Prominent publications by J Gareth Jones

KOL Index score: 10713

Chest wall movement, partitioned into rib cage and abdomen/diaphragm contributions, was measured using four mercury-in-rubber strain gauges and an analog computer. The relative volume contribution of the rib cage and the abdomen/diaphragm to tidal volume was measured in 13 subjects before and during anaesthesia with thiopentone and halothane. In awake subjects, movement of the abdomen/diaphragm contributed more than 70% of the tidal volume, the smaller rib cage contribution ranged from 5 ...

Known for Rib Cage |  Halothane Anaesthesia |  Tidal Volume |  Paradoxical Breathing |  Subjects Increase
KOL Index score: 8717

We have developed a method for the measurement of respiratory resistance and specific airways conductance (s.Gaw) using the forced airflow oscillation method, and have used it to study the effects of halothane and enflurane on airway mechanics in anaesthetized patients. Resistance (Rrs) was determined over a range of lung volumes and s.Gaw was obtained by computer-aided analysis of the hyperbolic relationship between Rrs and lung volume. Patients received diazepam orally, followed by ...

Known for Halothane Enflurane |  Bronchomotor Tone |  Resistance Anesthesia |  10 Patients |  Specific Conductance
KOL Index score: 8124

Alveolar fluid and plasma proteins were analyzed in 24 patients with florid pulmonary edema, in 21 of whom pulmonary capillary wedge pressure (Pcw) was also measured. In all patients with Pcw less than 20 mm Hg, the edema fluid to plasma protein ratio exceeded 0.6; the mean edema fluid to plasma protein ratio in the four patients with cardiogenic edema (increased Pcw) was 0.46. In the 21 patients in whom full data were available, the net intravascular filtration force (Pcw - plasma ...

Known for Edema Fluid |  Osmotic Pressure |  Protein Ratio |  Patients Pulmonary |  Increased Permeability
KOL Index score: 8057

The effect of increasing end-tidal enflurane concentration on the auditory evoked response was studied in six patients. After a standard induction, anesthesia was maintained with 70% nitrous oxide in oxygen and the end-tidal enflurane concentration was increased gradually from 0 to 1% over a period of 30 min. The averaged auditory evoked response was derived from the electroencephalogram and measurements were made of the latencies and amplitudes of waves I, III, V, Pa and Nb within the ...

Known for Auditory Evoked Response |  Pa Nb |  Latencies Amplitudes |  Waves Iii |  Enflurane Evoked
KOL Index score: 7749

The respiratory effects of two postoperative analgesic regimens were compared in two groups of 16 patients each, recovering from general anesthesia and major surgery. One group received a pain-relieving dose of iv morphine (mean, 18.1 mg), with the same dose repeated as a continuous intravenous infusion over the subsequent 24 h. The other group received regional anesthesia using bupivacaine. The patients were monitored for 16 h after surgery. The two analgesic regimens provided patients ...

Known for Regional Anesthesia |  Patients Morphine |  Respiratory Effects |  Episodic Oxygen Desaturation |  Ventilatory Pattern
KOL Index score: 7743

The effects of increasing concentrations of halothane and enflurane on selected components of the auditory evoked response were studied in 12 patients; six received halothane and six enflurane. After the induction of anaesthesia with thiopentone, anaesthesia was maintained with 70% nitrous oxide in oxygen. Ventilation was controlled. The inspired concentration of the inhalation agent was increased incrementally, halothane in steps of 0.5% up to 2.5%, and enflurane in steps of 1% up to ...

Known for Controlled Ventilation |  Halothane Enflurane |  Pa Nb |  Evoked Potentials |  Waves Iii
KOL Index score: 7261

Pulmonary fat embolism occurs frequently after trauma but its functional significance is often unclear. To obtain direct evidence of lung damage caused by fat embolism we have measured changes in permeability of the alveolar-capillary interface. A permeability index was derived from the half time clearance from lung to blood (T1/2LB) of 99mTcDTPA introduced into the lung in a 1 ml bolus. Three groups of rabbits were studied. Baseline T1/2LB. did not differ significantly between groups. ...

