Hiroaki Akai

Hiroaki Akai

The Third Department Of Internal Medicine, Tohoku University School Of Medicine, 1-1, Seiryou-Cho, Aoba-Ku, Sendai 980, Japan

Direct Impact

Concepts for which Hiroaki Akai has direct influence:

mitochondrial dna
diabetic amyotrophy
normal glucose tolerance
insulin sensitivity
urinary chiro-inositol excretion
diabetes mellitus
group-specific component protein

External impact

Concepts related to the work of other authors for which Hiroaki Akai has influence:

diabetes mellitus
glucagon provocation test
mitochondrial dna
pancreatic polypeptide
point mutation
insulin sensitivity
minimal model

Prominent publications by Hiroaki Akai

KOL-Index: 31 Recent evidence suggests possible linkage between diabetes mellitus and mitochondrial gene mutation. We surveyed mitochondrial tRNALEU(UUR) (3243) mutation in 7 mitochondrial encephalomyopathy, lactic acidosis and stroke-like episode (MELAS) families and identified 24 mutated subjects (7 MELAS probands and 17 non-MELAS relatives) as well as 11 non-mutant family members. An OGTT in the 24 ...
Known for
Mutated Impaired | Trnaleuuur Gene | Insulinogenic | Mutation Mitochondrial
KOL-Index: 20 The open trial was designed to evaluate the effects of long-term antihypertensive treatment with the calcium-channel blocker, manidipine and the angiotensin converting enzyme (ACE) inhibitor, delapril on insulin sensitivity in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients with essential hypertension. We measured the insulin sensitivity index (SI) and the ...
Known for
Niddm | Enzyme Ace Inhibitor | Calcium-Channel Blocker | Bergmans Minimal Model Method
KOL-Index: 19 A case of somatostatin and pancreatic polypeptide (PP) producing tumor of the pancreas is presented. A 65-year-old woman was admitted for the evaluation of the tumor in the right upper quadrant of the abdomen. Clinical abnormalities included diabetic glucose intolerance, pancreatic insufficiency and marked dilatation of gallbladder. Marked high concentration of plasma PP and low levels of ...
Known for
Ww | Somatostatin Pancreatic | Insulin Concentrations | 65-Year-Old Woman
KOL-Index: 19 A 61-year-old woman with hyper-catecholaminemia and hyper-glucocorticoidemia due to a mixed tumor of the right adrenal gland is described. The patient, who had been medicated for hypertension since 1977, complained of thirst and general malaise in 1986. Body weight loss was remarkable. There was neither absolute truncal obesity nor moon face. In September 1986, her blood pressure was 180/110 ...
Known for
Blood Glucose Level | 61-Year-Old Woman | 131i-Adosterol | Urinary 17-Ohcs
KOL-Index: 16
Known for
Dependent Diabetes | Acid 3256c | Mitochondrial Deoxyribonucleic
KOL-Index: 15 Lower esophageal sphincter pressure (LESP), gastric emptying, small bowel transit time and plasma motilin levels were measured in diabetics and normal subjects in order to investigate the disturbances of the alimentary tract motility and the participation of motilin in these motility disorders. Hypermotilinemia was observed in all diabetics with or without autonomic neuropathy. Low response ...
Known for
Motilin Diabetics | Motility Disorders | Bowel Transit | Emptying Small
KOL-Index: 13 Mitochondrial dysfunctions of the muscle in diabetic amyotrophy and of the liver in diabetic fatty liver have been reported. We investigated mitochondrial gene mutations in three cases: (1) a patient with diabetic amyotrophy in the muscles of the lower extremities, and neuropathy; (2) 5 diabetics with myoatrophy, diabetic nephropathy, and chronic renal failure; and (3) an IDDM patient with a ...
Known for
Amyotrophy Myoatrophy | Muscle Diabetic | Mitochondrial Gene Mutations | Nd3
KOL-Index: 12 OBJECTIVE: To solve a possible relationship between mtDNA mutation of tRNALYS(8344) and diabetes, we have surveyed the tRNALYS mutation, glucose intolerance, and insulin secretory capacity in a Japanese family with diabetes and myoclonic epilepsy with ragged-red fiber disease. Several lines of evidence suggested possible linkage between mtDNA mutation and diabetes (1-4). RESEARCH DESIGN AND ...
Known for
Peripheral Lymphocytes | Age-Matched Normal | Mutation Mtdna | Ragged-Red Fiber
KOL-Index: 12 Abstract The locus of the vitamin D-binding protein (DBP; also known as group-specific component protein or Gc) gene, chromosome 4q12, has been reported to be associated with glucose metabolism in several ethnic groups, including Pima Indians. We have recently reported the association of the DBP genotype with type 2 diabetes mellitus in Japan. The aim of this study was to ...
Known for
Dbp Gene | Chromosome 4q12 | 1s-2 | Pima Indians
KOL-Index: 10 The locus of the vitamin D-binding protein (DBP; also known as group-specific component protein or Gc) gene, chromosome 4q12, has been reported to be associated with glucose metabolism in several ethnic groups, including Pima Indians. We have recently reported the association of the DBP genotype with type 2 diabetes mellitus in Japan. The aim of this study was to investigate whether genetic ...
Known for
Plasma Glucose Concentration | Insulin Japanese | Protein Fasting | Gc 1f

The Third Department of Internal Medicine, Tohoku University School of Medicine, 1-1, Seiryou-cho, Aoba-ku, Sendai 980, Japan

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