Joe Leigh Leigh SimpsonShow email address
Department of Human and Molecular Genetics Department of Obstetrics and Gynecology Herbert Wertheim College of MedicineFlorida International University Miami Florida USA | ...
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Joe Leigh Leigh Simpson:Expert Impact
Concepts for whichJoe Leigh Leigh Simpsonhas direct influence:Maternal blood,Prenatal diagnosis,Fetal cells,Chorionic villus sampling,Situ hybridization,Premature ovarian failure,Spontaneous abortion,Preterm birth.
Joe Leigh Leigh Simpson:KOL impact
Concepts related to the work of other authors for whichfor which Joe Leigh Leigh Simpson has influence:Prenatal diagnosis,Preterm birth,Maternal blood,Fetal cells,Situ hybridization,Pregnant women,Gestational age.
KOL Resume for Joe Leigh Leigh Simpson
Department of Human and Molecular Genetics Department of Obstetrics and Gynecology Herbert Wertheim College of MedicineFlorida International University Miami Florida USA
Department of Human and Molecular Genetics, Florida International University, Florida, United States
Reproductive Genetic Innovations, Northbrook, IL, USA
Reproductive Genetic Innovations, Chicago, IL
Florida International University, Miami, FL
Department of Biomedical Engineering, Florida International University, Herbert Wertheim College of Medicine, Miami, FL.
Reproductive Genetics Institute, Inc. (RGI), Northbrook, IL, USA
March of Dimes Foundation, White Plains, NY
C/O Amphibian and Reptile Monitoring Initiative for a better Environment, Department of Biology, Geology and Environmental Science, #2653, 215 Holt Hall, University of Tennessee at Chattanooga, 615 McCallie Avenue, Chattanooga, TN 37403.
March of Dimes Foundation, White Plains, New York, New York
Reproductive Genetics Innovation, 2910 MacArthur Blvd., Northbrook, IL 60062, USA
Herbert Wertheim College of Medicine, Florida International University, Miami
March of Dimes Foundation, White Plains, New York.
Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
Florida International University, 11200 SW 8 th St, Miami, FL 33199,
Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, AHC2 693, 33199, Miami, FL, USA
Human & Molecular Genetics, Obstetrics and Gynecology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
Boston Consulting Group, Boston, MA
From the Herbert Wertheim College of Medicine, Florida International University, Miami.
March of Dimes Foundation, 1275 Mamaroneck Avenue, White Plains, NY, 10605, USA
Human and Molecular Genetics, Obstetrics and Gynecology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America
Professor, Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Luigi Mastroianni, Jr., Professor and Chair, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania
Florida International University, College of Medicine, Miami, FL, USA
Professor and Chief of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado at Denver Health Sciences Center, Aurora, Colorado
Senior Vice President for Research, and Global Programs, March of Dimes Foundation, White Plains, New York
Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 33174, Miami, FL, USA
Departments of Human & Molecular Genetics and Obstetrics & Gynecology, Wertheim College of Medicine, Florida International University, Miami, FL, USA
Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Florida International University, College of Medicine, Miami 33199
Dr. Rock is founding dean and senior vice president, Medical Affairs, and professor of obstetrics and gynecology, Florida International University College of Medicine, Miami, Florida. Dr. Simpson is executive associate dean, Academic Affairs, professor of human and molecular genetics, and professor of obstetrics and gynecology, Florida International University College of Medicine, Miami, Florida. Dr. Dambach is associate dean, Curricular Affairs, Florida International University College of Medicine, Miami, Florida. Dr. O’Leary is assistant vice president, Medical Affairs, executive associate dean, Clinical Affairs, and professor of surgery, Florida International University College of Medicine, Miami, Florida. Dr. Markham is executive associate dean, Student Affairs, and professor of obstetrics and gynecology, Florida International University College of Medicine, Miami, Florida. Mr. Bagby was formerly executive associate dean, Finance and Administration, Florida International University, Miami, Florida. Mr. Seecharan is director of operations, Florida International University College of Medicine, Miami, Florida. Dr. Berkman was formerly executive vice president and provost, Florida International University College of Medicine, Miami, Florida. He is now president, Cleveland State University, Cleveland, Ohio.
Florida International University, College of Medicine, Miami, Florida, USA
College of Medicine, Florida International University, Building HLS II, Room 672, Miami, FL 33315, USA
Professor and Head, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, University of Iowa College of Medicine, Iowa City, Iowa
Department of Obstetrics and Gynecology; Department of Molecular and Human Genetics, Baylor College of Medicine, Department of Obstetrics and Gynecology, 1709 Dryden Road, Suite 1100, Houston, TX 77030, USA
Florida International University College of Medicine, Miami, Florida
Cancer Biology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA
From the Departments of Obstetrics and Gynecology, Molecular and Human Genetics, and Immunology, Baylor College of Medicine, Houston, Texas., From the Departments of Obstetrics and Gynecology, Molecular and Human Genetics, and Immunology, Baylor College of Medicine, Houston, Texas.
