care, the University of Texas Health Science Center at San Antonio, San Antonio, Tex (D.J.M., A.A., M.I.R.); Department of Radiology, University of California, San Diego, Calif (A.Y.); Division of Sleep Medicine and Circadian Disorders (W.W.), Division of Pulmonary and Critical Care Medicine, Department of Medicine (W.R.D., A.A.D.), and Department of Radiology (R.S.J.E.), Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115; Department of Radiology, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan (Y.O.); Quinnipiac University School of Medicine, Hamden, Conn (C.M.); South Texas Veterans Health Care System, San Antonio, Tex (A.A., M.I.R.); Pulmonary Disease and Critical Care Medicine, Mayo Clinic, Rochester, Minn (T.R.A.); Division of Pulmonary, Critical Care & Sleep Medicine, New York University School of Medicine, New York, NY (A.B.); Department of Pathophysiology and Transplantation, University of Milan Internal Medicine, and Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy (S.A.); Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colo (K.A.Y., G.L.K.); Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Ala (J.M.W.); and Department of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

      Imbio LLC, 1015 Glenwood Ave, Minneapolis, MN 55405 (C.R.H.); School of Medicine and Public Health, Division of Radiology, University of Michigan, Ann Arbor, Mich (C.R.H.); Department of Radiology, National Jewish Health, Denver, Colo (A.S.O., D.A.L., S.M.H.); Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (N.A.O.); and Thirona, Nijmegen, the Netherlands (J.P.C.).

      National Jewish Health, Denver, CO, USA.

      Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine.


      Department of Radiology, Denver, CO, USA

      Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan; and

      Division of Radiology, National Jewish Health, Denver, Colorado.

      National Jewish Health, Radiology, Denver, Colorado, United States


      National Jewish Health, Denver, Colorado


      Department of Radiology, National Jewish Health, Denver, Colorado

      4 National Jewish Health Main Campus, Denver, CO.

      National Jewish Health, 80206, Denver, CO, USA


      4 Department of Radiology, National Jewish Health, Denver, Colorado.

      National Jewish Health Department of Radiology Denver USA


      Department of Radiology, National Jewish Health


      National Jewish Health, Denver, CO USA

      Divisions of, Radiology


      Dept of Radiology, National Jewish Medical and Research Center, Denver, CO, USA

      Division of Radiology, National Jewish Health, Denver, Colorado

      Department of RadiologyNational Jewish Health, Denver, CO



      David A Lynch: Influence Statistics

      Sample of concepts for which David A Lynch is among the top experts in the world.
      Concept World rank
      trace emphysema #1
      86 participants ila #1
      emphysema deployers #1
      emphysema progression #1
      cc90001 placebo #1
      findings rheumatoid #1
      ipf specific findings #1
      nsip confident diagnosis #1
      tests genotype #1
      reticulation tissue characterization #1
      multicenter classification copd #1
      lung fwl #1
      mri lv volume #1
      standardization numbers #1
      slb specimens #1
      progression cpfe #1
      slb specimens risks #1
      cumulative rdm #1
      intersoftware #1
      inspiratory attenuation #1
      increased rdm #1
      probable uip category #1
      emphysema subsegmental #1
      patterns ggo #1
      adult patients bronchiolitis #1
      common complications mimics #1
      severity smokers #1
      specific findings #1
      begindocumentcscnn enddocument #1
      46 ppv #1
      degrees air trapping #1
      begindocumentescnn enddocument #1
      cle chest images #1
      hrct findings hp #1
      confident diagnosis nsip #1
      data frequency space #1
      semiquantitative ratio nonsmokers #1
      presence honeycombing #1
      participants emphysema #1
      cases lung function #1
      promising biomarker copd #1
      independent parameters d1 #1
      uip uip patterns #1
      lower quantitative #1
      randomized national #1
      centrilobular panlobular #1
      prevalence cpfe #1
      ila early #1
      uip predictor #1
      presence 1 ncn #1


      Prominent publications by David A Lynch

      KOL-Index: 16360

      PurposeWe retrospectively compared the survival rate in patients with non-small-cell lung cancer (NSCLC) treated with radiofrequency ablation (RFA), surgery, or chemotherapy according to lung cancer staging.Materials and MethodsFrom 2000 to 2004, 77 NSCLC patients, all of whom had WHO performance status 0–2 and were >60 years old, were enrolled in a cancer registry and retrospectively evaluated. RFA was performed on patients who had medical contraindications to surgery/unsuitability for ...

