Prominent publications by Jorge N Moll

KOL Index score: 11242

CONTEXT: Proneness to overgeneralization of self-blame is a core part of cognitive vulnerability to major depressive disorder (MDD) and remains dormant after remission of symptoms. Current neuroanatomical models of MDD, however, assume general increases of negative emotions and are unable to explain biases toward emotions entailing self-blame (eg, guilt) relative to those associated with blaming others (eg, indignation). Recent functional magnetic resonance imaging (fMRI) studies in ...

Also Ranks for: Major Depressive Disorder |  anterior temporal |  remitted mdd |  negative emotions |  guilt indignation
KOL Index score: 10297

Inappropriate social behaviours are early and distinctive symptoms of the temporal and frontal variants of frontotemporal lobar degeneration (FTLD). Knowledge of social behaviour is essential for appropriate social conduct. It is unknown, however, in what way this knowledge is degraded in FTLD. In a recent functional MRI study, we have identified a right-lateralized superior anterior temporal lobe (aTL) region showing selective activation for 'social concepts' (i.e. concepts describing ...

Also Ranks for: Social Concepts |  ftld patients |  superior atl |  selective impairments |  anterior temporal
KOL Index score: 10090

Previous studies have indicated that amputation or deafferentation of a limb induces functional changes in sensory (S1) and motor (M1) cortices, related to phantom limb pain. However, the extent of cortical reorganization after lower limb amputation in patients with nonpainful phantom phenomena remains uncertain. In this study, we combined functional magnetic resonance (fMRI) and diffusion tensor imaging (DTI) to investigate the existence and extent of cortical and callosal plasticity in ...

Also Ranks for: Limb Amputees |  cortical reorganization |  adult amputation |  deafferented hemisphere |  phantom pain
KOL Index score: 9670

Major advances have been made in the understanding of the neurobiology of psychopathy in the past years, yet the distribution and extent of neuroanatomical abnormalities underlying the disorder are still poorly known. It is also unclear if different dimensions of the construct of psychopathy (e.g., emotional callousness, antisocial behavior) correspond to structural abnormalities in distinct regions of the brain. We tested the following hypotheses: (1) psychopathy is related to grey ...

Also Ranks for: Moral Brain |  structural abnormalities |  psychopathy disorder |  matter reductions |  based morphometry
KOL Index score: 9621

Attention-deficit/hyperactivity disorder (ADHD) is characterized by symptoms of inattention and hyperactivity/impulsivity that often persist in adulthood. There is a growing consensus that ADHD is associated with abnormal function of diffuse brain networks, but such alterations remain poorly characterized. Using resting-state functional magnetic resonance imaging, we characterized multivariate (complex network measures), bivariate (network-based statistic), and univariate (regional ...

Also Ranks for: Functional Brain |  hyperactivity disorder |  adhd symptoms |  clinical sample |  attention deficit
KOL Index score: 9572

Social concepts such as "tactless" or "honorable" enable us to describe our own as well as others' social behaviors. The prevailing view is that this abstract social semantic knowledge is mainly subserved by the same medial prefrontal regions that are considered essential for mental state attribution and self-reflection. Nevertheless, neurodegeneration of the anterior temporal cortex typically leads to impairments of social behavior as well as general conceptual knowledge. By using ...

Also Ranks for: Social Concepts |  anterior temporal |  functional mri |  emotional valence |  enhanced activation
KOL Index score: 9537

IntroductionThe aim of this study was to investigate white matter (WM) abnormalities in obsessive-compulsive disorder (OCD) and its relationship to severity of obsessive-compulsive symptoms.

METHODS: Conventional and diffusion tensor imaging were acquired in nine patients with OCD and nine gender- and age-matched healthy volunteers. Changes in fractional anisotropy (FA) and mean diffusivity (MD) were investigated using selected regions of interest (ROIs) analyses and whole brain ...

Also Ranks for: White Matter |  diffusion tensor imaging |  patients ocd |  posterior limb |  internal capsule
KOL Index score: 9347

BACKGROUND: One widespread view holds that vulnerability to major depressive disorder (MDD) is linked to overall increases in negative emotionality. In contrast, cognitive attribution theories emphasize the importance of blaming oneself rather than others for negative events. Thus far, the contrasting predictions of these models have not been directly compared. Following the attributional perspective, we tested the hypothesis that people with remitted MDD show no overall bias towards ...