Departments of Obstetrics and Gynecology and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas
Baylor Coll. of Medicine, Houston, TX.
|study moral attitudes||#1|
|common female infertility||#1|
|cfdna realtime pcr||#1|
|attitudes sex preselection||#1|
|congenital embryo transfer||#1|
|transcription factor figla||#1|
|10 123 mothers||#1|
|aneuploid fetuses trisomy||#1|
|timing pregnancy losses||#1|
|longer intervals couples||#1|
|10 female sibs||#1|
|genome equivalents blood||#1|
|villi fetomaternal transfusion||#1|
|oncogenes quantitative trait||#1|
|male male translocation||#1|
|fetal singlegene disorders||#1|
|women natural planning||#1|
|vitro fertilization pgd||#1|
|pregency publication abortion||#1|
|chromosomes flowsorted nuclei||#1|
|— cell embryo||#1|
|chromosomal abnormalities exclusion||#1|
|text extensive references||#1|
|cytogenetic preparations march||#1|
|fetal cell analysis||#1|
|mesenchymal core cultures||#1|
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Prominent publications by Joe Leigh Leigh Simpson
Developing a core outcome set for future infertility research: an international consensus development study
[ PUBLICATION ]
STUDY QUESTION: Can a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed?
SUMMARY ANSWER: A minimum data set, known as a core outcome set, has been developed for randomized controlled trials (RCTs) and systematic reviews evaluating potential treatments for infertility.
WHAT IS KNOWN ALREADY: Complex issues, including a failure to consider the perspectives of people with fertility problems when selecting outcomes, ...
|Known for Core Outcome | Future Infertility | Sponsorship Ferring | Consultancy Fees | Consensus Development|
OBJECTIVE: Risk of trisomy 18 in a fetus with ultrasonographic diagnosis of choroid plexus cysts and no other anomalies is controversial. Using our data and current literature, we performed a meta-analysis and estimated the positive predictive value of isolated choroid plexus cysts for trisomy 18.
STUDY DESIGN: Between Jan. 1, 1989, and Dec. 31, 1992, all women undergoing ultrasonographic examination at our institution were prospectively evaluated for fetal choroid plexus cysts and ...
|Known for Choroid Plexus Cysts | Trisomy 18 | Isolated Fetal | Predictive Tests | Pregnancy Pregnancy Trimester|
Prenatal diagnosis with use of fetal cells isolated from maternal blood: Five-color fluorescent in situ hybridization analysis on flow-sorted cells for chromosomes X, Y, 13, 18, and 21
[ PUBLICATION ]
OBJECTIVE: Currently, prenatal diagnosis of chromosome abnormalities requires invasive techniques such as amniocentesis and chorionic villus sampling that carry small but finite risks of fetal loss. A noninvasive approach is to isolate fetal cells from maternal blood by flow sorting followed by genetic interphase analysis with fluorescence in situ hybridization. Because the ratio of fetal to maternal cells is relatively low after flow sorting and to detect 90% to 95% of fetal ...
|Known for Situ Hybridization | Maternal Blood | Prenatal Diagnosis | Fetal Cells | Chromosomes Human|
Association of extreme first-trimester free human chorionic gonadotropin-β, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregna
[ PUBLICATION ]
OBJECTIVE: The purpose of this study was to determine the association between first-trimester trisomy 21 screening markers (free human chorionic gonadotropin-beta [hCG], pregnancy-associated plasma protein A [PAPP-A], and nuchal translucency) and adverse pregnancy outcome.
STUDY DESIGN: This was a cohort study of 8012 patients enrolled in a National Institute of Child Health and Human Development-sponsored study of first-trimester trisomy 21 and 18 screening. Trisomy 21 and 18 risk ...
|Known for Nuchal Translucency | Intrauterine Growth Restriction | Trimester Free | Plasma Protein | Adverse Pregnancy|
Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index
[ PUBLICATION ]
BACKGROUND: Every year, 1·1 million babies die from prematurity, and many survivors are disabled. Worldwide, 15 million babies are born preterm (<37 weeks' gestation), with two decades of increasing rates in almost all countries with reliable data. The understanding of drivers and potential benefit of preventive interventions for preterm births is poor. We examined trends and estimate the potential reduction in preterm births for countries with very high human development index (VHHDI) ...
|Known for Preterm Births | Human Development | Labour Induction | Birth Rate | Caesarean Delivery|
Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis
[ PUBLICATION ]
PROBLEM: Genetic predisposition to endometriosis is well established, but the gene(s) involved largely remain unknown. Although endometriosis is considered a benign disease, it displays several features similar to malignancy: altered morphology, disregulated growth, invasion. We hypothesize endometriosis arises as result of somatic DNA alterations occurring in a multi-step process, analogous to origin of neoplasia. Since chromosome 17 and TP53 tumor suppressor gene (TSG) alterations ...
