Ludwig M Deppisch

BACKGROUND/AIMS: Treatment options for patients with endoscopically removed malignant colorectal polyps are polypectomy alone vs. polypectomy followed by surgery. The aim of this study was to define histopathologic parameters that can be used for clinically relevant treatment decisions.

METHODS: Five pathologists evaluated 140 polyps for the presence or absence of unfavorable histology. Unfavorable histology was tumor at or near (< or = 1.0 mm) the margin and/or grade III and/or ...

Three patients, 24, 24 and 25 years of age, with systemic lupus erythematosus had signs of myocardial infarction. Two had serial electrocardiographic changes indicative of infarction without any cardiac symptoms. The third patient had clinical evidence of an acute massive myocardial infarction, which was proved at autopsy to be due to coronary atherosclerosis. This case is presented in detail and the association between systemic lupus erythematosus and myocardial infarction is reviewed. ...

A case of generalized melanosis secondary to malignant melanoma is described. The tyrosinase activity of serum and tissues from this patient has been measured. The first 2 steps of melanogenesis (tyrosine → dopa and dopa → dopachrome) have been separately assayed. Serum and homogenates from skin and spleen showed the highest activity in both steps. Weak activity was detected in vagina and lung, but no activity was detected in the adrenals, kidney, liver, and rectum. An endogenous ...

Six cases of coronary embolism and myocardial infarction associated with nonbacterial thrombotic endocarditis were seen at the Mount Sinai Hospital over a ten-year period. Every patient had an underlying malignant neoplasm. The vegetations were found on aortic, mitral, tricuspid and pulmonic valves and were located on the free or closure margins. The clinical diagnosis of this condition is difficult because of simultaneous embolization to the brain, causing widespread neurologic ...

Sixty-five cases of nonbacterial thrombotic endocarditis (NBTE) were discovered at autopsy during a 10 year period--an incidence of 1.6 per cent in the adult autopsy population. In 51 cases, one or more malignant neoplasms were associated; adenocarcinoma represented the most frequent histologic type of related neoplasm. Coagulation abnormalities suggestive of disseminated intravascular coagulation (DIC) were present in 18.5 per cent of the cases. It is possible that both the valvular and ...

Several histologic variants of parotid gland mixed tumors were examined ultrastructurally to determine the nature of the cells present within the myxoid stroma of these neoplasms. The stellate cells within the myxoid stroma of some of these cases resembled certain epithelial elements present within the glandular areas of others. In addition, the presence of desmosomal attachments further suggested an epithelial, rather than a mesenchymal, origin for these elements. No evidence was found ...

The pathology and clinical follow-up of seven solid ovarian teratomas diagnosed over a 25-year period were reviewed. Prognosis could be related, within limits, to the histologic degree of maturation of the component tissue—tumors composed solely of adult elements pursued a benign course, while teratomas consisting principally of immature elements were fatal. The behavior of tumors of intermediate maturation was hazardous to predict. The benign behavior of neoplasms with mature glial ...

Historians have suggested that US president Andrew Jackson (1767-1845) experienced lead and mercury poisoning following his therapeutic use of calomel (mercurous chloride) and sugar of lead (lead acetate). To evaluate these claims, we performed direct physical measurement of 2 samples of Jackson's hair (1 from 1815, 1 from 1839). Following pretreatment and acid digestion, mercury was measured using cold vapor generation techniques, while lead levels were measured by electrothermal atomic ...

Three of eight female patients with cytomegalovirus disease had evidence of ovarian infection at autopsy. All three patients with ovarian lesions were postmenopausal; the remaining five were premenopausal. The lesions, which may be bilateral and may occur without evidence of cytomegalovirus infection elsewhere, are distinctive macroscopically, pathognomonic microscopically, and characterized by acute focal ovarian cortical necrosis with numerous cytomegalic cells and a variable but ...

Deppisch, Ludwig M., and Donowho, Everett M.: Pulmonary coccidioidomycosis. Am. J. Clin. Pathol. 58: 489–500, 1972. Thirty-eight cases of pulmonary coccidioidomycosis were disclosed by review of the surgical pathology files of a general hospital in an area endemic for Coccidioides immitis. All lesions were localized inflammations, the chronic coccidioidal residual that evolves from primary coccidioidomycosis infection of the lungs in only a small percentage of cases. Peripheral location, ...

The third documented case of primary squamous cell carcinoma of the urachus in the English literature is reported. The interesting coincidental occurrence of the dermoid cyst of the right ovary and a complete longitudinal septum of the vagina and uterine cervix is described.