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    • Lysophosphatidic Acid
    • Glenn D Prestwich
    • Glenn D Prestwich: Influence Statistics

      Glenn D Prestwich

      Glenn D Prestwich

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      Department of Medicinal Chemistry, The University of Utah, Salt Lake City, UT, USA | Health Sciences Spokane, Washington State University, Spokane, WA, USA | Department of ...

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      Glenn D Prestwich:Expert Impact

      Concepts for whichGlenn D Prestwichhas direct influence:Lysophosphatidic acid,Hyaluronic acid,Juvenile hormone,Binding proteins,Extracellular matrix,Photoaffinity labeling,Binding protein,Wound healing.

      Glenn D Prestwich:KOL impact

      Concepts related to the work of other authors for whichfor which Glenn D Prestwich has influence:Hyaluronic acid,Tissue engineering,Stem cells,Drug delivery,Wound healing,Extracellular matrix,Regenerative medicine.

      KOL Resume for Glenn D Prestwich

      Year
      2022

      Department of Medicinal Chemistry, The University of Utah, Salt Lake City, UT, USA

      2021

      Department of Medicinal Chemistry, The University of Utah, Salt Lake City, UT 84112 USA

      2020

      The University of Utah, College of Pharmacy Salt Lake City Utah 84112-5820 USA.

      2018

      Symic Bio, Inc., 5980 Horton St., 94608, Emeryville, CA, USA

      Department of Medicinal Chemistry and Center for Therapeutic Biomaterials, University of Utah, Salt Lake City, Utah, United States of America

      2017

      Center for Therapeutic Biomaterials, Department of Medicinal Chemistry, University of UtahSalt Lake City, UT.

      The University of Utah, Salt Lake City, UT, USA

      2016

      GlycoMira Therapeutics, Inc. Salt Lake City UT

      Division of Head and Neck Surgery, Rhinology − Sinus and Skull Base Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah, 84108, United States

      2015

      Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108, United States of America.

      2014

      Metallosensors Inc., 675 Arapeen Dr Ste 302, Salt Lake City, UT 84108, USA

      Department of Medicinal Chemistry, The University of Utah, Salt Lake City, Utah.

      2013

      GlycoMira Therapeutics, Inc. Salt Lake City, Utah, United States of America

      Department of Medicinal Chemistry, University of Utah Salt Lake City, Utah

      2012

      Department of Medicinal Chemistry, University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108-1257, United States

      Authors to whom any correspondence should be addressed

      2011

      Department of Medicinal Chemistry, Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108, USA

      Center for Therapeutic Biomaterials, University of Utah, Salt Lake City, Utah, United States of America

      2010

      Department of Medicinal Chemistry and The Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108‐1257

      Dep. Med. Chem. Biochem., Univ. Utah, Salt Lake City, UT 84112, USA

      Foundation (1981–1985) and Camille and Henry Dreyfus Teacher‐Scholar (1981–1986)

      2009

      The University of Utah.

      University of Utah Health Sciences Center, Salt Lake City, UT, USA

      2008

      Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108, USA

      University of Utah.

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      Sample of concepts for which Glenn D Prestwich is among the top experts in the world.
      Concept World rank
      hhbs plastic #1
      metabolomic profiles hhpscs #1
      kes1p golgi region #1
      photoaffinity labels ptdinspn #1
      8βtrinervita1112 #1
      z11–16∶ac #1
      inositol phospholipid binding #1
      amiteol #1
      345‐ #1
      fluorescence atx activity #1
      centaurinalpha binding specificity #1
      aspaspthralagluala #1
      combining disulfide #1
      26hydroxysqualene #1
      proliferation hydrogels #1
      ll37 ihc #1
      ouvrières cire #1
      habms heparin binding #1
      10∶oac #1
      mast cell axis #1
      gm0111 ll37 #1
      jheh jh #1
      tetrahedral polyethylene glycol #1
      pi45p2 epr spectrum #1
      jhjhbp complex #1
      lpa pa analogues #1
      tetrapeg13 #1
      nasute termite soldiers #1
      carrier polyamines complexes #1
      healing sinonasal mucosa #1
      mutagenesis binding #1
      purified rjhbp #1
      phosphoinositide delivery #1
      br2bpa #1
      cysteine active site #1
      hadtph pegda #1
      ecdysone biogenesis #1
      proteins corpora allata #1
      cshpbfgf films #1
      fluorinated analogs #1
      cmhasx hydrogels #1
      oacyl oalkyl chains #1
      oslc inhibitor #1
      jh jhbp·jh complex #1
      ptdins4 #1
      doxorubicin dox bioconjugates #1
      ecm gelatindtph #1
      synaptogmin #1
      phytate sensing #1
      immunofluorescent labeling bsmcs #1
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      Prominent publications by Glenn D Prestwich

      KOL-Index: 14662

      Lysophosphatidic acid (LPA) is a pluripotent lipid mediator acting through plasma membrane-associated LPA(x) receptors that transduce many, but not all, of its effects. We identify peroxisome proliferator-activated receptor gamma (PPARgamma) as an intracellular receptor for LPA. The transcription factor PPARgamma is activated by several lipid ligands, but agonists derived from physiologic signaling pathways are unknown. We show that LPA, but not its precursor phosphatidic acid, displaces ...

