• Disease
  • Xeroderma
  • Xeroderma Pigmentosum
  • Yared Herouy

    Prominent publications by Yared Herouy

    KOL Index score: 13137

    BACKGROUND: CD40L-CD40 interactions induce inflammatory signals in cells of the vascular wall. We evaluated the effects of glycoprotein (GP) IIb/IIIa (alpha(IIb)beta3) engagement that occurs during platelet-endothelium interactions on CD40L surface exposure on platelets and initiation of proteolytic activity in human umbilical vein endothelial cells (HUVECs).

    METHODS AND RESULTS: Transient (60-minute) adhesion of thrombin-prestimulated platelets enhanced HUVEC expression of ...

    Also Ranks for: Endothelial Cells |  glycoprotein iib |  platelets cd40l |  mmp2 mmp9 |  platelet adhesion
    KOL Index score: 12926

    BACKGROUND: Matrix metalloproteinases (MMPs) contribute to matrix remodelling in venous leg ulcers. Extracellular MMP inducer (EMMPRIN; CD147) has been reported to increase MMP expression, and membrane type 1 MMP (MT1-MMP) has been implicated in the activation of MMPs.

    OBJECTIVES: To examine whether and to what degree EMMPRIN, MMP-2, MT1-MMP and membrane type 2 MMP (MT2-MMP) are expressed in venous leg ulcers as well as the association with MMP activity.


    Also Ranks for: Venous Leg Ulcers |  matrix metalloproteinase |  emmprin mmp2 |  elevated expression |  membrane type
    KOL Index score: 12674

    Lipodermatosclerosis refers to skin induration of the lower extremities and is associated with patients preceding venous ulcerations. To better understand the pathogenesis of ulcer formation we investigated the expression of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in lipodermatosclerosis. By preparing biopsies from healthy skin and liposclerotic lesions, MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were analyzed by using reverse ...

    Also Ranks for: Matrix Metalloproteinases |  elevated expression |  ulcer formation |  mmp1 mmp2 |  healthy skin
    KOL Index score: 11635

    Dendritic cells (DCs) are specialized antigen-presenting cells characterized by their ability to migrate into target sites, process antigens, and activate naive T cells. In this study, we analyzed the biological activity and intracellular signaling of adenosine by using reverse transcriptase-polymerase chain reaction assays to investigate mRNA expression of A(1), A(2a) and A(3) adenosine receptors in immature and mature human DCs. Functional experiments on adenosine stimulation showed ...

    Also Ranks for: Adenosine Receptors |  dendritic cells |  messenger receptor |  immature dcs |  actin polymerization
    KOL Index score: 10866

    The neurotransmitter 5-hydroxytryptamine (5-HT), commonly known as serotonin, is stored at peripheral sites in mast cells and released from this peripheral source upon IgE cross-linking. In this study, we investigated the expression of serotoninergic receptors (5-HTR), the signaling pathway, and biological activity of 5-HT on human dendritic cells (DC), showing that immature and mature DC expressed mRNA for different serotoninergic receptors. Thereby, the mRNA of 5-HTR(1B), 5-HTR(1E), ...

    Also Ranks for: Serotoninergic Receptors |  dendritic cells |  cytokine release |  peripheral sites |  immature mature
    KOL Index score: 10351

    BACKGROUND: Histamine is a well-known mediator eliciting different responses in immune and nonimmune cells, but its role in modulating dendritic cell (DC) functions has been marginally investigated.

    OBJECTIVE: The purpose of this investigation was to analyze whether human monocyte-derived DCs express functional histamine receptors according to their maturation stage.

    METHODS: DCs were derived from monocytes and used as immature or LPS-differentiated cells. DCs were tested for histamine ...

    Also Ranks for: Histamine Receptors |  dendritic cell |  immature dcs |  human monocyte |  actin polymerization
    KOL Index score: 10213

    The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types. During cellular interactions homotypic EMMPRIN-EMMPRIN interactions are known to induce the synthesis of matrix metalloproteinases. Recently, we have identified EMMPRIN as a novel receptor on platelets. To our knowledge EMMPRIN has not been shown to serve as adhesion receptor, yet. Here we characterise platelet glycoprotein VI (GPVI) as a novel ...

