• Disease
  • Recognition
  • Recognition Memory
  • Larry R Squire

    Prominent publications by Larry R Squire

    KOL Index score: 16676

    During the past decade, work with monkeys has helped identify the structures in the medial temporal lobe that are important for memory: the hippocampal region (including the hippocampus proper, the dentate gyrus, and the subicular complex) and adjacent cortical areas that are anatomically linked to the hippocampus, i.e., the entorhinal, perirhinal, and parahippocampal cortices. One idea that has emerged from this work is that the severity of memory impairment might increase as more ...

    Also Ranks for: Memory Impairment |  medial temporal lobe |  hippocampal region |  damage lesion |  entorhinal cortex
    KOL Index score: 16590

    Key PointsRecollection has been proposed to be especially dependent on the hippocampus, and familiarity on the adjacent perirhinal cortex. The authors instead suggest that the hippocampus and the perirhinal cortex both play a role in recollection and familiarity, and that these two regions of the medial temporal lobe differ mainly in the degree to which stimuli are encoded in a concrete (in the case of the perirhinal cortex) or abstract (in the case of the hippocampus) manner.The authors ...

    Also Ranks for: Hippocampus Familiarity |  recognition memory |  perirhinal cortex |  medial temporal lobe |  role recollection
    KOL Index score: 13870

    Perirhinal cortex and area TE are immediately adjacent to each other in the temporal lobe and reciprocally interconnected. These areas are thought to lie at the interface between visual perception and visual memory, but it has been unclear what their separate contributions might be. In three experiments, monkeys with bilateral lesions of the perirhinal cortex exhibited a different pattern of impairment than monkeys with bilateral lesions of area TE. In experiment 1, lesions of the ...

    Also Ranks for: Perirhinal Cortex |  lesions area |  animal conditioning |  visual memory |  temporal lobe
    KOL Index score: 13469

    Patient RB became amnesic following an episode of global ischemia that resulted in a bilateral lesion of the CA1 field of the hippocampus. This finding suggested that damage restricted to the hippocampus is sufficient to produce clinically significant memory impairment. To evaluate further the effect of ischemic brain damage on memory, we have developed an animal model of cerebral ischemia in the monkey. Monkeys were subjected to 15 min of reversible ischemia, using a noninvasive ...

    Also Ranks for: Memory Impairment |  ischemic damage |  cerebral ischemia |  hippocampus loss |  monkeys lesion
    KOL Index score: 13365

    It has been suggested that the hippocampus selectively supports recollection and that adjacent cortex in the medial temporal lobe can support familiarity. Alternatively, it has been suggested that the hippocampus supports both recollection and familiarity. We tested these suggestions by assessing the performance of patients with hippocampal lesions on recognition memory tests that differ in the extent to which recollection and familiarity contribute to the recognition decision. When ...

    Also Ranks for: Recognition Memory |  recollection familiarity |  performance patients |  targets foils |  hippocampus humans
    KOL Index score: 12174

    We asked what kind of memory is operating when eye movements change as the result of experience. Participants viewed scenes that were either novel, repeated, or manipulated (i.e., a change was introduced in one region of the scene). Eye movements differed depending on the past viewing history of each scene. Participants made fewer fixations and sampled fewer regions when scenes were repeated than when scenes were novel. When scenes were altered, participants made more fixations in the ...

    Also Ranks for: Eye Movements |  scene participants |  conscious memory |  hippocampus dependent |  fewer fixations
    KOL Index score: 12089

    Despite severe deficits of recall and recognition, amnesic patients can exhibit normal priming effects. Amnesic patients have also been reported to perform well on tests of paired-associate learning that involve related word pairs (e.g., table-chair). The present study investigated the role of priming effects in paired-associate learning. Experiment 1 illustrated the distinction between the memory impairment of amnesic patients and their intact priming ability. Amnesic patients were ...

    Also Ranks for: Amnesic Patients |  associate learning |  priming effects |  word pairs |  tests paired
    KOL Index score: 12054

    Patients with frontal lobe lesions, amnesic patients with Korsakoff's syndrome, other (non-Korsakoff) amnesic patients, and control subjects were given tests of memory for temporal order. In the first experiment, subjects were presented with a list of 15 words and then asked to reproduce the list order from a random array of the words. In the second experiment, they were asked to arrange in chronological order a random display of 15 factual events that occurred between 1941 and 1985. In ...

    Also Ranks for: Amnesic Patients |  frontal lobe lesions |  temporal order |  korsakoffs syndrome |  item memory
    KOL Index score: 11875

    In an effort to bring into correspondence the findings from human amnesic patients and the findings from monkeys with surgical lesions of those brain regions thought to be affected in the human cases, we have addressed in three experiments the implication of findings that human amnesia spares motor and cognitive skills. In the first experiment, monkeys with conjoint lesions of hippocampus and amygdala (H-A), which reproduced the surgical removal sustained by the noted amnesic case H.M., ...

    Also Ranks for: Monkeys Lesions |  human amnesia |  preserved learning |  medial temporal |  brain regions
    KOL Index score: 11762

    In monkeys, bilateral damage to the medial temporal region produces severe memory impairment. This lesion, which includes the hippocampal formation, amygdala, and adjacent cortex, including the parahippocampal gyrus (the H+A+ lesion), appears to constitute an animal model of human medial temporal lobe amnesia. Reexamination of histological material from previously studied monkeys with H+A+ lesions indicated that the perirhinal cortex had also sustained significant damage. Furthermore, ...

