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    • Alvaro Pascual PASCUAL‐LEONE

      Alvaro Pascual PASCUAL‐LEONE

      Department of Neurology, Harvard Medical School, Boston MA, USA. | Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, ...



      KOL Resume for Alvaro Pascual PASCUAL‐LEONE


      Department of Neurology, Harvard Medical School, Boston MA, USA.

      Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA USA

      Guttmann Brain Health Institute, Institut Universitari de Neurorehabilitació, Barcelona, Spain

      Linus Health, Waltham, MA, United States

      Hebrew Senior Life


      Departament de Medicina, Facultat de Medicina i Ciències de la Salut i Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain

      Deanna and Sidney Wolk Center for Memory Health, Arthur and Hinda Marcus Institute for Aging Research and Hebrew SeniorLife, Boston, MA, United States

      Harvard Medical School, Boston, MA, USA

      Hinda and Arthur Marcus Institute for Aging Research and Center for Memory Health, Hebrew SeniorLife, Boston, Massachusetts



      Alvaro Pascual PASCUAL‐LEONE: Influence Statistics

      Sample of concepts for which Alvaro Pascual PASCUAL‐LEONE is among the top experts in the world.
      Concept World rank
      fiber tracts ptr #1
      common causal circuits #1
      risk adult humans #1
      independent cohort authors #1
      nbs tbi #1
      improvement lems #1
      individuals cognitive training #1
      anosognosia functional connectivity #1
      nibs intervention #1
      biappa pulses lici #1
      cortical plasticity tms #1
      new parameters stimulation #1
      tms current #1
      baseline rcbf patients #1
      neurologic diseases life #1
      m1nl #1
      behavior transcranial #1
      passagere funktionsunterbrechung #1
      region sham #1
      rtms hemisphere sites #1
      tdcs sham stimulation #1
      μcoil #1
      fname test sfname #1
      lifespan apoe ε4 #1
      excitability rtms #1
      meps ctbs #1
      cortical function schizophrenia #1
      conceptual representations lpmtg #1
      direct current tdcs #1
      systematic review nibs #1
      occipital cortex activation #1
      tmsalone #1
      corticospinal excitability tms #1
      extrastriate cortical activation #1
      rtms studies #1
      modulation motor excitability #1
      neuroplasticity individuals #1
      neuroprotective effects tms #1
      gf efs #1
      mirrorcondition #1
      action verbs retrieval #1
      language improvements #1
      clinical tms society #1
      lpmtg precentral gyrus #1
      evoked mmg #1
      cognitive reserve role #1
      modulating brain circuitry #1
      action word production #1
      dmn tbs #1
      groups val val #1


      Prominent publications by Alvaro Pascual PASCUAL‐LEONE

      KOL-Index: 15133

      Two chronic, nonfluent aphasia patients participated in overt naming fMRI scans, pre- and post-a series of repetitive transcranial magnetic stimulation (rTMS) treatments as part of a TMS study to improve naming. Each patient received 10, 1-Hz rTMS treatments to suppress a part of R pars triangularis. P1 was a 'good responder' with improved naming and phrase length; P2 was a 'poor responder' without improved naming. Pre-TMS (10 years poststroke), P1 had significant activation in R and L ...

      Known for Improved Naming | Nonfluent Aphasia | Post Tms | Patient Response | Magnetic Stimulation
      KOL-Index: 14486

      BACKGROUND AND PURPOSE: Functional MRI (fMRI) studies could provide crucial information on the neural mechanisms of motor recovery in patients with stroke. Resting-state fMRI is applicable to patients with stroke who are not capable of proper performance of the motor task. In this study, we explored neural correlates of motor recovery in patients with stroke by investigating longitudinal changes in resting-state functional connectivity of the ipsilesional primary motor cortex ...

