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    • Jean‐marc Léger
    • Jean‐Marc Léger

      Jean‐Marc Léger

      Académie nationale de médecine, 16 rue Bonaparte, 75006 Paris, France | National Referral Center for Rare Neuromuscular DiseasesHôpital Pitié‐Salpêtrière and University Paris ...

       

       

      KOL Resume for Jean‐Marc Léger

      Year
      2022

      Académie nationale de médecine, 16 rue Bonaparte, 75006 Paris, France

      2019

      National Referral Center for Rare Neuromuscular DiseasesHôpital Pitié‐Salpêtrière and University Paris VI Paris France

      2018

      Centre National de Référence Maladies Neuromusculaires Rares, Hôpital Pitié Salpêtrière et Université Paris VI, Paris, France

      2017

      Paris, France

      2016

      Hôpitaux universitaires La-Pitié-Salpêtrière - Charles-Foix, centre de référence maladies neuromusculaires, bâtiment Babinski, 75013 Paris, France

      Centre de Référence Maladies Neuromusculaires Bâtiment Babinski.

      2015

      National Reference Center for Rare Neuromuscular Diseases, Groupe Hospitalier Pitrie Salpêtrière and University Paris VI, Paris Cedex 13, France

      2014

      From the Department of Neurology (T.H.P.D., E.K.V., C.G.F., I.S.J.M.), University Medical Centre Maastricht; Department of Neurology (S.I.v.N., P.A.v.D.), Erasmus Medical Centre Rotterdam, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; Department of Neurology (W.L.V.d.P., N.C.N., L.H.v.d.B.), Rudolf Magnus Institute of Neuroscience University Medical Centre Utrecht, the Netherlands; Department of Neurological Sciences (E.N.-O.), Milan University, Humanitas Clinical Institute, Rozzano, Milan, Italy; Department of Neurology (J.M.L.), Hôpital de la Salpêtrière, Paris, France; Department of Neurology (P.Y.K.V.d.B.), Catholique University of Louvain, Belgium; Department of Clinical Neurosciences (G.L.), 3rd Neurology Unit, Milan, Italy; Department of Neurology (V.B., H.K.), Toronto General Hospital, Canada; Department of Neurology (M.P.T.L.), Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Department of Neurology (J.P.), Centre de Référence des Maladies Neuromusculaires et de la SLA, Hôpital de La Timone, Marseille, France; Department of Neurology (A.J.v.d.K.), Academic Medical Centre, Amsterdam, the Netherlands; Department of Neurology (A.F.H.), London Health Science Center, London, Canada; Department of Neurology (D.R.C.), Johns Hopkins School of Medicine, Baltimore, MD; and Department of Neurology (I.S.J.M.), Spaarne Hospital, Hoofddorp, the Netherlands.

      University Hospital Pitié‐Salpêtrière and University Paris VI National Referral Centre for Neuromuscular Diseases Paris France

      2013

      Boulevard de l'Hopital, /INS;Paris/INS;,/INS; France

      Chair Local Organizing Committee

      2012

      Centre de Référence de Pathologie Neuromusculaire Paris Est

      Department of Neurology, Groupe Hospitalier Pitié-Salpetrière, Paris, France;

      2011

      Consultation de Pathologie Neuromusculaire, Centre de Référence de Paris Est, Pitié-Salpêtrière Hospital, AP-HP, Paris, France

      2010

      Consultation de Pathologie Neuromusculaire Groupe Hospitalier, Pitié Saltpêtrière, Paris, France

      Centre de Référence Maladies Neuromusculaires rares Paris Est, Bâtiment Babinski. Hôpital de la Salpêtrière, 47 bld de l’Hôpital, 75651 Paris, cedex, 13

      2009

      Centre de Référence Maladies Neuromusculaires Rares Paris Est. Bâtiment Babinski. Hôpital de la Salpêtrière, 47, bld de l’Hôpital, 75651 Paris cedex 13

      2008

      APHP, Centre de référence de pathologie neuromusculaire Paris-Est, Bâtiment Babinski, Fédération de Neurologie Mazarin, GH Pitié-Salpêtrière, Paris, France

      2007

      Department of Neurology, Hôpital de la Salpêtriere, Paris, France

      Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom

      2006

      Consultation de Pathologic Neuromusculaire Groupe Hospitalier, Pitie Saltpetriere, France

      Centre de Référence des Maladies Neuro-musculaires rares Paris-Est, Hôpital de la Salpêtrière, Paris.

      Members of Joint Task Force of the EFNS and the PNS

      2005

      Groupe Neuropathies Pitié-Salpêtrière, University Hospital La Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris, Cedex 13, France.

