• Disease
  • Stargardt
  • Stargardt Disease
  • Janet S Sunness

    Prominent publications by Janet S Sunness

    KOL Index score: 18148

    PURPOSE: To study fixation patterns and reading rates in eyes with central scotomas from geographic atrophy (GA) of age-related macular degeneration and to compare fixation patterns with those of patients with Stargardt disease.

    METHODS: Scanning laser ophthalmoscope analysis of fixation patterns in eyes with 20/80 to 20/200 visual acuity. Included were 41 eyes of 35 patients with GA and 10 eyes of 5 patients with Stargardt disease. The patients with GA also were tested for maximum ...

    Also Ranks for: Stargardt Disease |  fixation patterns |  central scotomas |  reading rate |  macular degeneration
    KOL Index score: 18115

    OBJECTIVE: To determine the rate of developing choroidal neovascularization (CNV) in eyes with geographic atrophy (GA) from age-related macular degeneration (AMD) and the characteristics of the CNV in these eyes.

    DESIGN: Prospective natural history study with cohort analysis.

    PARTICIPANTS: One hundred fifty-two patients with GA and no CNV by fluorescein angiography in at least 1 eye, with annual follow-up.

    MAIN OUTCOME MEASURES: The development of CNV.

    RESULTS: Thirteen eyes with GA ...

    Also Ranks for: Choroidal Neovascularization |  eyes cnv |  macular degeneration |  fellow eye |  2 years
    KOL Index score: 15314

    PURPOSE: To evaluate the effects of subfoveal choroidal neovascularization secondary to age-related macular degeneration on functional parameters obtained by scanning laser ophthalmoscope microperimetry.

    DESIGN: Retrospective observational case series and cross-sectional study.

    METHODS: At the Doheny Retina Institute and Wilmer Eye Institute a consecutive series of 179 eyes of 175 patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration was ...

    Also Ranks for: Choroidal Neovascularization |  visual loss |  laser ophthalmoscope |  macular degeneration |  central fixation
    KOL Index score: 15299

    OBJECTIVE: To describe the progression of geographic atrophy (GA) from age-related macular degeneration (AMD) with respect to visual acuity (VA) loss and enlargement of atrophy.

    DESIGN: A prospectively observed case series.

    SETTING: Tertiary retinal referral center.

    PARTICIPANTS: One hundred twenty-three patients with GA due to AMD who completed at least 1 year of follow-up (median follow-up, 3 years) were examined annually.

    METHODS: At each examination, a protocol best-corrected VA of ...

    Also Ranks for: Visual Acuity |  geographic atrophy |  fellow eye |  2 years |  macular degeneration
    KOL Index score: 15106

    PURPOSE: To describe, in a group of patients with moderately advanced retinitis pigmentosa (RP), the prevalence of cystoid macular edema (CME), the variation in foveal thickness over a 48-week period, the correlation of visual acuity (VA) with retinal thickness, and the lack of response of CME to lutein administration.

    METHODS: Optical coherence tomography (OCT) imaging of the macula and clinical examination were evaluated for 77 eyes of 39 patients with RP over 11 months, with a scan ...

    Also Ranks for: Retinal Thickness |  eyes cme |  macular edema |  retinitis pigmentosa |  visual acuity
    KOL Index score: 14263

    PURPOSE: To describe the design and baseline characteristics of patients enrolled into 2 natural history studies of Stargardt disease (STGD1).

    DESIGN: Multicenter retrospective and prospective cohort studies.

    PARTICIPANTS: Three hundred sixty-five unique patients aged 6 years and older at baseline harboring disease-causing variants in the ABCA4 gene and with specified ocular lesions were enrolled from 9 centers in the United States and Europe.

    METHODS: In the retrospective study, ...

    Also Ranks for: Baseline Characteristics |  atrophy secondary |  areas ddaf |  progression stgd1 |  retrospective studies
    KOL Index score: 13726

    Importance: New outcome measures for treatment trials for Stargardt disease type 1 (STGD1) and other macular diseases are needed. Microperimetry allows mapping of light sensitivity of the macula and provides topographic information on visual function beyond visual acuity.

    Objective: To measure and analyze retinal light sensitivity of the macula in STGD1 using fundus-controlled perimetry (microperimetry).

    Design, Setting, and Participants: This was a multicenter prospective cohort study. ...

    Also Ranks for: Stargardt Disease |  macular sensitivity |  atrophy secondary |  deep scotomas |  visual acuity
    KOL Index score: 12748

    PURPOSE: Geographic atrophy (GA) may cause significant compromise of visual function, even when there still is good visual acuity (VA), because of parafoveal scotomas and foveal function abnormalities antedating visible atrophy. This study evaluates the visual function abnormalities at baseline and the 2-year worsening of VA and reading rate for eyes with GA compared with a group of eyes with drusen only.

    METHODS: Seventy-four eyes with GA and VA greater than or equal to 20/50 from a ...

    Also Ranks for: Visual Function |  2 years |  geographic atrophy |  eyes drusen |  scotoma fixation
    KOL Index score: 11658

    OBJECTIVES: To evaluate the use of the scanning laser ophthalmoscope (SLO) as a predictor for potential visual improvement in eyes with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) undergoing limited macular translocation.

    DESIGN: Retrospective noncomparative case series.