    Also Ranks for: Hippocampal Formation |  memory impairment |  monkeys lesions |  perirhinal cortex damage |  adjacent cortex
    KOL Index score: 11473

    Studies of circumscribed amnesia have been a useful source of information about the organization of human memory functions. In an effort to obtain neuroanatomical information about the patients being studied, we have used 2 high-resolution protocols for imaging the human brain with magnetic resonance (MR). One provides images of the hippocampus, permitting visualization of the hippocampal formation in considerable detail. The second provides images of the mammillary nuclei. Four amnesic ...

    Also Ranks for: Hippocampal Formation |  magnetic resonance |  temporal lobe |  diencephalic amnesia |  mammillary nuclei
    KOL Index score: 11436

    Patient RB (Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus, S. Zola-Morgan, L. R. Squire, and D. G. Amaral, 1986, J Neurosci 6:2950-2967) was the first reported case of human amnesia in which detailed neuropsychological analyses and detailed postmortem neuropathological analyses demonstrated that damage limited to the hippocampal formation was sufficient to produce anterograde memory ...

    Also Ranks for: Hippocampal Formation |  memory impairment |  bilateral damage |  amnesic patients |  ca1 region
    KOL Index score: 11293

    The formation of new associations between items is critical for establishing episodic memories. It has been suggested that the hippocampus is essential for creating such associations but is not involved, or is much less involved, in memory for single items. In Experiment 1, we tested controls and amnesic patients with bilateral lesions thought to be limited primarily to the hippocampal region in both single-item and associative recognition memory tasks. In the single-item task, a ...

    Also Ranks for: Recognition Memory |  hippocampal region |  single items |  amnesic patients |  associative task
    KOL Index score: 11258

    Damage to the hippocampus typically produces temporally graded retrograde amnesia, whereby memories acquired recently are impaired more than memories acquired remotely. This phenomenon has been demonstrated repeatedly in a variety of species and tasks. It has also figured prominently in theoretical treatments of memory and hippocampal function. Yet temporally graded retrograde amnesia has not been demonstrated following hippocampal damage in spatial tasks like the water maze. We have ...

    Also Ranks for: Spatial Memory |  water maze |  hippocampal lesions |  hippocampus memories |  1 day


    Larry R Squire: Influence Statistics

    Sample of concepts for which Larry R Squire is among the top experts in the world.
    Concept World rank
    rb memory impairment #1
    mtl associations #1
    longterm declarative memories #1
    decades experimental work #1
    participants recognition decisions #1
    adolescence recollections #1
    patients hippocampal lesions #1
    amnesic patients controls #1
    controls extended exposure #1
    hippocampal lesions impairment #1
    disyllabic kroll #1
    implications rest periods #1
    classical humans lovibond #1
    temporal order ect #1
    stimulus contingencies acquisition #1
    task memory load #1
    function studytest interval #1
    shanks clark #1
    prolonged retrograde amnesia #1
    delay intervals severity #1
    case memories #1
    evidence normal subjects #1
    nonmatching sample #1
    independent awareness #1
    patients pencil #1
    expression declarative memory #1
    knowledge stimulus contingencies #1
    incorrect source judgments #1
    capacity distress cries #1
    formspecific #1
    hippocampus supports #1
    patient rb #1
    neuropsychology memory #1
    anisomycin amnesic #1
    volunteers dot patterns #1
    neuropsychology human memory #1
    remote autobiographical memory #1
    visual discriminations objects #1
    chronic anterograde #1
    hippocampal lesions experiments #1
    cxm activity #1
    memory impairment lesions #1
    hippocampal lesions hippocampus #1
    new declarative knowledge #1
    memory brain structures #1
    recognition memory damage #1
    humans robust capacity #1
    shifts 0 degrees #1
    40–80 treatment #1
    mirrorreading skill #1

    Key People For Recognition Memory

    Top KOLs in the world
    Larry R Squire
    recognition memory amnesic patients medial temporal lobe
    Andrew P Yonelinas
    recognition memory recollection familiarity acute stress
    Endel Tulving
    episodic memory recognition failure prefrontal cortex
    John Patrick Aggleton
    retrosplenial cortex recognition memory anterior thalamic nuclei
    Malcolm Watson Brown
    perirhinal cortex recognition memory familiarity discrimination
    Daniel L Schacter
    false recognition future events episodic simulation

    Larry R Squire:Expert Impact

    Concepts for whichLarry R Squirehas direct influence:Recognition memory,  Amnesic patients,  Medial temporal lobe,  Perirhinal cortex,  Temporal lobe,  Retrograde amnesia,  Hippocampal formation,  Memory impairment.

    Larry R Squire:KOL impact

    Concepts related to the work of other authors for whichfor which Larry R Squire has influence:Episodic memory,  Temporal lobe,  Prefrontal cortex,  Dentate gyrus,  Magnetic resonance,  Synaptic plasticity,  Protein synthesis.



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    Department of Psychology, University of California San Diego, La Jolla, CA 92093 | Veterans Affairs Medical Center, San Diego, CA 92161 | Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 | Department of Neurosciences,