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    • Michael H J Maes
    • Michael H J Maes

      Michael H J Maes

      Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand | Department of Psychiatry, Faculty of Medicine, Chulalongkorn ...



      KOL Resume for Michael H J Maes


      Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand

      School of Medicine, IMPACT Strategic Research Centre, Deakin University, VIC, 3220, Australia.

      IMPACT Strategies Research Center, Deakin University, Geelong, VIC, Australia


      Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Impact Research Center, Deakin University, Geelong, Australia.

      IMPACT Research Center, Deakin University, Geelong, Australia

      Chulalongkorn University, Thailand

      College of Pharmacy, Hawler Medical University, Havalan City, Iraq

      Medical University of Plovdiv, Bulgaria



      Michael H J Maes: Influence Statistics

      Sample of concepts for which Michael H J Maes is among the top experts in the world.
      Concept World rank
      cfs pem #1
      breastcraving #1
      lower trp #1
      zonulin schizophrenia #1
      increased aopp #1
      increased levels clnk #1
      antioxidants stnfr2 #1
      neuroprogressive pathways #1
      violent suicide rate #1
      postdst cortisol values #1
      ua ats #1
      lowered lipid #1
      ndscz #1
      root canal endotoxin #1
      296x2 #1
      mdd mor #1
      affective symptoms t2dm #1
      phenome scores classification #1
      mdle children #1
      bp2 igm responses #1
      c2285tcparp1 #1
      inflammatory response irs #1
      stnfr1 age #1
      schizophrenia amci #1
      term early puerperium #1
      deficit schizophrenia schizophrenia #1
      homocysteine folate levels #1
      nibca immune biomarkers #1
      mhpg flow #1
      depression special #1
      muramidase neopterin #1
      lower complement #1
      neuronitrosative stress pathways #1
      oxidative stress cfs #1
      intermediate position #1
      depression major depression #1
      ua mor #1
      smd lowered neuroprotection #1
      trycats trycat #1
      insulin resistance atherogenicity #1
      trhtest #1
      depression lower #1
      physiosomatic #1
      normal mcpp #1
      restricted maximumlikelihood #1
      40 healthy #1
      rdw platelets #1
      zn depression #1
      smoking pon1 #1
      il6 tfr #1


      Prominent publications by Michael H J Maes

      KOL-Index: 18738

      This paper reviews the body of evidence that not only tryptophan and consequent 5-HT depletion, but also induction of indoleamine 2,3-dioxygenase (IDO) and the detrimental effects of tryptophan catabolites (TRYCATs) play a role in the pathophysiology of depression. IDO is induced by interferon (IFN)γ, interleukin-6 and tumor necrosis factor-α, lipopolysaccharides and oxidative stress, factors that play a role in the pathophysiology of depression. TRYCATs, like kynurenine and quinolinic ...

      Known for Immune Activation | Depression Ido | Trycat Pathway | Plasma Tryptophan | Detrimental Effects
      KOL-Index: 17260

      There is much debate on the diagnostic classification of Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS) and chronic fatigue (CF). Post-exertional malaise (PEM) is stressed as a key feature. This study examines whether CF and CFS, with and without PEM, are distinct diagnostic categories. Fukuda's criteria were used to diagnose 144 patients with chronic fatigue and identify patients with CFS and CF, i.e. those not fulfilling the Fukuda's criteria. PEM was rated by means of ...

      Known for Chronic Fatigue | Myalgic Encephalomyelitis | Cfs Pem | Fukudas Criteria | Subjective Feeling
      KOL-Index: 16215

      Deficit schizophrenia is accompanied by mucosa-associated activation of the tryptophan catabolite (TRYCAT) pathway, as indicated by increased IgA responses to noxious (NOX) TRYCATs, but not regulatory or protective (PRO) TRYCATs, suggesting increased neurotoxic, excitotoxic, inflammatory, and oxidative potential. No previous studies examined IgM-mediated autoimmune responses to the TRYCAT pathway in deficit versus nondeficit schizophrenia. We measured IgM responses to NOX TRYCATs, ...

      Known for Deficit Schizophrenia | Trycat Pathway | Igm Responses | Negative Symptoms | Quinolinic Acid
      KOL-Index: 15665

      BACKGROUND: Major depression and bipolar disorder are accompanied by the activation of immune-inflammatory and Oxidative and Nitrosative Stress (O&NS) pathways and lowered levels of antioxidants. Paraoxonase (PON)1 (EC is an antioxidant bound to High Density Lipoprotein (HDL). Polymorphisms in the PON1 Q192R coding sequence determine three functional genotypes, i.e. 192QQ, 192QR and 192RR.

      AIMS: This study was carried out to delineate the associations of plasma PON1 activity and ...