    PARTICIPANTS: Consecutive series of 71 eyes of 70 patients with subfoveal CNV secondary to AMD that underwent effective and uncomplicated limited macular translocation ...

    Also Ranks for: Macular Translocation |  visual acuity |  scanning laser |  eyes amd |  sensitivity specificity
    KOL Index score: 11541

    OBJECTIVE: To show that low luminance visual dysfunction is predictive of subsequent visual acuity (VA) loss in eyes with geographic atrophy (GA) resulting from age-related macular degeneration (AMD).

    DESIGN: Cohort study examining the prospective natural history study of GA from 1992 through 2000 at the Wilmer Eye Institute.

    PARTICIPANTS: Ninety-one participants with GA resulting from AMD without choroidal neovascularization in at least 1 eye who completed a 2-year study ...

    Also Ranks for: Low Luminance |  geographic atrophy |  visual acuity |  macular degeneration |  eye baseline
    KOL Index score: 11200

    PURPOSE: To study whether fixation patterns changed over time in patients with central scotomas from geographic atrophy from age-related macular degeneration.

    DESIGN: Prospective cohort study.

    METHODS: setting: Institutional. patient or study population: Prospective natural history study of geographic atrophy included 34 eyes of 25 patients with baseline acuity between 20/80 and 20/200 and with subsequent follow-up. observation procedures: Baseline and annual follow-up visits included ...

    Also Ranks for: Geographic Atrophy |  central scotomas |  fixation patterns |  macular degeneration |  reading rate
    KOL Index score: 11117

    PURPOSE: We explored the clinical impression that geographic atrophy of the retinal pigment epithelium, a form of advanced age-related macular degeneration, is perceived by the patient as progressing gradually, even when fixation switches from foveal to extrafoveal.

    METHODS: We analyzed the responses of 60 patients with geographic atrophy to a questionnaire administered as part of a five-year study of the natural course of geographic atrophy, funded by the National Eye Institute. We ...

    Also Ranks for: Geographic Atrophy |  visual loss |  fixation patients |  scanning laser |  macular degeneration
    KOL Index score: 10946

    OBJECTIVE: To characterize the traits of low vision patients who seek outpatient low vision rehabilitation (LVR) services in the United States.

    METHODS: In a prospective observational study, we enrolled 764 new low vision patients seeking outpatient LVR services from 28 clinical centers in the United States. Before their initial appointment, multiple questionnaires assessing daily living and vision, physical, psychological, and cognitive health states were administered by telephone. ...

    Also Ranks for: United States |  vision patients |  baseline traits |  outpatient clinical |  lvr services
    KOL Index score: 10570

    BACKGROUND: Age-related macular degeneration is the most common cause of irreversible visual impairment in the developed world. Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown.

    METHODS: We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine ...

    Also Ranks for: Geographic Atrophy |  receptor 3 |  choroidal neovascularization |  agerelated macular degeneration |  doublestranded rna


    Janet S Sunness: Influence Statistics

    Sample of concepts for which Janet S Sunness is among the top experts in the world.
    Concept World rank
    field evaluation insights #1
    visual perceptual effects #1
    mottled autofluorescence #1
    visible atrophy #1
    scotoma fixation #1
    reading rate followup #1
    measurement enlargement rate #1
    attending vision #1
    bcva bcea #1
    laser opthalmoscope perimetry #1
    dense scotoma atrophy #1
    fovea fellow eye #1
    choroidal neovascularisation atrophy #1
    stargardt stargardt disease #1
    effects ocular medications #1
    scotoma bullseye #1
    area visible atrophy #1
    disease dense #1
    mapping enlargement #1
    emphasis patients perspectives #1
    new lowvision patients #1
    fixation patterns eyes #1
    fixation scotoma superior #1
    study eyes prl #1
    retinal faculty #1
    scotoma visible #1
    atrophy stargardt disease #1
    patient foveal #1
    lasers macula #1
    size atrophic #1
    dense scotomas #1
    stgd1 adult #1
    laser ophthalmoscopic analysis #1
    scotoma macular #1
    nonwhite predominance #1
    autofluorescence imaging patients #1
    lowvision population #1
    hallucinations bcva #1
    uniform mottled loss #1

    Key People For Stargardt Disease

    Top KOLs in the world
    Rando L Allikmets
    stargardt disease macular degeneration abca4 gene
    Edwin M Stone
    retinitis pigmentosa stargardt disease leber congenital amaurosis
    Gerald Allen Fishman
    retinitis pigmentosa visual acuity stargardt disease
    James R Lupski
    human pair intellectual disability situ hybridization
    Richard Alan Lewis
    aicardi syndrome stargardt disease retinitis pigmentosa
    Michael C Dean
    cystic fibrosis breast cancer binding cassette

    Janet S Sunness:Expert Impact

    Concepts for whichJanet S Sunnesshas direct influence:Stargardt disease,  Geographic atrophy,  Visual acuity,  Dense scotoma,  Macular degeneration,  Fixation location,  Fixation patterns,  Central scotomas.

    Janet S Sunness:KOL impact

    Concepts related to the work of other authors for whichfor which Janet S Sunness has influence:Geographic atrophy,  Macular degeneration,  Visual acuity,  Stargardt disease,  Retinitis pigmentosa,  Optical coherence,  Retinal sensitivity.



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