Prominent publications by Cecília Rajda

KOL Index score: 8100

BACKGROUND AND OBJECTIVE: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort.

METHODS: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum ...

Known for Multiple Sclerosis |  Clinically Isolated Syndrome |  Conversion Cdms |  Csf Igg |  Age Cis
KOL Index score: 7208

OBJECTIVE: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS).

METHODS: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for ...

Known for Ocb Kflc |  Sensitivity Specificity |  Light Chains |  Kappa Free |  Multiple Sclerosis
KOL Index score: 6762

OBJECTIVE: The aim of this study was to determine the prevalence of multiple sclerosis (MS) in the population of Csongrád County, Hungary (400,128 inhabitants) and to determine the functional status (based on the Expanded Disability Status Scale; EDSS) of the patients according to the clinical forms of the disease.

METHODS: The diagnosis was established with the aid of the Poser diagnostic criteria, and the degree of physical disability was determined using the Kurtzke EDSS.


Known for Csongrád County |  Multiple Sclerosis |  Clinical Forms |  Relapsing Remitting |  Chronic Progressive
KOL Index score: 6523

Tryptophan and its metabolites are of great interest in understanding the pathogenesis of multiple sclerosis (MS). The total levels of tryptophan and its metabolites, kynurenine and kynurenic acid were determined in plasma by capillary liquid chromatography electrospray ionisation tandem mass spectrometry. This is the first report of the plasma levels of these analytes in healthy controls and relapsing-remitting MS patients receiving long-term and acute interferon-beta (IFN-beta) ...

Known for Multiple Sclerosis |  Metabolites Kynurenine |  Kynurenic Acid |  Tryptophan Metabolism |  Ifn Beta
KOL Index score: 6180

Health-related quality of life measurements are gaining more importance in the study and clinical practice of multiple sclerosis. The aim of our study was the adaptation of the Multiple Sclerosis Quality of Life Instrument (MSQOL-54) in Hungarian. The study was carried out at the Department of Neurology, University of Szeged and two other multiple sclerosis centers. The Hungarian translation of the questionnaire was given to patients at the outpatient units of the neurology departments. ...

Known for Multiple Sclerosis |  Quality Life |  Msqol54 Instrument |  Hungarian Version |  Edss Score
KOL Index score: 5742

Neurofilament light (NFL) has proved to be a good prognostic factor in multiple sclerosis (MS), as its level is proportionally elevated with extended neuraxonal damage. The involvement of the kynurenine pathway in neuroinflammation has been proved. The precursor of this pathway is the essential amino acid tryptophan, which is catabolized 95% towards kynurenine metabolites. Quinolinic acid (QUIN) within the brain is only produced in activated microglia and macrophages, leading to axonal ...

Known for Multiple Sclerosis |  Neurofilament Light |  Kynurenine Pathway |  Cerebrospinal Fluid |  Quinolinic Acid
KOL Index score: 5742

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. Anti-aquaporin-4 antibodies in serum are currently useful for the diagnosis of neuromyelitis optica (NMO), but we could expect novel CSF biomarkers that help define prognosis and response to treatment for this disease. One of the most critical factors in biomarker research is ...

Known for Biomarker Studies |  Csf Samples |  Preanalytical Factors |  Neuromyelitis Optica |  Standardized Protocols
KOL Index score: 5638

Tryptophan is one of the essential amino acids, 80% of which is catabolised in the extrahepatic tissues by indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme of the kynurenine pathway. Metabolites along the kynurenine pathway have been implicated to play a role in the pathomechanism of neuroinflammatory and neurodegenerative disorders. Changes in the concentration levels of kynurenines can shift the balance to pathological conditions. The ability to influence the metabolism ...

Known for Multiple Sclerosis |  Kynurenine Pathway |  Amyotrophic Lateral |  Neurodegenerative Diseases |  Blood–brain Barrier
KOL Index score: 5502

The simultaneous quantitative estimation of tryptophan (TRP) and its metabolites represents a great challenge because of their diverse chemical properties, e.g., presence of acidic, basic, and nonpolar functional groups and their immensely different concentrations in biological matrices. A short ultra high-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS) method was validated for targeted analysis of TRP and its 11 most important metabolites derived via both ...

Known for Multiple Sclerosis |  Tryptophan Metabolites |  Kynurenic Acid |  Kyn Kyna |  Cerebrospinal Fluid
KOL Index score: 5470

Multiple sclerosis is an inflammatory disease of the central nervous system, in which axonal transection takes place in parallel with acute inflammation to various, individual extents. The importance of the kynurenine pathway in the physiological functions and pathological processes of the nervous system has been extensively investigated, but it has additionally been implicated as having a regulatory function in the immune system. Alterations in the kynurenine pathway have been described ...

