• Disease
  • Pancreatic
  • Pancreatic Cancer
  • Thilo Welsch

    Prominent publications by Thilo Welsch

    KOL Index score: 15020

    BACKGROUND: Aldehyde dehydrogenase 1 (ALDH1) has been characterised as a cancer stem cell marker in different types of tumours. Additionally, it plays a pivotal role in gene regulation and endows tumour cells with augmented chemoresistance. Recently, ALDH1A1 has been described as a prognostic marker in a pancreatic cancer tissue microarray. The aim of this study was to reevaluate the expression of ALDH1A1 as a prognostic marker on whole-mount tissue sections.

    METHODS: ...

    Also Ranks for: Pancreatic Cancer |  expression aldh1a1 |  tumor carcinoma |  poor survival |  prognostic marker
    KOL Index score: 10998

    BACKGROUND: Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy. The International Study Group of Pancreatic Surgery (ISGPS) definition of DGE has not been evaluated and validated in a high-volume centre.

    METHODS: Complete data sets including assessment of gastric emptying were identified from a database of patients undergoing pancreatoduodenectomy between 2001 and 2008. Factors associated with DGE (grades A, B and C) were assessed by univariable and ...

    Also Ranks for: Pancreatic Surgery |  gastric emptying |  patients dge |  international study |  common complication
    KOL Index score: 10267

    BACKGROUND: Restorative proctocolectomy has become the surgical procedure of choice in patients with ulcerative colitis. Only smaller studies have compared postoperative to preoperative quality of life (QoL).

    METHODS: Patients with ulcerative colitis who had undergone restorative proctocolectomy at least 5 years before and who had filled out a disease-specific validated questionnaire (Gastrointestinal Quality of Life Index, GIQLI) prior to surgery (n = 128) were included into this ...

    Also Ranks for: Restorative Proctocolectomy |  ulcerative colitis |  life qol |  surgical procedure |  multivariate analysis
    KOL Index score: 9757

    BACKGROUND: Phospholipids are essential for the normal function of the intestinal mucus barrier. The objective of this study was to systematically investigate phospholipids in the intestinal mucus of humans suffering from inflammatory bowel diseases, where a barrier defect is strongly supposed to be pathogenetic.

    METHODS: Optimal mucus recovery was first validated in healthy mice and the method was then transferred to the endoscopic acquisition of ileal and colonic mucus from 21 patients ...

    Also Ranks for: Ulcerative Colitis |  intestinal mucus |  patients uc |  inbred c57bl mice |  barrier defect
    KOL Index score: 9587

    PurposeExtralevator abdominoperineal resection (APR) for low rectal cancer has been adopted by centers to improve oncological outcome. The present study aimed to investigate oncological results, wound complications, and quality of life (QoL).MethodsPatients who underwent extralevator APR for rectal cancer between 2007 and 2011 were identified retrospectively. QoL status was assessed using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CR30 and CR29 ...

    Also Ranks for: Wound Complications |  rectal cancer |  perineal resection |  quality life |  extralevator apr
    KOL Index score: 9510

    Mice lacking the 80-kDa CD2-associated protein (CD2AP) develop progressive renal failure that starts soon after birth with proteinuria and foot process effacement by unknown mechanisms. CD2AP has been identified and cloned independently by virtue of its interaction with the T cell protein CD2 and with the docking protein p130Cas. In the present study we examined the localization of CD2AP and p130Cas in the mouse glomerulus and in cultured podocytes. In glomeruli, CD2AP and p130Cas ...

    Also Ranks for: Cultured Podocytes |  actin structures |  protein cd2ap |  focal adhesions |  foot processes
    KOL Index score: 9352

    PurposeThis study evaluates the anorectal and genitourinary function of patients treated by preoperative short-term radiotherapy (RT) or chemoradiotherapy (CRT) followed by surgery and surgery alone for rectal cancer.MethodsFor this study, a total of 613 patients, who were identified from a prospective rectal cancer database, underwent anterior resection of the rectum between October 2001 and December 2007. Standardized questionnaires were used to determine fecal incontinence, urinary, ...

    Also Ranks for: Fecal Incontinence |  functional outcome |  surgery rectal cancer |  sexual function |  chemoradiotherapy crt
    KOL Index score: 9275

    Since the beginning of organ transplantation, graft preservation has been one of the most important concerns. Ischemia reperfusion injury (IRI), which plays an important role in the quality and function of the graft, is a major cause for increased length of hospitalization and decreased long term graft survival. Among numerous attempts which have been made to minimize graft damage associated with IRI, the use of Thymoglobulin (TG) seems to offer potential benefits. TG is a polyclonal ...

    Also Ranks for: Reperfusion Injury |  liver transplantation |  graft function |  rejection rates |  polyclonal antibody
    KOL Index score: 8853

    PurposePostpancreatectomy hemorrhage (PPH) is one of the most serious complications after pancreatoduodenectomy (PD). This study analyzed and validated the International Study Group of Pancreatic Surgery (ISGPS) definition of PPH and aimed to identify risk factors for early (<24 h) and late PPH.MethodsPatients who underwent PD for pancreatic head tumors between 2001 and 2008 were included and complications were prospectively recorded. Factors associated with PPH were assessed by uni- and ...

    Also Ranks for: Pancreatic Surgery |  postoperative hemorrhage |  international study |  pph risk factors |  multivariate analysis
    KOL Index score: 8674

    Eps8 controls actin dynamics directly through its barbed end capping and actin-bundling activity, and indirectly by regulating Rac-activation when engaged into a trimeric complex with Eps8-Abi1-Sos1. Recently, Eps8 has been associated with promotion of various solid malignancies, but neither its mechanisms of action nor its regulation in cancer cells have been elucidated. Here, we report a novel association of Eps8 with the late endosomal/lysosomal compartment, which is independent from ...

