• KOL
    • Matrix Metalloproteinases
    • Massimo Castagnaro
    • Massimo Castagnaro: Influence Statistics

      Massimo Castagnaro

      Massimo Castagnaro

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      Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, Italy;, valentina.zappulli@unipd.it, (V.Z.);, ...

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      Massimo Castagnaro:Expert Impact

      Concepts for whichMassimo Castagnarohas direct influence:Matrix metalloproteinases,Lectin histochemistry,Veterinary oncology,Canine lymphoma,Damselae subsp,Feline mammary,Beef cattle,Feline mammary tumours.

      Massimo Castagnaro:KOL impact

      Concepts related to the work of other authors for whichfor which Massimo Castagnaro has influence:Leishmania infantum,Canine leishmaniosis,Androgen receptor,Mammary carcinomas,Diseases dogs,Matrix metalloproteinases,Clinical signs.

      KOL Resume for Massimo Castagnaro

      Year
      2020

      Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, Italy;, (V.Z.);, (F.B.);, (G.B.);, (A.C.);, (L.C.);, (C.C.);, (G.C.);, (S.D.V.);, (M.E.G.);, (S.M.);, (V.M.);, (N.R.);, (A.S.);, (F.T.);, (R.V.);, (M.C.)

      2019

      Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Padua, Italy

      2016

      Department of Comparative Biomedicine and Food Science, Faculty of Veterinary Medicine, AGRIPOLIS, Viale dell'Università 16, Legnaro, Italy

      2014

      Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro, Padova, Italy

      2013

      University of Padua Department of Comparative Biomedicine and Nutrition Legnaro Italy

      2012

      Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020, Legnaro, Padova, Italy

      2011

      Department of Public Health, Comparative Pathology and Veterinary Hygiene, Faculty of Veterinary Medicine, University of Padova, Viale dell’Università 16, Legnaro, Italy

      2010

      Universita degli Studi di Padova, Dipartimento di Sanità Pubblica, Patologia Comparata e Igiene Veterinaria, Facoltà di Medicina Veterinaria, Viale dell'Universita 16, 35020 Agripolis, Padova, Italy

      2009

      Dipartimento di Sanità Pubblica, Patologia Comparata ed Igiene Veterinaria, Facoltà di Medicina Veterinaria, Università degli Studi di Padova, Agripolis, Legnaro, Padova, Italy

      Department of Public Health, Comparative Pathology, and Veterinary Hygiene, University of Padova, Legnaro (PD)

      2008

      Department of Public Health, Comparative Pathology and Veterinary Hygiene, University of Padova, Padova

      2007

      Department of Public Health, Comparative Pathology and Veterinary Hygiene, Faculty of Veterinary Medicine, University of Padua, Padua

      2006

      Department of Public Health, Comparative Pathology and Veterinary Hygiene, Faculty of Veterinary Medicine, Università degli Studi di Padova, Viale dell'Università, 16, 35020 Legnaro, Padova, Italy

      2005

      From the Department of Public Health, Faculty of Veterinary Medicine, Comparative Pathology and Veterinary Hygiene University of Padua, Agripolis, Legnaro (PD), Italy (Petterino, Ferro, Castagnaro); and Veterinary Practice of Dr Paolo Spelta, Modena (MO), Italy (Guazzi). Corresponding author: Professor Claudio Petterino (). © 2005 American Society for Veterinary Clinical Pathology

      Dipartimento di Sanità Pubblica, Patologia Comparata e Igiene Veterinaria, Facoltà di Medicina Veterinaria, Agripolis, Viale dell'Università 16, 35020 Legnaro, Padova, Italy

      2004

      Veterinary Pathology and Hygiene Institute, University of Padua, Padua, Italy

      2003

      Istituto Neurologico Besta, Via Celoria 20129 Milan, Italy

      Veterinary Pathology and Hygiene Institute

      2002

      Department of Public Health Comparative Pathology and Veterinary Hygiene, School of Veterinary Medicine, University of Padova, Italy

      2000

      Istituto di Patologia e Igiene Veterinaria, Università degli Studi di Padova, Italy;

      1998

      Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Torino, Via Nizza 52, I-10126 Torino, Italy e-mail: Tel.: +39-11-6509053, Fax: +39-11-6502687, IT

      Istituto di Patologia ed Igiene Veterinaria, Facoltà di Medicina Veterinaria, Università degli Studi di Padova, Agripolis, Legnaro, Italy

      1997

      Dipartimento di Patologia Animale, Università degli Studi di Torino, Via Nizza 52, 10126 Torino, Italy

      1996

      Departments of Pathology (E.M., M.C., H.J.W.) and Orthopaedics (B.A.A.), the New England Medical Center Hospital and Tufts University School of Medicine, Boston, Massachusetts; and the Department of Pathology, University of Vermont, Burlington, Vermont (D.W.Y.).

      1995

      Dipartimento di Patologia Animale, Università degli Studi, Torino.

