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    • Patrick S Moore
    • Patrick S Moore: Influence Statistics

      Patrick  S Moore

      Patrick S Moore

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      Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA | Cancer Virology Program, Hillman Cancer Center, ...

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      Patrick S Moore:Expert Impact

      Concepts for whichPatrick S Moorehas direct influence:Merkel cell,Merkel cell polyomavirus,Cell polyomavirus,Merkel cell carcinoma,Kaposi sarcoma,Cell lines,Human herpesvirus,Kaposis sarcoma.

      Patrick S Moore:KOL impact

      Concepts related to the work of other authors for whichfor which Patrick S Moore has influence:Human herpesvirus,Kaposi sarcoma,Merkel cell carcinoma,Pancreatic cancer,Gene expression,Primary effusion lymphoma,Endothelial cells.

      KOL Resume for Patrick S Moore

      Year
      2022

      Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

      2021

      Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

      2020

      Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

      Hillman Cancer Center, Cancer Virology Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

      2019

      Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

      2018

      Cancer Virology Program, University of Pittsburgh, Pittsburgh, PA, USA

      2017

      Cancer Virology Program, University of Pittsburgh, Pittsburgh, PA 15213

      2016

      Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.

      2015

      Cancer Virology Program, University of Pittsburgh Cancer Institute, Suite 1.8, 5117 Centre Avenue, Pittsburgh, PA 15213, United States

      2014

      Cancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania

      2013

      Cancer Virology Program, University of Pittsburgh, Pittsburgh, PA 15213, USA

      2012

      School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, Cancer Virology Program, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA and, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany

      Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

      2011

      From the, Cancer Virology Program,

      UNIVERSITY OF PITTSBURGH CANCER INSTITUTE

      Author affiliations: University of Pittsburgh, Pittsburgh, Pennsylvania, USA (Y.L. Tolstov, A. Knauer, T.W. Kensler, L.A. Kingsley, P.S. Moore, Y. Chang);

      Johns Hopkins University, Baltimore, Maryland, USA (T.W. Kensler)

      Qidong Liver Cancer Institute, Jiangsu, People’s Republic of China (J.G. Chen);

      2010

      Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania

      Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY Jane Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California School of Medicine, Los Angeles Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA

      2009

      Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA

      2008

      Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1.8, Pittsburgh, PA 15213; and ‡Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611

      Department of Pathology, University of Verona, Verona, Italy

      University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

      2007

      Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

      2006

      Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania

      From the Dipartimento di Sanità Pubblica, Sezione di Medicina del Lavoro, Università di Cagliari, Cagliari (P.C., M.G.T., A.I., M.M., G.S., C.F.); Dipartimento di Patologia, Università di Verona (P.S.M., S.M., A.S.); Dipartimento di Citomorfologia, Università di Cagliari, Monserrato, Cagliari (M.G.E., S.C., M.Z.); and Divisione di Ematologia, Ospedale San Francesco, ASL 3, Nuoro, Italy (M.M., G.P.)

      Department of Pathology, Section of Anatomic Pathology, University of Verona, Verona, Italy

      2005

      Deparment of Pathology, Section of Anatomic Pathology, Università di Verona, Verona, Italy

      University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA

      2004

      Dipartimento di Patologia, Università degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy

      2003

      Molecular Virology Program, Hillman Cancer Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-1863; email:

      Department of Pathology, Università di Verona, Italy

      University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA

      Departamento de Anatomia Patologica, Instituto del Cancer de Solca, Cuenca, Ecuador

      2002

      Division of Epidemiology, Columbia University School of Public Health, 10032, New York, New York

      Dipartimento di Patologia − Sezione Anatomia Patologica, Università di Verona, Verona, Italy

      Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA.

      2001

      Division of Epidemiology, School of Public Health, Columbia University, New York, New York 10032

      Department of Pathology Columbia University, New York, NY, USA

      Dipartimento di Patologia, Sezione di Anatomia Patologica, Università di Verona, Strada Le Grazie, Verona, Italy

      2000

      Department of Pathology‐Section of Anatomical Pathology, Università di Verona, Italy

      Division of Epidemiology, Columbia University, New York, New York

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      Sample of concepts for which Patrick S Moore is among the top experts in the world.
      Concept World rank
      enzyme pig kidney #1
      73500 bhutanese refugees #1
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      kaposi tissue donors #1
      molecular standpoint alterations #1
      africanendemic classic ks #1
      saah phair #1
      kshv years #1
      mcc advanced age #1
      335 420 nm #1
      ketone active #1
      ks accumulation #1
      endosomal protein effector #1
      dihydroxyphenylacetone #1
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      mcc bias carcinoma #1
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      cmyc p16ink4 #1
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      orf73 component #1
      human humans kaposi #1
      cancers mcc diagnosis #1
      virusinduced neoplasia #1
      surprisingly rich source #1
      emergence human herpesvirus #1
      methyldopa dopa decarboxylase #1
      ddc enzyme #1
      eastern tropical lowland #1
      missing vps3 #1
      deadend quinonoidal species #1
      1970s herpesvirus #1
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      Prominent publications by Patrick S Moore

      KOL-Index: 19430

      BACKGROUND: Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, may be the infectious cause of KS. Its prevalence in the general population, on the basis of detection of the virus genome, is controversial. To investigate the seroprevalence, we measured antibodies to a recombinant capsid-related (lytic cycle) KSHV antigen and a latent antigen complex.