      Known for Major Depression | Bipolar Disorder | Smoking Interactions | Pon1 Q192r | Functional Genotypes
      KOL-Index: 15308

      Importance: Previous studies suggest that depression and anxiety are common in patients with hidradenitis suppurativa (HS), more so than other dermatological conditions. Yet, to the authors' knowledge, no previous systematic review or meta-analysis has estimated the prevalence or odds ratio (OR) for those psychiatric comorbidities in this population.

      Objective: To assess the prevalence and odds for depression and anxiety in patients with HS.

      Data Sources: From July 25 to September 30, ...

      Known for Hidradenitis Suppurativa | Depression Anxiety | Prevalence Odds | Heterogeneity Studies | Psychiatric Comorbidities
      KOL-Index: 14973

      There is some evidence that lowered tryptophan and an activated tryptophan catabolite (TRYCAT) pathway play a role in depression, somatoform disorder, and postpartum blues. The aim of this study is to delineate the associations between the TRYCAT pathway and premenstrual syndrome (PMS) and perinatal depressive and physio-somatic symptoms. We examine the associations between end of term serum IgM and IgA responses to tryptophan and 9 TRYCATs in relation to zinc, C-reactive protein (CRP), ...

      Known for Premenstrual Syndrome | Prenatal Depression | Igm Responses | Somatic Symptoms | Trycat Pathway
      KOL-Index: 14895

      Evidence indicates that schizophrenia and in particular negative symptoms and deficit schizophrenia are accompanied by neurocognitive impairments and changes in the patterning of the tryptophan catabolite (TRYCAT) pathway. This cross-sectional study was carried out to examine the associations between cognitive functions (as measured with Consortium to Establish a Registry for Alzheimer’s disease (CERAD)) and TRYCAT pathway patterning in patients with (n = 40) and without (n = 40) deficit ...

      Known for Deficit Schizophrenia | Vft Wlm | Episodic Memory | Negative Symptoms | Iga Nox
      KOL-Index: 14651

      OBJECTIVE: This study examines the effects of malondialdehyde (MDA) and uric acid on insulin resistance and atherogenicity in subjects with and without mood disorders, the metabolic syndrome (MetS) and tobacco use disorder (TUD).

      METHODS: We included 314 subjects with depression and bipolar depression, with and without the MetS and TUD and computed insulin resistance using the updated homeostasis model assessment (HOMA2IR) and atherogenicity using the atherogenic index of plasma (AIP), ...

      Known for Insulin Resistance | Mood Disorders | Metabolic Syndrome | Uric Acid | Tud Bmi
      KOL-Index: 14187

      BACKGROUND: There is now evidence that the availability of plasma tryptophan is decreased during pregnancy and the puerperium and also in patients with major depression and inflammation. The aims of the present study were to examine: (i) the effects of pregnancy and delivery on plasma tryptophan and the amino acids known to compete for the same cerebral uptake mechanism (CAAs), valine, leucine, tyrosine, phenylalanine and isoleucine; (ii) the relationships between the availability of ...

      Known for Plasma Tryptophan | Early Puerperium | Immune Activation | Postpartum Depression | Term Delivery
      KOL-Index: 14153

      Serotonin (5-HT) is a neurotransmitter and immune modulator. The effect of 5-HT on the production of cytokines by human macrophages and lymphocytes is poorly recognized. In the present article we examine the role of 5-HT in modulating the production of two pro-inflammatory cytokines, i.e. interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFalpha), as well as the role of 5-HT(1A) and 5-HT(2) receptors in this process. The specific aims were to examine the effects of 5-HT, ...

      Known for Serotonin 5 | Tumor Necrosis | Production Il6 | Human Macrophages | Factor Α
      KOL-Index: 14153

      Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and depression are considered to be neuro-immune disorders (Maes and Twisk, BMC Medicine 8:35, 2010). There is also evidence that depression and ME/CFS are accompanied by oxidative and nitrosative stress (O&NS) and by increased autoantibodies to a number of self-epitopes some of which have become immunogenic due to damage by O&NS. The aim of this study is to examine IgM-mediated autoimmune responses to different self-epitopes in ...

      Known for Autoimmune Responses | Chronic Fatigue | Major Depression | Myalgic Encephalomyelitis | Serum Igm

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      Michael H J Maes:Expert Impact

      Concepts for whichMichael H J Maeshas direct influence:Major depression,  Mood disorders,  Bipolar disorder,  Chronic fatigue,  Deficit schizophrenia,  Chronic fatigue syndrome,  Depressive disorder,  Oxidative stress.

      Michael H J Maes:KOL impact

      Concepts related to the work of other authors for whichfor which Michael H J Maes has influence:Bipolar disorder,  Depressive symptoms,  Oxidative stress,  Major depression,  Gut microbiota,  Fatty acids,  Multiple sclerosis.



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      Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand | Department of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Ban

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