Prominent publications by Peter J Krause

KOL Index score: 14075

Babesia microti and Borrelia burgdorferi, the respective causative agents of human babesiosis and Lyme disease, are maintained in their enzootic cycles by the blacklegged tick (Ixodes scapularis) and use the white-footed mouse (Peromyscus leucopus) as primary reservoir host. The geographic range of both pathogens has expanded in the United States, but the spread of babesiosis has lagged behind that of Lyme disease. Several studies have estimated the basic reproduction number (R0) for B. ...

闻名 United States |  babesia microti |  borrelia burgdorferi |  lyme disease |  peromyscus leucopus
KOL Index score: 12896

Babesia microti, the primary cause of human babesiosis in the United States, is transmitted by Ixodes scapularis ticks; transmission may also occur through blood transfusion and transplacentally. Most infected people experience a viral-like illness that resolves without complication, but those who are immunocompromised may develop a serious and prolonged illness that is sometimes fatal. The geographic expansion and increasing incidence of human babesiosis in the northeastern and ...

闻名 Babesia Microti |  quantitative pcr |  human babesiosis |  ixodes scapularis |  united states
KOL Index score: 12816

BACKGROUND: The tick-borne pathogen Babesia microti has become recognized as the leading infectious risk associated with blood transfusion in the United States, yet no Food and Drug Administration-licensed screening tests are currently available to mitigate this risk. The aim of this study was to evaluate the performance of an investigational enzyme immunoassay (EIA) for B. microti as a screening test applied to endemic and nonendemic blood donor populations.


闻名 United States |  babesia microti |  blood donors |  new york |  enzyme immunoassay
KOL Index score: 12743

BACKGROUND: Transfusion-transmitted babesiosis caused by Babesia microti has emerged as a significant risk to the US blood supply. This study estimated the prevalence of B. microti antibodies in blood donors using an investigational enzyme immunoassay (EIA).

STUDY DESIGN AND METHODS: A peptide-based EIA that detects both immunoglobulin (Ig)G and IgM antibodies to B. microti was developed and validated. Donor samples randomly selected from areas defined as high-risk endemic, lower-risk ...

闻名 Babesia Microti |  investigational enzyme |  blood donor |  pcr eia |  transmitted babesiosis
KOL Index score: 12700

Objective. —To determine whether patients coinfected with Lyme disease and babesiosis in sites where both diseases are zoonotic experience a greater number of symptoms for a longer period of time than those with either infection alone.Design. —Community-based yearly serosurvey and clinic-based cohort study.Setting. —Island community in Rhode Island and 2 Connecticut medical clinics from 1990 to 1994.Study Participants. —Long-term residents of the island community and patients seeking ...

闻名 Lyme Disease |  increased severity |  babesiosis patients |  duration symptoms |  rhode island
KOL Index score: 12697

We used multiparameter flow cytometry to characterize leukocyte immunophenotypes and cytokines in skin and peripheral blood of patients with erythema migrans (EM). Dermal leukocytes and cytokines were assessed in fluids aspirated from epidermal suction blisters raised over EM lesions and skin of uninfected controls. Compared with corresponding peripheral blood, EM infiltrates were enriched for T cells, monocytes/macrophages, and dendritic cells (DCs), contained lower proportions of ...

闻名 Erythema Migrans |  adaptive immunity |  tolllike receptor |  peripheral blood |  cell surface
KOL Index score: 11980

Borrelia miyamotoi is a relapsing fever Borrelia group spirochete that is transmitted by the same hard-bodied (ixodid) tick species that transmit the agents of Lyme disease. It was discovered in 1994 in Ixodes persulcatus ticks in Japan. B. miyamotoi species phylogenetically cluster with the relapsing fever group spirochetes, which usually are transmitted by soft-bodied (argasid) ticks or lice. B. miyamotoi infects at least six Ixodes tick species in North America and Eurasia that ...