      Known for Lung Cancer | Radiofrequency Ablation | Chemotherapy Patients | Surgery Rfa | Small Cell
      KOL-Index: 15273

      BACKGROUND: Cigarette smoking is associated with emphysema and radiographic interstitial lung abnormalities. The degree to which interstitial lung abnormalities are associated with reduced total lung capacity and the extent of emphysema is not known.

      METHODS: We looked for interstitial lung abnormalities in 2416 (96%) of 2508 high-resolution computed tomographic (HRCT) scans of the lung obtained from a cohort of smokers. We used linear and logistic regression to evaluate the associations ...

      Known for Interstitial Lung Abnormalities | Lung Volumes | 95 P0001 | Emphysema Smokers | Hrct Scans
      KOL-Index: 14714

      Background CT is used to quantify abnormal changes in the lung parenchyma of smokers that might overlap chronic obstructive pulmonary disease (COPD), but studies on the progression of expiratory air trapping in smokers are scarce. Purpose To evaluate the relationship between longitudinal changes in forced expiratory volume in 1 second (FEV1) and CT-quantified emphysema and air trapping in smokers. Materials and Methods Cigarette smokers with and those without COPD participating in the ...

      Known for Air Trapping | Pulmonary Disease | Chronic Obstructive | Smokers Copd | Emphysema Progression
      KOL-Index: 14595

      BACKGROUND: The 5-year overall survival rate of lung cancer patients is approximately 15%. Most patients are diagnosed with advanced-stage disease and have shorter survival rates than patients with early-stage disease. Although screening for lung cancer has the potential to increase early diagnosis, it has not been shown to reduce lung cancer mortality rates. In 1993, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was initiated specifically to determine whether ...

      Known for Cancer Screening | Lung Colorectal | Current Smokers | Screen Detected | Small Cell
      KOL-Index: 14382

      RATIONALE: Former smoking history and chronic obstructive pulmonary disease (COPD) are potential risk factors for osteoporosis and fractures. Under existing guidelines for osteoporosis screening, women are included but men are not, and only current smoking is considered.

      OBJECTIVES: To demonstrate the impact of COPD and smoking history on the risk of osteoporosis and vertebral fracture in men and women.

      METHODS: Characteristics of participants with low volumetric bone mineral density ...

      Known for Vertebral Fractures | Bone Density | Copd Patients | Osteoporosis Risk | Current Smoking
      KOL-Index: 14248

      OBJECTIVE: This study evaluates the relationships between quantitative CT (QCT) and spirometric measurements of disease severity in cigarette smokers with and without chronic obstructive pulmonary disease (COPD).

      MATERIALS AND METHODS: Inspiratory and expiratory CT scans of 4062 subjects in the Genetic Epidemiology of COPD (COPDGene) Study were evaluated. Measures examined included emphysema, defined as the percentage of low-attenuation areas≤-950 HU on inspiratory CT, which we refer to ...

      Known for Air Trapping | Pulmonary Disease | Fev1 Fvc | Inspiratory Expiratory | Wall Area
      KOL-Index: 12907

      BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization, is of major importance. Severe pulmonary hypertension is an important complication of advanced COPD and predicts acute exacerbations, though pulmonary vascular abnormalities also occur early in the course of the disease. We hypothesized that a computed ...

      Known for Acute Exacerbations | Pa Ratio | Pulmonary Arterial Enlargement | Disease Copd | Lung Function
      KOL-Index: 12713

      OBJECTIVE: To assess the accuracy of high-resolution computed tomography (HRCT) in the diagnosis of nonspecific interstitial pneumonia (NSIP). We hypothesized that the computed tomography (CT) features of NSIP could be distinguished from those of usual interstitial pneumonia (UIP).

      METHODS: The HRCT images of 47 patients with surgical lung biopsy-proven NSIP (n = 25) and UIP (n = 22) were independently reviewed by 2 thoracic radiologists. Predominant imaging patterns, most likely ...

      Known for Usual Interstitial Pneumonia | Nsip Uip | Computed Tomography | Nonspecific Interstitial | Presence Honeycombing
      KOL-Index: 12682

      OBJECTIVE: We sought to characterize a novel cohort of patients with lung disease, anti-cyclic citrullinated peptide (CCP) antibody positivity, without rheumatoid arthritis (RA) or other connective tissue disease (CTD).

      METHODS: The study sample included 74 subjects with respiratory symptoms, evaluated January 2008-January 2010 and found to have a positive anti-CCP antibody but no evidence for RA or other CTD. Each underwent serologic testing, pulmonary physiology testing, and thoracic ...