|Known for Chromosome 17 | P53 Loss | Situ Hybridization | Somatic Mutations | Female Genes|
The Safety and Efficacy of Chorionic Villus Sampling for Early Prenatal Diagnosis of Cytogenetic Abnormalities
[ PUBLICATION ]
Chorionic villus sampling is a method of prenatal diagnosis in the first trimester of pregnancy in which tissue for genetic study is aspirated from the developing placenta by means of a catheter inserted transcervically under the guidance of ultrasonography. In this seven-center study, we compared the safety and efficacy of chorionic villus sampling in 2278 women with those of amniocentesis at 16 weeks' gestation in 671 women. Both groups were made up primarily of well-educated private ...
|Known for Chorionic Villus Sampling | Women Amniocentesis | Cytogenetic Abnormalities | Trimester Pregnancy | Early Prenatal Diagnosis|
[ PUBLICATION ]
BACKGROUND: Screening for aneuploid pregnancies is routinely performed after 15 weeks of gestation and has a sensitivity of approximately 65 percent, with a false positive rate of 5 percent. First-trimester markers of aneuploidy have been developed, but their use in combination has not been adequately evaluated in clinical practice.
METHODS: We conducted a multicenter study of screening for trisomies 21 and 18 among patients with pregnancies between 74 and 97 days of gestation, based on ...
|Known for Trimester Screening | False Positive Rate | Trisomies 21 | Beta Subunit | Human Pair|
[ PUBLICATION ]
Cytogenetic data are presented for 11,473 chorionic villus sampling (CVS) procedures from nine centres in the U.S. NICHD collaborative study. A successful cytogenetic diagnosis was obtained in 99.7 per cent of cases, with data obtained from the direct method only (26 per cent), culture method only (42 per cent), or a combination of both (32 per cent). A total of 1.1 per cent of patients had a second CVS or amniocentesis procedure for reasons related to the cytogenetic diagnostic ...
|Known for Culture Method | Collaborative Study | Cases Mosaicism | Maternal Cell Contamination | Trisomy Case|
Incidence of Spontaneous Abortion among Normal Women and Insulin-Dependent Diabetic Women Whose Pregnancies Were Identified within 21 Days of Conception
[ PUBLICATION ]
Whether pregnant women with insulin-dependent diabetes mellitus have an increased risk of spontaneous abortion is controversial. To address this question, we enrolled 386 women with insulin-dependent diabetes and 432 women without diabetes before or within 21 days after conception and followed both groups prospectively. Sixty-two diabetic women (16.1 percent) and 70 control women (16.2 percent) had pregnancy losses (odds ratio, 0.99; 95 percent confidence interval, 0.67 to 1.46). After ...
|Known for Diabetic Women | Spontaneous Abortion | Glucose Levels | 21 Conception | Metabolic Control|
OBJECTIVE: Our purpose was to determine whether obese women and underweight women have an increased risk of birth defects in their offspring.
STUDY DESIGN: A geographically based case-control study of women living in California and Illinois was performed. There were 499 mothers of offspring with neural tube defects, 337 mothers of offspring with other major birth defects, and 534 mothers of offspring without birth defects who participated.
RESULTS: Compared with women of normal weight, ...
|Known for Obese Women | Birth Defects | Pregnancy Risk | Offspring Neural | Normal Weight|
Physiological reduction in fasting plasma glucose concentration in the first trimester of normal pregnancy: The diabetes in early pregnancy study
[ PUBLICATION ]
Previous studies indicate that fasting plasma glucose decreases during gestation, but the timing and extent are not consistent from study to study. We had an opportunity to examine this question in the normal pregnancy cohort of women studied in the Diabetes in Early Pregnancy Study. Subjects were monitored to identify pregnancy by human chorionic gonadotropin testing, enrolled within 21 days of conception, and screened to rule out gestational diabetes at the juncture of the second and ...
|Known for Plasma Glucose | Normal Pregnancy | Weeks Gestation | Mass Bmi | Diabetes Early|
[ PUBLICATION ]
OBJECTIVES: The National Institute of Child Health and Human Development Fetal Cell Isolation Study (NIFTY) is a prospective, multicenter clinical project to develop non-invasive methods of prenatal diagnosis. The initial objective was to assess the utility of fetal cells in the peripheral blood of pregnant women to diagnose or screen for fetal chromosome abnormalities.
METHODS: Results of fluorescence in situ hybridization (FISH) analysis on interphase nuclei of fetal cells recovered ...
|Known for Fetal Cells | Maternal Blood | Aneuploidy Detection | Situ Hybridization | Cell Analysis|