      Babinski Building, Salpêtrière Hospital, Paris, France

      2004

      Groupe Neuropathies Périphériques Pitié-Salpêtrière (GNPS), Hôpital de la Pitié-Salpêtrière, Paris

      2003

      Service d'Explorations Fonctionnelles, Neurologie, Hôpital de la Salpêtrière, Paris, France

      2002

      Service de Neurologie, Groupe Hospitalier, Paris, France

      2001

      2000

      Fédération de Neurologie, Bâtiment Mazarin, Hôpital de la Salpêtrière, 47, boulevard de l'Hôpital, Paris.

      1999

      Department of Neurology, Division Mazarin, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris cedex 13, France

      1998

      Peripheral Neuropathy Group, Salpêtrière Hospital, Paris, France

      1997

      Service d'Explorations Fonctionnelles Neurologiques, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France

      1996

      Laboratoire d'Explorations Fonctionelles Neurologie Hôpital de la Salpêtrière, Paris, France.

      1995

      Laboratoire INSERM U 289 et Service de Neurologie, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, F-75651, Paris, Cedex 13, France

      1994

      Department of Neurology, Hôpital de la Salpêtrière, Paris, France.

      1993

      Service d'Explorations Fonctionnelles, Clinique des Maladies du Système Nerveux, Hôpital de la Salpêtrière, 74, Boulevard de l'Hôpital, F-75013, Paris, France

      1992

      Clinique des Maladies du Système Nerveux, Hôpital de la Salpêtrière, Paris, France.

      Laboratoire d'immunochimie, Hôpital Pitié-Salpétrière, Paris, France

      1991

      Clinique des Maladies du Système Nerveux, Hôpital de la Salpêtrière, Paris.

       

       

      Jean‐Marc Léger: Influence Statistics

      Sample of concepts for which Jean‐Marc Léger is among the top experts in the world.
      Concept World rank
      avec blocs #1
      motrice multifocale #1
      mmncb polyneuropathy #1
      avril 2015 #1
      search etiological diagnosis #1
      demyelinating clinical #1
      igmmg #1
      ivigpretreated patients #1
      responder rate completion #1
      purely motor diseases #1
      dnp mag #1
      aging electromyography humans #1
      multifocal mononeuropathies chronic #1
      multifocale avec #1
      periodic ivig #1
      dysimmune peripheral #1
      3 chronic forms #1
      gm2 striking features #1
      ivig predictive #1
      predictive criteria response #1
      demyelinating tibial #1
      traitement polyneuropathies dysimmunitaires #1
      percent ppps #1
      electrophysiologicalal #1
      polyneuropathy efficacy #1
      distal asymmetrical #1
      treatment 93 patients #1
      firstline treatment corticosteroids #1
      immunotherapy small subset #1
      slowing peroneal #1
      immunemediated disorders corticosteroids #1
      chronic neuropathy #1
      polyneuropathies multifocal mononeuropathies #1
      corrélations clinico #1
      shortterm longterm responses #1
      hps ppps #1
      polyneuropathies igg #1
      igm serum antibodies #1
      touches upper limbs #1
      alpha improvement #1
      antibodies sensory #1
      polyneuropathies igm #1
      traitement polyneuropathies #1
      cidp considered #1
      unsolved frequent association #1
      challenges choice #1
      ivignaïve patients #1
      peripheral nerve society #1

       

      Prominent publications by Jean‐Marc Léger

      KOL-Index: 14370

      OBJECTIVE: Hepatitis C virus (HCV)-related vasculitis may involve multiple organs, including the skin, kidneys, and nervous system, and may be life-threatening. Although HCV is increasingly recognized as a cause of systemic vasculitis, limited data are available regarding the optimal treatment of this potentially serious condition. Therefore, we retrospectively analyzed the response to treatment in patients with chronic hepatitis C complicated by systemic vasculitis who had received ...

      Known for Systemic Vasculitis | Ribavirin Treatment | Antiviral Therapy | Hcv Rna | Followup Patients
      KOL-Index: 14181

      BACKGROUND: Mixed cryoglobulinemia (MC) is frequently associated with clinical and biological evidence of liver disease and has recently been reported in cases of hepatitis C virus (HCV) infection. The aim of this study was to assess prospectively in a large series of MC patients: (1) the prevalence of HCV markers (anti-HCV antibodies and HCV RNA in serum and cryoprecipitate); (2) the main clinical, biologic and liver histologic features in patients with or without HCV ...

