Prominent publications by Robert B Nadelman

KOL Index score: 15807

A randomized, multicenter, investigator-blinded clinical trial was undertaken in order to compare the efficacies of cefuroxime axetil and doxycycline in the treatment of patients with Lyme disease associated with erythema migrans. A total of 232 patients with physician-documented erythema migrans were treated orally for 20 days with either cefuroxime axetil, 500 mg twice daily (119 patients), or doxycycline, 100 mg three times daily (113 patients), and clinical evaluations were conducted ...

Also Ranks for: Cefuroxime Axetil |  early lyme disease |  erythema migrans |  doxycycline treatment |  patients lyme
KOL Index score: 13014

BACKGROUND: A comparison of patients with erythema migrans due to Borrelia garinii versus Borrelia burgdorferi has not been reported.

PATIENTS AND METHODS: One hundred nineteen patients from New York State with erythema migrans caused by B. burgdorferi were compared with 116 patients from Slovenia with erythema migrans due to B. garinii infection.

RESULTS: Patients with B. garinii infection were older, more often reported a tick bite, and developed larger lesions (median largest ...

Also Ranks for: Erythema Migrans |  borrelia burgdorferi |  tick bite |  central clearing |  patients garinii
KOL Index score: 12213

Eight strains of Borrelia burgdorferi sensu lato were tested with serum samples from persons who had Lyme borreliosis or syphilis in class-specific enzyme-linked immunosorbent assays (ELISAs). Antigens of B. burgdorferi sensu stricto, of Borrelia garinii, and of Borrelia spirochetes in group VS461 were prepared from cultured bacteria isolated from ticks, a white-footed mouse (Peromyscus leucopus), or human tissues in North America, the former Soviet Union, and Japan. Nearly all of the ...

Also Ranks for: Borrelia Burgdorferi |  sensu lato |  bacterial antigens |  linked immunosorbent |  lyme borreliosis
KOL Index score: 11893

BACKGROUND: Borrelia burgdorferi, the etiologic agent of Lyme borreliosis, has occasionally been isolated from tissues or body fluids of patients after antimicrobial treatment. A prospective study of patients with Lyme borreliosis associated with erythema migrans (EM) was initiated in Westchester County, New York, to determine: (1) the clinical and laboratory parameters associated with culture positivity, and (2) the microbiologic response to treatment.

METHODS: Skin biopsies were ...

Also Ranks for: Erythema Migrans |  lyme borreliosis |  antimicrobial therapy |  borrelia burgdorferi |  skin biopsy
KOL Index score: 11610

BACKGROUND: It is unclear whether antimicrobial treatment after an Ixodes scapularis tick bite will prevent Lyme disease.

METHODS: In an area of New York where Lyme disease is hyperendemic we conducted a randomized, double-blind, placebo-controlled trial of treatment with a single 200-mg dose of doxycycline in 482 subjects who had removed attached I. scapularis ticks from their bodies within the previous 72 hours. At base line, three weeks, and six weeks, subjects were interviewed and ...

Also Ranks for: Lyme Disease |  tick bite |  ixodes scapularis |  dose doxycycline |  erythema migrans
KOL Index score: 10993

Tickborne rickettsial diseases continue to cause severe illness and death in otherwise healthy adults and children, despite the availability of low-cost, effective antibacterial therapy. Recognition early in the clinical course is critical because this is the period when antibacterial therapy is most effective. Early signs and symptoms of these illnesses are nonspecific or mimic other illnesses, which can make diagnosis challenging. Previously undescribed tickborne rickettsial diseases ...

Also Ranks for: United States |  rickettsial diseases |  spotted fever |  diagnosis management |  rocky mountain
KOL Index score: 10634

BACKGROUND: The clinical value of antibiotic prophylaxis in preventing Lyme disease remains uncertain, owing to a meta-analysis lacking sufficient power to demonstrate efficacy and a more recent trial showing effectiveness but lacking precision. Our objective was to update our prior meta-analysis on antibiotic prophylaxis for the prevention of Lyme disease, to obtain a more precise estimate of treatment effect.

