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    • Stefan Schwartz: Influence Statistics

      Stefan Schwartz

      Stefan Schwartz

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      Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, ...

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      Stefan Schwartz:Expert Impact

      Concepts for whichStefan Schwartzhas direct influence:Cns aspergillosis,Lymphoblastic leukemia,Acute leukaemia,Acute leukemia,Physical performance,Flt3 mutations,Hematological patients,Carboxypeptidase g2.

      Stefan Schwartz:KOL impact

      Concepts related to the work of other authors for whichfor which Stefan Schwartz has influence:Lymphoblastic leukemia,Invasive aspergillosis,Stem cell,Fungal infections,Central nervous,Minimal residual disease,Philadelphia chromosome.

      KOL Resume for Stefan Schwartz

      Year
      2022

      Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

      2021

      Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

      2020

      Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany

      2019

      Department of Hematology, Charité Campus Benjamin Franklin, Berlin, Germany

      2018

      Medical Department, Division of Haematology, Oncology and Tumour Immunology, Charité, Berlin, Germany

      2017

      Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany

      2016

      Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Charité − Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany

      Department of Hematology and Oncology, Charité University Medicine, Campus Benjamin Franklin, Berlin

      2014

      Charité, Campus Benjamin Franklin, Berlin, Germany

      2013

      Department of Hematology and Oncology, Charité–Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany

      2012

      Medizinische Klinik III, Charité Campus Benjamin Franklin, Berlin, Deutschland

      Hematology and Oncology, Charité, University Medicine, Campus Benjamin Franklin, Berlin, Germany,

      Klinik für Hämatologie, Charité CBF, Hindenburgdamm 30, 12200, Berlin, Germany

      2011

      Medizinische Klinik III, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany

      Department of Internal Medicine, Charité University Medicine, Campus Benjamin Franklin, Berlin

      2010

      Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany

      2009

      Medical Department III, Hematology and Oncology, Charité University Hospital Benjamin Franklin, Berlin, Germany,

      Medizinische Klinik III, Charite Campus Benjamin Franklin, Berlin, Germany.

      Med. Klinik für Hämatologie, Onkologie, Charité, CBF, Berlin

      2008

      Medizinische Klinik III, Charité–Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200, Berlin, Germany

      Department of Hematology

      2007

      Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt/Main, Germany

      and The Ohio State University Comprehensive Cancer Center, Columbus, OH

      Medizinische Klinik III,

      2006

      From the Departments of Hematology and Oncology of the Johann Wolfgang Goethe University, Frankfurt; the University of Essen; the University of Mainz; the University of Münster; the University of Dresden; the University of Regensburg; the University of Heidelberg; the University of Düsseldorf; the University of Hannover; the University of Ulm; the University of Tübingen; the Ludwig Maximilans University, Munich; the Robert Bosch Krankenhaus, Stuttgart; Novartis Pharma, Nuremberg; and Charité, Campus Benjamin Franklin, Berlin, Germany

      Department of Biostatistics and Clinical Epidemiology, Charité, Campus Benjamin Franklin Berlin, University Hospital, Berlin

      and Ohio State University, Comprehensive Cancer Center, Columbus, OH

      2005

      1 Hematology, Oncology and Transfusion Medicine, Charité Campus Benjamin Franklin, Berlin, Germany.

      Charité Campus Benjamin Franklin, Berlin, Germany; Protherics PLC, Runcorn, United Kingdom

      Department of Medicine, Charite, Campus Benjamin Franklin, Berlin, Germany

      2004

      Medizinische Klinik III, Charit, Campus Benjamin Franklin, 12200 Berlin, Germany.

      University Charite, Campus Benjamin Franklin, Berlin, Germany

      2003

      Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Freie Universität, Hindenburgdamm 30, D-12200 Berlin, Germany.

      Department of Haematology/Oncology, University Hospital Benjamin Franklin, Berlin