    Also Ranks for: Cancer Cells |  mediated autophagy |  lysosomal membrane |  eps8 levels |  lysosomes cma
    KOL Index score: 8596

    IntroductionPancreaticoduodenectomy (PD) is the standard operation for cancer of the pancreatic head. To achieve complete tumor resection and, thus, improve long-term survival, venous resection of the portal or superior mesenteric vein with reconstruction has become routine for advanced pancreatic adenocarcinoma (PDAC). However, its clinical benefit still remains controversial. The aim of this study was to investigate morbidity, mortality, and survival of patients with advanced PDAC ...

    Also Ranks for: Venous Resection |  pancreatic cancer surgery |  mortality survival |  clinical data |  portal vein
    KOL Index score: 8477

    BackgroundEpithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets for an oncological therapy. In this study, we focused on the evaluation of the transcription factor Six1 (Sine oculis 1). This protein is involved in embryologic development and its contribution to carcinogenesis has been described in several ...

    Also Ranks for: Pancreatic Cancer |  expression six1 |  transcription factors |  neoplastic stem |  mesenchymal transition
    KOL Index score: 8410

    In over 70% of the cases, patients with curative surgery and adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC) develop recurrent tumors. The cancer stem cell (CSC) hypothesis suggests that CSCs are chemoresistant and enriched in recurrent tumors. This study analyzes tumorbiology, expression of the metastasis-promoting CXCR4 and actinin-4, and of the CSC marker CD133 in primary and recurrent PDAC. Twenty-six patients underwent resection for primary and recurrent PDAC and ...

    Also Ranks for: Pancreatic Ductal |  tumor cells |  expression cxcr4 |  western carcinoma |  pdac cd133
    KOL Index score: 8131

    OBJECTIVE: The aim of this study was to test the hypothesis that intraoperative frozen section (FS) and re-resection results to achieve R0 status are associated with different long-term outcomes in pancreatic cancer patients.

    BACKGROUND: Recent data have challenged the survival benefit of additional resection in patients with pancreatic cancer in case of positive FS to achieve clear pathological section (PS).

    METHODS: Patients who underwent surgery for exocrine pancreatic malignancy with ...

    Also Ranks for: Pancreatic Cancer |  r0 status |  resection margin |  intraoperative frozen |  survival benefit
    KOL Index score: 7945

    BackgroundDue to the considerable variety in the clinical presentation of anorectal and rectovaginal fistulas in Crohn’s disease, data on treatment results for each type of fistula are limited. The aim of this study was to summarize the results after surgical treatment of such fistulas in a large consecutive series of patients.Patients and methodsAll patients with anorectal or rectovaginal fistula due to Crohn’s disease requiring surgery in our institution between 1991 and 2001 were ...

    Also Ranks for: Crohn Disease |  surgical treatment |  patients fistula |  aged rectovaginal |  term success


    Thilo Welsch: Influence Statistics

    Sample of concepts for which Thilo Welsch is among the top experts in the world.
    Concept World rank
    stump gastroduodenal #1
    infiltration pi− #1
    prophylactic wrapping #1
    wrapping gda #1
    p−i− statistical analysis #1
    p−i− 001 #1
    161 gastric resections #1
    activity tracking #1
    metaanalysis intraoperative bacterobilia #1
    popf octreotide #1
    ics mesh #1
    resultssix randomised trials #1
    distant metastasis differences #1
    pancreatic surgery popf #1
    popf led #1
    stump prevention #1
    perioperative mobilization #1
    pdmethodsfive relevant outcomes #1
    octreotide pasireotide prophylaxis #1
    monitor increase #1
    mutual rhogtpase balance #1
    postoperative mobilization patients #1
    pdac question #1
    pdac pi− #1
    postoperative serum crp #1
    preoperative dm survival #1
    resultsthirtyone cases #1
    pasireotide effectiveness #1
    bacterobilia morbidity #1
    strategies popf #1
    69 salinomycin #1
    wrap gastroduodenal #1
    major visceral #1
    548 major pancreatic #1
    major visceral surgery #1
    eps8 increased #1
    gastroduodenal artery stump #1
    pancreatic surgery stratification #1
    months pi− #1

    Key People For Pancreatic Cancer

    Top KOLs in the world
    Ralpha H Hruban†
    pancreatic cancer gene expression tumor carcinoma
    Ahmedin M Jemal
    united states breast cancer addis ababa
    Rebecca L Siegel
    united states colorectal cancer incidence rates
    Anirban Maitra
    pancreatic cancer precursor lesions early detection
    Markus Wolfgang Büchler†
    pancreatic cancer chronic pancreatitis liver transplantation
    Helmut M Friess†
    pancreatic cancer chronic pancreatitis growth factor

    Thilo Welsch:Expert Impact

    Concepts for whichThilo Welschhas direct influence:Pancreatic cancer,  Pancreatic surgery,  Major visceral surgery,  Somatostatin analogs,  Pancreatic ductal adenocarcinoma,  Hepatic artery,  Falciform ligament wrap,  Chronic pancreatitis.

    Thilo Welsch:KOL impact

    Concepts related to the work of other authors for whichfor which Thilo Welsch has influence:Pancreatic cancer,  Anastomotic leakage,  Colorectal surgery,  Postoperative complications,  Delayed gastric,  Autoimmune pancreatitis,  Superior mesenteric.



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    Department of General, Visceral and Thoracic Surgery, Oberschwabenklinik Ravensburg, Ravensburg, Germany | Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dr