      METHODS: We selected potentially immunoreactive capsid-related proteins of KSHV by expressing them as ...

      Known for Capsid Protein | Antibodies Kshv | Viral Antigens | Herpesvirus Infection | Latent Antigen
      KOL-Index: 16594

      BACKGROUND: Herpesvirus-like DNA sequences have recently been found in lesions from patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS). It is not known whether these sequences are also present in classic Kaposi's sarcoma or in the Kaposi's sarcoma that occurs in homosexual men who are seronegative for the human immunodeficiency virus (HIV).

      METHODS: We analyzed DNA in tissue samples from patients with AIDS-associated Kaposi's sarcoma, patients with classic ...

      Known for Dna Sequence | Patients Kaposis Sarcoma | Hiv Infection | Aids Kaposi
      KOL-Index: 15496

      BACKGROUND: DNA fragments that appeared to belong to an unidentified human herpesvirus were recently found in more than 90 percent of Kaposi's sarcoma lesions associated with the acquired immunodeficiency syndrome (AIDS). These fragments were also found in 6 of 39 tissue samples without Kaposi's sarcoma, including 3 malignant lymphomas, from patients with AIDS, but not in samples from patients without AIDS.

      METHODS: We examined the DNA of 193 lymphomas from 42 patients with AIDS and 151 ...

      Known for Dna Sequences | Patients Aids | Based Lymphomas | Kaposi Sequence Analysis | Viral Herpesviridae Herpesvirus
      KOL-Index: 15260

      Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma. Recently, a new polyoma virus has been identified that is clonally integrated in the genome of the majority of MCCs, with truncating mutations in the viral large T antigen gene. We examined the presence of Merkel cell polyomavirus (MCV) in a set of 17 frozen tumor samples by quantitative polymerase chain reaction; 15 of them (88%) were positive. Sections from corresponding archival material were ...

      Known for Neuroendocrine Carcinomas | Merkel Cell Carcinoma | Combined Tumors | Cell Polyomavirus | Neoplasm Dna
      KOL-Index: 14796

      BACKGROUND: Merkel cell polyomavirus (MCV) was discovered by digital transcriptome subtraction as a monoclonal infection of Merkel cell carcinoma (MCC) tumors. Subsequent studies have repeatedly confirmed that MCV is the likely cause for most MCC. Polymerase chain reaction-based detection of the virus in other nonmelanoma skin cancers, however, has been inconsistent and controversial.

      OBJECTIVE: We sought to directly assay for MCV infection in squamous cell carcinoma (SCC) or basal cell ...

      Known for Merkel Cell Carcinoma | Cell Polyomavirus | Immunocompetent Patients | Viral Female Humans | Mcv Mcc
      KOL-Index: 14587

      Merkel cell polyomavirus (MCV) is a recently discovered human virus closely related to African green monkey lymphotropic polyomavirus. MCV DNA is integrated in approximately 80% of Merkel cell carcinomas (MCC), a neuroendocrine skin cancer linked to lymphoid malignancies such as chronic lymphocytic leukemia (CLL). To assess MCV infection and its association with human diseases, we developed a monoclonal antibody that specifically recognizes endogenous and transfected MCV large T (LT) ...

      Known for Merkel Cell | Polyomavirus Infection | Antigen Expression | Mcc Mcv | Dna Viral
      KOL-Index: 14474

      Alterations of K- ras, p53, p16 and DPC4/Smad4 characterize pancreatic ductal cancer (PDC). Reports of inactivation of these latter two genes in pancreatic endocrine tumours (PET) suggest that common molecular pathways are involved in the tumorigenesis of pancreatic exocrine and endocrine epithelia. We characterized 112 primary pancreatic tumours for alterations in p16 and DPC4 and immunohistochemical expression of DPC4. The cases included 34 PDC, 10 intraductal papillary-mucinous ...

      Known for Acinar Cell Carcinoma | Pancreatic Tumours | Molecular Pathways | Ductal Cancer | Immunohistochemistry Loss
      KOL-Index: 13888

      BACKGROUND: Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph).

      METHODS: We selected 12 single-nucleotide polymorphisms for analysis, on the basis of previous functional or association data, in nine genes that have important ...

