• Disease
  • Methylene
  • Methylene Blue
  • William B Gill

    Prominent publications by William B Gill

    KOL Index score: 7149

    Intravesical instillation of methylene blue resulted in selective surface staining of bladder tumors in vivo without staining the background of normal urothelium. Staining of human bladder tumors in vivo was accomplished by the intravesical instillation of 0.1% methylene blue in 0.9% saline through a foley catheter under 20 cm of hydrostatic pressure up to a maximum volume of 400 ml. After 5 minutes contact time, the methylene blue solution was drained, and the bladder was washed with ...

    Also Ranks for: Methylene Blue |  bladder tumors |  transitional cell |  vivo staining |  5 minutes
    KOL Index score: 6924

    Epididymal cysts and/or hypoplastic testes have been found in 31.5 per cent of 308 men exposed to diethylstilbestrol in utero, compared to 7.8 per cent of 307 placebo-exposed controls. Analyses of the spermatozoa have revealed severe pathological changes (Eliasson score greater than 10) in 134 diethylstilbestrol-exposed men (18 per cent) and 87 placebo-exposed men (8 per cent). Further investigation of the 26 diethylstilbestrol-exposed men with testicular hypoplasia has revealed that 65 ...

    Also Ranks for: Diethylstilbestrol Exposure |  cryptorchidism testicular |  publication abnormalities |  luteinizing hormone |  male maternal
    KOL Index score: 4664

    Heparin was found to prevent calcium oxalate crystal adhesion to chemically injured rat bladder urothelium. Heparin was the only polysaccharide tested which restored injured urothelium to the functional status of normal, uninjured urothelium with respect to anticrystal adhesion properties. Other sulfated glycosaminoglycans, sulfated polysaccharides and monosaccharides were without restorative or protective effects. 3H-heparin was found to bind to injured urothelium but not to normal urothelium.

    Also Ranks for: Injured Urothelium |  crystal adhesion |  glycosaminoglycans heparin |  calcium oxalate |  urinary bladder
    KOL Index score: 3442

    Using a cystoscopic light source and methylene blue as the sensitizing dye, photoactivation was examined in two types of experiments. In the first, the in vitro study destruction of two enzymes (glucose-6-phosphate dehydrogenase and lactic dehydrogenase) was examined in suspensions of whole and homogenized tumor cells from a transplantable bladder tumor. In the second or in vivo study rats were used to demonstrate that tumor cell suspensions treated with methylene blue plus light, when ...

    Also Ranks for: Methylene Blue |  tumor cells |  urinary bladder |  lactic dehydrogenase |  sensitizing agents
    KOL Index score: 2727

    Supervoltage external radiotherapy has been sandwiched around radical retropubic prostatectomy as a potentially curative procedure for Stage C or D1 adenocarcinoma of the prostate. Preoperatively, 3,000 rads were delivered to the pelvis and prostate by approximately 18 by 20 cm. AP-PA opposing ports over a three-week period. After three weeks' rest, radical retropubic prostatectomy was done. After three weeks' postoperative recovery, additional radiotherapy was delivered as follows: ...

    Also Ranks for: Prostatic Carcinoma |  radical retropubic |  prostatectomy stage |  lymph node |  years complications
    KOL Index score: 2382

    Cytoxan (cyclophosphamide) given to rats intraperitoneally produced a severe cystitis within four hours with marked inflammatory edema and hemorrhagic ulcerations of the mucosa. An in vivo staining test with methylene blue showed deep staining of the urothelium as has been demonstrated with other types of urothelial injuries; uninjured urothelium does not stain. The cytoxan cystitis is probably not due to cytoxan itself, but to a breakdown product acrolein, an aldehyde appearing in the ...

    Also Ranks for: Urinary Bladder |  cyclophosphamide cystitis |  acetylcysteine acrolein |  female rats
    KOL Index score: 2206

    Microscopic chromocystoscopy is a new in vivo procedure that we have developed to aid in the detection and treatment of bladder tumors. Intravesical ionic dye chromocystoscopy was introduced by our group to permit cystoscopic viewing with ordinary light of selectively stained malignant urothelial surfaces by the cationic dye, methylene blue. With the recent availability of the Hamou hysteroscope, a microscopic endoscope, we have combined intravesical ionic dye chromocystoscopy with ...

    Also Ranks for: Microscopic Chromocystoscopy |  methylene blue |  urinary bladder |  urothelial surfaces
    KOL Index score: 2187

    In resonse to the limitations of urinary cytology which have resulted in a high incidence of false negative reports, a technique of retrograde brush biopsy has been developed. This technique aids in the diagnosis of carcinomas of the ureteral and renal collecting systems, thereby permitting earlier and more intensive treatment of malignant lesions of the urinary tract.

