• KOL
    • KOLs Community
    • Multiple
    • Multiple Sclerosis
    • Cecília Rajda
    • Cecília Rajda

      Cecília Rajda

      Department of Neurology, Faculty of Medicine, University of Szeged, Szeged, Hungary | Department of Neurology, Interdisciplinary Centre of Excellence, Faculty of Medicine, ...

       

       

      KOL Resume for Cecília Rajda

      Year
      2021

      Department of Neurology, Faculty of Medicine, University of Szeged, Szeged, Hungary

      2020

      Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6., H-6725 Szeged, Hungary;, (H.P.);, (K.B.);, (L.V.)

      2018

      Szegedi Tudományegyetem, Neurológiai Klinika, Szeged.

      2017

      Department of Neurology, University of Szeged, 6725 Szeged, Hungary;, (C.R.);, (D.P.);, (Z.B.);, (Z.M.)

      2016

      University of Szeged, Department of Neurology, Szeged, Hungary.

      2015

      Department of Neurology, University of Szeged, Szeged H-6725, Hungary; E-Mails:, (C.R.);, (Z.M.);, (D.P.)

      2014

      Neurology Department, Faculty of Medicine, University of Szeged, Szeged, Hungary.

      2012

      Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, 6725, Szeged, Hungary

      2010

      Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary

      2009

      Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, 6 Semmelweis u., H-6725, Szeged, Hungary

      2008

      Department of Neurology, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged

      2007

      University of Szeged, Department of Neurology, Semmelweis u. 6, H-6725 Szeged, Hungary

      2006

      Department of Neurology, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Semmelweis u. 6., H-6725 Szeged, Hungary, Department of Psychiatry and Neurochemistry, Institute of Clinical Neuroscience, Göteborg University, Sahlgrenska University Hospital Mölndal, SE-431 80 Mölndal, Sweden

      2005

      Department of Neurology, Albert Szent‐Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary

      2003

      Department of Neurology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary

      2002

      Department of Psychiatry and Neurochemistry, Institute of Clinical Neuroscience, Göteborg University, Sahlgrenska University Hospital Mölndal, SE-431 80 Mölndal, Sweden

      2001

      Department of Neurology, Faculty of General Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Hungary

      1999

      From the Department of Neurology, Albert Szent‐Györgyi Medical University, Szeged, Hungary (Rajda, Tajti, Seres, Klivényi, and Vécsei), and

      1998

      Department of Neurology, Albert Szent‐Gyorgyi Medical Uniersity, Szeged, Hungary

       

       

      Cecília Rajda: Influence Statistics

      Sample of concepts for which Cecília Rajda is among the top experts in the world.
      Concept World rank
      determined kurtzke #1
      aid poser #1
      edss csongrád #2
      prealence #2
      csongrád county prevalence #2
      patients csongrád county #2
      4565 points #2
      400128 inhabitants #2
      ldopa 700 #3
      progressive disease aim #3
      cases 1500 patients #3
      hungarian rrms #3
      illness catecholamines humans #3
      neurologically molecules #3
      auc independent predictors #3
      tyrosine wide range #3
      metabolites neurologically #3
      auc neopterin #3
      patients drug electrophoresis #3
      immunologically stable phase #3
      bestknown association #3
      clinical subgroups relapsingremitting #3
      patients csongrád #3
      firstattack patients p0028 #3
      ldopa 30 day #3
      dopamine ratio controls #3
      30 neurologically #3
      kynurenine neurofilaments #3
      time interactions dopamine #3
      ifnnaïve rrms patients #3
      longterm ifn patients #3
      pbls capillary electrophoresis #3
      rrms tnf #3
      remission catecholamines #3
      tnf ppms #3
      nfl kynurenine metabolites #3
      alteration mitochondrial homeostasis #3
      guanine allele ppms #3
      energy disposal failure #3
      ppms adenine #3
      p05854 #3
      neopterin quin #3
      excitotoxins redox #3
      nfl quin #3
      p06192 #3
      ε4 allele ppms #3
      population csongrád #3
      ppms hungary #3
      familial accumulation cases #3
      csf quin neopterin #3

       

      Prominent publications by Cecília Rajda

      KOL-Index: 8100

      BACKGROUND AND OBJECTIVE: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort.