      Known for Interlymph Consortium | Hodgkin Lymphoma | Tnf Il10 | Genetic Variation | Genotype Data
      KOL-Index: 13419

      BACKGROUND: If Kaposi's sarcoma-associated herpesvirus (KSHV) is the cause of Kaposi's sarcoma, serologic evidence of infection should be present in patients before the disease develops.

      METHODS: Using an immunoblot assay for two latent nuclear antigens of KSHV, we tested serum samples from homosexual male patients with the acquired immunodeficiency syndrome (AIDS) with and without Kaposi's sarcoma (HIV-infected men with hemophilia), HIV-seronegative blood donors, and HIV-seronegative ...

      Known for Nuclear Antigens | Kaposis Sarcoma | Kaposi Sensitivity | Infection Kshv | Seroconversion Antibodies
      KOL-Index: 13268

      Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, is associated with three proliferative diseases ranging from viral cytokine-induced hyperplasia to monoclonal neoplasia: multicentric Castleman's disease (CD), Kaposi's sarcoma (KS), and primary effusion lymphoma (PEL). Here we report a new latency-associated 1,704-bp KSHV spliced gene belonging to a cluster of KSHV sequences having homology to the interferon regulatory factor (IRF) family of transcription factors. ...

      Known for Viral Protein | Herpesvirus Lana2 | Pel Kshv | Transcription Factors | Ks Lesions
      KOL-Index: 12939

      Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of Merkel cell carcinoma (MCC). The rate of MCV infection among persons without MCC is unknown. We developed a MCV virus-like particle (VLP) enzyme-linked immunoassay (EIA) that does not cross-react with human BK or murine polyomaviruses. Peptide mapping of the MCV VP1 gene and immunoblotting with denatured MCV VLP are less sensitive than the MCV EIA in detecting MCV antibodies suggesting ...

      Known for Human Merkel | Polyomavirus Infection | Mcc Patients | Mcv Antibodies | Aged 80
      KOL-Index: 12812

      Deep sequencing studies frequently identify small RNA fragments of abundant RNAs. These fragments are thought to represent degradation products of their precursors. Using sequencing, computational analysis, and sensitive northern blot assays, we show that constitutively expressed non-coding RNAs such as tRNAs, snoRNAs, rRNAs and snRNAs preferentially produce small 5' and 3' end fragments. Similar to that of microRNA processing, these terminal fragments are generated in an asymmetric ...

      Known for Small Rna | 5 Trfs | Dicer Processing | Human Cells | Degradation Products
      KOL-Index: 12811

      Dopa decarboxylase (DDC) catalyzes the cleavage of alpha-methylDopa into 3,4-dihydroxyphenylacetone and ammonia, via the intermediate alpha-methyldopamine, which does not accumulate during catalysis. The ketone has been identified by high-performance liquid chromatography and mass spectroscopic analysis, and ammonia by means of glutamate dehydrogenase. Molecular oxygen is consumed during the reaction in a 1:2 molar ratio with respect to the products. The kcat and Km of this reaction were ...

      Known for Dopa Decarboxylase | Active Site | Reaction Ddc | Molecular Oxygen | Anaerobic Conditions
      KOL-Index: 12788

      Establishment of a chronic infection is a key event in virus-mediated carcinogenesis. Several cancer-associated, double-stranded DNA (dsDNA) viruses act via their oncoproteins to downregulate Toll-like receptor 9 (TLR9), a key receptor in the host innate immune response that senses viral or bacterial dsDNA. A novel oncogenic virus, Merkel cell polyomavirus (MCPyV), has been recently identified that causes up to 80% of Merkel cell carcinomas (MCCs). However, it is not yet known whether ...

      Known for Merkel Cell | 9 Expression | Tumor Carcinoma | Polyomavirus Mcpyv | Oncogenic Virus
      KOL-Index: 12371

      Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high mortality rate. The majority of MCC (70-80%) harbor clonally integrated Merkel cell polyomavirus (MCV) in the tumor genome and express viral T antigen oncoproteins. The characterization of an early passage MCV-positive MCC cell line MS-1 is described, and its cellular, immunohistochemical, and virological features to MCV-negative (UISO, MCC13, and MCC26) and MCV-positive cell lines (MKL-1 and MKL-2) were compared. The ...

      Known for Merkel Cell | Tumor Carcinoma | Animals Antigens Viral | Polyomavirus Mcv | Positive Mcc

      Key People For Merkel Cell

      Top KOLs in the world
      #1
      Paul T Nghiem
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      #2
      Patrick S Moore
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      #3
      Timothy M Johnson
      lymph node cutaneous melanoma merkel cell
      #4
      Yuan‐Hsiang Chang
      merkel cell digitized mammograms kaposi sarcoma
      #5
      Masahiro Shuda
      merkel cell tumor carcinoma gene expression
      #6
      Huichen Feng
      merkel cell viral genes polyomavirus mcv

      Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA | Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA | C

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