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    • John Christine Rothwell

      John Christine Rothwell

      Queen Square Institute of Neurology, University College London, Queen Square, London, London, WC1E 6BT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND. | Department of ...



      KOL Resume for John Christine Rothwell


      Queen Square Institute of Neurology, University College London, Queen Square, London, London, WC1E 6BT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

      Department of Clinical and Movement Neurosciences, University College London, London, UK.



      Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom.

      Institute of Neurology, University College London, London, UK


      Sobell Department of Motor Neuroscience and Movement Disorders, University College London, United Kingdom.

      Institute of Neurology, University College London, London WC1N 3BG, UK;,

      University College London, Department of Clinical and Movement Neurosciences, London, United Kingdom


      Sobell Department of Motor Neuroscience and movement Disorders, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

      UCL Queen's Square, Institute of Neurology, London, United Kingdom

      Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology University College London, London, UK


      Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK

      University College London, United Kingdom

      Institute of Neurology, and



      John Christine Rothwell: Influence Statistics

      Sample of concepts for which John Christine Rothwell is among the top experts in the world.
      Concept World rank
      cortical neuroplasticity stroke #1
      hemispheres patients #1
      tms protocols #1
      mfc smi #1
      sicicsap #1
      isis inhibition #1
      motor m1 #1
      subcortical mechanisms icf #1
      linguistic tasks excitability #1
      mep iemg ratio #1
      mylohyoid muscles pharynx #1
      plasticity motor #1
      medical diagnostic apps #1
      intact arm #1
      response mmax #1
      intracortical circuits #1
      triplepulse tms #1
      ulnar stimulus response #1
      application current stimulation #1
      evidence fdcb #1
      nonconvulsive brain stimulation #1
      s1 corticospinal output #1
      arat fst cpt #1
      ten‐year reflections #1
      cortex time #1
      agonist emg #1
      leg area #1
      m1 pmd #1
      performance motor #1
      mdyt1 nmdyt1 #1
      psychological electric #1
      separate movements #1
      patients psychogenic blepharospasm #1
      excitability cortical #1
      limb adaptation #1
      chronic unilateral tinnitus #1
      deymed #1
      seps humans #1
      amplitude mep #1
      dao ihi #1
      rest fdi #1
      tppa ihf #1
      10 15 cathodal #1
      dystonia symptoms #1
      llsr long flexors #1
      human premotor #1
      baseline neural measures #1
      cddbs #1
      multiple sclerosis origin #1


      Prominent publications by John Christine Rothwell

      KOL-Index: 16029

      OBJECTIVE: To study whether trains of subthreshold 1 Hz repetitive transcranial magnetic stimulation (rTMS) over premotor, prefrontal, or parietal cortex can produce changes in excitability of motor cortex that outlast the application of the train.

      BACKGROUND: Prolonged 1 Hz rTMS over the motor cortex can suppress the amplitude of motor-evoked potentials (MEP) for several minutes after the end of the train. Because TMS can produce effects not only at the site of stimulation but also at ...

      Known for Motor Cortex | Corticospinal Excitability | 1 Hz | Hand Area | Distant Sites
      KOL-Index: 15867

      OBJECTIVE: To study the after-effect of theta burst stimulation (TBS) over the left sensorimotor cortex on the size of somatosensory as well as motor evoked potentials evoked from both hemispheres in healthy human subjects.

      METHODS: We used a continuous TBS paradigm for 40 s (600 pulses) in which a burst of 3 transcranial magnetic stimuli at 50 Hz is repeated at 5 Hz [Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron ...

      Known for Motor Cortex | Evoked Potentials | Burst Stimulation | Tbs M1 | Median Nerve
      KOL-Index: 14466

      Intracortical inhibition and facilitation in different representations of the human motor cortex. J. Neurophysiol. 80: 2870-2881, 1998. Intracortical inhibition (ICI) and intracortical facilitation (ICF) of the human motor cortex can be studied with paired transcranial magnetic stimulation (TMS). Plastic changes and some neurological disorders in humans are associated with changes in ICI and ICF. Although well characterized in the hand representation, it is not known if ICI and ICF vary ...

      Known for Human Motor Cortex | Intracortical Inhibition | Ici Icf | Mep Recruitment | Motor Representations
      KOL-Index: 13962

      1. The effects of different forms of brain stimulation on the discharge pattern of single motor units were examined using the post-stimulus time histogram (PSTH) technique and by recording the compound surface electromyographic (EMG) responses in the first dorsal interosseous (FDI) muscle. Electrical and magnetic methods were used to stimulate the brain through the intact scalp of seven normal subjects. Electrical stimuli were applied either with the anode over the lateral central scalp ...

      Known for Surface Emg | Magnetic Stimulation | Peaks Peak | Motor Unit | Higher Intensities
      KOL-Index: 13877

      Interhemispheric interactions between the primary motor cortices (M1) have been described with a variety of TMS methods. Here we give a detailed description of the interhemispheric interactions of a period of theta burst simulation (TBS), a rapid method of producing long lasting after-effects on the excitability of the stimulated M1. A total of 18 right handed healthy subjects participated. In most experiments, continuous and intermittent TBS (cTBS and iTBS) were delivered over the right ...