      Known for Ppargamma Lpa | Lysophosphatidic Acid | Intracellular Receptor | Lipid Ligands | Pparγ Agonist
      KOL-Index: 14554

      Insulin stimulates glucose uptake into muscle and fat cells by translocating glucose transporter 4 (GLUT4) to the cell surface, with input from phosphatidylinositol (PI) 3-kinase and its downstream effector Akt/protein kinase B. Whether PI 3,4,5-trisphosphate (PI(3,4,5)P(3)) suffices to produce GLUT4 translocation is unknown. We used two strategies to deliver PI(3,4,5)P(3) intracellularly and two insulin-sensitive cell lines to examine Akt activation and GLUT4 translocation. In 3T3-L1 ...

      Known for Glucose Uptake | Plasma Membrane | Intracellular Delivery | Glut4 Translocation | Transporter 4
      KOL-Index: 14302

      We previously reported the cloning of a cDNA encoding human phosphatidylcholine-specific phospholipase D1 (PLD1), an ADP-ribosylation factor (ARF)-activated phosphatidylcholine-specific phospholipase D (Hammond, S. M., Tsung, S., Autschuller, Y., Rudge, S. A., Rose, K., Engebrecht, J., Morris, A. J., and Frohman, M. A. (1995) J. Biol. Chem. 270, 29640-29643). We have now identified an evolutionarily conserved shorter splice variant of PLD1 lacking 38 amino acids (residues 585-624) that ...

      Known for Binding Proteins | Protein Kinase | Monomeric Gtp | Ribosylation Factor | Phosphatidylinositol 45bisphosphate
      KOL-Index: 14169

      Recent cloning of a rat brain phosphatidylinositol 3,4, 5-trisphosphate binding protein, centaurin alpha, identified a novel gene family based on homology to an amino-terminal zinc-binding domain. In Saccharomyces cerevisiae, the protein with the highest homology to centaurin alpha is Gcs1p, the product of the GCS1 gene. GCS1 was originally identified as a gene conditionally required for the reentry of cells into the cell cycle after stationary phase growth. Gcs1p was previously ...

      Known for Actin Polymerization | Saccharomyces Cerevisiae | Activating Protein | Adp Ribosylation | Cell Cycle
      KOL-Index: 13527

      Oxysterol binding proteins (OSBPs) comprise a large conserved family of proteins in eukaryotes. Their ubiquity notwithstanding, the functional activities of these proteins remain unknown. Kes1p, one of seven members of the yeast OSBP family, negatively regulates Golgi complex secretory functions that are dependent on the action of the major yeast phosphatidylinositol/phosphatidylcholine Sec14p. We now demonstrate that Kes1p is a peripheral membrane protein of the yeast Golgi complex, ...

      Known for Golgi Complex | Kes1p Function | Binding Protein | Tertiary Receptors | Yeast Osbp
      KOL-Index: 13340

      Bone morphogenetic protein-2 (BMP-2) is known to enhance fracture healing when delivered via a bovine collagen sponge. However, collagen rapidly releases BMP-2 with a high burst phase that is followed by a low sustained phase. As a result, supra-physiological doses of BMP-2 are often required to successfully treat bone defects. High BMP-2 dosing can introduce serious side effects that include edema, bone overgrowth, cyst-like bone formation and significant inflammation. As the release ...

      Known for Bone Formation | Sustained Release | Morphogenetic Protein | Fracture Healing | Bmp2 Delivery
      KOL-Index: 13041

      Using bone marrow derived mast cells from SH2-containing inositol-5-phosphatase (SHIP) +/+ and minus sign/minus sign mice, we found that the loss of SHIP leads to a dramatic increase in Steel Factor (SF)-stimulated phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)), a substantial reduction in PI(3,4)P(2), and no change in PI(4,5)P(2) levels. We also found that SF-induced activation of protein kinase B (PKB) is increased and prolonged in SHIP -/- cells, due in large part to more PKB ...