METHODS: Clinical trials were identified by searching MEDLINE, Embase, the ...

Also Ranks for: Lyme Disease |  antibiotic prophylaxis |  updated systematic review |  study quality |  cochrane library
KOL Index score: 10357

Two hundred seventeen isolates of Borrelia burgdorferi originally cultured from skin biopsy samples or blood of early Lyme disease patients were genetically characterized by PCR-restriction fragment length polymorphism (RFLP) typing of the 16S-23S ribosomal DNA intergenic spacer. Three major RFLP types were observed. Of the cultured isolates, 63 of 217 (29.0%) were type 1, 85 of 217 (39.2%) were type 2, and 58 of 217 (26.7%) were type 3; mixtures of two RFLP types were obtained in 6.0% ...

Also Ranks for: Genetic Diversity |  lyme disease patients |  16s rna |  borrelia burgdorferi |  clinical specimens
KOL Index score: 10192

Ninety-three Borrelia burgdorferi isolates obtained from erythema migrans lesions or blood of Lyme disease patients in Westchester County, N.Y., between 1991 and 1994 were characterized by PCR-restriction fragment length polymorphism (PCR-RFLP) analysis of the 16S-23S rRNA gene spacer. All isolates could be classified into three distinct RFLP types. Among the 82 skin biopsy isolates studied, 21 (25.6%) were type 1, 37 (45.1%) were type 2, and 21 (25.6%) were type 3. Three (3.7%) cultures ...

Also Ranks for: Lyme Disease Patients |  molecular typing |  restriction fragment |  length polymorphism |  borrelia burgdorferi
KOL Index score: 10157

BACKGROUND: The diagnosis of erythema migrans (EM), the characteristic rash of early Lyme borreliosis, is based primarily on its clinical appearance since it often occurs prior to the development of a specific antibody response. Other skin disorders, however, may be confused with EM.

METHODS: Between June 1991 and September 1993, a prospective study was conducted at the Lyme Disease Diagnostic Center of the Westchester County Medical Center to isolate Borrelia burgdorferi systematically ...

Also Ranks for: Early Lyme Borreliosis |  erythema migrans |  patients culture |  systemic symptoms |  clinical manifestations
KOL Index score: 10126

We investigated the appearance and evolution of immunoglobulin M (IgM) and IgG antibodies to Borrelia burgdorferi in 46 patients with culture-proven erythema migrans (EM). All patients received antimicrobial treatment and were prospectively evaluated for up to 1 year. A total of 257 serially collected serum samples were tested by commercial IgG-IgM enzyme-linked immunosorbent assay and separate IgM and IgG immunoblots (IBs). At the baseline, 33% of the patients had a positive ELISA ...

Also Ranks for: Erythema Migrans |  bacterial antigens |  serologic response |  borrelia burgdorferi |  igm antibodies
KOL Index score: 9906

BACKGROUND: The most common and most recognizable feature of Borrelia burgdorferi infection (Lyme disease) is the skin lesion erythema migrans (EM). An illness associated with an EM-like skin lesion, but which is not caused by B. burgdorferi, occurs in many southern states in the United States (southern tick-associated rash illness [STARI], also known as Masters disease).

METHODS: Clinical features of 21 cases of EM-like skin lesions in 21 patients from Missouri were compared in a ...

Also Ranks for: New York |  erythema migrans |  skin lesions |  patients missouri |  tick bite

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Robert B Nadelman:Expert Impact

Concepts for whichRobert B Nadelmanhas direct influence:Lyme disease,  Erythema migrans,  New york,  Borrelia burgdorferi,  Early lyme disease,  Antibiotic prophylaxis,  Cefuroxime axetil,  Lyme borreliosis.

Robert B Nadelman:KOL impact

Concepts related to the work of other authors for whichfor which Robert B Nadelman has influence:Lyme disease,  Borrelia burgdorferi,  Erythema migrans,  United states,  Sensu lato,  Tick bite,  Cefuroxime axetil.



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Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA | New York Medical College, Valhalla, New York | Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY USA | Division of Infe