Allan L CoatesShow email address
Division of Respiratory medicine, Dept of Pediatrics, Physiology and Environmental Medicine, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ...
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Allan L Coates:Expert Impact
Concepts for whichAllan L Coateshas direct influence:Cystic fibrosis,Lung function,Cardiac output,Emergency department,Pulse oximetry,Pulmonary function,Nutritional status,Patients cystic fibrosis.
Allan L Coates:KOL impact
Concepts related to the work of other authors for whichfor which Allan L Coates has influence:Lung function,Cystic fibrosis,Copd patients,Pulmonary disease,Chronic obstructive,Physical activity,Exercise capacity.
KOL Resume for Allan L Coates
Division of Respiratory medicine, Dept of Pediatrics, Physiology and Environmental Medicine, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Division of Respiratory Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
1 University of Toronto Toronto, Ontario, Canada.
Division of Respiratory Medicine, Translational Medicine, Research Institute-Hospital for Sick Children, University of Toronto, ON, Canada
Division of Respiratory Medicine, Department of Pediatrics, Physiology and Experimental Medicine, Research Institute–Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Hospital for Sick Children, Toronto, Ontario.
Pulmonary Function Laboratory of the Division of Respiratory Medicine University of Toronto Department of Pediatrics, Hospital for Sick Children Toronto Ontario Canada
Division of Respiratory Medicine,
Emeritus Scientist in the Division of Respiratory Medicine of the Department of Physiology and Experimental Medicine in the Research Institute at the Hospital for Sick Children, and Professor in the Department of Paediatrics at the University of Toronto in Ontario.
Physiology and Experimental Medicine–Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada, .
Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada
Professor Emeritus, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
Head, Division of Respiratory Medicine, Sellers Chair of Cystic Fibrosis
Pediatrician in Chief, Cardinal Glennon Children's Hospital, St. Louis, Missouri
Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Director, Breathing Institute, Children's Hospital Colorado, University of Colorado, Aurora, Colorado
Department of Physiology and Experimental Medicine [G.D.W.], Division of Respiratory Medicine [G.D.W., D.L.W., J.E.S., M.E., S.D., F.R., A.L.C.], Department of Diagnostic Imaging [T.R.], Department of Pediatrics [I.T.], The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8; Imaging Research Centre [M.D.N.], St. Joseph's Healthcare, Hamilton, Ontario, Canada L8N 4A6; Department of Laboratory Medicine and Pathobiology [I.T.], The University of Toronto, Toronto, Ontario, Canada M5G 1L5; Department of Respiratory Medicine [H.S.], The Children's Hospital at Westmead, Westmead 2145, Australia
Divisions of Nuclear Medicine and Respiratory Medicine, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada, .
Division of Respiratory Medicine, Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, University of Toronto, 555 University Avenue, Toronto Ontario M5G 1X8, Canada
Dept of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
Department of Physiology and Experimental Medicine; and
Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Canada
Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto.
The Lung Biology Program, Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, Canada.
Divisions of Respiratory Medicine and Lung Biology Research, Hospital for Sick Children, Research Institute, University of Toronto, Toronto, Canada
Divisions of Pediatric Emergency Medicine (Drs Scolnik and Schuh), Clinical Pharmacology and Toxicology (Dr Scolnik), and Respiratory Medicine (Dr Coates), the Research Institute (Drs Scolnik, Schuh, and Coates and Mr Stephens), Department of Respiratory Therapy (Ms Da Silva), and Department of Pediatrics (Drs Scolnik, Schuh, Lavine, and Coates), The Hospital for Sick Children, and University of Toronto, Toronto, Ontario.
Consultant Paediatric Chest Physician, Department of Paediatrics, Royal Brompton Hospital, London, United Kingdom
Director, Cincinnati Children's Research Foundation
INSERM U618, Tours, France
Professor and Chair, Department of Pediatrics, University of Cincinnati College of Medicine
aDivision of Intensive Care and Pulmonology, University Children’s Hospital, Basel, Switzerland, b Division of Respiratory Medicine,The Hospital for Sick Children, Toronto, Ontario, Canada
For affiliations, please see Acknowledgements section
Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
Department of Pediatrics, The Hospital for Sick Children
Divisions of Emergency, Respiratory Medicine, and Paediatric Medicine, the Paediatric Outcomes Research Team and Research Institute, The Hospital for Sick Children, and the Department of Pediatrics, University of Toronto, Ontario, Canada
From the Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto
Division of Respiratory Medicine, Hospital for Sick Children, 555 University Ave., Toronto Ontario M5G 1X8, Canada
Divisions of Respiratory Medicine and Lung Biology Research, The Hospital for Sick Children, Research Institute, and the University of Toronto, Toronto, Ontario, Canada
Division of Respiratory Medicine, Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada
Divisions of Respiratory Medicine, Montreal Children’s Hospitald-McGill University Research Institute, Montreal, Canada
Respiratory Medicine Division of Montreal Children's Hospital
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Prominent publications by Allan L Coates
The Long-Term Pulmonary Sequelae of Prematurity: The Role of Familial Airway Hyperreactivity and the Respiratory Distress Syndrome
[ PUBLICATION ]
Respiratory distress syndrome of the newborn, prematurity, and familial airway hyperreactivity may contribute to long-term pulmonary sequelae. We assessed the role of each by testing pulmonary function and airway reactivity in 11 prematurely born children who survived the respiratory distress syndrome and in 11 prematurely born children who had no neonatal respiratory disease, each of whom was paired with a sibling born at term. The subjects were between 7 and 12 years of age when ...