    Also Ranks for: Platelet Gpvi |  receptor emmprin |  cell adhesion |  matrix metalloproteinases |  cd147 basigin
    KOL Index score: 10195

    Dendritic cells (DCs) express functional purinergic type 1 receptors, but the effects of adenosine in these antigen-presenting cells have been only marginally investigated. Here, we further characterized the biologic activity of adenosine in immature DCs (iDCs) and lipopolysaccharide (LPS)-matured DCs (mDCs). Chronic stimulation with adenosine enhanced the macropinocytotic activity and the membrane expression of CD80, CD86, major histocompatibility complex (MHC) class I, and HLA-DR ...

    Also Ranks for: Dendritic Cells |  adenosine receptor adenosine |  mhc class |  dcs mdcs |  necrosis factor
    KOL Index score: 10110

    Upon coincubation with platelets, CD34(+) progenitor cells have the potential to differentiate into foam cells, and thereby may promote the progression of atherosclerosis. The exact mechanism of MMP-regulation during the cellular differentiation process to foam cells is still unclear. Thus, we investigated the role of EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) during foam cell formation originating from both monocytes/macrophages and CD34(+) progenitor cells.


    Also Ranks for: Foam Cells |  mmp9 emmprin |  atherosclerotic plaques |  ligand cyclophilin |  cell differentiation
    KOL Index score: 9896

    Dendritic cells (DCs) are specialized antigen-presenting cells characterized by their ability to migrate into target sites, process antigens, and activate naive T-cells. Biological activities of platelet-activating factor (PAF) and the cytokine macrophage inflammatory protein-3beta (MIP-3beta) as well as the mRNA expression of their receptors were characterized in human DCs during lipopolysaccharide (LPS)-promoted maturation. Platelet-activating factor induced calcium transients, ...

    Also Ranks for: Dendritic Cells |  activating factor |  messenger receptors |  immature dcs |  mrna expression
    KOL Index score: 9796

    Lysophosphatidic acid (LPA) is a bioactive lipid mediator, which is generated by secretory type II phospholipase A(2) and is thought to play a major role in the pathogenesis of atopic diseases. In this study, the biological activity of LPA on human eosinophils was characterized. We showed by reverse transcription and PCR that human eosinophils express the mRNA of the LPA receptors endothelial differentiation gene (EDG)-2 and EDG-7. Experiments revealed that LPA has chemotactic activity ...

    Also Ranks for: Human Eosinophils |  pertussis toxin |  lysophosphatidic acid |  lpa receptors |  reactive oxygen
    KOL Index score: 9508

    Lysophosphatidic acid (LPA) is a bioactive lipid mediator which is generated by secretory phospholipase A(2). In this study, we studied the biological activity of LPA on human dendritic cells (DCs), which are specialized APCs characterized by their ability to migrate into target sites and secondary lymphoid organs to process Ags and activate naive T cells. We show that immature and mature DCs express the mRNA for different LPA receptors such as endothelial differentiation gene (EDG)-2, ...

    Also Ranks for: Lysophosphatidic Acid |  lpa receptors |  actin polymerization |  cells dcs |  human dendritic
    KOL Index score: 9342

    1. Extracellular nucleotides are the focus of increasing attention for their role as extracellular mediators since they are released into the extracellular environment in a regulated manner and/or as a consequence of cell damage. 2. Here, we show that human eosinophils stimulated with different nucleotides release eosinophil cationic protein (ECP) and the chemokine interleukin 8 (IL-8), and that release of these two proteins has a different nucleotide requirement. 3. Release of ECP was ...

    Also Ranks for: Human Eosinophils |  purinergic receptors |  extracellular nucleotides |  atp secretion |  cell damage
    KOL Index score: 9277

    Sphingosine 1-phosphate (S1P) is a potent extracellular lysolipid phosphoric acid mediator that is released after IgE-stimulation of mast cells. Here we investigated the biological activity and intracellular signaling of S1P on human dendritic cells (DC), which are specialized antigen presenting cells with the ability to migrate into peripheral tissues and lymph nodes, as well as control the activation of naive T cells. We show that immature and mature DC express the mRNA for different ...