      Known for Ctbs M1 | Burst Stimulation | Meps Sici | Primary Motor | Cortex Excitability
      KOL-Index: 13737

      Short-interval intracortical inhibition (SICI), intracortical facilitation (ICF) and short-interval intracortical facilitation (SICF) were assessed in the cortical motor area of the first dorsal interosseous muscle (FDI) of 16 healthy subjects. Paired-pulse TMS was delivered to the left hemisphere at the following interstimulus intervals (ISIs): 2 and 3 ms for SICI, 10 and 15 ms for ICF and 1-5 ms for SICF. Motor-evoked potentials were recorded from the resting and active right FDI. The ...

      Known for Intracortical Inhibition | Sici S1 | Motor Cortex | Muscle Contraction | Icf Sicf
      KOL-Index: 13561

      OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression. The authors conducted a multicenter randomized, controlled trial to test the equivalence of rTMS with ECT.

      METHOD: Forty-six patients with major depression referred for ECT were randomly assigned to either a 15-day course of rTMS of the left dorsolateral prefrontal cortex (N=24) or a standard course of ECT (N=22). The primary outcome ...

      Known for Electroconvulsive Therapy | Rtms Ect | Controlled Trial | Magnetic Stimulation | 6 Months
      KOL-Index: 13436

      1. To find out whether muscle afferents influence the excitability of corticospinal projections to antagonist muscles, we studied sixteen healthy subjects and one patient with a focal brain lesion. 2. Using transcranial magnetic and electrical brain stimulation we tested the excitability of corticomotoneuronal connections to right forearm muscles at rest after conditioning stimulation of the median nerve at the elbow. Somatosensory potentials evoked by median nerve stimulation were also ...

      Known for Antagonist Muscles | Median Nerve Stimulation | Forearm Flexor | Muscle Afferents | Emg Responses
      KOL-Index: 13279

      Random number generation is an attention-demanding task that engages working memory and executive processes. Random number generation requires holding information 'on line', suppression of habitual counting, internally driven response generation and monitoring of responses. Evidence from PET studies suggests that the dorsolateral prefrontal cortex (DLPFC) is involved in the generation of random responses. We examined the effects of short trains of transcranial magnetic stimulation (TMS) ...

      Known for Habitual Counting | Random Generation | Tms Dlpfc | Prefrontal Cortex | Magnetic Stimulation
      KOL-Index: 13276

      1. The time constants of motor and sensory nerve fibres were studied in normal human ulnar nerves by the method of latent addition, using threshold tracking to follow the recovery of excitability after brief conditioning current pulses. The 60 microseconds test and conditioning stimuli were applied at the wrist, and the conditioning stimuli were set to 90, 60, 30, -30, -60 and -90% of the control threshold current. Compound muscle action potentials were recorded from abductor digiti ...

      Known for Latent Addition | Sensory Fibres | Peripheral Nerve | Sodium Channels | Conditioning Stimuli
      KOL-Index: 13219

      Writer's cramp, or focal hand dystonia, is characterized by involuntary coactivation of antagonist or unnecessary muscles while writing or performing other tasks. Although the mechanism underlying this muscle overactivation is unknown, recent studies of changes in cerebral blood flow during writing have demonstrated a reduction in the activation of the primary motor cortex (MC) and hyperactivity of parts of the frontal non-primary motor areas. Therefore, any measures that decrease the ...

      Known for Motor Cortex | Magnetic Stimulation | Pmc Mc | Repetitive Transcranial | Writers Cramp
      KOL-Index: 12945

      1. In ten normal volunteers, a transcranial magnetic or electric stimulus that was subthreshold for evoking an EMG response in relaxed muscles was used to condition responses evoked by a later, suprathreshold magnetic or electric test shock. In most experiments the test stimulus was given to the lateral part of the motor strip in order to evoke EMG responses in the first dorsal interosseous muscle (FDI). 2. A magnetic conditioning stimulus over the hand area of cortex could suppress ...

      Known for Hand Area | Corticocortical Inhibition | Conditioning Test | Motor Cortex | Magnetic Stimulus

      Key People For Motor Cortex

      Top KOLs in the world
      John Christine Rothwell
      motor cortex magnetic stimulation corticospinal excitability
      HALLETT Hallett
      essential tremor motor cortex magnetic stimulation
      Leonardo G Cohen
      motor cortex magnetic stimulation chronic stroke
      Alvaro Pascual PASCUAL‐LEONE
      magnetic stimulation prefrontal cortex cortical excitability
      Ulf Ziemann
      motor cortex magnetic stimulation multiple sclerosis
      C David Marsden
      parkinsons disease basal ganglia substantia nigra

      John Christine Rothwell:Expert Impact

      Concepts for whichJohn Christine Rothwellhas direct influence:Motor cortex,  Magnetic stimulation,  Transcranial magnetic,  Corticospinal excitability,  Human motor cortex,  Evoked potentials,  Parkinsons disease,  Primary motor cortex.

      John Christine Rothwell:KOL impact

      Concepts related to the work of other authors for whichfor which John Christine Rothwell has influence:Motor cortex,  Magnetic stimulation,  Parkinson disease,  Cortical excitability,  Essential tremor,  Evoked potentials,  Multiple sclerosis.



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      Queen Square Institute of Neurology, University College London, Queen Square, London, London, WC1E 6BT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND. | Department of Clinical and Movement Neurosciences, University College London, London, UK.

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