      2001

      Klinikum Benjamin Franklin, Free University Berlin

      2000

      Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin

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      Sample of concepts for which Stefan Schwartz is among the top experts in the world.
      Concept World rank
      aspergillus gmelisa #1
      192 fungal #1
      therapy ifds #1
      aspergillus gm eia #1
      qol scores placebo #1
      aspergillusspezies #1
      amphotericin echinocandinen #1
      rzv qol #1
      patients cerebral aspergillosis #1
      brain abscess material #1
      patients cns aspergillosis #1
      fungal palate #1
      documented ifds #1
      682 rzv #1
      ihpcr #1
      847 blood samples #1
      31 studie sowie #1
      pcr 847 #1
      1–81 years #1
      perforator artery territories #1
      mllaf10 t1119q23p131 #1
      cns molecular size #1
      neurochirurgischen eingriffe #1
      selected combination therapies #1
      wesentlicher grund #1
      cerebral aspergillus #1
      bildgebende diagnostikverfahren #1
      kirmediated alloreactivity #1
      long lasting granulocytopenia #1
      556 775 #1
      image processing myeloid #1
      suspected fungal infections #1
      conventional mycological culture #1
      leukemia lung diseases #1
      underlying conditions success #1
      rzv autologous hsct #1
      qol rzv #1
      letalität aspergillose #1
      high‐dose methotrexate therapy #1
      zbpi burden illness #1
      81 patienten #1
      p001 fse #1
      zbpi rzv #1
      31 survivalrate #1
      total cd3 cd4 #1
      70 etp #1
      implantable intravenous devices #1
      humans neuroaspergillosis #1
      ifds infections #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Stefan Schwartz

      KOL-Index: 15902

      Importance: Herpes zoster, a frequent complication following autologous hematopoietic stem cell transplantation (HSCT), is associated with significant morbidity. A nonlive adjuvanted recombinant zoster vaccine has been developed to prevent posttransplantation zoster.

      Objective: To assess the efficacy and adverse event profile of the recombinant zoster vaccine in immunocompromised autologous HSCT recipients.

      Design, Setting, and Participants: Phase 3, randomized, observer-blinded study ...

      Known for Zoster Vaccine | Stem Cell | Incidence Herpes | Placebo Recipients | Autologous Hsct
      KOL-Index: 15332

      PURPOSE: Expression of the genes ERG (v-ets erythroblastosis virus E26 oncogene homolog) and BAALC (brain and acute leukemia, cytoplasmic) shows similarity during hematopoietic maturation and predicts outcome in acute myeloid leukemia. We hypothesized that like ERG, BAALC expression might be of prognostic significance in acute T-lymphoblastic leukemia (T-ALL) and that ERG and BAALC expression together would better identify the patient's risk profile.

      PATIENTS AND METHODS: ERG and BAALC ...

      Known for Baalc Expression | Favorable Outcome | Low Erg | Lymphoblastic Leukemia | New Subgroup
      KOL-Index: 14593

      BACKGROUND: NOTCH1 mutations have been associated with a favorable outcome in pediatric acute T-lymphoblastic leukemia. However, the results of studies on the prognostic significance of NOTCH1 mutations in adult T-lymphoblastic leukemia remain controversial.

      DESIGN AND METHODS: Here we have investigated the prognostic impact of mutations in the NOTCH1 pathway, in particular, the NOTCH1 and FBXW7 genes, in a large cohort of adult patients with T-lymphoblastic leukemia (n=126). We ...

      Known for Fbxw7 Mutations | Lymphoblastic Leukemia | Patients Notch1 | Prognostic Impact | Favorable Outcome
      KOL-Index: 13855

      Overexpression of the embryonic transcription factor, Wilms' tumour protein 1 (WT1), is common in acute myeloid leukaemias (AML). Mutations of Wilms' tumour gene 1 (WT1) in AML are rare and WT1 expression may be increased by other transcription factors. PAX2, PAX8 and GATA-1 are known physiological regulators of WT1. In the present study, we analysed either bone marrow or blood samples of 43 AML patients for the expression levels of WT1, PAX2, PAX8 and GATA-1 by real-time reverse ...

      Known for Acute Myeloid | Paired Box | Messenger Rna | Wt1 Expression | Tumour Gene
      KOL-Index: 13727

      Infections of the central nervous system (CNS) are infrequently diagnosed in immunocompetent patients, but they do occur in a significant proportion of patients with hematological disorders. In particular, patients undergoing allogeneic hematopoietic stem-cell transplantation carry a high risk for CNS infections of up to 15%. Fungi and Toxoplasma gondii are the predominant causative agents. The diagnosis of CNS infections is based on neuroimaging, cerebrospinal fluid examination and ...

      Known for Cns Infections | Medical Oncology | German Society | Infectious Diseases | Cell Transplantation
      KOL-Index: 13363

      The expression of the chondroitin sulfate proteoglycan neuron-glial antigen 2 (NG2) has been demonstrated in association with rearrangement of the mixed lineage leukemia (MLL) gene in acute leukemia, but the frequency of NG2 expression in adult acute lymphoblastic leukemia (ALL) is yet unknown. We evaluated NG2 expression in 313 adult ALL patients by flow cytometry and simultaneously determined MLL rearrangement in 120 adult patients out of them with B-precursor ALL by reverse ...