      Known for Knockout Mice | Protein Kinase | Pkb Activity | Plasma Membrane | Pi345p3 Levels
      KOL-Index: 12925

      The gypsy moth, Lymantria dispar, uses (7R, 8S)-cis-2-methyl-7, 8-epoxyoctadecane, (+)-disparlure, as a sex pheromone. The (-) enantiomer of the pheromone is a strong behavioral antagonist. Specialized sensory hairs, sensillae, on the antennae of male moths detect the pheromone. Once the pheromone enters a sensillum, the very abundant pheromone binding protein (PBP) transports the odorant to the sensory neuron. We have expressed the two PBPs found in gypsy moth antennae, PBP1 and PBP2, ...

      Known for Pheromone Binding | Gypsy Moth | Lymantria Dispar | Pbp1 Pbp2 | Higher Affinity
      KOL-Index: 12873

      While heparin has been used almost exclusively as a blood anticoagulant, important literature demonstrates that it also has broad anti-inflammatory activity. Herein, using low anti-coagulant 2-O,3-O-desulfated heparin (ODSH), we demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). ...

      Known for Anticoagulant Heparin | Intravenous Injections | Induced Thrombocytopenia | Anti Inflammatory | Platelet Activation
      KOL-Index: 12789

      Lysophosphatidic acid (LPA) is both a potential marker and a therapeutic target for ovarian cancer. It is critical to identify the sources of elevated LPA levels in ascites and blood of patients with ovarian cancer. We show here that human peritoneal mesothelial cells constitutively produce LPA, which accounts for a significant portion of the chemotactic activity of the conditioned medium from peritoneal mesothelial cells to ovarian cancer cells. Both production of LPA by peritoneal ...

      Known for Mesothelial Cells | Lysophosphatidic Acid | Ovarian Cancer Lpa | Migration Invasion | Human Peritoneal
      KOL-Index: 12772

      The myristoylated alanine-rich protein kinase C substrate (MARCKS) is a major protein kinase C (PKC) substrate in many different cell types. MARCKS is bound to the plasma membrane, and several recent studies suggest that this binding requires both hydrophobic insertion of its myristate chain into the bilayer and electrostatic interaction of its cluster of basic residues with acidic lipids. Phosphorylation of MARCKS by PKC introduces negative charges into the basic cluster, reducing its ...

      Known for Kinase Substrate | Myristoylated Alanine | Lateral Domains | Marcks Pkc | Acidic Lipids
      KOL-Index: 12522

      Controlled release of human vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) from hydrogels composed of chemically modified hyaluronan (HA) and gelatin (Gtn) was evaluated both in vitro and in vivo. We hypothesized that inclusion of small quantities of heparin (Hp) in these gels would regulate growth factor (GF) release over an extended period, while still maintaining the in vivo bioactivity of released GFs. To test this hypothesis, HA, Gtn, and Hp (15 ...

      Known for Growth Factor | Hyaluronan Hydrogels | Gfs Vivo | Inbred Balb Neovascularization | Controlled Release
      KOL-Index: 11864

      Synthetic hydrogel mimics of the extracellular matrix (ECM) were created by crosslinking a thiol-modified analog of heparin with thiol-modified hyaluronan (HA) or chondroitin sulfate (CS) with poly(ethylene glycol) diacrylate (PEGDA). The covalently bound heparin provided a crosslinkable analog of a heparan sulfate proteoglycan, thus providing a multivalent biomaterial capable of controlled release of basic fibroblast growth factor (bFGF). Hydrogels contained >97% water and formed ...

      Known for Controlled Release | Growth Factor | Polyethylene Glycol | Glycosaminoglycan Hydrogels | Extracellular Matrix
      KOL-Index: 11776

      OBJECTIVES: A prospective, controlled animal study was performed to determine whether the use of injectable, chemically modified hyaluronic acid (HA) derivatives at the time of intentional vocal fold resection might facilitate wound repair and preserve the unique viscoelastic properties of the vocal fold extracellular matrix.

      METHODS: We performed bilateral vocal fold biopsies on 33 rabbits. Two groups of rabbits were unilaterally treated with 2 different HA derivatives--Carbylan-SX and ...

      Known for Extracellular Matrix | Vocal Fold | Tissue Repair | Hyaluronic Acid | Vivo Engineering
      KOL-Index: 11573

      The acceptance of the new paradigm of 3-D cell culture is currently constrained by the lack of a biocompatible material in the marketplace that offers ease of use, experimental flexibility, and a seamless transition from in vitro to in vivo applications. I describe the development of a covalently cross-linked mimic of the extracellular matrix (sECM), now commercially available, for 3-D culture of cells in vitro and for translational use in vivo. These bio-inspired, biomimetic materials ...

      Known for Drug Discovery | Cell Culture | Vivo Applications | Biomimetic Materials | Tumor Model

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      Department of Medicinal Chemistry, The University of Utah, Salt Lake City, UT, USA | Health Sciences Spokane, Washington State University, Spokane, WA, USA | Department of Medicinal Chemistry, The University of Utah, Salt Lake City, UT 84112 USA | He

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