|Known for Respiratory Distress | Pulmonary Sequelae | Newborn Infant | Airway Reactivity | Expiratory Volume|
Inhaled mannitol has been developed for bronchial challenge testing in adults. This study determined if mannitol could identify children with active asthma and responsive to methacholine, and whether mannitol challenge was faster to complete than methacholine challenge. Twenty-five children (aged 6-13 years) responsive to methacholine and 10 nonasthmatic children unresponsive to methacholine were studied. The methacholine challenge (Cockcroft protocol) was followed by a mannitol ...
|Known for Inhaled Mannitol | Active Asthma | Challenge Children | 95 Confidence Interval | Bronchial Provocation|
Provocative Dose of Methacholine Causing a 20% Drop in FEV1 Should Be Used to Interpret Methacholine Challenge Tests with Modern Nebulizers
[ PUBLICATION ]
RATIONALE: The American Thoracic Society guidelines (1999) for methacholine challenge tests (MCTs) using the 2-minute tidal breathing protocol were developed for the now-obsolete English-Wright (EW) nebulizer. In addition, the guideline recommendation to use the provocative concentration of methacholine causing a 20% drop in FEV1 (PC20) rather than the provocative dose of methacholine causing a 20% drop in FEV1 (PD20) for determining the level of bronchial hyperresponsiveness has been ...
|Known for Provocative Dose | Methacholine Challenge Tests | Pd20 Pc20 | Airway Responsiveness | Asthma Bronchial|
[ PUBLICATION ]
Age-related reference ranges are useful for assessing growth in children. The LMS method is a popular technique for constructing growth charts that model the age-changing distribution of the measurement in terms of the median, coefficient of variation and skewness. Here the methodology is extended to references that depend on body size as well as age, by exploiting the flexibility of the generalised additive models for location, scale and shape (GAMLSS) technique. GAMLSS offers general ...
|Known for Height Age | Reference Ranges | Fev1 Fvc | Body Size | Lms Method|
Pulmonary function tests in adults with sickle cell disease have shown a restrictive pattern that has been attributed to the sequelae of acute chest syndrome (ACS). We compared pulmonary function test results in 37 children with sickle cell anemia (20 with SS hemoglobin (HbSS), 14 with SC hemoglobin, and 3 with S beta hemoglobin) with those in 22 control subjects matched for sex, race, and height and compared pulmonary function in patients with and without a history of ACS. Of the 10 ...
|Known for Pulmonary Function | Sickle Cell | Airway Obstruction | Patients Hbss | Total Lung Capacity|
High-Dose Inhaled Fluticasone Does Not Replace Oral Prednisolone in Children With Mild to Moderate Acute Asthma
[ PUBLICATION ]
BACKGROUND: Inhaled corticosteroids are not as effective as oral corticosteroids in school-aged children with severe acute asthma. It is uncertain how inhaled corticosteroids compare with oral corticosteroids in mild to moderate exacerbations.
PRIMARY OBJECTIVE: The purpose of this work was to determine whether there is a significant difference in the percentage of predicted forced expiratory volume in 1 second in children with mild to moderate acute asthma treated with either inhaled ...
|Known for Acute Asthma | Emergency Department | Inhaled Fluticasone | Oral Corticosteroids | Inhalation Administration|
Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department
[ PUBLICATION ]
Importance: While intravenous magnesium decreases hospitalizations in refractory pediatric acute asthma, it is variably used because of invasiveness and safety concerns. The benefit of nebulized magnesium to prevent hospitalization is unknown.
Objective: To evaluate the effectiveness of nebulized magnesium in children with acute asthma remaining in moderate or severe respiratory distress after initial therapy.
