Prominent publications by Ronald Carl Petersen

KOL Index score: 20936

Alzheimer disease and type 2 diabetes are characterized by increased prevalence with aging, a genetic predisposition, and comparable pathological features in the islet and brain (amyloid derived from amyloid beta protein in the brain in Alzheimer disease and islet amyloid derived from islet amyloid polypeptide in the pancreas in type 2 diabetes). Evidence is growing to link precursors of amyloid deposition in the brain and pancreas with the pathogenesis of Alzheimer disease and type 2 ...

Also Ranks for: Alzheimer Disease |  type 2 diabetes |  islet amyloid |  pancreas brain |  increased prevalence
KOL Index score: 19222

BACKGROUND: Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9ORF72) are the most common known genetic cause of frontotemporal dementia (FTD) and motor neuron disease (MND). We assessed whether expansion size is associated with disease severity or phenotype.

METHODS: We did a cross-sectional Southern blot characterisation study (Xpansize-72) in a cohort of individuals with FTD, MND, both these diseases, or no clinical phenotype. All participants had GGGGCC repeat ...

Also Ranks for: Repeat Size |  ftd mnd |  frontal cortex |  age onset |  clinical phenotype
KOL Index score: 18936

BACKGROUND AND PURPOSE: This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia. Vascular contributions to cognitive impairment and dementia of later life are common. Definitions of vascular cognitive impairment (VCI), neuropathology, basic science and pathophysiological aspects, role of neuroimaging and vascular and other associated risk factors, and potential opportunities for prevention and treatment are reviewed. ...

Also Ranks for: Cognitive Impairment |  vascular contributions |  vci dementia |  alzheimer disease |  heart association
KOL Index score: 18747

BACKGROUND: A new classification for biomarkers in Alzheimer's disease and cognitive ageing research is based on grouping the markers into three categories: amyloid deposition (A), tauopathy (T), and neurodegeneration or neuronal injury (N). Dichotomising these biomarkers as normal or abnormal results in eight possible profiles. We determined the clinical characteristics and prevalence of each ATN profile in cognitively unimpaired individuals aged 50 years and older.

METHODS: All ...

Also Ranks for: Amyloid Pet |  cognitively unimpaired |  individuals aged |  80 years |  alzheimers disease
KOL Index score: 18671

The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing, longitudinal, multicenter study designed to develop clinical, imaging, genetic, and biochemical biomarkers for the early detection and tracking of Alzheimer's disease (AD). The study aimed to enroll 400 subjects with early mild cognitive impairment (MCI), 200 subjects with early AD, and 200 normal control subjects; $67 million funding was provided by both the public and private sectors, including the National Institute ...

Also Ranks for: Disease Neuroimaging |  csf biomarkers |  early detection |  clinical tests |  establishment adni
KOL Index score: 17968

OBJECTIVE: To assess the correlations of both MRI and CSF biomarkers with clinical diagnosis and with cognitive performance in cognitively normal (CN) subjects and patients with amnestic mild cognitive impairment (aMCI) and Alzheimer disease (AD).

METHODS: This is a cross-sectional study with data from the Alzheimer's Disease Neuroimaging Initiative, which consists of CN subjects, subjects with aMCI, and subjects with AD with both CSF and MRI. Baseline CSF (t-tau, Abeta(1-42), and ...

Also Ranks for: Csf Biomarkers |  amci subjects |  cognitive scores |  proteins aged |  mri scans
KOL Index score: 17635

The behavioural variant of frontotemporal dementia is a progressive neurodegenerative syndrome characterized by changes in personality and behaviour. It is typically associated with frontal lobe atrophy, although patterns of atrophy are heterogeneous. The objective of this study was to examine case-by-case variability in patterns of grey matter atrophy in subjects with the behavioural variant of frontotemporal dementia and to investigate whether behavioural variant of frontotemporal ...

Also Ranks for: Behavioural Variant |  anatomical subtypes |  frontotemporal dementia |  frontal lobes |  grey matter loss
KOL Index score: 17379

OBJECTIVES: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes.

DESIGN: Association study of AD and CLU, PICALM, CR1, and APOE genotypes.

SETTING: Academic research institutions in the United States, Canada, and Israel.

PARTICIPANTS: Seven thousand seventy cases with AD, 3055 with autopsies, and 8169 elderly cognitively normal controls, 1092 ...

