Toshiyuki Yamamoto: Influence Statistics

Toshiyuki Yamamoto

Toshiyuki Yamamoto

Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, Japan. | Tokyo Women’s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan ...

Toshiyuki Yamamoto: Expert Impact

Concepts for which Toshiyuki Yamamoto has direct influence: Palmoplantar pustulosis , Japanese patients , Pyoderma gangrenosum , Mast cells , Psoriasis vulgaris , Developmental delay , Systemic sclerosis .

Toshiyuki Yamamoto: KOL impact

Concepts related to the work of other authors for which for which Toshiyuki Yamamoto has influence: Systemic sclerosis , Moyamoya disease , Mast cells , Intellectual disability , Skin fibrosis , Corpus callosum , Psoriatic arthritis .

KOL Resume for Toshiyuki Yamamoto

Year
2022

Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, Japan.

Tokyo Women’s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan

2021

Department of Genomic Medicine, Tokyo Women's Medical University, Tokyo, Japan

2020

Institute of Medical Genetics, Tokyo Women’s Medical University, Shinjuku, Japan

Departamento de Dermatología. Universidad de Medicina de Fukushima, Fukushima, Japón

Department of Dermatology, Fukushima Medical University

2019

Institute of Medical Genetics, Tokyo Women's Medical University, Tokyo, Japan; Tokyo Women's Medical University Institute of Integrated Medical Sciences, Tokyo, Japan. Electronic address:

Department of Dermatology, Fukushima Medical University, Fukushima, Japan. E-mail:

National Center Hospital, National Center of Neurology and Psychiatry, Japan

2018

Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan

Unidad de Dermatología, Facultad de Medicina, Universidad de Fukushima, Fukushima, Japón

2017

National Center of Neurology and Psychiatry Department of Neurology Tokyo Japan

2016

Tokyo Women’s Medical University Institute for Integrated Medical Sciences, Shinjuku, Tokyo, Japan

2015

Fukushima Medical University

2014

Institute for Integrated Medical Science, Tokyo Women’s Medical University, Tokyo, Japan

