Paul J. Bédard

Paul J. Bédard

Laboratoire De Neurobiologie, Department Of Anatomy, Laval University, Québec, Qué., G1k 7p4 Canada

Direct Impact

Concepts for which Paul J Bédard has direct influence:

mptp monkeys
basal ganglia
l-dopa-induced dyskinesias
dopaminergic agents
dopamine receptors
postural tremor
motor complications

External impact

Concepts related to the work of other authors for which Paul J Bédard has influence:

levodopa-induced dyskinesias
serotonin markers
basal ganglia
dopamine receptor
antiparkinsonian activity
adrenal medulla grafts
flexor reflex

Prominent publications by Paul J. Bédard

KOL-Index: 42 Long-term treatment of parkinsonian patients with L-DOPA leads to a loss of efficacy over time and the appearance of important side effects such as dyskinesias. Grafts of chromaffin cells of the adrenal medulla or fetal ventral mesencephalic neurons bring behavioral improvement in animal models of Parkinson's disease. These improvements are likely to be related to the secretion of dopamine ...
Known for
Parkinson Improvements | Dopa Cells | Techniques Addition | Fetal Tissue
KOL-Index: 20 Nine monkeys (Macaca fascicularis) were rendered parkinsonian after intravenous administration of the toxin MPTP. Three of these animals received pulsatile administration of the D1 receptor agonist SKF 82958 (1 mg/kg, three times daily) while three were treated by continuous infusion via an osmotic mini-pump with SKF 82958 (at an equivalent amount daily) for 29 days. Untreated MPTP as well ...
Known for
Untreated Mptp-Monkeys | Macaca Fascicularis | Agonist Skf | Dyskinesia Putaminal
KOL-Index: 20 The motor effects of dopamine D1 receptor activation and the optimal way to stimulate these receptors were studied in a primate model of parkinsonism induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), using 2 selective full dopamine D1 receptor agonists: A-77636 ([1 R,3S] 3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1 H-2-benzopyran hydrochloride), and ...
Known for
Antiparkinsonian | Monkeys Drugs | A-77636 Administered | Thrice Skf
KOL-Index: 19 Publisher Proper execution of voluntary movements results from the correct processing of feedback loops involving the cortex, thalamus, and basal ganglia (BG). The BG includes a subset of subcortical structures involved in a variety of processes including motor behavior and also motor learning and memory process. The BG are located in the basal telencephalon and consist of interconnected ...
Known for
Bg Components | Feedback Loops | Subcortical Structures | Motor Associative Functions
KOL-Index: 19 (S)-(-)-3-(3-(methylsulfonyl)phenyl)-1-propylpiperidine ((-)-OSU6162) is a phenylpiperidine derivative which exhibits low affinity to the dopamine D2 receptor in vitro. However, in vivo, positron emission tomography scanning studies show that the compound displaces the selective dopamine D2 receptor antagonist, raclopride. We have evaluated, in this study, the effect of (-)-OSU6162, on ...
Known for
Advanced Parkinsons | L-Dopa Methyl Ester | Selective Dopamine Receptor Antagonist | S---3-3-Methylsulfonylphenyl-1-Propylpiperidine
KOL-Index: 19
Known for
Circling Behaviour
KOL-Index: 18 OBJECTIVE: To determine whether dopamine (DA) D1 or DA D2 receptors are associated predominantly with the antiparkinsonian versus the dyskinetic effect of levodopa. METHODS: The authors used four L-dopa-primed, dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys to test whether acute and selective blockade of the DA D1 receptor subtype, using SCH 23390 and NNC 01-112, ...
Known for
Sulpiride | Low-Dose Clozapine | Neurotransmitter Systems | D1 Receptor Subtype
KOL-Index: 18 The effect of various chronic dopaminergic treatments in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys on the brain gamma-aminobutyric acid type A (GABA(A)) /benzodiazepine receptor complex and GABA content was investigated in order to assess the GABAergic involvement in dopaminomimetic-induced dyskinesia. Three MPTP monkeys received for one month pulsatile administrations of ...
KOL-Index: 17 The effect of administration of estrogens parenterally for 1 week was tested on apomorphine-induced circling in a group of castrated female rats with a lesion of the left entopednucluar nucleus. We observed a significant decrease in the number of turns per minute in estrogen-treated animals as compared with controls. Our tentative explanation is that estrogens decrease the sensitivity of ...
Known for
Estrogen-Treated Animals | Castrated Female Rats | Circling | Apomorphine Induced
KOL-Index: 17 The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal lesion and dopaminomimetic treatment on parameters of glutamatergic activity within the basal ganglia of monkeys were studied in relation with the development of dyskinesias. Drug-naive controls, saline-treated MPTP monkeys, as well as MPTP monkeys treated with either a long-acting D2 agonist ...
Known for
Cabergoline Mptp | Dyskinesias Agonist | Pulsatile

Laboratoire de Neurobiologie, Department of Anatomy, Laval University, Québec, Qué., G1K 7P4 Canada

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