Also Ranks for: Apoe Genotypes |  alzheimer disease risk |  clu picalm |  single nucleotide receptors |  european ancestry
KOL Index score: 17366

To date, most diagnostic imaging comparisons between amyloid labelling ligands and other imaging modalities have been between the use of amyloid labelling ligand (11)C Pittsburgh Compound B (PiB) and FDG-PET. Our objectives were to compare cognitive performance and diagnostic group-wise discrimination between cognitively normal, amnestic mild cognitive impairment (MCI) and Alzheimer's disease subjects with MRI-based measures of hippocampal volume and PiB retention, and secondly to ...

Also Ranks for: Pib Retention |  structural mri |  hippocampal volume |  matter loss |  amnestic mild
KOL Index score: 17197

Importance: The association between the microtubule-associated protein tau (MAPT) H1 haplotype and the risk of progressive supranuclear palsy (PSP) has been well documented. However, the specific H1 subhaplotypes that drive the association have not been evaluated in large studies, nor have they been studied in relation to neuropathologic severity of disease.

Objective: To comprehensively evaluate the associations of MAPT haplotypes with the risk of PSP and the severity of tau pathology ...

Also Ranks for: Tau Pathology |  progressive supranuclear |  mapt subhaplotypes |  risk psp |  case control
KOL Index score: 17167

IMPORTANCE: Typical cognitive aging may be defined as age-associated changes in cognitive performance in individuals who remain free of dementia. Ideally, the full adult age spectrum should be included to assess brain imaging findings associated with typical aging.

OBJECTIVE: To compare age, sex, and APOE ε4 effects on memory, brain structure (adjusted hippocampal volume [HVa]), and amyloid positron emission tomography (PET) in cognitively normal individuals aged 30 to 95 years ...

Also Ranks for: Apoe Ε4 |  brain structure |  age memory |  amyloid pet |  adult life span
KOL Index score: 16252

BACKGROUND: As preclinical Alzheimer's disease becomes a target for therapeutic intervention, the overlap between imaging abnormalities associated with typical ageing and those associated with Alzheimer's disease needs to be recognised. We aimed to characterise how typical ageing and preclinical Alzheimer's disease overlap in terms of β-amyloidosis and neurodegeneration.

METHODS: We measured age-specific frequencies of amyloidosis and neurodegeneration in individuals with normal ...

Also Ranks for: Neurodegeneration Age |  cognitive function |  amyloid pet |  cerebral β |  alzheimers disease
KOL Index score: 16108

Neurodegenerative disorders are pathologically characterized by the deposition of abnormal proteins in the brain. It is likely that future treatment trials will target the underlying protein biochemistry and it is therefore increasingly important to be able to distinguish between different pathologies during life. The aim of this study was to determine whether rates of brain atrophy differ in neurodegenerative dementias that vary by pathological diagnoses and characteristic protein ...

Also Ranks for: Cerebral Atrophy |  alzheimers disease |  cbd progressive supranuclear |  rates dlb |  scan interval
KOL Index score: 16092

OBJECTIVE: To use multiple serial MRI to assess rates and trajectories of brain and hippocampal atrophy in subjects with frontotemporal dementia (FTD) with progranulin (GRN) or microtubule-associated protein tau (MAPT) gene mutations.

METHODS: In this case-control study, we identified 8 subjects with mutations in GRN and 12 subjects with mutations in MAPT who had at least 2 serial MRIs. Serial MRIs were registered to baseline MRI for each subject using 9 df registration and rate of whole ...

Also Ranks for: Hippocampal Atrophy |  mapt grn |  frontotemporal dementia ftd |  rates brain |  tau proteins
KOL Index score: 15860

CONTEXT: Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).

OBJECTIVES: To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously published GWAS on more than 35,000 persons (8371 AD cases).


Also Ranks for: Genetic Loci |  alzheimer disease |  independent sample |  clu picalm |  risk prediction

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Ronald Carl Petersen:Expert Impact

Concepts for whichRonald Carl Petersenhas direct influence:Mild cognitive impairment,  Alzheimer disease,  Cognitive impairment,  Lewy bodies,  Alzheimers disease,  Cognitive decline,  Mild cognitive,  Frontotemporal dementia.

Ronald Carl Petersen:KOL impact

Concepts related to the work of other authors for whichfor which Ronald Carl Petersen has influence:Cognitive impairment,  Alzheimer disease,  Frontotemporal dementia,  Amyotrophic lateral sclerosis,  Magnetic resonance,  White matter,  Lewy bodies.



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Department of Neurology, Mayo Clinic-Minnesota, 200 First Street SW, 55905, Rochester, MN, USA | Department of Quantitative Health Sciences, Mayo Clinic-Minnesota, Rochester, MN, USA. | Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.