2013

Departments of Dermatology, Fukushima Medical University, Japan

Tokyo Women's Medical University Institute for Integrated Medical Sciences Tokyo

Prominent publications by Toshiyuki Yamamoto

KOL-Index: 20900 . STUDY QUESTION: Can preimplantation genetic testing for aneuploidy (PGT-A) improve the live birth rate and reduce the miscarriage rate in patients with recurrent pregnancy loss (RPL) caused by an abnormal embryonic karyotype and recurrent implantation failure (RIF)? SUMMARY ANSWER: PGT-A could not improve the live births per patient nor reduce the rate of miscarriage, in both groups. WHAT ...
Known for Live Birth | Patients Rpl | Pregnancy Loss | Genetic Testing
KOL-Index: 17523 . Interleukin-10 (IL-10) is a cytokine with many regulatory functions. In particular, IL-10 exerts neutralizing effect on other cytokines, and therefore IL-10 is thought to have important therapeutic implications. Recent reports suggest that IL-10 regulates not only immunocytes but also collagen and collagenase gene expression in fibroblasts. In this study, we investigated the effect of ...
Known for Gene Expression | Monocyte Chemoattractant | Human Skin Fibroblasts | Growth Factor
KOL-Index: 15403 . Transforming growth factor-beta is responsible for triggering a cascade of events leading to fibrosis in scleroderma. The Smads are intracellular signal transducers recently shown to mediate fibroblast activation and other profibrotic responses elicited by transforming growth factor-betain vitro. To understand better the involvement of Smads in the pathogenesis of fibrosis, we examined ...
Known for Growth Factor | Smad Signaling | Murine Model | Sustained Activation
KOL-Index: 15050 . BACKGROUND: Mutations of the SET binding protein 1 gene (SETBP1) on 18q12.3 have recently been reported to cause Schinzel-Giedion syndrome (SGS). As rare 18q interstitial deletions affecting multiple genes including SETBP1 correlate with a milder phenotype, including minor physical anomalies and developmental and expressive speech delay, mutations in SETBP1 are thought to result in a ...
Known for Setbp1 Haploinsufficiency | Expressive Language | Multiple Blotting | Reduced Expression
KOL-Index: 14875 . BACKGROUND: Mutations in SCN1A, the gene encoding the alpha1 subunit of the sodium channel, have been found in severe myoclonic epilepsy of infancy (SMEI) and generalized epilepsy with febrile seizures plus (GEFS+). Mutations in SMEI include missense, nonsense, and frameshift mutations more commonly arising de novo in affected patients. This finding is difficult to reconcile with the ...
Known for Sodium Channel | Infantile Spasms | Severe Myoclonic Epilepsy | Mutations Smei
KOL-Index: 12802 . Abstract We have recently established a mouse model for scleroderma by repeated local bleomycin treatment. In this study, we compared the susceptibility to bleomycin in the development of dermal sclerosis among Balb/c, C3H/He, C57BL/6J, A/J, DBA/2, B10.BR, B10.A, and B10.D2 mouse strains. After either bleomycin or PBS treatment, skin from the injection site was histologically examined. ...
Known for Sclerotic Skin | Animal Model | Bleomycin Treatment | Dermal Sclerosis
KOL-Index: 12547 . Mast cell infiltration and accumulation is known to occur in tissue fibrosis. Increased numbers of mast cells are detected in scleroderma or hypertrophic scar skin, however, neither the role of mast cells nor the interaction of fibroblasts and mast cells in fibrosis are fully understood. A growing body of evidence indicate that mast cells are rich source of cytokines, growth factors or ...
Known for Mast Cells | Monocyte Chemoattractant | Cell Factor | Fibroblasts Fibrosis
KOL-Index: 11894 . We have established a mouse model for scleroderma induced by repeated local injections of bleomycin (BLM). Daily injection of BLM at a dose of >10 microg per ml for 4 wk induced histologic changes of dermal sclerosis, but not fibrosis, with thickened and homogenous collagen bundles and cellular infiltrates in BALB/C mice, whereas clinical signs of scleroderma were not apparent. In ...
Known for Sclerotic Skin | Animal Model | Dermal Sclerosis | Local Injections
KOL-Index: 11893 . Mutations in PRRT2 genes have been identified as a major cause of benign infantile epilepsy and/or paroxysmal kinesigenic dyskinesia. We explored mutations in PRRT2 in Japanese patients with BIE as well as its related conditions including convulsion with mild gastroenteritis and benign early infantile epilepsy. We explored PRRT2 mutations in Japanese children who had had unprovoked ...
Known for Prrt2 Mutation | Benign Infantile Epilepsy | Mild Gastroenteritis | Japanese Patients
KOL-Index: 11831 . Reorganization of the extracellular matrix is important in many biological and pathophysiological processes, including tissue remodelling, wound healing, or cancer metastasis. The ability of cultured fibroblasts to reorganize and contract three-dimensional type I collagen gels is regarded as an in vitro model for this process. In tissue fibrosis, complex interactions among fibroblasts, ...
Known for Mast Cells | Cell Factor | Collagen Lattices | Gel Contraction
KOL-Index: 11583 . FOXG1 on chromosome 14 has recently been suggested as a dosage-sensitive gene. Duplication of this gene could cause severe epilepsy and developmental delay, including infantile spasms. Here, we report on a female patient diagnosed with maternal uniparental disomy of chromosome 14 and West syndrome who carried a small supernumerary marker chromosome. A chromosomal analysis revealed ...
Known for Chromosome 14 | Maternal Uniparental Disomy | West Syndrome | Infantile Spasms
KOL-Index: 11437 . Monocyte chemoattractant protein-1 (MCP-1), a member of the C-C chemokine superfamily, has recently been shown to be involved in the pathogenesis of tissue fibrosis. In vitro studies demonstrated that MCP-1 up-regulates type I collagen gene expression via endogenous production of TGF-beta in rat lung fibroblasts. We here show that recombinant human MCP-1 affects gene expression of ...
Known for Gene Expression | Monocyte Chemoattractant | Matrix Metalloproteinase | Human Fibroblasts
KOL-Index: 11409 . Scleroderma is a connective tissue disorder with unknown etiology. Myofibroblasts appear during fibrotic processes such as scleroderma, hypertrophic scarring, and wound healing. We previously established a mouse model for scleroderma by local injections of bleomycin. To determine the phenotype of the fibroblasts in sclerotic skin after bleomycin treatment, we examined the expression of ...
Known for Sclerotic Skin | Animal Model | Increased Expression | Bleomycin Treatment
KOL-Index: 11340 . Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by development of unusual tumor-like growths. Involvement of the brain is associated with the most problematic clinical manifestations of TSC, including intellectual retardation, epilepsy and abnormal behaviors. Until now, over 300 mutations of TSC1 and TSC2 were reported. Here, we report one novel mutation of TSC1 ...
Known for Tuberous Sclerosis | Tsc2 Mutations | Japanese Patients | Preschool Codon

Key People For Palmoplantar Pustulosis

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Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, Japan. | Tokyo Women’s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan | Institute of Medical Genetics, Tokyo Women’s Medical University, Tokyo, J