      1994

      Department of Pathology, University of Torino Veterinary School, Torino, Italy

      1993

      Department of Animal Pathology, University of Torino Veterinary School, Torino, Italy

      New England Medical Center, Boston, MA, USA

      1992

      Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università degli Studi, Via Nizza, 52, 10126, Turin, Italy

      1991

      Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy

      1990

      Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università degli Studi di Torino, Italy

      1987

      Departments of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, 136 Harrison Avenue, 02111, Boston, Massachusetts, USA

      University of Torino, School of Veterinary Medicine, Torino, Italy

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      Sample of concepts for which Massimo Castagnaro is among the top experts in the world.
      Concept World rank
      biopsylike tissue #1
      perfusion technical problems #1
      endometriosis animal age #1
      endometriosis equine #1
      remarkable modifications aspect #1
      diameter asgs #1
      ultrastructural observations autolytic #1
      typical autolytic #1
      animal age role #1
      24 hours asgs #1
      entirewall samples #1
      mmp14 stromal cells #1
      metalloproteinases equine #1
      35 uterine samples #1
      organelles remarkable modifications #1
      granules asgs #1
      seventeen uterine samples #1
      autolytic atrial #1
      asgs samples #1
      biopsylike samples #1
      asgs 24 #1
      57 queens #2
      lectins hpg #2
      catenin feline #2
      fibrillar fluffymaterial #2
      long caudal limbs #2
      isoforms erdeltae4 #2
      small curled ears #2
      leishmania t0 #2
      chemotherapy mmp9 #2
      hepatoid perianal #2
      korat gm1gangliosidosis #2
      normal neoplastic hpg #2
      haired european #2
      hpg adenomas majority #2
      cystic atrophied glomeruli #2
      concentrically whorled lamellae #2
      hpg adenomas #2
      leishmaniaseropositive dogs #2
      control lymphoma dogs #2
      frequent fmcs #2
      βgalactosidase deficiency korat #2
      immersion cent #2
      hpg basal cells #2
      ductal βcatenin #2
      erdeltae4 erdeltae7 #2
      hepatoid hpg #2
      6183 base pairs #2
      lowgrade tcell lymphomas #2
      53 mammary tumours #2
      Sign-in to see all concepts, it's free!

      Prominent publications by Massimo Castagnaro

      KOL-Index: 11663

      BACKGROUND: Malignant canine mammary tumors represent 50% of all neoplasms in female dogs. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are thought to be involved in tumor progression, and they are also associated with the reactive stroma, which provides structural and vascular support for tumor growth.

      RESULTS: MMP-2, MMP-9 and MT1-MMP were expressed at both the mRNA and protein levels in tumor samples. MMP-2 and MMP-9 immunohistochemical ...

      Known for Matrix Metalloproteinases | Mammary Tumors | Mmp2 Mmp9 | Tissue Inhibitor | Active Form
      KOL-Index: 10826

      Degradation of the extracellular matrix and angiogenesis are associated with tumour invasion and metastasis in human and canine neoplasia. Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and vascular endothelial growth factor-A (VEGF-A) are key mediators of these respective processes. Mast cell tumour (MCT) is the most common malignant cutaneous tumour in dogs. MCTs are always considered potentially malignant, but their true metastatic potential is ...

      Known for Matrix Metalloproteinases | Mmp2 Mmp9 | Mast Cell | Growth Factor | Vascular Endothelial
      KOL-Index: 9357

      BACKGROUND: Canine lymphoma represents the most frequent haematopoietic cancer and it shares some similarities with human non-Hodgkin lymphoma. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) play a coordinated role during invasion and proliferation of malignant cells; however, little is known about their role in canine haematologic malignancies. The aim of this study was to investigate the mRNA and protein expression of VEGF and the most relevant MMPs in ...

      Known for Canine Lymphoma | Matrix Metalloproteinases | Growth Factor | Vascular Endothelial | Mmp9 Vegf
      KOL-Index: 9005

      RON is a member of the receptor tyrosine kinase gene family that includes the MET oncogene, whose germline mutations have been causally related to human tumorigenesis. In vitro, RON and MET receptors cross-talk, synergize in intracellular signaling, and cooperate in inducing morphogenic responses. Here we show that the RON and MET oncogenes were expressed in 55% and 56% of human ovarian carcinomas, respectively, and were significantly coexpressed in 42% (P < 0.001). In ovarian carcinoma ...

      Known for Human Ovarian | Oncogene Proteins | Ron Receptors | Hgf Msp | Cell Lines
      KOL-Index: 7621

      Toll-Like Receptors (TLRs) have recently emerged as key sensors of invading microbes, acting through recognition of pathogen-associated molecular patterns. It has been demonstrated that TLR9 is involved in the recognition of unmethylated CpG motifs in mice, humans, and pigs. We report here the full-length sequence of TLR9 cDNA in the gilthead sea bream (Sparus aurata L.). The predicted protein (1063 amino acids) was similar to mammalian TLR9s, showing 21 leucine-rich repeats in the ...