      Known for Functional Connectivity | Patients Stroke | Ipsilesional M1 | Motor Recovery | 6 Months
      KOL-Index: 14033

      The aim of this study was to evaluate the analgesic effect of transcranial direct current stimulation of the motor cortex and techniques of visual illusion, applied isolated or combined, in patients with neuropathic pain following spinal cord injury. In a sham controlled, double-blind, parallel group design, 39 patients were randomized into four groups receiving transcranial direct current stimulation with walking visual illusion or with control illusion and sham stimulation with visual ...

      Known for Visual Illusion | Neuropathic Pain | Current Stimulation | Transcranial Direct | Spinal Cord Injury
      KOL-Index: 12825

      Repetitive transcranial magnetic stimulation (rTMS) is emerging as a new therapeutic tool in epilepsy, where it can be used to suppress seizures or treat comorbid conditions such as mood disorder. However, as rTMS carries a risk of inducing seizures among other adverse events, its safety and tolerability in the population with epilepsy warrant distinct consideration, as this group is especially seizure-prone. Accordingly, we performed a review of the literature to estimate the risk of ...

      Known for Patients Epilepsy | Adverse Events Rtms | Magnetic Stimulation | Risk Seizures | Repetitive Transcranial
      KOL-Index: 12728

      This proof-of-concept, double-blind study was designed to determine the effects of transcranial direct current stimulation (tDCS) on the 'cost' of performing a secondary cognitive task on gait and postural control in healthy young adults. Twenty adults aged 22 ± 2 years completed two separate double-blind visits in which gait and postural control were assessed immediately before and after a 20 min session of either real or sham tDCS (1.5 mA) targeting the left dorsolateral prefrontal ...

      Known for Postural Control | Cognitive Task | Current Stimulation | Transcranial Direct | Gait Speed
      KOL-Index: 12600

      To explore the neural networks used for Braille reading, we measured regional cerebral blood flow with PET during tactile tasks performed both by Braille readers blinded early in life and by sighted subjects. Eight proficient Braille readers were studied during Braille reading with both right and left index fingers. Eight-character, non-contracted Braille-letter strings were used, and subjects were asked to discriminate between words and non-words. To compare the behaviour of the brain ...

      Known for Braille Reading | Neural Networks | Blind Subjects | Secondary Somatosensory Area | Discrimination Tasks
      KOL-Index: 12182

      We sought to determine whether motor evoked potentials (MEPs) as well as silent periods could be produced in hand and shoulder muscles by transcranial magnetic stimulation (TMS) of the ipsilateral cerebral hemisphere and, if so, whether their cortical representations could be mapped with respect to those of contralateral muscles. In six normal subjects, we delivered ten stimuli each to a grid of sites 1 cm apart on the scalp. The EMG was recorded and averaged from the contralateral first ...

      Known for Ipsilateral Hand | Motor Representation | Silent Periods | Normal Subjects | Contralateral Muscles
      KOL-Index: 12166

      We examined the dynamic involvement of different brain regions in implicit and explicit motor sequence learning using PET. In a serial reaction time task, subjects pressed each of four buttons with a different finger of the right hand in response to a visually presented number. Test sessions consisted of 10 cycles of the same 10-item sequence. The effects of explicit and implicit learning were assessed separately using a different behavioural parameter for each type of learning: correct ...

      Known for Reaction Time | Motor Sequence | Pet Study | Explicit Learning | Dynamic Cortical Involvement
      KOL-Index: 11912

      Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), ...

      Known for Cortical Stimulation | Motor Function | Parkinsons Disease | Cortex M1 | Transcranial Direct
      KOL-Index: 11909

      Transcranial magnetic stimulation (TMS) is a useful tool to induce and measure plasticity in the human brain. However, the cortical effects are generally indirectly evaluated with motor-evoked potentials (MEPs) reflective of modulation of cortico-spinal excitability. In this study, we aim to provide direct measures of cortical plasticity by combining TMS with electroencephalography (EEG). Continuous theta-burst stimulation (cTBS) was applied over the primary motor cortex (M1) of young ...

