Vivette Denise D’Agati: Influence Statistics

Vivette Denise D’Agati

Vivette Denise D’Agati

Department of Pathology and Cell Biology, Columbia University, New York, New York, USA. | Department of Pathology and Cell Biology, Columbia University Irving Medical Center, ...

Vivette Denise D’Agati: Expert Impact

Concepts for which Vivette Denise D’Agati has direct influence: Kidney injury , Kidney disease , Nephrotic syndrome , Lupus nephritis , Iga nephropathy , Reperfusion injury , Focal segmental .

Vivette Denise D’Agati: KOL impact

Concepts related to the work of other authors for which for which Vivette Denise D’Agati has influence: Lupus nephritis , Kidney disease , Nephrotic syndrome , Diabetic nephropathy , Renal function , Oxidative stress , Gene expression .

KOL Resume for Vivette Denise D’Agati

Year
2022

Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.

2021

Department of Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA

2020

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY, USA

Columbia University School of Medicine, New York City, New York.

2019

Department of Pathology, Columbia University Medical Center, New York, NY

Renal Pathology Laboratory, Columbia University Medical Center, New York, New York, USA.

Columbia University School of Medicine, New York City, New York

2018

Department of Pathology Cell Biology, Columbia University Medical Center, New York, New York, USA

Pathology and.

2017

Department of Pathology, Renal Pathology Laboratory, Columbia University College of Physicians and Surgeons, New York, NY

From Columbia University, New York, New York; VU University Medical Center, Amsterdam, the Netherlands; Nephrology Associates, Newark, Delaware; Krysiewicza Children's Hospital, Poznań, Poland; Poznań University of Medical Sciences and Center for Medical Genetics GENESIS, Poznań, Poland; IRCCS Giannina Gaslini Children's Hospital, Genova, Italy; IRCCS San Raffaele Scientific Institute, Milan, Italy; New York University School of Medicine, New York, New York; University of Texas Southwestern Medical Center, Dallas, Texas; and French Institute of Health and Medical Research (INSERM) U1163, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, and Necker Hospital, Paris, France.

2016

Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA

Renal Pathology Laboratory, College of Physicians and Surgeons, Columbia University, New York, New York

Pathology.

2015

Department of Pathology, Columbia University Medical Center, New York, New York;

