• Disease
  • Messenger
  • Messenger Rna
  • George T Gallagher

    Prominent publications by George T Gallagher

    KOL Index score: 10365

    Transforming growth factor-alpha (TGF-alpha) and TGF-beta 1 have been proposed as important regulators of processes critical to successful wound healing. Although various cells present in wounds represent potential sources of either TGF-alpha and/or TGF-beta, including macrophages, neutrophils, keratinocytes, fibroblasts, and endothelial cells, we recently identified eosinophils as an additional potential source of these cytokines. We therefore used in situ hybridization and ...

    Also Ranks for: Wound Healing |  transforming growth |  beta 1 |  tgf alpha |  situ hybridization
    KOL Index score: 9632

    Transforming growth factor alpha (TGF-alpha) is a pleuripotential cytokine with diverse biological effects, including the ability to influence the proliferation of normal cells or neoplastic epithelial cells. Eosinophils are a subset of granulocytes that normally enter the peripheral tissues, particularly those beneath gastrointestinal, respiratory, and urogenital epithelium, where they reside in close proximity to the epithelial elements. In this study, we demonstrate that the great ...

    Also Ranks for: Human Eosinophils |  transforming growth |  messenger rna |  hypereosinophilic syndrome |  situ hybridization
    KOL Index score: 8626

    Using hamster as an oral wound healing model, we examined eosinophils and their expression of transforming growth factor-alpha (TGF-alpha) and transforming growth factor-beta 1 (TGF-beta 1). Oral wounds healed approximately two times faster than their cutaneous counterparts. Eosinophils infiltrated prominently into oral wounds; however, unlike the dual expression of TGF-alpha and TGF-beta 1 in skin wounds, oral wound-associated eosinophils expressed TGF-beta 1, but not TGF-alpha. Because ...

    Also Ranks for: Oral Wounds |  alpha tgf |  growth factor |  wound healing |  beta 1
    KOL Index score: 7839

    Aberrant expression of TGF-alpha is associated with human malignant oral epithelium. Experiments were initiated to determine the cellular sources of transforming growth factor-alpha (TGF-alpha) in human oral cancer. Ten freshly resected human oral cancers and four specimens of normal human oral epithelium were studied by in situ hybridization and immunohistochemistry. Tissues were probed with 35S-labeled sense and antisense riboprobes to (i) human TGF-alpha (hTGF-alpha), (ii) human ...

    Also Ranks for: Human Oral Cancer |  growth factor |  tgf alpha |  epithelial cells |  oral epithelium
    KOL Index score: 7365

    Carcinoma associated fibroblasts (CAFs) form the main constituents of tumor stroma and play an important role in tumor growth and invasion. The presence of CAFs is a strong predictor of poor prognosis of head and neck squamous cell carcinoma. Despite significant progress in determining the role of CAFs in tumor progression, the mechanisms contributing to their activation remain poorly characterized, in part due to fibroblast heterogeneity and the scarcity of reliable fibroblast surface ...

    Also Ranks for: Squamous Cell |  tumor carcinoma |  caf markers |  collagen type |  derived growth
    KOL Index score: 7075

    Inflammatory mediators of periradicular lesions are poorly understood. Transforming growth factors-alpha and -beta 1 (TGF-alpha and TGF-beta 1) have been linked with the cellular processes for both soft and hard tissue wound healing. The purpose of this study is to demonstrate the cellular sources of TGF-alpha and TGF-beta 1 mRNA and protein in periapical lesions by in situ hybridization and immunohistochemistry. Nine periapical granulomas and nine periapical cysts were examined. ...

    Also Ranks for: Transforming Growth |  periapical granulomas |  tgf beta |  inflammatory mediators |  wound healing
    KOL Index score: 7053

    We recently demonstrated that eosinophils infiltrate prominently into cutaneous wounds in the Syrian hamster and represent a source of transforming growth factor-alpha and transforming growth factor-beta. In this study, we assessed the role of the eosinophil and eosinophil-derived transforming growth factors in human oral ulcers that exhibit delayed healing, descriptively termed traumatic ulcerative granuloma with stromal eosinophilia. Our aim was to determine whether eosinophils, which ...