      Known for Neural Basis | Tms Eeg | Theta Burst | Cortical Plasticity | Ctbs Induced
      KOL-Index: 11733

      BACKGROUND: Transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is used clinically for the treatment of depression. However, the antidepressant mechanism remains unknown and its therapeutic efficacy remains limited. Recent data suggest that some left DLPFC targets are more effective than others; however, the reasons for this heterogeneity and how to capitalize on this information remain unclear.

      METHODS: Intrinsic (resting state) functional magnetic ...

      Known for Subgenual Cingulate | Functional Connectivity | Magnetic Stimulation | Dlpfc Tms | Therapeutic Efficacy
      KOL-Index: 11688

      A traditional and widely used approach for linking neurological symptoms to specific brain regions involves identifying overlap in lesion location across patients with similar symptoms, termed lesion mapping. This approach is powerful and broadly applicable, but has limitations when symptoms do not localize to a single region or stem from dysfunction in regions connected to the lesion site rather than the site itself. A newer approach sensitive to such network effects involves functional ...

      Known for Brain Lesion | Neurological Symptoms | Network Localization | Patients Approach | Extrastriate Visual Cortex
      KOL-Index: 11683

      Cognitive deficits that are reported in heavy marijuana users (attention, memory, affect perception, decision-making) appear to be completely reversible after a prolonged abstinence period of about 28 days. However, it remains unclear whether the reversibility of these cognitive deficits indicates that (1) chronic marijuana use is not associated with long-lasting changes in cortical networks or (2) that such changes occur but the brain adapts to and compensates for the drug-induced ...

      Known for Prefrontal Cortex | Anodal Stimulation Dlpfc | Transcranial Direct | Stimulation Tdcs | Risk Task
      KOL-Index: 11652

      INTRODUCTION: Depression and memory dysfunction significantly impact the quality of life of patients with epilepsy. Current therapies for these cognitive and psychiatric comorbidities are limited. We explored the efficacy and safety of transcranial direct current stimulation (TDCS) for treating depression and memory dysfunction in patients with temporal lobe epilepsy (TLE).

      METHODS: Thirty-seven (37) adults with well-controlled TLE were enrolled in a double-blinded, sham-controlled, ...

      Known for Transcranial Direct | Temporal Lobe | Stimulation Tdcs | Patients Epilepsy | Seizure Frequency

      Key People For Magnetic Stimulation

      Top KOLs in the world
      Alvaro Pascual PASCUAL‐LEONE
      magnetic stimulation prefrontal cortex cortical excitability
      HALLETT Hallett
      essential tremor motor cortex magnetic stimulation
      John Christine Rothwell
      motor cortex magnetic stimulation corticospinal excitability
      Leonardo G Cohen
      motor cortex magnetic stimulation chronic stroke
      Rossini Paolo Maria Rossini
      eeg rhythms alzheimer disease evoked potentials
      Eric M Wassermann
      magnetic stimulation motor cortex frontotemporal dementia

      Alvaro Pascual PASCUAL‐LEONE:Expert Impact

      Concepts for whichAlvaro Pascual PASCUAL‐LEONEhas direct influence:Magnetic stimulation,  Transcranial magnetic,  Brain stimulation,  Prefrontal cortex,  Motor cortex,  Noninvasive brain stimulation,  Cortical excitability,  Current stimulation.

      Alvaro Pascual PASCUAL‐LEONE:KOL impact

      Concepts related to the work of other authors for whichfor which Alvaro Pascual PASCUAL‐LEONE has influence:Magnetic stimulation,  Motor cortex,  Direct current,  Functional connectivity,  Cortical excitability,  Stroke patients,  Evoked potentials.



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      Department of Neurology, Harvard Medical School, Boston MA, USA. | Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA USA | Berenson-Allen Center for Noninvasive Bra

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