Prominent publications by Inger K Damon

KOL Index score: 14297

Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma 1 heavy-chain constant regions. The three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K(d) of 0.14 nM to 20 nM) and may recognize the same epitope, which was determined to be conformational and located within amino acid residues 99 to 185 at the C terminus of A33. One or more of the MAbs were ...

Also Ranks for: Vaccinia Virus |  monoclonal antibodies |  a33 mabs |  protective efficacy |  human anti
KOL Index score: 14137

IMPORTANCE: The rabies virus causes a fatal encephalitis and can be transmitted through tissue or organ transplantation. In February 2013, a kidney recipient with no reported exposures to potentially rabid animals died from rabies 18 months after transplantation.

OBJECTIVES: To investigate whether organ transplantation was the source of rabies virus exposure in the kidney recipient, and to evaluate for and prevent rabies in other transplant recipients from the same donor.

DESIGN: Organ ...

Also Ranks for: Rabies Virus |  organ transplantation |  donor recipients |  kidney recipient |  cerebrospinal fluid
KOL Index score: 12777

Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human gamma 1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (Kd of 0.2 and 0.7 nM). The mAb 8AH8AL inhibited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro, protected mice from subsequent intranasal challenge with virulent vaccinia virus, protected mice when ...

Also Ranks for: Vaccinia Virus |  human mabs |  causative agent |  binding affinities |  chimpanzee fabs
KOL Index score: 12572

During 2014-2016, CDC, working with U.S. and international partners, mounted a concerted response to end the unprecedented epidemic of Ebola virus disease (Ebola) in West Africa. CDC's response, which was the largest in the agency's history, was directed simultaneously at controlling the epidemic in West Africa and strengthening preparedness for Ebola in the United States. Although experience in responding to approximately 20 Ebola outbreaks since 1976 had provided CDC and other ...

Also Ranks for: West Africa |  ebola epidemic |  united states |  lessons learned |  disease control
KOL Index score: 11023

INTRODUCTION: LC16m8 is an attenuated cell culture-adapted Lister vaccinia smallpox vaccine missing the B5R protein and licensed for use in Japan.

METHODS: We conducted a phase I/II clinical trial that compared the safety and immunogenicity of LC16m8 with Dryvax in vaccinia-naive participants. Adverse events were assessed, as were electrocardiography and laboratory testing for cardiotoxicity and viral culturing of the vaccination sites. Neutralization titers to vaccinia, monkeypox, and ...

Also Ranks for: Smallpox Vaccine |  neutralizing antibodies |  vaccinia virus |  vaccination dryvax |  attenuated cell
KOL Index score: 10973

Smallpox was declared eradicated in 1980 after an intensive vaccination program using different strains of vaccinia virus (VACV; Poxviridae). VACV strain IOC (VACV-IOC) was the seed strain of the smallpox vaccine manufactured by the major vaccine producer in Brazil during the smallpox eradication program. However, little is known about the biological and immunological features as well as the phylogenetic relationships of this first-generation vaccine. In this work, we present a ...

Also Ranks for: Smallpox Vaccine |  vaccinia virus |  vacv strain |  evolutionary relationships |  sequence analysis
KOL Index score: 10823

A screening assay for real-time LightCycler (Roche Applied Science, Mannheim, Germany) PCR identification of smallpox virus DNA was developed and compiled in a kit system under good manufacturing practice conditions with standardized reagents. In search of a sequence region unique to smallpox virus, the nucleotide sequence of the 14-kDa fusion protein gene of each of 14 variola virus isolates of the Russian World Health Organization smallpox virus repository was determined and compared ...

Also Ranks for: Smallpox Virus |  viral genes |  time pcr |  strains variola |  simultaneous identification
KOL Index score: 10680

Since Ebola virus disease was identified in West Africa on March 23, 2014, the Centers for Disease Control and Prevention (CDC) has undertaken the most intensive response in the agency's history; >3,000 staff have been involved, including >1,200 deployed to West Africa for >50,000 person workdays. Efforts have included supporting incident management systems in affected countries; mobilizing partners; and strengthening laboratory, epidemiology, contact investigation, health care infection ...