Mayo Clinic, Rochester, Minnesota

2014

Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York

Prominent publications by Vivette Denise D’Agati

KOL-Index: 19137 . BACKGROUND: Normal human podocytes are terminally differentiated and quiescent cells. It is not known why podocytes fail to proliferate in response to most forms of injury. Proliferation is regulated by cell cycle proteins and their inhibitors. The Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27, p57) in general prevent proliferation by inhibiting cyclin-CDK complexes. ...
Known for Podocyte Proliferation | Kinase Inhibitor | Glomerular Disease | P27 P57
KOL-Index: 15790 . GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud (UB) branching morphogenesis during kidney development in mice and humans. Furthermore, many other mutant genes that cause renal agenesis exert their effects via the GDNF/RET pathway. Therefore, RET signaling is believed to play a central role in renal organogenesis. Here, we re-examine the extent to ...
Known for Kidney Development | Gdnf Ret | Renal Agenesis | Etv4 Etv5
KOL-Index: 15400 . There is very limited human renal sodium gradient-dependent glucose transporter protein (SGLT2) mRNA and protein expression data reported in the literature. The first aim of this study was to determine SGLT2 mRNA and protein levels in human and animal models of diabetic nephropathy. We have found that the expression of SGLT2 mRNA and protein is increased in renal biopsies from human ...
Known for Diabetic Nephropathy | Sglt2 Inhibition | Renal Lipid | Protein Expression
KOL-Index: 14848 . The receptor for advanced glycation end-products (RAGE) has been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury in the isolated perfused heart. To test the hypothesis that RAGE-dependent mechanisms modulated responses to I/R in a murine model of transient occlusion and reperfusion of the left anterior descending coronary artery (LAD), we subjected male homozygous ...
Known for Myocardial Injury | Murine Model | Rage Mice | 48 Reperfusion
KOL-Index: 14155 . We showed previously that activation of A(1) adenosine receptors (AR) protects against renal ischemia-reperfusion (IR) injury in rats and mice. In the heart, transient A(1)AR activation produces biphasic protective effects: acute protection wanes after several hours but protective effects return 24-72 h later (second window of protection). In this study, we determined whether A(1)AR ...
Known for Renal Protection | Adenosine Receptors | A1ar Activation | Reperfusion Injury
KOL-Index: 14145 . BACKGROUND AND OBJECTIVES: Renal biopsies performed in diabetic patients are increasing in number and complexity. This study sought to determine the usefulness of renal biopsy in patients with diabetes and the predictability of diagnosing diabetic nephropathy (DN) versus nondiabetic renal disease (NDRD) from clinical and laboratory data. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: To ...
Known for Dn Ndrd | Renal Biopsy | Modern Spectrum | Hypertensive Nephrosclerosis
KOL-Index: 14057 . Acute as well as delayed ischemic preconditioning (IPC) provides protection against cardiac and neuronal ischemia reperfusion (IR) injury. This study determined whether delayed preconditioning occurs in the kidney and further elucidated the mechanisms of renal IPC in mice. Mice were subjected to IPC (four cycles of 5 min of ischemia and reperfusion) and then to 30 min of renal ischemia ...
Known for Renal Ischemia | Reperfusion Injury | Ischemic Preconditioning | Delayed Ipc
KOL-Index: 13888 . During kidney development, factors from the metanephric mesenchyme induce the growth and repeated branching of the ureteric bud, which gives rise to the collecting duct system and also induces nephrogenesis. One signaling pathway known to be required for this process includes the receptor tyrosine kinase RET and co-receptor GFR(&agr)-1, which are expressed in the ureteric bud, and the ...
Known for Ureteric Bud | Ret Receptor | Knockout Mice | Kidney Development
KOL-Index: 13396 . GATA-1 is a zinc-finger transcription factor believed to play an important role in gene regulation during the development of erythroid cells, megakaryocytes and mast cells. Other members of the GATA family, which can bind to the same DNA sequence motif, are co-expressed in several of these hemopoietic lineages, raising the possibility of overlap in function. To examine the specific roles ...
Known for Hematopoietic Cells | Cell Differentiation | Role Gata1 | Megakaryocytes Mice
KOL-Index: 13200 . Obesity and diabetes mellitus are the leading causes of renal disease. In this study, we determined the regulation and role of the G protein-coupled bile acid receptor TGR5, previously shown to be regulated by high glucose and/or fatty acids, in obesity-related glomerulopathy (ORG) and diabetic nephropathy (DN). Treatment of diabetic db/db mice with the selective TGR5 agonist INT-777 ...
Known for Kidney Disease | Tgr5 Activation | Bile Acid | Oxidative Stress
KOL-Index: 13197 . Advanced glycation end products (AGE) contribute to diabetic tissue injury by two major mechanisms, i.e., the alteration of extracellular matrix architecture through nonenzymatic glycation, with formation of protein crosslinks, and the modulation of cellular functions through interactions with specific cell surface receptors, the best characterized of which is the receptor for AGE (RAGE). ...
Known for Diabetic Nephropathy | Age Rage | Advanced Glycation | Lupus Nephritis
KOL-Index: 13192 . Cellular migration is a fundamental process linked to diverse pathological states such as diabetes and its complications, atherosclerosis, inflammation, and cancer. The receptor for advanced glycation end products (RAGE) is a multiligand cell surface macromolecule which binds distinct ligands that accumulate in these settings. RAGE-ligand interaction evokes central changes in key ...
Known for Cytoplasmic Domain | Cellular Migration | Rac1 Cdc42 | Binding Protein
KOL-Index: 13177 . Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective roles in diabetes- and obesity-related kidney disease. Here, we determined whether these effects are mediated through differential or synergistic signaling pathways. We administered the FXR/TGR5 dual agonist INT-767 ...
Known for Fxr Tgr5 | Messenger Receptors | Diabetic Mice | Bile Acids
KOL-Index: 12984 . Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eligible to receive an allograft based on a negative complement-dependent ...
Known for Patients Dsa | Donor Kidney | Transplantation Spa | Graft Survival

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Department of Pathology and Cell Biology, Columbia University, New York, New York, USA. | Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York. | Department of Pathology, Columbia University Medical