      Known for Lung Disease | Connective Tissue | Rheumatoid Arthritis | Ctd Ild | Anti Ccp
      KOL-Index: 12672

      BACKGROUND: Interstitial lung disease (ILD) frequently complicates connective tissue diseases (CTDs). Glucocorticoids and immunomodulatory agents are regarded as mainstays of therapy for CTD-related ILD; however, apart from those studies that have evaluated certain medications for patients with scleroderma, few studies have been performed. In this study, our objectives were to examine the safety and tolerability of mycophenolate mofetil (MMF) and to determine its impact on lung function ...

      Known for Lung Function | Patients Mmf | Mycophenolate Mofetil | Connective Tissue | Ctd Ild
      KOL-Index: 12053

      RATIONALE: A significant proportion of smokers have lung function impairment characterized by a reduced FEV(1) with a preserved FEV(1)/FVC ratio. These smokers are a poorly characterized group due to their systematic exclusion from chronic obstructive pulmonary disease (COPD) studies.

      OBJECTIVES: To characterize the clinical, functional, and radiographic features of Global Initiative for Chronic Obstructive Lung Disease (GOLD)-Unclassified (FEV(1)/FVC ≥ 0.7 and FEV(1) < 80% predicted) ...

      Known for Copdgene Study | Subjects Copd | Reduced Fev1 | Smokers Lung | Aged Pulmonary
      KOL-Index: 11979

      OBJECTIVE: The purpose of this study was to prospectively see if quantitative computed tomography (QCT) could separate asthmatic patients from normal control subjects. The QCT results were also correlated with the pulmonary function tests (PFT) that were done on both the asthmatic patients and control subjects.

      SUBJECTS AND METHODS: Eighteen adult nonsmoking asthmatics and 22 adult control subjects were entered into the study. Quantitative CT was performed at the level of the transverse ...

      Known for Air Trapping | Asthmatic Patients | Quantitative Computed | Normal Subjects | Residual Volume
      KOL-Index: 11794

      PURPOSE: To evaluate computed tomographic (CT) findings of rheumatoid arthritis-related lung disease and categorize findings according to pathologic features.

      MATERIALS AND METHODS: CT scans obtained in 63 patients (27 men, 36 women; mean age, 61.7 years +/- 11.2 [SD]; range, 28-81 years) with rheumatoid arthritis were assessed. Mean duration of disease was 7.6 years +/- 9.2. Lung parenchymal abnormalities that included airspace consolidation, ground-glass opacity (GGO), reticulation, ...

      Known for Lung Diseases | Rheumatoid Arthritis | Interstitial Pneumonia | Chest Radiologists | Pathologic Features
      KOL-Index: 11650

      OBJECTIVES: The purposes of this study were to evaluate the reference range of quantitative computed tomography (QCT) measures of lung attenuation and airway parameter measurements in healthy nonsmoking adults and to identify sources of variation in those measures and possible means to adjust for them.

      MATERIALS AND METHODS: Within the COPDGene study, 92 healthy non-Hispanic white nonsmokers (29 men, 63 women; mean [SD] age, 62.7 [9.0] years; mean [SD] body mass index [BMI], 28.1 [5.1] ...

      Known for Quantitative Computed Tomography | Multivariate Analysis | Scanner Type | Lung Attenuation | Airway Wall Thickness

      Key People For Lung Disease

      Top KOLs in the world
      Athol Umfrey Wells
      idiopathic pulmonary fibrosis lung disease pulmonary hypertension
      Fernando J Martinez
      idiopathic pulmonary fibrosis chronic obstructive pulmonary disease
      Jay Hoon Ryu
      idiopathic pulmonary fibrosis lung disease rheumatoid arthritis
      David M Hansell
      computed tomography idiopathic pulmonary fibrosis lung cancer
      Kevin K Brown
      idiopathic pulmonary fibrosis lung disease interstitial pneumonia
      Roland M Du Bois
      idiopathic pulmonary fibrosis systemic sclerosis lung disease

      David A Lynch:Expert Impact

      Concepts for whichDavid A Lynchhas direct influence:Lung disease,  Pulmonary fibrosis,  Idiopathic pulmonary fibrosis,  Computed tomography,  Lung cancer,  Hypersensitivity pneumonitis,  Air trapping,  Fleischner society.

      David A Lynch:KOL impact

      Concepts related to the work of other authors for whichfor which David A Lynch has influence:Lung cancer,  Idiopathic pulmonary fibrosis,  Computed tomography,  Pulmonary disease,  Chronic obstructive,  Rheumatoid arthritis,  Interstitial pneumonia.



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      National Jewish Health, Radiology, Denver, Colorado, United States; lynchd@njhealth.org. | Department of Radiology, National Jewish Health, Denver, CO, USA | Department of Radiology, National Jewish Health, 1400 Jackson St, Denver, CO 80206 USA | Sch

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