Prominent publications by Elaine S Jaffe

KOL Index score: 20119

PURPOSE: Diffuse large B-cell lymphoma (DLBCL) is curable in 60% of patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). MYC translocations, with or without BCL2 translocations, have been associated with inferior survival in DLBCL. We investigated whether expression of MYC protein, with or without BCL2 protein expression, could risk-stratify patients at diagnosis.

PATIENTS AND METHODS: We determined the correlation between presence of ...

Known for Concurrent Expression |  Patients Dlbcl |  Myc Bcl2 Proteins |  Lymphoma Treated |  Doxorubicin Vincristine
KOL Index score: 19525

Anaplastic large cell lymphoma (ALCL) is composed of large, frequently bizarre, cells of T- or null-cell phenotype that show a preferential sinusoidal growth pattern and consistent CD30 positivity. Whether these tumors represent a single entity or several, and what the exact cell origin, is controversial. Recently, granzyme B, a cytotoxic granule component, was reported in a small percentage of ALCL, suggesting that some cases may originate from cytotoxic lymphocytes. To further ...

Known for Cytotoxic Cell |  Anaplastic Large |  Antigen Expression |  Tia1 Perforin |  Polyabinding Proteins
KOL Index score: 17361

The paired box containing gene PAX-5 encodes the transcription factor BSAP (B-cell-specific activator protein), which plays a key role in B-lymphocyte development. Despite its known involvement in a rare subtype of non-Hodgkin's lymphoma (NHL), a detailed examination of BSAP expression in NHL has not been previously reported. In this study, we analyzed normal and malignant lymphoid tissues and cell lines, including 102 cases of B-cell NHL, 23 cases of T- and null-cell NHL, and 18 cases ...

Known for Cell Lymphoma |  Lymphocytic Chronic |  Transcription Factor Bsap |  Neoplastic Genes |  Activator Protein
KOL Index score: 15472

p27 is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S progression, and whose activity is, in part, regulated through interactions with D-type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation resulting in deregulated cyclin D1. We previously showed that p27 expression in MCL, as assessed by immunohistochemistry (IHC), does not show the usual inverse relationship to proliferate seen in most other lymphomas that do not ...

Known for Cyclin D1 |  Mantle Cell |  Human Pair |  Kinase Inhibitor |  P27 Protein
KOL Index score: 15366

BACKGROUND: Diffuse large-B-cell lymphoma is curable, but when treatment fails, outcome is poor. Although imaging can help to identify patients at risk of treatment failure, they are often imprecise, and radiation exposure is a potential health risk. We aimed to assess whether circulating tumour DNA encoding the clonal immunoglobulin gene sequence could be detected in the serum of patients with diffuse large-B-cell lymphoma and used to predict clinical disease recurrence after frontline ...

Known for Tumour Dna |  Cell Lymphoma |  Patients Risk |  Treatment Failure |  Diffuse Large
KOL Index score: 15317

p27Kip1 is a cyclin-dependent kinase inhibitor that regulates the decision to enter S phase or withdraw from the cell cycle. In resting cells, the level of p27Kip1 provides an inhibitory threshold above which G1 cyclin D/E/cyclin-dependent kinases accumulate before activation; however, in cycling cells, p27Kip1 protein is sequestered by high levels of active cyclin D/cyclin-dependent kinase 4 complexes. As a group, the cyclin-dependent kinase inhibitors have been proposed to act as tumor ...

Known for Cell Lymphomas |  Dependent Kinase |  P27kip1 Expression |  Proliferation Rate |  Blastic Variant
KOL Index score: 15269

ALK-positive large B-cell lymphoma is an aggressive lymphoid neoplasm characterized by a monomorphic proliferation of immunoblast-like cells expressing a plasmablastic phenotype and carrying ALK rearrangements. MYC rearrangements are frequent in plasmablastic lymphomas, advanced plasma cell myelomas and a subgroup of diffuse large B-cell lymphomas, but their presence in ALK-positive large B-cell lymphomas is unknown. MYC expression is downregulated by BLIMP1, a master modulator of plasma ...

Known for Cell Lymphomas |  Myc Rearrangements |  Positive Large |  Plasmablastic Differentiation |  Lymphoma Kinase
KOL Index score: 15263

Histiocytic and interdigitating dendritic cell sarcomas are rare tumors originating from bone marrow-derived myeloid stem cells. Recent studies have shown evidence of cross-lineage transdifferentiation of B cells in follicular lymphoma to histiocytic and dendritic cell sarcomas. In this study, we report the morphologic, molecular and cytogenetic analysis of seven cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) associated with histiocytic and dendritic cell ...