      Known for Mll Rearrangement | Ng2 Expression | Acute Lymphoblastic | Oncogene Proteins | Situ Hybridization
      KOL-Index: 12850

      BACKGROUND: Mucormycosis is an uncommon invasive fungal disease with high mortality and few treatment options. Isavuconazole is a triazole active in vitro and in animal models against moulds of the order Mucorales. We assessed the efficacy and safety of isavuconazole for treatment of mucormycosis and compared its efficacy with amphotericin B in a matched case-control analysis.

      METHODS: In a single-arm open-label trial (VITAL study), adult patients (≥18 years) with invasive fungal disease ...

      Known for Isavuconazole Treatment | Mucormycosis Efficacy | Vital Study | Control Analysis | Invasive Fungal
      KOL-Index: 12587

      PURPOSE: In adult T-lymphoblastic leukemia (T-ALL) disease-free survival remains limited to 32% to 46%. The adverse prognosis in T-ALL has not been attributed to cytogenetic or molecular aberrations. We have determined the prognostic impact of the oncogenic transcription factor ERG in T-ALL.

      PATIENTS AND METHODS: ERG expression was analyzed by real-time polymerase chain reaction (PCR) in 105 adults with newly diagnosed T-ALL treated on the German ALL protocols. Patients were dichotomized ...

      Known for Erg Expression | Adverse Outcome | Lymphoblastic Leukemia | Prognostic Impact | Tall Patients
      KOL-Index: 12201

      The value of dual-color fluorescence in situ hybridization (FISH) with BCR and ABL probes for the detection of the Philadelphia (Ph) translocation and of other alterations involving ABL and/or BCR was evaluated in adult acute lymphoblastic leukemia (ALL). One hundred and four patients were studied prospectively using interphase nuclei FISH, chromosome analysis (CA), and PCR assays for the chimeric BRC/ABL transcript. FISH detected a Ph translocation in 24 cases (23.1%), as was confirmed ...

      Known for Situ Hybridization | Lymphoblastic Leukemia | Bcr Abl | Adult Acute | Chromosome Abnormalities
      KOL-Index: 12166

      Over expression of BAALC (brain and acute leukemia, cytoplasmic) predicts an inferior outcome in acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients. To identify BAALC-associated genes that give insights into its functional role in chemotherapy resistance, gene expression signatures differentiating high from low BAALC expressers were generated from normal CD34+ progenitors, T-acute lymphoblastic leukemia (T-ALL) and AML samples. The insulin-like growth factor binding ...

      Known for Acute Leukemia | Gene Expression | Tumor Cell | Chemotherapy Resistance | Igfbp7 Proliferation
      KOL-Index: 11869

      The receptor tyrosine kinase Flt3 is expressed on leukaemic blasts of most cases with acute myeloid leukaemia (AML). In order to evaluate the presence and significance of constitutive activation of Flt3 for leukaemogenesis, we (1) analysed the expression and activation status of the receptor in AML blasts; and (2) evaluated the functional consequences of constitutively active Flt3 in a myeloid progenitor cell line. Immunoprecipitation studies revealed Flt3 expression in a high proportion ...

      Known for Constitutive Activation | 32d Cells | Acute Myeloid Leukaemia | Aml Cases | Myeloid Cell
      KOL-Index: 10708

      Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults. To unravel the underlying pathomechanisms and the clinical course we assessed molecular alterations and clinical characteristics in a large cohort of ETP-ALL (n = 68) in comparison to non-ETP T-ALL adult patients. Interestingly, we found a high rate of FLT3-mutations in ETP-ALL samples (n = 24, ...

      Known for Tyrosine Kinase | Stem Cell | Flt3 Mutations | Leukemia Etp | Clinical Characteristics
      KOL-Index: 10695

      Because of conflicting reports on the prognosis of patients with c-kit receptor positive AML and lacking correlations with cytogenetic analyses, we prospectively evaluated the c-kit receptor expression in 917 AML patients (750 adult patients; 167 children) using flow cytometry and compared the results to the immunophenotype, morphological and cytogenetic findings as well as clinical outcome. Expression of the c-kit receptor was present in 63% of all AML investigated. Among these an ...

      Known for Kit Receptor | Prognostic Significance | Aml Patients | Child Child | Flow Cytometry

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      Department of Hematology, Oncology and Tumor Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany | Department of Hematology, Oncology and Tumor Immunology (C

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