Also Ranks for: Negative Emotions |  major depressive disorder |  remitted mdd |  contempt disgust |  selective bias
KOL Index score: 9233

OBJECTIVES: We attempted to determine the prognostic value of coronary computed tomographic angiography (CTA) in patients with inconclusive functional stress tests.

BACKGROUND: Patients with suspected coronary artery disease (CAD) and inconclusive noninvasive cardiac stress tests represent a frequent management challenge.

METHODS: We examined 529 consecutive patients with suspected CAD and prior inconclusive functional stress tests. All patients underwent a coronary CTA scan using a ...

Also Ranks for: Coronary Cta |  stress tests |  patients cad |  artery disease |  50 69
KOL Index score: 9083

Altered reward processing has been proposed to contribute to the symptoms of attention deficit hyperactivity disorder (ADHD). The neurobiological mechanism underlying this alteration remains unclear. We hypothesize that the transfer of dopamine release from reward to reward-predicting cues, as normally observed in animal studies, may be deficient in ADHD. Functional magnetic resonance imaging (fMRI) was used to investigate striatal responses to reward-predicting cues and reward delivery ...

Also Ranks for: Reward Anticipation |  adhd ventral striatum |  bold responses |  dopamine release |  opposite pattern
KOL Index score: 8965

In this fMRI study, we investigated the development between adolescence and adulthood of the neural processing of social emotions. Unlike basic emotions (such as disgust and fear), social emotions (such as guilt and embarrassment) require the representation of another's mental states. Nineteen adolescents (10-18 years) and 10 adults (22-32 years) were scanned while thinking about scenarios featuring either social or basic emotions. In both age groups, the anterior rostral medial ...

Also Ranks for: Social Emotion |  neural processing |  adolescents adults |  development adolescence |  fmri study
KOL Index score: 8786

Social values are composed of social concepts (e.g., "generosity") and context-dependent moral sentiments (e.g., "pride"). The neural basis of this intricate cognitive architecture has not been investigated thus far. Here, we used functional magnetic resonance imaging while subjects imagined their own actions toward another person (self-agency) which either conformed or were counter to a social value and were associated with pride or guilt, respectively. Imagined actions of another ...

Also Ranks for: Social Values |  neural basis |  functional mri |  indignation anger |  pride gratitude
KOL Index score: 8633

Humans are endowed with a natural sense of fairness that permeates social perceptions and interactions. This moral stance is so ubiquitous that we may not notice it as a fundamental component of daily decision making and in the workings of many legal, political, and social systems. Emotion plays a pivotal role in moral experience by assigning human values to events, objects, and actions. Although the brain correlates of basic emotions have been explored, the neural organization of "moral ...

Also Ranks for: Moral Emotions |  neural correlates |  magnetic resonance |  prefrontal cortex |  human values
KOL Index score: 8601

Proneness to self-blaming moral emotions such as shame and guilt is increased in major depressive disorder (MDD), and may play an important role in vulnerability even after symptoms have subsided. Social psychologists have argued that shame-proneness is relevant for depression vulnerability and is distinct from guilt. Shame depends on the imagined critical perception of others, whereas guilt results from one's own judgement. The neuroanatomy of shame in MDD is unknown. Using fMRI, we ...

Also Ranks for: Shame Guilt |  depressive disorder |  remitted major |  vulnerability mdd |  posterior insula
KOL Index score: 8590

It has been hypothesized that the experience of different moral sentiments such as guilt and indignation is underpinned by activation in temporal and fronto-mesolimbic regions and that functional integration between these regions is necessary for the differentiated experience of these moral sentiments. A recent fMRI study revealed that the right superior anterior temporal lobe (ATL) was activated irrespective of the context of moral feelings (guilt or indignation). This region has been ...

Also Ranks for: Guilt Indignation |  moral sentiments |  anterior temporal |  selective functional |  superior atl

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Jorge N Moll:Expert Impact

Concepts for whichJorge N Mollhas direct influence:Depressive disorder,  Major depressive disorder,  Altruistic decisions,  Behavioral variant,  Social behaviour,  Negative emotions,  Social feelings,  Acquired sociopathy.

Jorge N Moll:KOL impact

Concepts related to the work of other authors for whichfor which Jorge N Moll has influence:Moral judgment,  Social cognition,  Prefrontal cortex,  Functional connectivity,  Corpus callosum,  Magnetic resonance,  Neural correlates.



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Scients Institute, USA | Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil | Cognitive and Behavioral Neuroscience Unit, D’Or Institute for Research and Education, Rio de Janeiro, Brazil | The Scientist Institute Palo Alto, CA, United State