    Also Ranks for: Stromal Eosinophilia |  transforming growth |  traumatic ulcerative granuloma |  human eosinophils |  oral ulcer
    KOL Index score: 6743

    Sclerosing polycystic adenosis (SPCA) of the salivary gland is a rarely encountered lesion of uncertain pathogenesis that shares histologic features with sclerosing adenosis and fibrocystic disease of the mammary gland. To date, fewer than 40 cases of SPCA have been reported in the literature; all but one have arisen in the major salivary glands. We report 3 cases of SPCA involving minor salivary glands and discuss the characteristic histopathologic features of SPCA , which include a ...

    Also Ranks for: Salivary Gland |  polycystic adenosis |  cysts diagnosis |  differential female |  features sclerosing
    KOL Index score: 6470

    Large scale gene expression profiling was carried out on laser capture microdissected (LCM) tumor and normal oral epithelial cells and analysed on high-density oligonucleotide microarrays. About 600 genes were found to be oral cancer associated. These oral cancer associated genes include oncogenes, tumor suppressors, transcription factors, xenobiotic enzymes, metastatic proteins, differentiation markers, and genes that have not been implicated in oral cancer. The database created ...

    Also Ranks for: Oral Cancer |  laser capture |  gene expression |  reverse transcriptase |  microarray analysis
    KOL Index score: 6258

    Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) are known to promote the healing of epithelial wounds. Eosinophils are present in healing wounds and have recently been shown to be capable of producing TGF-alpha. This investigation was done to determine if eosinophils infiltrated into healing wounds are capable of expressing this cytokine. Using the rabbit cutaneous open wound model, the study found that the eosinophil is one of the predominant cell types in ...

    Also Ranks for: Growth Factor |  healing wound |  cellular source |  alpha tgf |  situ hybridization
    KOL Index score: 5427

    Wound healing is critical to the survival of the species after injury. Using hamsters as an experimental model, we have shown that eosinophils infiltrate prominently into skin wounds and that they express transforming growth factor-alpha and -beta 1 mRNAs and proteins. We hypothesized that eosinophils are important in wound healing. As no animal model is genetically deficient in eosinophils, a suitable way to test the hypothesis is to selectively reduce and/or deplete the influx of ...

    Also Ranks for: Eosinophil Infiltration |  wound healing |  monoclonal antibody |  experimental model |  publication animals antibodies


    George T Gallagher: Influence Statistics

    Sample of concepts for which George T Gallagher is among the top experts in the world.
    Concept World rank
    mediators periradicular #2
    protein periapical lesions #2
    origin periapical #2
    eosinophils periapical #2
    reflectance fluorescence spectroscopy #3
    060 combination #3
    21 heterophils #4
    granulation layer wound #4
    day heterophils #4
    rabbit eosinophil peroxidase #4
    α eosinophils #4
    sites anatomy #4
    normal body mechanism #4
    wounds capable #4
    heterophils cutaneous #4
    eosinophil squamous #4
    infiltrate prominently #4
    wounds 33diaminobenzidine #4
    eosinophils rabbit #4
    tgfα granulation layer #4
    sites spectral properties #4
    heterophils granulation layer #4
    epithelial wounds eosinophils #4
    selective dab #4
    infiltrated clot #4
    granulocytic cell types #4
    healing wounds cytokine #4
    healing wounds tgfalpha #4
    eosinophil experimental model #4
    granulation base #4
    method routine biopsy #4
    central laboratory 2 #4
    cycling cells tissues #4
    biopsies autopsy materials #4
    eosinophil cellular source #4
    potential role eosinophil #4
    immunohistochemistry delivery #4
    model heterophils #4
    eosinophils tumorpromoting role #4
    tumor development eosinophils #4
    anatomybased algorithms #4
    retrospective studies biopsies #4
    eosinophils tumor development #4
    trfk5 clinical observations #4
    seventh day majority #4
    proliferation dependent gene #4
    tgfalpha investigation #4
    diagnostic algorithms combinations #4
    eosinophils healing wound #4
    objectives eosinophils #4

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    George T Gallagher:Expert Impact

    Concepts for whichGeorge T Gallagherhas direct influence:Messenger rna,  Situ hybridization,  Oral cancer,  Salivary gland,  Transforming growth,  Tgf alpha,  Growth factor,  Transforming growth factor.

    George T Gallagher:KOL impact

    Concepts related to the work of other authors for whichfor which George T Gallagher has influence:Oral cancer,  Growth factor,  Squamous cell,  Wound healing,  Situ hybridization,  Polycystic adenosis,  Head neck.



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    Division of Oral Pathology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA | Division of Oral Pathology, Boston University School of Dental Medicine, Boston, Massachusetts, United States of America. | From the G. R. Har