    Also Ranks for: Messenger Receptors |  human dendritic cells |  immature dendritic |  sphingosine 1 |  immune responses
    KOL Index score: 8765

    To evaluate the use of eosinophil cationic protein (ECP) in monitoring disease activity in childhood asthma, serum ECP in 175 asthmatic children was assessed. Forty five patients with cystic fibrosis, 23 with lower respiratory tract infections (LRTI), and 87 healthy children were used as controls. Serum ECP concentrations (34.3 micrograms/l v 9.8 micrograms/l) were significantly higher in children with bronchial asthma than in healthy control subjects. In symptomatic patients with asthma ...

    Also Ranks for: Eosinophil Activity |  serum ecp |  bronchial asthma |  cystic fibrosis |  treatment modalities


    Yared Herouy: Influence Statistics

    Sample of concepts for which Yared Herouy is among the top experts in the world.
    Concept World rank
    lipodermatosclerosis #1
    localized venous #1
    comparison healthy skin #1
    tissue samples lipodermatosclerosis #1
    samples lipodermatosclerosis #1
    principle initiators #2
    fibrin‐stabilizing factor xiii #2
    induces chemotaxis #2
    asthmatic children assessment #2
    serum mpo participation #2
    proteincoupled cx3cr1 #2
    maturation¶conclusions #2
    lrti neutrophil #2
    polymerization chemotaxis #2
    hiv actins #2
    metalloproteinases venous #2
    neutrophil asthmatic #2
    flow cytometry¶results #2
    cx3cr1 immature #2
    neutrophil activation assessment #2
    assessment serum myeloperoxidase #2
    participation neutrophils #2
    fractalkine mature dcs #2
    chemotaxins¶methods #2
    metalloproteinase3 varicose ulcer #2
    serum mpo #2
    hiv actins chemokines #2
    fractalkine actin polymerization #2
    childhood asthma addition #2
    34 viral infection #2
    neutrophil counts crp #2
    timp1 lesional skin #3
    dermatitis upregulates #3
    inflammation stasis #3
    mmp1 comparison #3
    48well boyden chambers #3
    nonhealing leg ulcers #3
    dcs actins #3
    cxcrii #3
    mmp1 primers dermatitis #3
    timp1 stasis dermatitis #3
    venous ulcer formation #3

    Key People For Xeroderma Pigmentosum

    Top KOLs in the world
    Kenneth H Kraemer
    xeroderma pigmentosum dna repair skin cancer
    Alan Robert LEHMANN
    xeroderma pigmentosum dna repair cockayne syndrome
    James E Cleaver
    xeroderma pigmentosum dna repair ultraviolet light
    Dirk Bootsma
    xeroderma pigmentosum dna repair human chromosome
    Jay H Robbins
    xeroderma pigmentosum dna repair cockayne syndrome
    Jan H J Hoeijmakers
    dna repair xeroderma pigmentosum cockayne syndrome

    Yared Herouy:Expert Impact

    Concepts for whichYared Herouyhas direct influence:Xeroderma pigmentosum,  Dendritic cells,  Venous leg ulcers,  Matrix metalloproteinases,  Human eosinophils,  Human dendritic cells,  Messenger receptors,  Stasis dermatitis.

    Yared Herouy:KOL impact

    Concepts related to the work of other authors for whichfor which Yared Herouy has influence:Dendritic cells,  Adenosine receptors,  Lysophosphatidic acid,  Wound healing,  Matrix metalloproteinase,  Platelet activation,  Immune response.



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    Private Clinic for Dermatology, Baden-Baden, Germany; Department of Dermatology, Freiburg Medical School, Freiburg, Germany. Electronic address: yared@herouy.de. | Department of Dermatology, University Medical Centre Freiburg, Freiburg, Germany | Dep