• Disease
  • Lung
  • Lung Function
  • David Peter Strachan

    Prominent publications by David Peter Strachan

    KOL Index score: 17923

    BACKGROUND: Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). We used UK Biobank data to study the genetic causes of smoking behaviour and lung health.

    METHODS: We sampled individuals of European ancestry from UK Biobank, from the middle and extremes of the forced expiratory volume in 1 s (FEV1) distribution among heavy smokers (mean 35 pack-years) and never smokers. We ...

    Also Ranks for: Uk Biobank |  lung function |  genetic association |  smoking behaviour |  chronic obstructive
    KOL Index score: 15449

    BACKGROUND: As part of the International Study of Asthma and Allergies in Childhood (ISAAC), prevalence surveys were conducted among representative samples of school children from locations in Europe, Asia, Africa, Australia, North and South America.

    SUBJECTS: 257,800 children aged 6-7 years from 91 centres in 38 countries, and 463,801 children aged 13-14 years from 155 centres in 56 countries.

    METHODS: Written symptom questionnaires were translated from English into the local language ...

    Also Ranks for: Allergic Rhinoconjunctivitis |  international study |  prevalence rhinitis |  worldwide variations |  asthma allergies
    KOL Index score: 15443

    OBJECTIVE: To describe the incidence and prognosis of wheezing illness from birth to age 33 and the relation of incidence to perinatal, medical, social, environmental, and lifestyle factors.

    DESIGN: Prospective longitudinal study.

    SETTING: England, Scotland and Wales.

    SUBJECTS: 18,559 people born on 3-9 March 1958. 5801 (31%) contributed information at ages 7, 11, 16, 23, and 33 years. Attrition bias was evaluated using information on 14, 571 (79%) subjects.


    Also Ranks for: Wheezing Illness |  early childhood |  incidence age |  prognosis asthma |  fever eczema
    KOL Index score: 15362

    OBJECTIVE: To investigate variations in the prevalence of self reported symptoms, diagnosis, and treatment of asthma in 12-14 year old children.

    DESIGN: Self completion questionnaire.

    SETTING: Great Britain.

    SUBJECTS: All pupils aged 12-14 years in a stratified cluster sample of 93 large mixed secondary schools in 1995.

    MAIN OUTCOME MEASURES: Self reported prevalence of symptoms, diagnosis, and treatment of asthma at four geographical levels.

    RESULTS: 27,507 questionnaires were completed ...

    Also Ranks for: Asthma Symptoms |  great britain |  international study |  prevalence diagnosis |  14 year
    KOL Index score: 15254

    BACKGROUND: A study was undertaken to investigate the relationship between daily hospital admissions for asthma and air pollution in London in 1987-92 and the possible confounding and modifying effects of airborne pollen.

    METHODS: For all ages together and the age groups 0-14, 15-64 and 65+ years, Poisson regression was used to estimate the relative risk of daily asthma admissions associated with changes in ozone, sulphur dioxide, nitrogen dioxide and particles (black smoke), controlling ...

    Also Ranks for: Air Pollution |  daily admissions |  nitrogen dioxide |  asthma london |  black smoke
    KOL Index score: 15113

    BACKGROUND: Data for trends in prevalence of asthma, allergic rhinoconjunctivitis, and eczema over time are scarce. We repeated the International Study of Asthma and Allergies in Childhood (ISAAC) at least 5 years after Phase One, to examine changes in the prevalence of symptoms of these disorders.

    METHODS: For the ISAAC Phase Three study, between 2002 and 2003, we did a cross-sectional questionnaire survey of 193,404 children aged 6-7 years from 66 centres in 37 countries, and 304,679 ...

    Also Ranks for: Isaac Phase |  prevalence symptoms |  sectional surveys |  allergic rhinoconjunctivitis |  time trends
    KOL Index score: 14568

    BACKGROUND: Associations between traffic pollution on the street of residence and a range of respiratory and allergic outcomes in children have been reported in developed countries, but little is known about such associations in developing countries.

    METHODS: The third phase of the International Study of Asthma and Allergies in Childhood (ISAAC) was carried out in 13- to 14-year-old and 6- to 7-year-old children across the world. A question about frequency of truck traffic on the street ...

    Also Ranks for: Truck Traffic |  isaac phase |  symptoms asthma |  questionnaires vehicle emissions |  rhinoconjunctivitis eczema
    KOL Index score: 14523

    International comparative studies, investigating whether disease incidence or prevalence rates differ between populations and, if so, which factors explain the observed differences, have made important contributions to the understanding of disease aetiology in many areas. In Phase I of the International Study of Asthma and Allergies in Childhood (ISAAC), the prevalence rates of symptoms of asthma, allergic rhinitis and atopic eczema in 13-14-yr-olds, assessed by standardised ...

    Also Ranks for: International Study |  asthma allergies |  prevalence rates |  atopic eczema |  childhood isaac
    KOL Index score: 14371

    OBJECTIVE: To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors.

    DESIGN: Cross sectional study of a population based random sample of men. Coronary heart disease was assessed by electrocardiography, Rose angina questionnaire, and a history of myocardial infarction; serum antibody levels to H pylori and C pneumoniae were measured, risk factor levels ...