      Known for Mixed Cryoglobulinemia | Patients Hcv | Essential Mc | Hepatitis Antibodies | Rna Serum
      KOL-Index: 13255

      BACKGROUND: Multifocal motor neuropathy is a distinct clinical entity characterised by progressive, predominantly distal, asymmetrical limb weakness and minimal sensory abnormality. The pathognomonic feature of this condition is the presence of multiple partial motor nerve conduction blocks. Controlled trials have demonstrated the efficacy of regular intravenous immunoglobulin infusions. Immunosuppressive agents have been used as primary, second-line or adjunctive agents for its ...

      Known for Multifocal Motor | Immunosuppressive Agents | Treatment Review | Intravenous Immunoglobulin | Randomised Controlled Trials
      KOL-Index: 12250

      We conducted a double-blind, placebo-controlled, study of 19 patients fulfilling eligibility criteria for multifocal motor neuropathy with persistent conduction block. They were enrolled and divided into two groups: those who had never been treated previously with intravenous immunoglobulins (IVIg) (Group 1: 10 patients) and those who presented recurrent symptoms after previously successful treatment with IVIg (Group 2: nine patients). They were randomized prospectively to receive either ...

      Known for Patients Ivig | Multifocal Motor | 3 Months | Mrc Score | Intravenous Immunoglobulin
      KOL-Index: 12061

      BACKGROUND: Revision of the guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy, published in 2005, has become appropriate owing to publication of more relevant articles. Most of the new studies focused on small fiber neuropathy (SFN), a subtype of neuropathy for which the diagnosis was first developed through skin biopsy examination. This revision focuses on the use of this technique to diagnose SFN.

      METHODS: Task force members searched the Medline database ...

      Known for Skin Biopsy | Peripheral Nerve | Small Fiber | Diagnosis Sfn | Ienf Density
      KOL-Index: 11915

      OBJECTIVE: To relate X-linked Charcot-Marie-Tooth disease (CMTX) phenotypes to gender and type of neuropathy by the study of a large series of CMTX patients with proven Cx32 point mutations.

      BACKGROUND: CMTX is an X-linked form of Charcot-Marie-Tooth disease, caused by mutations in the connexin 32 gene. Males are usually more severely affected and have slower nerve conduction velocities than females.

      METHODS: Forty-eight patients from 10 families with Cx32 mutations were examined ...

      Known for Connexin 32 Mutations | Tooth Disease | Linked Charcot | Cmtx Patients | 32 Gene
      KOL-Index: 11725

      BACKGROUND: Increased titres of serum IgM antibodies to GM1 ganglioside are often associated with multifocal motor neuropathy (MMN). Testing for IgM antibodies to other antigens including GM2, the mixture of GM1 and galactocerebroside (GM1/GalC) and the disulfated heparin disaccharide NS6S were reported to increase the sensitivity of antibody testing in MMN even if it is unclear whether the specificity and positive (PPV) or negative predictive value (NPV) for MMN were also ...

      Known for Multifocal Motor | Igm Antibodies | Mmn Patients | Gm1 Galc | Sensitivity Specificity
      KOL-Index: 11491

      Numerous sets of diagnostic criteria have sought to define chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and randomized trials and systematic reviews of treatment have been published. The objective is to prepare consensus guidelines on the definition, investigation and treatment of CIDP. Disease experts and a patient representative considered references retrieved from MEDLINE and Cochrane Systematic Reviews in May 2004 and prepared statements which were agreed in an ...

      Known for European Federation | Task Force | Chronic Inflammatory | Peripheral Nerve Society | Neurological Societies
      KOL-Index: 10905

      Non-systemic vasculitic neuropathy (NSVN) is routinely considered in the differential diagnosis of progressive axonal neuropathies, especially those with asymmetric or multifocal features. Diagnostic criteria for vasculitic neuropathy, classification criteria for NSVN, and therapeutic approaches to NSVN are not standardized. The aim of this guideline was to derive recommendations on the classification, diagnosis, investigation, and treatment of NSVN based on the available evidence and, ...

      Known for Systemic Vasculitic | Neuropathy Nsvn | Peripheral Nerve | Differential Diagnosis | Immunosuppressive Therapy
      KOL-Index: 10813

      BACKGROUND: Fingolimod is approved for the treatment of relapsing-remitting multiple sclerosis and was effective in experimental autoimmune neuritis in rats, a possible model for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to evaluate the efficacy of fingolimod in delaying disability progression in patients with CIDP who withdrew from currently effective treatments (intravenous immunoglobulin [IVIg] or corticosteroids).

      METHODS: This double-blind, ...