      Known for Sparus Aurata | Gilthead Seabream | Receptor 9 | Complementary Evolution | Sequence Expression
      KOL-Index: 7556

      There is an increasing need for more accurate prognostic and predictive markers in veterinary oncology because of an increasing number of treatment options, the increased financial costs associated with treatment, and the emotional stress experienced by owners in association with the disease and its treatment. Numerous studies have evaluated potential prognostic and predictive markers for veterinary neoplastic diseases, but there are no established guidelines or standards for the conduct ...

      Known for Prognostic Studies | Veterinary Oncology | Conduct Reporting | Recommended Guidelines | Medicine Animals
      KOL-Index: 7272

      In canine leishmaniosis (CanL), kidneys are affected in virtually all dogs. Treatment of CanL is limited in Europe to meglumine antimoniate and miltefosine. This study evaluated the pharmacological, toxicological, and pathological effects of both drugs in healthy beagle dogs. Four male and four female dogs were divided into two groups. The animals in Group 1 were administered an oral solution of 2% of miltefosine at 2 mg/kg b.w. once a day, for twenty-eight days. The animals in Group 2 ...

      Known for Meglumine Antimoniate | Healthy Dogs | Treatment Canl | Canine Leishmaniosis | Diseases Kidney
      KOL-Index: 7117

      E-cadherin and its associated cytoplasmic proteins, including β-catenin, have been examined as potential oncogenic markers due to the significant correlation between tumour dedifferentiation and the invasive capacity of epithelial tumours. The purpose of this study was to evaluate the expression of E-cadherin and β-catenin in canine colorectal cancer using immunohistochemistry and to examine the relationship between this expression and various clinicopathological variables. The ...

      Known for Catenin Expression | Canine Colorectal | Cadherin Β | Epithelial Cells | Tissue Architecture
      KOL-Index: 6378

      Vascular endothelial growth factor (VEGF) and metalloproteinase (MMP) 2 and 9 are useful biomarkers in human lymphoma. During cancerogenesis, transforming growth factor beta (TGF-β) stimulates VEGF and MMPs production. VEGF and TGF-β plasma levels were tested by ELISA, MMP-2 and MMP-9 by gelatine zymography in 37 dogs with lymphoma, 13 of which were also monitored during chemotherapy. Ten healthy dogs served as control. Lymphoma dogs showed higher act-MMP-9 (P < 0.01) and VEGF ...

      Known for Canine Lymphoma | Mmp9 Vegf | Healthy Dogs | Endothelial Growth | Metalloproteinase 9
      KOL-Index: 6371

      We have compared the pattern of lectin staining with the ultrastructural features of kidneys from normal cats and 19 cats with 6 different lysosomal storage diseases. The diseases studied include GM1 and GM2 gangliosidosis, mucopolysaccharidosis (MPS)-I and MPS-VI, sphingomyelinlipidosis (i.e., Niemann-Pick disease) and mannosidosis. Ten different biotinylated lectins were used as histochemical probes for carbohydrate residues and avidin-biotin-peroxidase complex as ...

      Known for Storage Diseases | Lectin Histochemistry | Gm1 Gangliosidosis | Ricinus Communis | Normal Cats

      Canine Mammary Tumors


      [ PUBLICATION ]
      KOL-Index: 6339

      Although there have been several studies on the use of immunohistochemical biomarkers of canine mammary tumors (CMTs), the results are difficult to compare. This article provides guidelines on the most useful immunohistochemical markers to standardize their use and understand how outcomes are measured, thus ensuring reproducibility of results. We have reviewed the biomarkers of canine mammary epithelial and myoepithelial cells and identified those biomarkers that are most useful and ...

      Known for Canine Mammary Tumors | Estrogen Receptors | Human Breast Cancer | Positive Cells | Allred Score
      KOL-Index: 6326

      The goal of the present study was to investigate mRNA expression levels of several cytokines and inflammatory mediators in broncho-alveolar lavage (BAL) fluid and respiratory epithelium in recurrent airway obstruction (RAO)-affected horses. RAO, also called heaves, is a common, performance-limiting, equine respiratory disease with clinical signs and pathophysiological similarities to human asthma, and characterized by bronchospasm, neutrophilic infiltration and increased mucus in the ...

      Known for Airway Obstruction | Clinical Signs | Raoaffected Horses | Mrna Expression | Il1β Tnfα
      KOL-Index: 6311

      Methotrexate (MTX) has been used successfully as an immunosuppressant in rodent xenotransplantation models, but the data generated so far with MTX in pig-to-baboon cardiac transplantation studies have been disappointing. The potential of this agent was consequently explored in a life-supporting pig-to-primate renal model using the cynomolgus monkey as the recipient species. Introductory in vitro and in vivo pharmacokinetic and pharmacodynamic studies with MTX were conducted in three ...

      Known for Cynomolgus Monkey | Renal Xenotransplantation | Mycophenolate Sodium | Methotrexate Mtx | Kidney Transplantation

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      Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, Italy;, valentina.zappulli@unipd.it, (V.Z.);, federico.bonsembiante@unipd.it, (F.B.);, ginevra.brocca@phd.unipd.it, (G.B.);, alessandro.calore.1@studen

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