    Also Ranks for: Cardiovascular Risk Factors |  coronary heart disease |  helicobacter pylori |  pneumoniae infections |  outcome measures
    KOL Index score: 13609

    BACKGROUND: Patterns of wheezing during early childhood may indicate differences in aetiology and prognosis of respiratory illnesses. Improved characterisation of wheezing phenotypes could lead to the identification of environmental influences on the development of asthma and airway diseases in predisposed individuals.

    METHODS: Data collected on wheezing at seven time points from birth to 7 years from 6265 children in a longitudinal birth cohort (the ALSPAC study) were analysed. Latent ...

    Also Ranks for: Airway Responsiveness |  wheezing phenotypes |  6 years |  lung function |  early childhood
    KOL Index score: 13482

    BACKGROUND: We recently found that paracetamol (acetaminophen) use in late pregnancy was associated with an increased risk of early wheezing in the offspring.

    OBJECTIVE: To see whether use of paracetamol in late pregnancy is associated with an increased risk of asthma, wheezing and other atopic outcomes in the child at school age.

    METHODS: In the population-based Avon Longitudinal Study of Parents and Children, we measured associations of paracetamol and aspirin use in late pregnancy ...

    Also Ranks for: Paracetamol Exposure |  late pregnancy |  asthma wheezing |  school age |  children mothers
    KOL Index score: 13378

    Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals ...

    Also Ranks for: Bmi Whradjbmi |  body size |  genetic associations |  sex age |  interaction study
    KOL Index score: 13129

    Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with ...

    Also Ranks for: Genetic Loci |  bmi young adult |  weight gain |  european ancestry |  tnni3k sec16b
    KOL Index score: 13080

    OBJECTIVE: To investigate the extent to which geographical variations in mortality from ischaemic heart disease and stroke in Britain are influenced by factors in early life or in adulthood.

    DESIGN: Longitudinal study of migrants.

    SUBJECTS: 1% sample of residents in England and Wales born before October 1939 and enumerated at the 1971 census (the Office of Population Censuses and Surveys' longitudinal study).

    MAIN OUTCOME MEASURE: 18,221 deaths from ischaemic heart disease and 9899 ...

    Also Ranks for: Cardiovascular Disease |  greater london |  england wales |  geographical variations |  interregional migrants


    David Peter Strachan: Influence Statistics

    Sample of concepts for which David Peter Strachan is among the top experts in the world.
    Concept World rank
    onset analysis allergic #1
    atopic eczema allergic #1
    allergic rhinoconjunctivitis childhood #1
    logtransformed ige #1
    unpasteurized milk consumption #1
    seasonal allergens atopy #1
    child comorbidity crp #1
    synthetic associations variants #1
    control controlled environmental #1
    increases disorders #1
    95 hseshs #1
    antibacterials vaccinations #1
    clinical correlates bhr #1
    replication populations rs1588265 #1
    bhr classes #1
    asthma prevalence trends #1
    gram control #1
    rhas england #1
    atopy cigarette smoking #1
    respiratory insufficiency chlamydia #1
    rs1132200 #1
    risk hayfever #1
    primary exposures infections #1
    adjustment ffmi #1
    individuals greater london #1
    beta2‐adrenergic receptor #1
    illness british children #1
    total ige boys #1
    severe wheeze phase #1
    global associations #1
    components large cohort #1
    children farm exposure #1
    dpp10 adam33 #1
    reduced risk atopy #1
    male saliva edinburgh #1
    brothers trend #1
    healthy british adults #1
    infancy fever #1
    fever size #1
    mattress dust activeintervention #1
    cb stxbp5 #1
    ages strongest associations #1
    dampness relation #1
    isaac adolescents #1
    early exposures geohelminths #1
    greater london migrants #1
    rhinoconjunctivitis orad #1
    diseases sevenyear period #1
    acorn postcode linkage #1
    isaac allergic #1

    Key People For Lung Function

    Top KOLs in the world
    John L Hankinson
    lung function coal miners airway obstruction
    Paul L Enright
    cardiovascular health study lung function airway obstruction
    Ole Find Pedersen
    gas films acoustic rhinometry nasal cavity
    Robert O Crapo
    pulmonary function airway obstruction diffusing capacity
    Allan L Coates
    cystic fibrosis lung function cardiac output
    Per Magnus Gustafsson
    cystic fibrosis lung clearance ventilation inhomogeneity

    David Peter Strachan:Expert Impact

    Concepts for whichDavid Peter Strachanhas direct influence:Lung function,  International study,  Air pollution,  Atopic eczema,  Greater london,  Blood pressure,  Uk biobank,  Genetic loci.

    David Peter Strachan:KOL impact

    Concepts related to the work of other authors for whichfor which David Peter Strachan has influence:Atopic dermatitis,  Allergic rhinitis,  Lung function,  Genetic variants,  Air pollution,  Blood pressure,  Type 2 diabetes.



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    Population Health Research Institute, St George’s, University of London, Cranmer Terrace, London, SW17 0RE, UK | Full professor. | Population Health Research Institute, St George's, University of London, London, UK. | Population Health Research Insti