Herbert Yale Meltzer

Herbert Yale Meltzer

Department Of Psychiatry Vanderbilt University School Of Medicine Psychiatric Hospital 1601 23rd Avenue, Suite 306 Nashville, Tn 37212, Usa

Direct Impact

Concepts for which Herbert Yale Meltzer has direct influence:

major depression
antipsychotic drugs
nucleus accumbens
serum prolactin
tardive dyskinesia
weight gain
blood platelets

External impact

Concepts related to the work of other authors for which Herbert Yale Meltzer has influence:

bipolar disorder
tardive dyskinesia
dopamine release
nucleus accumbens
weight gain
cognitive impairment
prefrontal cortex

Prominent publications by Herbert Yale Meltzer

KOL-Index: 66 Larger CAG/CTG trinucleotide-repeat tracts in individuals affected with schizophrenia (SCZ) and bipolar affective disorder (BPAD) in comparison with control individuals have previously been reported, implying a possible etiological role for trinucleotide repeats in these diseases. Two unstable CAG/CTG repeats, SEF2-1B and ERDA1, have recently been cloned, and studies indicate that the ...
Known for
Cag Ctg | Highly Polymorphic Trinucleotide Repeat | Bipolar Affective Disorder | Alleles Bpad
KOL-Index: 65 BACKGROUND: Antipsychotic (AP) medications are the first line of treatment for schizophrenia. However, most conferr a risk of antipsychotic-induced weight gain (AIWG). The objective of this investigation was to conduct a genome-wide association study (GWAS) of AIWG, followed by comprehensive, post-GWAS approaches. METHODS: We investigated n = 201 schizophrenia or schizoaffective disorder ...
Known for
Irs1 | Dgkb | Antipsychotic Induced | Gain Europeans
KOL-Index: 53 BACKGROUND: Neuromedin U (NMU) is a neuropeptide enriched in the nucleus accumbens shell (NAcSh), a brain region associated with reward. While NMU and its receptor, NMU receptor 2 (NMUR2), have been studied for the ability to regulate food reward, NMU has not been studied in the context of drugs of abuse (e.g., cocaine). Furthermore, the neuroanatomical pathways that express NMUR2 and its ...
Known for
Cocaine Sensitization | Presynaptic Gamma-Aminobutyric Acidergic Nerve | Behavioral Responses | Raphe
KOL-Index: 50 Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By modulating chemical neurotransmission, antipsychotic drugs may influence a variety of functions regulating neuronal resilience and viability and have the potential for neuroprotection. This article reviews the current literature describing ...
Known for
Potential Neuroprotection
KOL-Index: 48 Tardive dyskinesia (TD) is a movement disorder that may occur after extended use of antipsychotic medications. The etiopathophysiology is unclear; however, genetic factors play an important role. The Perlecan (HSPG2) gene was found to be significantly associated with TD in Japanese schizophrenia patients, and this association was subsequently replicated by an independent research group. To ...
Known for
Perlecan Hspg2 Gene | Allele Occurrence | Dyskinesia Meta | Tardive
KOL-Index: 45 Suicide is a major cause of death among patients with schizophrenia. Research indicates that at least 5-13% of schizophrenic patients die by suicide, and it is likely that the higher end of range is the most accurate estimate. There is almost total agreement that the schizophrenic patient who is more likely to commit suicide is young, male, white and never married, with good premorbid ...
Known for
Illness Suicide | Schizophrenia Suicidal | Premorbid
KOL-Index: 43 BACKGROUND: Schizophrenia (SCZ) is a chronic severe neuropsychiatric disorder, where pharmacological treatment has been hindered by adverse effects, including antipsychotic-induced weight gain (AIWG) and related complications. Genetic studies have been exploring the appetite regulation and energy homeostasis pathways in AIWG with some promising leads. The serotonin system has been shown to ...
Known for
European Ancestry | Energy Homeostasis Pathways | Chronic Severe Neuropsychiatric Disorder | Serotonin Receptor Genes
KOL-Index: 42 The aim of this study was to determine if three biomarkers for suicide attempts previously identified and replicated in a genome-wide association (GWAS) study of bipolar disorder (BD) suicide attempters also predicted suicide attempts in patients prospectively diagnosed with schizophrenia (SCZ) or schizoaffective disorder (SAD). 162 genetically-verified Caucasian patients with SCZ or SAD ...
Known for
Genes Brain | Pathway Expression | Eqtl Acp1 | Disorder Suicide
KOL-Index: 41 BACKGROUND: Pregnenolone sulfate (PregS), an endogenous neurosteroid, which negatively and positively modulates gamma amino butyric acid subunit A (GABAA) and N-methyl D-aspartate (NMDA) receptors (R) respectively, among other potential neuroplastic changes on synaptic processes, has shown some beneficial effects on treating cognitive impairment associated with schizophrenia (CIAS) and ...
Known for
Sub-Effective Doses | Symptoms Schizophrenia | Atypical Antipsychotic Drug | Pregs Combination
KOL-Index: 39 BACKGROUND: Levels of tyrosine hydroxylase (TH) are regulated in the noradrenergic locus coeruleus (LC) in response to changes in the activity of LC neurons and in response to changes in brain levels of norepinephrine. To study the potential role of central noradrenergic neurons in the pathobiology of major depression, TH protein was measured in the LC from postmortem brains of 13 subjects ...
Known for
Noradrenergic Locus | Depression Tyrosine | Matched Axis | Diagnosis Major

Department of Psychiatry Vanderbilt University School of Medicine Psychiatric Hospital 1601 23rd Avenue, Suite 306 Nashville, TN 37212, USA

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