      METHODS: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum ...

      Known for Multiple Sclerosis | Clinically Isolated Syndrome | Conversion Cdms | Csf Igg | Age Cis
      KOL-Index: 7208

      OBJECTIVE: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS).

      METHODS: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for ...

      Known for Ocb Kflc | Sensitivity Specificity | Light Chains | Kappa Free | Multiple Sclerosis
      KOL-Index: 6762

      OBJECTIVE: The aim of this study was to determine the prevalence of multiple sclerosis (MS) in the population of Csongrád County, Hungary (400,128 inhabitants) and to determine the functional status (based on the Expanded Disability Status Scale; EDSS) of the patients according to the clinical forms of the disease.

      METHODS: The diagnosis was established with the aid of the Poser diagnostic criteria, and the degree of physical disability was determined using the Kurtzke EDSS.

      RESULTS: In ...

      Known for Csongrád County | Multiple Sclerosis | Clinical Forms | Relapsing Remitting | Chronic Progressive
      KOL-Index: 6523

      Tryptophan and its metabolites are of great interest in understanding the pathogenesis of multiple sclerosis (MS). The total levels of tryptophan and its metabolites, kynurenine and kynurenic acid were determined in plasma by capillary liquid chromatography electrospray ionisation tandem mass spectrometry. This is the first report of the plasma levels of these analytes in healthy controls and relapsing-remitting MS patients receiving long-term and acute interferon-beta (IFN-beta) ...

      Known for Multiple Sclerosis | Metabolites Kynurenine | Kynurenic Acid | Tryptophan Metabolism | Ifn Beta
      KOL-Index: 6180

      Health-related quality of life measurements are gaining more importance in the study and clinical practice of multiple sclerosis. The aim of our study was the adaptation of the Multiple Sclerosis Quality of Life Instrument (MSQOL-54) in Hungarian. The study was carried out at the Department of Neurology, University of Szeged and two other multiple sclerosis centers. The Hungarian translation of the questionnaire was given to patients at the outpatient units of the neurology departments. ...

      Known for Multiple Sclerosis | Quality Life | Msqol54 Instrument | Hungarian Version | Edss Score
      KOL-Index: 5742

      Neurofilament light (NFL) has proved to be a good prognostic factor in multiple sclerosis (MS), as its level is proportionally elevated with extended neuraxonal damage. The involvement of the kynurenine pathway in neuroinflammation has been proved. The precursor of this pathway is the essential amino acid tryptophan, which is catabolized 95% towards kynurenine metabolites. Quinolinic acid (QUIN) within the brain is only produced in activated microglia and macrophages, leading to axonal ...

      Known for Multiple Sclerosis | Neurofilament Light | Kynurenine Pathway | Cerebrospinal Fluid | Quinolinic Acid
      KOL-Index: 5742

      There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. Anti-aquaporin-4 antibodies in serum are currently useful for the diagnosis of neuromyelitis optica (NMO), but we could expect novel CSF biomarkers that help define prognosis and response to treatment for this disease. One of the most critical factors in biomarker research is ...

      Known for Biomarker Studies | Csf Samples | Preanalytical Factors | Neuromyelitis Optica | Standardized Protocols
      KOL-Index: 5638

      Tryptophan is one of the essential amino acids, 80% of which is catabolised in the extrahepatic tissues by indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme of the kynurenine pathway. Metabolites along the kynurenine pathway have been implicated to play a role in the pathomechanism of neuroinflammatory and neurodegenerative disorders. Changes in the concentration levels of kynurenines can shift the balance to pathological conditions. The ability to influence the metabolism ...

      Known for Multiple Sclerosis | Kynurenine Pathway | Amyotrophic Lateral | Neurodegenerative Diseases | Blood–brain Barrier
      KOL-Index: 5502

      The simultaneous quantitative estimation of tryptophan (TRP) and its metabolites represents a great challenge because of their diverse chemical properties, e.g., presence of acidic, basic, and nonpolar functional groups and their immensely different concentrations in biological matrices. A short ultra high-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS) method was validated for targeted analysis of TRP and its 11 most important metabolites derived via both ...

