Marcel Kool

Marcel Kool

Department Of Rheumatology, Medical Oncology, Pediatric Oncology And Pathology, Vu Medical Center, Po Box 7057, 1007 Mb, Amsterdam, The Netherlands Department Of Biology, The ...

Direct Impact

Concepts for which Marcel Kool has direct influence:

molecular subgroups
gene expression
rhabdoid tumor
multilayered rosettes
dna methylation
sonic hedgehog
atypical teratoid

External impact

Concepts related to the work of other authors for which Marcel Kool has influence:

gene fusions
infant high-grade gliomas
tert promoter mutations
shh medulloblastoma
central nervous
atypical teratoid
molecular groups

Prominent publications by Marcel Kool

KOL-Index: 195 BACKGROUND: Only few data are available on treatment-associated behavior of distinct rare CNS embryonal tumor entities previously treated as "CNS-primitive neuroectodermal tumors" (CNS-PNET). Respective data on specific entities, including CNS neuroblastoma, FOXR2 activated (CNS NB-FOXR2), and embryonal tumors with multilayered rosettes (ETMR) are needed for development of differentiated ...
Known for
Upfront Craniospinal Irradiation | Foxr2 Year | Classified Etmr | 24 ±
KOL-Index: 181 Background: Cranial radiation therapy is essential in treating many pediatric cancers, especially brain tumors; however, its use comes with the risk of developing second malignancies. Cranial radiation-induced gliomas (RIGs) are aggressive high-grade tumors with a dismal prognosis, for which no standard therapy exists. A definitive molecular signature for RIGs has not yet been established. ...
Known for
Pdgfra Tp53 Mutations | Cranial Radiation Therapy | 102 Unique Rigs | 1q Gain
KOL-Index: 156 Ependymomas (EPN) are tumors of the central nervous system (CNS) that can arise in the supratentorial brain (ST-EPN), hindbrain or posterior fossa (PF-EPN) or anywhere in the spinal cord (SP-EPN), both in children and adults. Molecular profiling studies have identified distinct groups and subtypes in each of these anatomical compartments. In this review, we give an overview on recent ...
Known for
Epn | Ependymomas | Pfa | H3k27me3
KOL-Index: 151 Embryonal tumor with multilayered rosettes (ETMR) is a rare, aggressive embryonal central nervous system tumor characterized by LIN28A expression and alterations in the C19MC locus. ETMRs predominantly occur in young children, have a dismal prognosis, and no definitive treatment guidelines have been established. We report on nine consecutive patients and review the role of initiation/timing ...
Known for
228 | Pineal | 25 Months | Dismal Prognosis
KOL-Index: 143 Medulloblastoma, a common pediatric malignant central nervous system tumour, represent a small proportion of brain tumours in adults. Previously it has been shown that in adults, Sonic Hedgehog (SHH)-activated tumours predominate, with Wingless-type (WNT) and Group 4 being less common, but molecular risk stratification remains a challenge. We performed an integrated analysis consisting of ...
Known for
Medulloblastoma Advanced Genomics International | Prognostic Significance | Chromosome 3p Loss | 41 4 Tumours
KOL-Index: 123 Papillary tumor of the pineal region (PTPR) is a neuroepithelial brain tumor, which might pose diagnostic difficulties and recurs often. Little is known about underlying molecular alterations. We therefore investigated chromosomal copy number alterations, DNA methylation patterns and mRNA expression profiles in a series of 24 PTPRs. Losses of chromosome 10 were identified in all 13 PTPRs ...
Known for
Tumor Pineal | Dna Methylation Profiling | Gains | Typical Chromosomal Alterations
KOL-Index: 105 Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(s) of primary resistance and identify pathways cooperating with aberrant SHH signaling, we sequenced and profiled a large cohort of SHH-MBs (n = 133). SHH pathway mutations involved PTCH1 (across all age groups), ...
Known for
Shh-Mb Xenograft Models | Frequent Tp53 Mutations | Downstream Mycn Gli2 Amplifications | Age Groups
KOL-Index: 102 Ependymomas (EPN) are central nervous system tumors comprising both aggressive and more benign molecular subtypes. However, therapy of the high-risk subtypes posterior fossa group A (PF-A) and supratentorial RELA-fusion positive (ST-RELA) is limited to gross total resection and radiotherapy, as effective systemic treatment concepts are still lacking. We have recently described fibroblast ...
Known for
Rela | Fgfr1
KOL-Index: 94 Direct interactions between pro- and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM). Here we report that three anti-apoptotic BCL-2 proteins (MCL-1, BCL-2 and BCL-XL) found untethered from the OMM function as transcriptional regulators of a prosurvival and growth program. Anti-apoptotic BCL-2 proteins engage a BCL-2 ...
Known for
Sufu Turnover | Chemical Strategy | Direct Interactions | Omm Function
KOL-Index: 91 Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining molecular markers. CNS neuroblastoma with forkhead box R2 (FOXR2) activation (CNS_NBL) emerged as a distinct pediatric brain tumor entity from a pool previously diagnosed as primitive neuroectodermal tumors of the central nervous ...
Known for
29 Entities | Markers Cns | 4 Ependymoma | Mimics

Department of Rheumatology, Medical Oncology, Pediatric Oncology and Pathology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands Department of Biology, The Technion, Israel Institute of Technology, Haifa, Israel Dept. of Biochemist

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