Design, Setting, and Participants: A randomized double-blind parallel-group ...
|Known for Refractory Acute Asthma | Emergency Department | Children Acute | Pram Score | Nebulized Magnesium|
Long-term pulmonary sequelae of premature birthwith and without idiopathic respiratory distress syndrome
[ PUBLICATION ]
Seven children born prematurely who survived the respiratory distress syndrome, seven children born prematurely who had no neonatal lung disease, and seven normal children born at term were studied by comparison of flow volume curves obtained while breathing air to those obtained while breathing 80% helium and 20% oxygen. Expiratory flow rates in air both groups of prematurely born children were lower than flow rates of the children born at term, and the volumes of iso-flow were higher ...
|Known for Respiratory Distress Syndrome | Newborn Infant | Flow Rates | Children Born | Pulmonary Sequelae|
ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests
[ PUBLICATION ]
This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of ...
|Known for Bronchial Challenge Testing | Methacholine Challenge | General Considerations | Ers Technical Standard | 20 Fall|
Initial evaluation of 22 patients with cystic fibrosis (CF) on entry into a trial of home oxygen therapy was used to elucidate the possible effects of poor nutritional status on exercise performance in CF. The patients had advanced lung disease (mean FEV1, 36 percent predicted) and all had a stable resting PaO2 less than or equal to 65 mm Hg. Nutritional status was determined by calculating weight as a percentage of ideal for height (Wt/Ht) for each subject. Exercise testing consisted of ...
|Known for Nutritional Status | Exercise Performance | Lung Function | Stroke Volume Sv | Cystic Fibrosis|
Accounting for Radioactivity before and after Nebulization of Tobramycin to Insure Accuracy of Quantification of Lung Deposition
[ PUBLICATION ]
The ability to predict drug deposition of inhaled drugs used in cystic fibrosis (CF) is important if there is a need to target specific doses of drug to the lungs of individual patients. The gold standard of measuring pulmonary deposition is the quantification of an aerosolized radiolabel either mixed with the drug solution or tagged directly to the compound of interest. Accuracy of the quantification could be assured if there is agreement between the amount of radioactivity before and ...
|Known for Lung Deposition | Cystic Fibrosis | Vaporizers Imaging Radiopharmaceuticals | Inhaled Drugs | Gold Standard|
[ PUBLICATION ]
RATIONALE: The Third National Health and Nutrition Examination Survey (NHANES III) reference is currently recommended for interpreting spirometry results, but it is limited by the lack of subjects younger than 8 years and does not continuously model spirometry across all ages.
OBJECTIVES: By collating pediatric data from other large-population surveys, we have investigated ways of developing reference ranges that more accurately describe the relationship between spirometric lung function ...
|Known for Reference Ranges | Height Age | Nhanes Iii | 4 Years | Values Spirometry|
Does the FEF25–75 or the FEF75 have any value in assessing lung disease in children with cystic fibrosis or asthma?
[ PUBLICATION ]
While the FEV1 had been recognized as an excellent indicator of disability, it is not very sensitive to early and mild disease. In cystic fibrosis (CF) small airway disease is believed to be one of the early hallmarks and indices such as the FEF25-75 and FEF75 have been proposed as sensitive markers of early disease. The site of early disease in asthma is not as well worked out. Recently a study of more than 20,000 spirometries found that neither of these indices added anything to the ...
|Known for Cystic Fibrosis | Lung Disease | Fev1 Fvc | Expiratory Volume Humans | Lower Limit|
Our objective was to study long-term respiratory outcomes of congenital diaphragmatic hernia (CDH) treated in the perinatal period. This was a cohort study with 26 adolescent survivors and age- and gender-matched controls. Medical histories were retrieved from hospital charts and questionnaires. Pulmonary function testing included measurement of maximum inspiratory and expiratory pressures (MIPS and MEPS) and maximum voluntary ventilation (MVV). Unpaired two-tailed t-test and nonlinear ...
|Known for Diaphragmatic Hernias | Pulmonary Morbidity | Residual Volume | Survivors Congenital | Lung Diseases|
The Effects of Nutritional Status and Hyperinflation on Respiratory Muscle Strength in Children and Young Adults
[ PUBLICATION ]
Malnutrition and hyperinflation may both lead to respiratory muscle weakness. To assess separately the effects of chronic hyperinflation and malnutrition on respiratory muscle strength (RMS), 22 subjects with cystic fibrosis (CF) with both hyperinflation and malnutrition were compared to 10 asthmatic patients, a group with hyperinflation without malnutrition, 9 subjects with anorexia nervosa (AN), a group with malnutrition without lung disease, and 14(6 males and 8 females) control ...
|Known for Nutritional Status | Respiratory Muscle | Hyperinflation Malnutrition | Bmp Piwt | Anorexia Nervosa|