      Known for Chronic Inflammatory | Ivig Corticosteroids | Patients Cidp | Controlled Trial | Intravenous Immunoglobulin
      KOL-Index: 10141

      X-linked dominant Charcot-Marie-Tooth (CMTX) disease is a motor and sensory neuropathy caused by mutations in the connexin 32 (CX32) gene. In this study we report the clinical, electrophysiological and genetic features of 93 patients (41 males, 52 females) from 37 unrelated families with CMTX. Age at onset was 15.4 +/- 9.6 years in males (range 1-40 years) and 18.7 +/- 13.1 years in females (range 1-56 years) (P = 0.22) and the duration of disease at the time of examination was 18.3 +/- ...

      Known for Tooth Disease | Females Males | Age Onset | Molecular Genetic | Linked Charcot
      KOL-Index: 9982

      BACKGROUND: Multifocal motor neuropathy is a distinct clinical entity characterised by progressive, predominantly distal, asymmetrical limb weakness and minimal sensory abnormality. The diagnostic feature of this condition is the presence of multiple partial motor nerve conduction blocks. Controlled trials have demonstrated the efficacy of regular intravenous immunoglobulin infusions. Immunosuppressive agents have been used as primary, second-line or adjunctive agents for its treatment. ...

      Known for Multifocal Motor | Immunosuppressive Agents | Intravenous Immunoglobulin | Conduction Block | Randomised Controlled Trials
      KOL-Index: 9819

      BACKGROUND: Consensus guidelines on the definition, investigation, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been previously published in European Journal of Neurology and Journal of the Peripheral Nervous System.

      OBJECTIVES: To revise these guidelines.

      METHODS: Disease experts, including a representative of patients, considered references retrieved from MEDLINE and Cochrane Systematic Reviews published between August 2004 and July 2009 and ...

      Known for European Federation | Neurological Societies | Peripheral Nerve Society | Chronic Inflammatory | Joint Task Force
      KOL-Index: 9141

      BACKGROUND AND PURPOSE: Some patients within the spectrum of chronic inflammatory demyelinating polyradiculoneuropathies (CIDP) have distal acquired demyelinating symmetric (DADS) neuropathy, usually associated with anti-myelin-associated-glycoprotein (MAG) IgM monoclonal gammopathy. The aim of this retrospective study was to investigate patients with DADS neuropathy without anti-MAG antibodies, and study their response to immunotherapy.

      METHODS: Patients were selected on the basis of ...

      Known for Dads Neuropathy | Patients Chronic Inflammatory | Antimag Antibodies | Response Immunotherapy | Laboratory Features
      KOL-Index: 8982

      Lewis-Sumner syndrome (LSS) is a dysimmune peripheral nerve disorder, characterized by a predominantly distal, asymmetric weakness mostly affecting the upper limbs with sensory impairment, and by the presence of multifocal persistent conduction blocks. The nosological position of this neuropathy in relation to multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is still debated. We report the clinical, biological and electrophysiological ...

      Known for Response Treatment | Cidp Lss | Multifocal Motor | Sumner Syndrome | Upper Limb

      Key People For Multifocal Motor

      Top KOLs in the world
      #1
      Eduardo Nobile‐Orazio
      multifocal motor chronic inflammatory intravenous immunoglobulin
      #2
      David Reid Cornblath
      chronic inflammatory barré syndrome multifocal motor
      #3
      Leonard Hendrik van den Berg
      amyotrophic lateral sclerosis multifocal motor chronic inflammatory
      #4
      Hessel Franssen
      multifocal motor chronic inflammatory brachial plexus
      #5
      John Wesley Griffin
      axonal transport wallerian degeneration schwann cells
      #6
      Alan Pestronk
      myasthenia gravis skeletal muscle alglucosidase alfa

      Jean‐Marc Léger:Expert Impact

      Concepts for whichJean‐Marc Légerhas direct influence:Multifocal motor,  Chronic inflammatory,  European federation,  Peripheral neuropathy,  Motor neuropathy,  Peripheral nervous,  Intravenous immunoglobulin,  Neurological complications.

      Jean‐Marc Léger:KOL impact

      Concepts related to the work of other authors for whichfor which Jean‐Marc Léger has influence:Chronic inflammatory,  Multifocal motor,  Intravenous immunoglobulin,  Peripheral neuropathy,  Neuropathic pain,  Small fiber,  Plasma exchange.


       

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      Académie nationale de médecine, 16 rue Bonaparte, 75006 Paris, France | National Referral Center for Rare Neuromuscular DiseasesHôpital Pitié‐Salpêtrière and University Paris VI Paris France | Centre National de Référence Maladies Neuromusculaires Ra

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