    Also Ranks for: Renal Pelvis |  retrograde brush biopsy |  urinary tract |  kidney neoplasms |  radiography ureteral
    KOL Index score: 1503
    Also Ranks for: Bladder Cancer |  vivo detection |  publication carcinoma |  methylene blue |  coloring agents
    KOL Index score: 1420

    A modified open renal biopsy technique was performed under local anesthesia on 129 patients over a 10-year period. This technique yielded sufficient tissue to establish a diagnosis for every patient. The mean number of glomeruli obtained was 54 +/- 3; the mean duration of the operation was 71 +/- 2 min. No deaths resulted and only one major complication developed following this procedure which required additional surgery. Two patients required blood transfusions following surgery and ...

    Also Ranks for: Kidney Biopsy |  percutaneous route
    KOL Index score: 1368
    Also Ranks for: Fibrous Histiocytoma |  male spermatic |  cord aged |  inguinal canal
    KOL Index score: 1163

    Understandings of the molecular mechanisms of urolithiasis and rationale antistone therapy have undergone significant advances with the application of biophysical theories and techniques to urine, uroliths, and the urinary tract. In addition, the development and combinations of radiologic and surgical techniques have dramatically improved the treatment of existing stones in both the upper and lower urinary tracts. This review is designed to cover the biophysical advances in diagnosis and ...

    Also Ranks for: Urinary Calculi |  calcium oxalate |  uric acid


    William B Gill: Influence Statistics

    Sample of concepts for which William B Gill is among the top experts in the world.
    Concept World rank
    enzymes methylene blue #2
    transplantable bladder tumor #2
    technique aids diagnosis #2
    antistone therapy advances #2
    cystoscopic light source #2
    enhance antistone #2
    mixed anaplastic seminoma #2
    procedure additional surgery #2
    antistone therapy understandings #2
    breakdown product acrolein #2
    deep staining urothelium #2
    acetylcysteine cytoxan #2
    25yearold study #2
    techniques bladder neoplasms #2
    resonse limitations #2
    intravesical methylene blue #2
    urolithiasis rationale #2
    biophysical radiologic #2
    urine rat experiments #2
    sensitizing dye photoactivation #2
    cystitis cytoxan #2
    experimental cytoxan cystitis #2
    surgery bleeding abnormality #2
    antistone preventive therapy #2
    photoactivation types #2
    308 diethylstilbestrol #2
    urinary cytology incidence #2
    cryptorchidism testicular hypoplasia #2
    operation 71 2 #2
    aldehyde urine #2
    rats severe cystitis #2
    cytoxan breakdown product #2
    hypoplasia 65 cent #2
    produced cystitis #2
    cytoxan cystitis #2
    lactic dehydrogenase suspensions #2
    aldehyde inactivating agent #2
    deaths major complication #2
    10year period technique #2
    association diethylstilbestrol exposure #2
    blue sensitizing #2
    cent cryptorchidism #2
    uninjured urothelium #2
    biophysical theories techniques #2
    utero cent #2
    calculi radiography kidney #2
    existing stones review #2
    intraperitoneally cystitis #2
    6 placeboexposed controls #2
    new tumors experiments #2

    Key People For Methylene Blue

    Top KOLs in the world
    Bassim Hamid Hameed
    activated carbon methylene blue aqueous solution
    Gordon McKay
    activated carbon bone char aqueous solution
    Vinod Kumar N Gupta
    activated carbon aqueous solutions contact time
    Guang Ming Guangming
    heavy metals phanerochaete chrysosporium aqueous solution
    Y S Ho
    aqueous solution divalent metal ions contact time
    Shaobin Wang
    fly ash phenol degradation active sites

    William B Gill:Expert Impact

    Concepts for whichWilliam B Gillhas direct influence:Methylene blue,  Microscopic chromocystoscopy,  Injured urothelium,  Bladder tumors,  Retrograde brush biopsy,  Diethylstilbestrol exposure,  Cytologic findings,  Testicular hypoplasia.

    William B Gill:KOL impact

    Concepts related to the work of other authors for whichfor which William B Gill has influence:Methylene blue,  Prenatal exposure,  Interstitial cystitis,  Testicular cancer,  Malignant fibrous histiocytoma,  Spermatic cord,  Endocrine disruptors.



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    From the Department of Surgery (Urology), University of Chicago, Chicago, Illinois | From the Department of Surgery (Urology), The University of Chicago, Chicago, Illinois | Departments of Surgery (Urology) and Pathology, University of Chicago, Chica