Known for Oleic Acid |  Fat Embolism |  Lung Damage |  Epithelial Permeability |  Animals Capillary
KOL Index score: 6784

Previous studies have shown a dose-related effect of a number of general anaesthetic agents on the early cortical waves in the auditory evoked response (AER). In this study the effect of surgical stimulation on these waves was examined in 11 patients anaesthetized with thiopentone, nitrous oxide and halothane and paralysed with pancuronium. The inspired nitrous oxide concentration and end-tidal halothane concentration were held constant at 70% and 0.3%, respectively, and baseline AER ...

Known for Surgical Stimulation |  Auditory Evoked Response |  Amplitude Waves |  Nitrous Oxide |  Anaesthetic Concentration
KOL Index score: 6593

We have examined the effects of isoflurane (0.6-2.9% end-tidal) on the auditory evoked response (AER) in six patients before elective surgery. Isoflurane produced significant dose-related changes in the AER: reductions in amplitude and increases in latency of the cortical waves Pa and Nb, and increases in the latency of the brainstem waves III and V. When isoflurane was compared with halothane and enflurane using an MAC-based comparison, we found no differences in the effect of the three ...

Known for Auditory Evoked Response |  Cortical Waves |  Drug Evoked Potentials |  Elective Surgery |  Isoflurane Halothane
KOL Index score: 5902

In anesthetized rabbits we measured clearance from lung to blood of eight aerosolized technetium-99m-labeled compounds: diethylenetriaminepentaacetate (99mTc-DTPA); cytochrome c; myoglobin; a myoglobin polymer; albumin; and anionic, cationic, and neutral dextrans of equivalent molecular size. We investigated the effect of applying positive end-expiratory pressure (PEEP) and, on a subsequent occasion, of injecting oleic acid intravenously to produce acute lung injury on the pulmonary ...

Known for Pulmonary Clearance |  Acute Lung Injury |  Oleic Acid |  Positive Endexpiratory Pressure |  Lung Male
KOL Index score: 5831

A new, non-invasive method of measuring pulmonary epithelial damage in man was compared with traditional tests of small-airway function. Pulmonary epithelial permeability was expressed as the half-time clearance from the lung into blood of (99m)Tc-diethylene triaminepenta-acetic acid ((99m)Tc-DTPA) deposited predominantly in the alveoli from an inhaled aerosol.Recovery from abnormal pulmonary permeability was recorded after stopping smoking for 21 days in a group of young symptomless ...

Known for Epithelial Permeability |  Time Clearance |  Airway Function |  Lung Blood |  Inhaled Aerosol
KOL Index score: 5777

The latency of the early cortical wave Nb of the auditory evoked response (AER) was compared with responses to Tunstall's isolated forearm test, while the concentration of nitrous oxide was progressively reduced during light anaesthesia in seven patients. A threshold Nb latency of 44.5 ms was chosen to discriminate between an early cortical AER containing three waves and that with two waves of longer latency. When Nb latency decreased below this threshold, four of the patients has ...

Known for Auditory Evoked Response |  Nb Latency |  Nitrous Oxide |  Anaesthesia Awareness |  Publication Anesthesia
KOL Index score: 5669

Lung injury and pulmonary edema were induced in rats after intraperitoneal injection of 10 mg/kg alpha-naphthylthiourea (ANTU). The time course of development of lung injury was assessed by the clearance of 99mTc-diethylenetriamine pentaacetate (99mTcDTPA) from the lung into the blood, the pharmacokinetics of tritiated prostaglandin E2 [( 3H]PGE2) in the isolated perfused lung, and by increase in the weight ratio (wet-to-dry) of lung. Two hours after ANTU administration, the clearance of ...