闻名 Miyamotoi Infection |  united states |  relapsing fever |  tick species |  lyme disease
KOL Index score: 11742

To determine whether human Borrelia miyamotoi infection occurs in the far-western United States, we tested archived sera from northwestern California residents for antibodies to this emerging relapsing fever spirochete. These residents frequently were exposed to I. pacificus ticks in a region where B. miyamotoi tick infection has been reported. We used a two-step B. miyamotoi rGlpQ assay and a B. miyamotoi whole-cell lysate (WCL) assay to detect B. miyamotoi antibody. We also employed ...

闻名 Borrelia Miyamotoi |  united states |  pacificus ticks |  infections california |  relapsing fever
KOL Index score: 11024

BACKGROUND: Babesiosis is an emerging tickborne malaria-like infection principally caused by Babesia microti. This infection typically resolves either spontaneously or after administration of a 7-10-day course of azithromycin plus atovaquone or clindamycin plus quinine. Although certain highly immunocompromised patients may respond suboptimally to these drug regimens, unlike the situation with malaria there has been no reported evidence that the cause of treatment failure is infection ...

闻名 Babesia Microti |  treatment babesiosis |  immunocompromised patients |  atovaquone azithromycin |  drug therapy
KOL Index score: 10553

BACKGROUND: Babesiosis is a tick-borne, malaria-like illness known to be enzootic in southern New England. A course of clindamycin and quinine is the standard treatment, but this regimen frequently causes adverse reactions and occasionally fails. A promising alternative treatment is atovaquone plus azithromycin.

METHODS: We conducted a prospective, nonblinded, randomized trial of the two regimens in 58 subjects with non-life-threatening babesiosis on Nantucket, on Block Island, and in ...

闻名 Clindamycin Quinine |  atovaquone azithromycin |  treatment babesiosis |  protozoan drug therapy |  southern new england
KOL Index score: 9780

OBJECTIVE: A recombinant lipoprotein outer surface protein A (OspA) Lyme disease (LD) vaccine (LYMErix) has been shown to be safe and effective in preventing LD in adults and in adolescents 15 years of age and older. Children are at risk for developing LD. This clinical study was conducted to address the safety and immunogenicity of LD vaccine in children 4 to 18 years of age.

METHODS: A randomized, placebo-controlled clinical trial was conducted at 17 investigational sites in ...

闻名 Lyme Disease |  outer surface |  borrelia burgdorferi |  united states |  bacterial vaccines
KOL Index score: 9655

Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases Society of America. These updated guidelines replace the previous treatment guidelines published in 2000 (Clin Infect Dis 2000; 31[Suppl 1]:1-14). The guidelines are intended for use by health care providers who care for patients who either have these ...

闻名 Lyme Disease |  granulocytic anaplasmosis |  clinical practice guidelines |  treatment prevention |  antimicrobial therapy
KOL Index score: 9574

OBJECTIVE: The objectives of this quality standard are 1) to provide an implementation mechanism that will facilitate the reliable administration of prophylactic antimicrobial agents to patients undergoing operative procedures in which such a practice is judged to be beneficial and 2) to provide a guideline that will help local hospital committees formulate policies and set up mechanisms for their implementation. Although standards in the medical literature spell out recommendations for ...

闻名 Surgical Procedures |  antimicrobial prophylaxis |  prophylactic antibiotics |  postoperative infection |  disease control

关键人物 Lyme Disease

Allen * ******
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Gary * *******
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Alan * *******
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Durland ****
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Stephen * *********
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Raymond * *********
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Peter J Krause:专家影响

哪个概念Peter J Krause具有直接影响:Lyme disease,  Babesia microti,  Human babesiosis,  United states,  Quality standard,  New england,  Borrelia miyamotoi,  Miyamotoi infection.

Peter J Krause:KOL的影响

与其他作者的工作有关的概念for which Peter J Krause 有影响力:Lyme disease,  Borrelia burgdorferi,  Babesia microti,  United states,  Human babesiosis,  Antibiotic prophylaxis,  Anaplasma phagocytophilum.



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Yale School of Public Health, Department of Epidemiology of Microbial Diseases and Yale School of Medicine, New Haven, Connecticut, USA. | Department of Epidemiology of Microbial Diseases, Yale School of Public Health and Yale School of Medicine, New