Scott Keeney

Scott Keeney

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, Usa Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, Usa

Direct Impact

Concepts for which Scott Keeney has direct influence:

meiotic recombination
mouse meiosis
dsb formation
dna double-strand breaks
saccharomyces cerevisiae
homologous chromosomes
pirna biogenesis

External impact

Concepts related to the work of other authors for which Scott Keeney has influence:

meiotic recombination
synthetic chromosome
saccharomyces cerevisiae
dsb formation
fission yeast
genome structure
mouse meiosis

Prominent publications by Scott Keeney

KOL-Index: 58 The programmed formation of DNA double-strand breaks (DSBs) in meiotic prophase I initiates the homologous recombination process that yields crossovers between homologous chromosomes, a prerequisite to accurately segregating chromosomes during meiosis I (MI). In the budding yeast Saccharomyces cerevisiae, proteins required for meiotic DSB formation (DSB proteins) accumulate to higher levels ...
Known for
Meiosis-Specific Cohesin Subunit | Crossovers | Chromosomes Dsbs | Formation Dsb
KOL-Index: 46 Piwi-interacting RNAs (piRNAs) play critical roles in protecting germline genome integrity and promoting normal spermiogenic differentiation. In mammals, there are two populations of piRNAs: pre-pachytene and pachytene. Transposon-rich pre-pachytene piRNAs are expressed in fetal and perinatal germ cells and are required for retrotransposon silencing, whereas transposon-poor pachytene piRNAs ...
Known for
Complementing Wild-Type Allele | Mov10l1 Terminal | Transposon-Rich Pre-Pachytene Pirnas | Rna Helicase Domain
KOL-Index: 42 Formation of meiotic DNA double-strand breaks (DSBs) by Spo11 is tightly regulated and tied to chromosome structure, but the higher-order assemblies that execute and control DNA breakage are poorly understood. We address this question through molecular characterization of Saccharomyces cerevisiae RMM proteins (Rec114, Mei4 and Mer2)—essential, conserved components of the DSB machinery. Each ...
Known for
Multilayered | Biophysical Properties | Dsb Machinery Self-Assembles | Phase-Separated Systems
KOL-Index: 40 Meiotic recombination is initiated by large numbers of developmentally programmed DNA double-strand breaks (DSBs), ranging from dozens to hundreds per cell depending on the organism. DSBs formed in single-copy sequences provoke recombination between allelic positions on homologous chromosomes, but DSBs can also form in and near repetitive elements such as retrotransposons. When they do, they ...
Known for
Dsb Formation | Sk1
KOL-Index: 38 Meiosis poses unique challenges because two rounds of chromosome segregation must be executed without intervening DNA replication. Mammalian cells express numerous temporally regulated cyclins, but how these proteins collaborate to control meiosis remains poorly understood. Here, we show that female mice genetically ablated for cyclin B3 are viable-indicating that the protein is dispensable ...
Known for
Cdk1 Meiotic | Cyclin Kinase | Apc Activation
KOL-Index: 36 Spo11, which makes DNA double-strand breaks (DSBs) essential for meiotic recombination, is poorly understood mechanistically because it has been recalcitrant to biochemical study. Here, we provide a molecular analysis of S. cerevisiae Spo11 purified with partners Rec102, Rec104 and Ski8. Rec102 and Rec104 jointly resemble the B subunit of archaeal Topoisomerase VI, with Rec104 similar to a ...
Known for
Distinct Biological Roles | Structural Functional Similarities | Mimicking Cleavage Products | Duplex-Duplex Junctions
KOL-Index: 30 Cyclins, as regulatory partners of cyclin-dependent kinases (CDKs), control the switch-like cell cycle transitions that orchestrate orderly duplication and segregation of genomes. Compared to mitosis, relatively little is known about how cyclin-CDK complexes control meiosis, the specialized cell division that generates gametes for sexual production. Mouse cyclin B3 was previously shown to ...
Known for
Meiosis Expression | Spermatogenesis Cyclins | Males Lacking
KOL-Index: 29 Summary Numerous DNA double-strand breaks (DSBs) arise during meiosis to initiate homologous recombination. These DSBs are usually repaired faithfully, but here we uncover a new type of mutational event in which deletions form via joining of ends from two closely spaced DSBs (double cuts) within a single hotspot or at adjacent hotspots on the same or different chromatids. Deletions occur in ...
Known for
Aborted Gap Repair | Distant Sites | Multi-Chromatid Damage | Summary Numerous Dna Double-Strand
KOL-Index: 26 Sex chromosomes in males share only a diminutive homologous segment, the pseudoautosomal region (PAR), wherein meiotic double-strand breaks (DSBs), pairing, and crossing over must occur for correct segregation. How cells ensure PAR recombination is unknown. Here we delineate cis-and trans-acting factors that control PAR ultrastructure and make the PAR the hottest area of DSB formation in the ...
Known for
Cis-And Trans-Acting | Sex Chromosomes | Double-Strand Breaks | Male Mouse Genome
KOL-Index: 25 Crossovers generated during the repair of programmed meiotic double-strand breaks must be tightly regulated to promote accurate homolog segregation without deleterious outcomes, such as aneuploidy. The Mlh1-Mlh3 (MutLγ) endonuclease complex is critical for crossover resolution, which involves mechanistically unclear interplay between MutLγ and Exo1 and polo kinase Cdc5. Using budding yeast ...
Known for
Programmed Meiotic Double-Strand Breaks | Mlh1 | Lower Frequency | Kinase Mutlγ

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, USA

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