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  • John F Thompson

    Prominent publications by John F Thompson

    KOL Index score: 21216

    BACKGROUND: The use of radiotherapy after therapeutic lymphadenectomy for patients with melanoma at high risk of further lymph-node field and distant recurrence is controversial. Decisions for radiotherapy in this setting are made on the basis of retrospective, non-randomised studies. We did this randomised trial to assess the effect of adjuvant radiotherapy on lymph-node field control in patients who had undergone therapeutic lymphadenectomy for metastatic melanoma in regional lymph ...

    Also Ranks for: Adjuvant Radiotherapy |  therapeutic lymphadenectomy |  observation patients |  node field |  melanoma risk
    KOL Index score: 17890

    Members of the Bcl-2 family of antiapoptotic proteins (Bcl-2, Bcl-XL and Mcl-1) are key regulators of apoptosis. The purpose of the present study was to examine and better define the role of Bcl-2, Bcl-XL and Mcl-1 in the progression of melanoma. Immunohistochemical staining for Bcl-2, Bcl-XL and Mcl-1 was performed on paraffin sections of 100 cases of benign nevi, primary melanoma and metastatic melanoma. Expression was correlated with histopathologic features, clinical progress and ...

    Also Ranks for: Melanoma Bcl2 |  stat3 expression |  mitf levels |  bclxl mcl1 |  transcription factors
    KOL Index score: 16212

    PURPOSE: To determine whether density and distribution of tumor-infiltrating lymphocytes (TILs; TIL grade) is an independent predictor of sentinel lymph node (SLN) status and survival in patients with clinically localized primary cutaneous melanoma.

    METHODS: From the Melanoma Institute Australia database, 1,865 patients with a single primary melanoma ≥ 0.75 mm in thickness were identified. The associations of clinical and pathologic factors with SLN status, recurrence-free survival ...

    Also Ranks for: Independent Predictor |  lymph node |  sln status |  tumor thickness |  cutaneous melanoma
    KOL Index score: 15648

    BACKGROUND: Sentinel-node biopsy, a minimally invasive procedure for regional melanoma staging, was evaluated in a phase 3 trial.

    METHODS: We evaluated outcomes in 2001 patients with primary cutaneous melanomas randomly assigned to undergo wide excision and nodal observation, with lymphadenectomy for nodal relapse (observation group), or wide excision and sentinel-node biopsy, with immediate lymphadenectomy for nodal metastases detected on biopsy (biopsy group). Results No significant ...

    Also Ranks for: Nodal Observation |  hazard ratio |  node biopsy |  survival melanoma |  wide excision
    KOL Index score: 15273

    A sentinel lymph node (SLN) that is melanoma negative by pathologic examination implies absence of melanoma metastasis to that regional lymph node field. However, a small proportion of patients develop regional node field recurrence after a negative SLN biopsy. In this study, we reviewed the histopathology of negative SLNs from such patients to determine whether occult melanoma cells were present in the SLNs, to characterize the pathologic features of false-negative SLNs, and to provide ...

    Also Ranks for: Melanoma Patients |  regional recurrence |  lymph node |  negative sentinel |  pathologic examination
    KOL Index score: 14750

    BACKGROUND: Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediate-thickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for patients with sentinel-node metastases is not clear.

    METHODS: In an international trial, we randomly assigned patients with sentinel-node metastases detected by means of standard pathological assessment or a multimarker ...

    Also Ranks for: Completion Dissection |  node metastasis |  patients melanoma |  logrank test |  specific survival
    KOL Index score: 14023

    BACKGROUND: Adjuvant radiotherapy is recommended for patients with melanoma after lymphadenectomy. We previously showed this treatment reduced risk of repeat lymph-node field cancer in patients with a high risk of recurrence but had no effect on overall survival. Here, we aim to update the relapse and survival data from that trial and assess quality of life and toxic effects.

    METHODS: In the ANZMTG 01.02/TROG 02.01 randomised controlled trial, we enrolled patients who had undergone ...

    Also Ranks for: Adjuvant Radiotherapy |  controlled trial |  patients risk |  lymph node |  field relapse
    KOL Index score: 14005

    BACKGROUND: We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma.

    METHODS: Patients with a primary cutaneous melanoma were randomly assigned to wide excision and postoperative observation of regional lymph nodes with lymphadenectomy if nodal relapse occurred, or to wide excision and sentinel-node biopsy with immediate lymphadenectomy if nodal micrometastases were detected on biopsy.

    RESULTS: Among 1269 patients with an ...

    Also Ranks for: Nodal Observation |  node biopsy |  hazard ratio |  wide excision |  5year survival rate
    KOL Index score: 13987

    BACKGROUND: Cutaneous melanoma accounts for 75% of skin cancer deaths. Standard treatment is surgical excision with a safety margin some distance from the borders of the primary tumour. The purpose of the safety margin is to remove both the complete primary tumour and any melanoma cells that might have spread into the surrounding skin.Excision margins are important because there could be trade-off between a better cosmetic result but poorer long-term survival if margins become too ...