Known for Lung Injury |  Pulmonary Edema |  Antu Administration |  Weight Ratio |  Capillary Permeability
KOL Index score: 5259

The pattern of ventilation was studied in eight healthy male volunteers breathing, in sequence, air and then two subanaesthetic concentrations of nitrous oxide (20% and 40%). The effect of these gas mixtures on the response to an added inspiratory resistance (3.88 kPa litre-1s-1) was examined. During unrestricted breathing of 40% nitrous oxide, there was a significant decrease (P less than 0.05) in inspiratory time (TI), a concomitant increase in the rate of ventilation and a significant ...

Known for Nitrous Oxide |  Tidal Volume |  Inspiratory Resistance |  Gas Mixture |  Pulmonary Ventilation
KOL Index score: 5222

The effect of etomidate on the auditory evoked response was examined in a double-blind study carried out before the start of surgery. Fourteen patients were anaesthetized with 70% nitrous oxide and oxygen after induction with thiopentone. Ventilation was controlled. Seven of the patients received a continuous infusion of etomidate, increasing in five equal steps from 0.01 mg kg-1 min-1 to 0.05 mg kg-1 min-1 over a period of 50 min. The other seven received similarly an equivalent volume ...

Known for Auditory Evoked Response |  Patients Etomidate |  Latencies Peaks |  Evoked Potentials |  Brain Stem


J Gareth Jones: Influence Statistics

Sample of concepts for which J Gareth Jones is among the top experts in the world.
Concept World rank
beneficial anaesthesia #1
permeability intravenous injection #1
300 triolein #1
large carboxyhaemoglobin values #1
enflurane controlled #1
relative volume contribution #1
closing volume vagus #1
1 90 micrograms #1
aer althesin #1
nicotine striking contrast #1
rrs vl #1
oxygen beneficial #1
brainstem waves iii #1
increase bronchomotor tone #1
light anaesthesia patients #1
clearance lung #1
glaucine placebo #1
glaucine bronchomotor #1
sglaw histamine #1
oxygen gradual improvement #1
permeability alveolarcapillary interface #1
antitussive agent glaucine #1
1 kpa litre−1 #1
cage subjects #1
waves iii pa #1
extensive embolisation triolein #1
baseline 2lb #1
blood 99mtcdtpa #1
aer publication anesthesia #1
lower airways conductance #1
hms excellent #1
early cortical wave #1
resistance antitussive #1
thiopentone ventilation #1
placebo sglaw #1
monoxide subjects #1
increased clearance lung #1
congestion airway #1
diethylenetriamine penta acetate #1
triolein permeability #1
etomidate saline #1
naloxone reverse #1
paired test enflurane #1

Key People For Auditory Evoked Response

Top KOLs in the world
Terence W Picton
evoked potentials auditory steady state responses
Robert Galambos
evoked potentials phase coherence auditory cortex
Steven A Hillyard
selective attention visual cortex evoked potentials
Walter Ritter
mismatch negativity evoked potentials reaction time
Risto Näätänen
mismatch negativity auditory cortex evoked potentials
Arnold Starr
evoked potentials auditory neuropathy binaural interaction

J Gareth Jones:Expert Impact

Concepts for whichJ Gareth Joneshas direct influence:Auditory evoked response,  Rib cage,  Lung volume,  Bronchomotor tone,  Surgical stimulation,  Gas exchange,  Oleic acid,  Carbon monoxide.

J Gareth Jones:KOL impact

Concepts related to the work of other authors for whichfor which J Gareth Jones has influence:Pulmonary edema,  Lung injury,  Evoked potentials,  Cigarette smoke,  General anesthesia,  Nitrous oxide,  Epithelial permeability.



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Division of Anaesthesia, Northwick Park Hospital, Harrow, Middlesex, United Kingdom. | Clinical Research Centre and Northwick Park HospitalWatford Road, Harrow, Middlesex HA1 3UJ | Department of Anaesthesia, University of Leeds24, Hyde Terrace, Leeds

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