Known for Dendritic Cell |  Chronic Lymphocytic |  Situ Hybridization |  7 Cases |  Sarcoma Histiocytic
KOL Index score: 15042

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and classical Hodgkin lymphoma (CHL) are classified separately because of their distinct clinical and pathologic features. Whereas Epstein-Barr virus (EBV) is detected in the neoplastic cells of 25% to 70% of CHL, NLPHL is generally considered to be EBV(-). We assessed EBV status in 302 pediatric and adult cases of NLPHL. A total of 145 pediatric (age 18 y or younger) and 157 adult cases of NLPHL were retrieved from 3 North American ...

Known for Lp Cells |  Nodular Lymphocyte |  Predominant Hodgkin |  Situ Hybridization |  Cases Ebv
KOL Index score: 15005

BACKGROUND: Kaposi sarcoma herpesvirus (KSHV) is the cause of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a form of Castleman disease (KSHV-MCD). Recently a KSHV-associated inflammatory cytokine syndrome (KICS) distinct from KSHV-MCD was reported.

METHODS: We prospectively characterized the clinical, laboratory, virologic and immunologic features of KICS by evaluating symptomatic adults with KSHV using a prespecified definition. These features and overall survival were ...

Known for Kaposi Sarcoma |  Inflammatory Cytokine Syndrome |  Kshv Kics |  Ks Pel |  Primary Effusion Lymphoma
KOL Index score: 14808

Background Primary mediastinal large B-cell lymphoma is a rare lymphoma accounting for no more than 3% of all B-cell lymphomas in children and adolescents. However, patients in this young age group with this lymphoma have the shortest event-free survival of patients with any B-cell lymphoma under current standard chemotherapy protocols. Lymphomas with features intermediate between primary mediastinal large B-cell lymphoma and classical Hodgkin's lymphoma (mediastinal gray zone lymphomas) ...

Known for Cell Lymphoma |  Mediastinal Large |  Gray Zone |  Children Adolescents |  Situ Hybridization


Elaine S Jaffe: Influence Statistics

Sample of concepts for which Elaine S Jaffe is among the top experts in the world.
Concept World rank
mediastinal lymphomas chl #1
lymphoid neoplasms controversy #1
nnmcl cmcl #1
periodic illness #1
specimens hd component #1
hstl setd2 #1
aberrations myc #1
myc protein presence #1
3 8 patients #1
efs gcbdlbcl #1
controversy lymphoma classification #1
tissues infectious mononucleosis #1
cd79a antigens #1
hodgkin lymphoma variant #1
host disease herpesvirus #1
classification real classification #1
patients microvessel density #1
sinus histiocytosis patient #1
eahp sh #1
mhcii locus #1
chronic follicular lymphoma #1
nmzl ptgc #1
small noncleaved #1
primary histiocytic sarcoma #1
lymphoma nomenclature #1
gzl pmbl #1
nets chl #1
scptcl #1
lymphoma new #1
deletions 11 cases #1
lymphoid neoplasms cases #1
flis pfl #1
lpd nhl #1
cd3− dimcd4 #1
reactive cells microenvironment #1
mhcii loci #1
lymphoma classical #1
ebna1 vivo #1
identification clusterin #1
epstein barr mzl #1
pediatricmbl #1
cancer amplicon genes #1
cns involvement pmlcl #1
nodal counterparts #1
lyg patients #1
new diagnostic marker #1
scptcl cytotoxic #1
barr virus lyg #1
positive mucocutaneous ulcer #1
pmbl chl #1

Key People For Cell Lymphoma

Top KOLs in the world
Elaine S Jaffe
cell lymphoma lymphoid neoplasms situ hybridization
Randy D Gascoyne
cell lymphoma diffuse large gene expression
Nancy Lee Harris
cell lymphoma abdominal pain cyclin d1
Elı́as Campo
cell lymphoma chronic lymphocytic leukemia cyclin d1
Dennis D Weisenburger
cell lymphoma bone marrow situ hybridization
James Olen Armitage
cell lymphoma bone marrow complete remission

Elaine S Jaffe:Expert Impact

Concepts for whichElaine S Jaffehas direct influence:Cell lymphoma,  Follicular lymphoma,  Large bcell,  Hodgkin lymphoma,  Lymphoid neoplasms,  Cell lymphomas,  Burkitt lymphoma,  Lymphoma cell.

Elaine S Jaffe:KOL impact

Concepts related to the work of other authors for whichfor which Elaine S Jaffe has influence:Cell lymphoma,  Diffuse large,  Bone marrow,  Situ hybridization,  Barr virus,  Mycosis fungoides,  Gene expression.



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National Cancer Institute. | Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA | National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States. | National Cancer Inst

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