Also Ranks for: West Africa |  disease control |  united states |  prevention cdc |  international health
KOL Index score: 10487

CONTEXT: On January 24, 2003, the US Department of Health and Human Services (DHHS) implemented a preparedness program in which smallpox (vaccinia) vaccine was administered to federal, state, and local volunteers who might be first responders during a bioterrorism event.

OBJECTIVE: To describe results from the comprehensive DHHS smallpox vaccine safety monitoring and response system.

DESIGN, SETTING, AND PARTICIPANTS: Descriptive study of adverse event reports from the DHHS smallpox ...

Also Ranks for: United States |  adverse event |  smallpox vaccination |  october 2003 |  disease control
KOL Index score: 10302

Almost all cases of human rabies result from dog bites, making the elimination of canine rabies a global priority. During recent decades, many countries in the Western Hemisphere have carried out large-scale dog vaccination campaigns, controlled their free-ranging dog populations and enforced legislation for responsible pet ownership. This article reviews progress in eliminating canine rabies from the Western Hemisphere. After briefly summarizing the history of control efforts and ...

Also Ranks for: Canine Rabies |  western hemisphere |  20th century |  herd immunity |  domestic animals
KOL Index score: 10226

Lofa County has one of the highest cumulative incidences of Ebola virus disease (Ebola) in Liberia. Recent situation reports from the Liberian Ministry of Health and Social Welfare (MoHSW) have indicated a decrease in new cases of Ebola in Lofa County. In October 2014, the Liberian MoHSW requested the assistance of CDC to further characterize recent trends in Ebola in Lofa County. Data collected during June 8-November 1, 2014 from three sources were analyzed: 1) aggregate data for newly ...

Also Ranks for: Lofa County |  ebola virus |  social welfare |  new cases |  liberian ministry
KOL Index score: 10192

BACKGROUND: Vaccinia virus (VACV)-DUKE was isolated from a lesion on a 54 year old female who presented to a doctor at the Duke University Medical Center. She was diagnosed with progressive vaccinia and treated with vaccinia immune globulin. The availability of the VACV-DUKE genome sequence permits a first time genomic comparison of a VACV isolate associated with a smallpox vaccine complication with the sequence of culture-derived clonal isolates of the Dryvax vaccine.

RESULTS: This ...

Also Ranks for: Smallpox Vaccine |  vaccinia virus |  genomic sequence |  viral genome |  dryvax vacv
KOL Index score: 9935

Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that ...

Also Ranks for: Congo Basin |  west africa |  virulence differences |  monkeypox virus |  reported cases
KOL Index score: 9911

Since the eradication of smallpox and the cessation of routine childhood vaccination for smallpox, the proportion of the world's population susceptible to infection with orthopoxviruses, such as variola virus (the causative agent of smallpox) and monkeypox virus, has grown substantially. In the United States, the only vaccines for smallpox licensed by the Food and Drug Administration (FDA) have been live virus vaccines. Unfortunately, a substantial number of people cannot receive live ...

Also Ranks for: Variola Virus |  vitro efficacy |  st246 smallpox |  antiviral drugs |  causative agent

Key People For United States

Top KOLs in the world
Ahmedin * *****
united states breast cancer addis ababa
Ronald * *******
mental disorders united states major depression
Katherine * ******
united states prevalence obesity blood lead levels
Margaret * *******
united states angeles county prevalence obesity
Walter ********* *******
breast cancer type 2 diabetes coronary heart disease
Cynthia * *****
united states children adolescents prevalence obesity

Inger K Damon:Expert Impact

Concepts for whichInger K Damonhas direct influence:United states,  Monkeypox virus,  Vaccinia virus,  Congo basin,  Smallpox vaccine,  Human monkeypox,  Variola virus,  Smallpox vaccination.

Inger K Damon:KOL impact

Concepts related to the work of other authors for whichfor which Inger K Damon has influence:Vaccinia virus,  Smallpox vaccine,  United states,  Sierra leone,  Public health,  West africa,  Infectious diseases.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA | 1Division of High Consequence Pathogens and Pathology, National C