Xavier Escoté

Xavier Escoté

Endocrinology And Diabetes Unit, Hospital Universitari Joan Xxiii, Tarragona, Spain Centro De Investigación Biomédica En Red De Diabetes Y Enfermedades Metabólicas Asociadas ...

Direct Impact

Concepts for which Xavier Escoté has direct influence:

adipose tissue
insulin resistance
cyclin g2
metabolic syndrome
gut microbiota
serum ccdc80
maresin 1

External impact

Concepts related to the work of other authors for which Xavier Escoté has influence:

insulin resistance
adipose tissue
gut microbiota
metabolic syndrome
bariatric surgery
fatty acids
3t3-l1 adipocytes

Prominent publications by Xavier Escoté

KOL-Index: 101 Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have emerged as the leading causes of chronic liver disease in the world. Obesity, insulin resistance, and dyslipidemia are multifactorial risk factors strongly associated with NAFLD/NASH. Here, a specific combination of metabolic cofactors (a multi-ingredient; MI) containing precursors of glutathione (GSH) ...
Known for
Fibrosis Insulin | Hfhfr Combination | Ameliorates Alcoholic | Decreasing Hepatic
KOL-Index: 82 The aim of this study was to characterize the effects of Maresin 1 (MaR1), a DHA-derived pro-resolving lipid mediator, on obesity-related colonic inflammation and gut dysbiosis in diet-induced obese (DIO) mice. In colonic mucosa of DIO mice, the MaR1 treatment decreased the expression of inflammatory genes, such as Tnf-α and Il-1β. As expected, the DIO mice exhibited significant changes in ...
Known for
Obesity Colonic | Synergistetes | Mice Mar1 | Abundant Phyla
KOL-Index: 81 The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not ...
Known for
Pre-Disease Stages | Syndrome Nmr | Markers Metabolomics | Early Metabolic
KOL-Index: 58 Obesity, characterized by excessive fat accumulation, is accompanied by low-grade chronic inflammation and increased oxidative stress. Dysfunctional hypertrophic adipose tissue in obesity exhibits a disturbed secretory pattern, characterized by increased release of proinflammatory factors and decreased production of antiinflammatory adipokines. There is a strong association between the ...
KOL-Index: 53 Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and ...
Known for
Role Omentin | Produced Visceral | Regulation Cardiotrophin-1
KOL-Index: 51 Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of this study was to analyze the changes in the expression of p27 and cdk2 in different adipose ...
Known for
Mice Obesity | Cdk2 Visceral | Aging Subcutaneous | Differential Adipose Depot-Dependent Regulation
KOL-Index: 49 The brain depends on glucose as a source of energy. This implies the presence of glucose transporters, being GLUT1 and GLUT3 the most relevant. Expression of GLUT12 is found in mouse and human brain at low levels. We previously demonstrated GLUT12 upregulation in the frontal cortex of aged subjects that was even higher in aged Alzheimer’s disease (AD) patients. However, the cause and the ...
Known for
Glucose Transporters | Β-Amyloid Aβ Deposition | Amyloidogenic Mouse Models | Glut12 Mouse
KOL-Index: 38 WNT/β-catenin signaling plays pivotal roles in mammary development and tumorigenesis; and aberrant activation of this pathway is frequently observed in human breast cancer, correlating with poor outcome. However, the mechanisms underlying WNT-driven mammary tumorigenesis remain incompletely understood. Here, we used mouse mammary tumor virus (MMTV)-Wnt1 transgenic mice, which develop ...
Known for
Tumorigenesis Lbh | Reduced Hyperplasia | Aberrant Activation | Mammary Epithelium
KOL-Index: 30 FGF21 has emerged as a key metabolism and energy homeostasis regulator. Dietary supplementation with eicosapentaenoic acid (EPA) and/or α-lipoic acid (LIP) has shown beneficial effects on obesity. In this study, we evaluated EPA and/or LIP effects on plasma FGF21 and the fatty acid (FA) profile in overweight/obese women following hypocaloric diets. At the baseline, FGF21 levels were ...
Known for
N-3 Pufas | Dpa | Lip-Supplemented Groups | Α-Lipoic Acid
KOL-Index: 26 Recently, hesperidin, a flavonone mainly present in citrus fruits, has emerged as a new potential therapeutic agent able to modulate several cardiovascular diseases (CVDs) risk factors. Animal and in vitro studies demonstrate beneficial effects of hesperidin and its derived compounds on CVD risk factors. Thus, hesperidin has shown glucose-lowering and anti-inflammatory properties in diabetic ...
Known for
Interindividual Hesperidin | Variability Bioavailability | Effects Trials

Endocrinology and Diabetes Unit, Hospital Universitari Joan XXIII, Tarragona, Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain Institut d'Investig

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