    Also Ranks for: Excision Margins |  primary cutaneous melanoma |  hazard ratio |  safety margin |  95 confidence interval
    KOL Index score: 13927

    BACKGROUND: The technique of lymphoscintigraphy may allow a more selective approach to the management of clinically negative neck nodes among patients with cutaneous head and neck melanoma.

    PATIENTS AND METHODS: A group of 97 patients with cutaneous head and neck melanoma had preoperative lymphoscintigraphy using intradermal injections of technetium 99m antimony trisulfide colloid to identify sentinel nodes. Fifty-one patients were eligible for clinical analysis after initial definitive ...

    Also Ranks for: Cutaneous Head |  neck melanoma |  sentinel nodes |  wide excision |  preoperative lymphoscintigraphy
    KOL Index score: 13786

    OBJECTIVE: This study aims to objectively define the criteria for assessing the presence of lymphedema and to report the prevalence of lymphedema after inguinal and ilio-inguinal (inguinal and pelvic) lymph node dissection for metastatic melanoma.

    SUMMARY BACKGROUND DATA: Lymphedema of the lower limb is a common problem after inguinal and ilio-inguinal dissection for melanoma. The problem is variably perceived by both patients and clinicians. Adding to the confusion is a lack of a clear ...

    Also Ranks for: Limb Lymphedema |  inguinal dissection |  tree analysis |  patients melanoma |  lymph node
    KOL Index score: 13681

    OBJECTIVE: To evaluate the multicenter application of intraoperative lymphatic mapping, sentinel lymphadenectomy, and selective complete lymph node dissection (LM/SL/SCLND) for the management of early-stage melanoma.

    SUMMARY BACKGROUND DATA: The multidisciplinary technique of LM/SL/SCLND has been widely adopted, but not validated in a multicenter trial. The authors began the international Multicenter Selective Lymphadenectomy Trial (MSLT) 5 years ago to evaluate the survival of patients ...

    Also Ranks for: Lymphatic Mapping |  blue dye |  lm sclnd |  stage melanoma |  wide excision


    John F Thompson: Influence Statistics

    Sample of concepts for which John F Thompson is among the top experts in the world.
    Concept World rank
    neck melanomas hnm #1
    regional toxicity ili #1
    melanomas risk #1
    australia ili #1
    induction regional chemotherapy #1
    limb toxicity outcome #1
    mm ulceration #1
    positive patients surgeons #1
    dacarbazine chemosensitisation #1
    tumours melanoma #1
    parameters melanoma #1
    specialist center patients #1
    implications staging #1
    histologic parameters #1
    lymphoscintigraphy sns #1
    breslow thickness patients #1
    supraclavicular node lymphoscintigraphy #1
    melanoma limb #1
    suspected melanoma #1
    83 cases initial #1
    centers procedure #1
    melanoma surgeons clnd #1
    apo app #1
    snb icl #1
    tumor mitotic #1
    node positivity #1
    histopathologic margin risk #1
    ili stage #1
    models sentinel #1
    cent stage disease #1
    lung resection melanoma #1
    s100b matv #1
    dactinomycin extremities #1
    immunostained sections s100 #1
    snb wex #1
    radiation treatment bms #1
    melanoma influence #1
    lymphadenectomy death #1
    psc fhf #1
    survival margin #1
    patient wex #1
    quality assurance parameters #1
    completion dissection observation #1
    refractory chromomycosis #1
    melanoma lymphadenectomy #1
    thickness ulceration #1
    ili limb #1
    perfusion dactinomycin #1
    intralesional rose bengal #1

    Key People For Melanoma Patients

    Top KOLs in the world
    John Munn Kirkwood
    metastatic melanoma adjuvant therapy advisory consultancy
    Dirk Schadendorf
    melanoma patients advisory consultancy braf v600
    John F Thompson
    melanoma patients node biopsy sentinel lymph
    Donald L Morton
    melanoma patients lymphatic mapping sentinel lymphadenectomy
    Jeffrey E Gershenwald
    melanoma patients lymph node joint committee
    Merrick I Ross†
    breast cancer lymph node melanoma patients

    John F Thompson:Expert Impact

    Concepts for whichJohn F Thompsonhas direct influence:Melanoma patients,  Metastatic melanoma,  Node biopsy,  Cutaneous melanoma,  Lymph node,  Sentinel lymph,  Sentinel node,  Lymph nodes.

    John F Thompson:KOL impact

    Concepts related to the work of other authors for whichfor which John F Thompson has influence:Cutaneous melanoma,  Lymph node,  Breast cancer,  Brain metastases,  Skin neoplasms,  Merkel cell carcinoma.



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    Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital and NSW Health Pathology, Sydney, New South Wales, Australia | Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia | Faculty of Medicine and Health,