      Known for Multiple Sclerosis | Tryptophan Metabolites | Kynurenic Acid | Kyn Kyna | Cerebrospinal Fluid
      KOL-Index: 5470

      Multiple sclerosis is an inflammatory disease of the central nervous system, in which axonal transection takes place in parallel with acute inflammation to various, individual extents. The importance of the kynurenine pathway in the physiological functions and pathological processes of the nervous system has been extensively investigated, but it has additionally been implicated as having a regulatory function in the immune system. Alterations in the kynurenine pathway have been described ...

      Known for Multiple Sclerosis | Central Nervous | Kynurenine Pathway | Autoimmune Diseases | Inflammatory Disease
      KOL-Index: 5446

      PurposeFatigue is one of the most frequent complaints of patients with multiple sclerosis (MS). The Fatigue Impact Scale (FIS), one of the 30 available fatigue questionnaires, is commonly applied because it evaluates multidimensional aspects of fatigue. The main purposes of this study were to test the validity, test–retest reliability, and internal consistency of the Hungarian version of the FIS.MethodsOne hundred and eleven MS patients and 85 healthy control (HC) subjects completed the ...

      Known for Fatigue Impact Scale | Patients Multiple Sclerosis | Internal Consistency | Hungarian Version | Healthrelated Quality
      KOL-Index: 5365

      Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) ...

      Known for Multiple Sclerosis | Necrosis Factor | Alpha Gene | Primary Progressive | −376 Polymorphism
      KOL-Index: 5127

      BACKGROUND: Neurofilament proteins (Nf) are highly specific biomarkers for neuronal death and axonal degeneration. As these markers become more widely used, an inter-laboratory validation study is required to identify assay criteria for high quality performance.

      METHODS: The UmanDiagnostics NF-light (R)enzyme-linked immunoabsorbent assays (ELISA) for the neurofilament light chain (NfL, 68kDa) was used to test the intra-assay and inter-laboratory coefficient of variation (CV) between 35 ...

      Known for Neurofilament Proteins | Protein Standards | Axonal Degeneration | Statistical Analyses | Factors Biomarkers
      KOL-Index: 5049

      PRINCIPLES: Apolipoprotein E (ApoE), an important glycoprotein in the transport, uptake and redistribution of cholesterol, is necessary in nerve tissue repair. The APOE gene (APOE) is involved in neurodegenerative diseases, the best-known association being that between the APOE ε4 allele and Alzheimer's disease. Multiple sclerosis (MS) is a chronic inflammatory neurological disease. The aim of this study was to assess (multicentre assessment) the possible influence of the APOE gene on ...

      Known for Primary Progressive | Ε2 Allele | Apoe Gene | Multiple Sclerosis | Ppms Patients

      Key People For Multiple Sclerosis

      Top KOLs in the world
      #1
      Alanda K Thompson
      multiple sclerosis spinal cord magnetic resonance
      #2
      Chris H Polman
      multiple sclerosis magnetic resonance spinal cord
      #3
      Fred D Lublin
      multiple sclerosis glatiramer acetate monoclonal antibodies
      #4
      Ludwig Kappos
      multiple sclerosis disability progression magnetic resonance
      #5
      Massimo Filippi
      multiple sclerosis magnetic resonance cervical cord
      #6
      Hans‐Peter Hartung
      multiple sclerosis chronic inflammatory schwann cells

      Cecília Rajda:Expert Impact

      Concepts for whichCecília Rajdahas direct influence:Multiple sclerosis,  Csongrád county,  Redox disturbances,  Clinical forms,  Central nervous,  Sclerosis patients,  Cerebrospinal fluid,  Kynurenine pathway.

      Cecília Rajda:KOL impact

      Concepts related to the work of other authors for whichfor which Cecília Rajda has influence:Multiple sclerosis,  Cerebrospinal fluid,  Kynurenine pathway,  Clinically isolated syndrome,  Human herpesvirus,  Central nervous,  Oligoclonal bands.


       

      Tools

      Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile


      Department of Neurology, Faculty of Medicine, University of Szeged, Szeged, Hungary | Department of Neurology, Interdisciplinary Centre of Excellence, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary. |

    Download on the App StoreGet it on Google Play

    Copyright © 2023 - KOL means Key Opinion Leaders .

    KOL does not provide medical advice, diagnosis or treatment.