Known for Multiple Sclerosis |  Central Nervous |  Kynurenine Pathway |  Autoimmune Diseases |  Inflammatory Disease
KOL Index score: 5446

PurposeFatigue is one of the most frequent complaints of patients with multiple sclerosis (MS). The Fatigue Impact Scale (FIS), one of the 30 available fatigue questionnaires, is commonly applied because it evaluates multidimensional aspects of fatigue. The main purposes of this study were to test the validity, test–retest reliability, and internal consistency of the Hungarian version of the FIS.MethodsOne hundred and eleven MS patients and 85 healthy control (HC) subjects completed the ...

Known for Fatigue Impact Scale |  Patients Multiple Sclerosis |  Internal Consistency |  Hungarian Version |  Healthrelated Quality
KOL Index score: 5365

Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) ...

Known for Multiple Sclerosis |  Necrosis Factor |  Alpha Gene |  Primary Progressive |  −376 Polymorphism
KOL Index score: 5127

BACKGROUND: Neurofilament proteins (Nf) are highly specific biomarkers for neuronal death and axonal degeneration. As these markers become more widely used, an inter-laboratory validation study is required to identify assay criteria for high quality performance.

METHODS: The UmanDiagnostics NF-light (R)enzyme-linked immunoabsorbent assays (ELISA) for the neurofilament light chain (NfL, 68kDa) was used to test the intra-assay and inter-laboratory coefficient of variation (CV) between 35 ...

Known for Neurofilament Proteins |  Protein Standards |  Axonal Degeneration |  Statistical Analyses |  Factors Biomarkers
KOL Index score: 5049

PRINCIPLES: Apolipoprotein E (ApoE), an important glycoprotein in the transport, uptake and redistribution of cholesterol, is necessary in nerve tissue repair. The APOE gene (APOE) is involved in neurodegenerative diseases, the best-known association being that between the APOE ε4 allele and Alzheimer's disease. Multiple sclerosis (MS) is a chronic inflammatory neurological disease. The aim of this study was to assess (multicentre assessment) the possible influence of the APOE gene on ...

Known for Primary Progressive |  Ε2 Allele |  Apoe Gene |  Multiple Sclerosis |  Ppms Patients


Cecília Rajda: Influence Statistics

Sample of concepts for which Cecília Rajda is among the top experts in the world.
Concept World rank
determined kurtzke #1
aid poser #1
400128 inhabitants #2
patients csongrád county #2
4565 points #2
prealence #2
csongrád county prevalence #2
edss csongrád #2
bestknown association #3
hungarian rrms #3
extended neuraxonal damage #3
45 ppms patients #3
auc independent predictors #3
excitotoxins mitochondrial #3
rrms tnf #3
familial accumulation cases #3
disease familial accumulation #3
immunologically stable phase #3
neopterin mass spectrometry #3
ppms adenine adult #3
neuroinflammation proved #3
ε4 allele ppms #3
tnf ppms #3
pbls capillary electrophoresis #3
neopterin quin #3
ldopa 700 #3
ldopa 30 day #3
clinical subgroups relapsingremitting #3
dopamine ratio controls #3
neurofilaments kynurenine #3
energy disposal failure #3
excitotoxins redox disturbances #3
auc neopterin #3
progressive disease aim #3
quin auc #3
remission catecholamines #3
neurodegenerative biomarkers biomarkers #3
auc quin #3
30 neurologically #3
hungarian 400 #3
patients drug electrophoresis #3
guanine allele ppms #3
tnfalpha clinical activity #3
80119 81117 #3
alteration mitochondrial homeostasis #3
patients csongrád #3
longterm ifn patients #3
pbls parkinson #3
ppms adenine #3
excitotoxins redox #3

Key People For Multiple Sclerosis

Top KOLs in the world
Alanda K Thompson
multiple sclerosis spinal cord magnetic resonance
Chris H Polman
multiple sclerosis magnetic resonance spinal cord
Fred D Lublin
multiple sclerosis glatiramer acetate monoclonal antibodies
Ludwig Kappos
multiple sclerosis disability progression magnetic resonance
Massimo Filippi
multiple sclerosis magnetic resonance cervical cord
Hans‐Peter Hartung
multiple sclerosis chronic inflammatory schwann cells

Cecília Rajda:Expert Impact

Concepts for whichCecília Rajdahas direct influence:Multiple sclerosis,  Csongrád county,  Redox disturbances,  Clinical forms,  Central nervous,  Sclerosis patients,  Cerebrospinal fluid,  Kynurenine pathway.

Cecília Rajda:KOL impact

Concepts related to the work of other authors for whichfor which Cecília Rajda has influence:Multiple sclerosis,  Cerebrospinal fluid,  Kynurenine pathway,  Clinically isolated syndrome,  Human herpesvirus,  Central nervous,  Oligoclonal bands.



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Department of Neurology, Faculty of Medicine, University of Szeged, Szeged, Hungary | Department of Neurology, Interdisciplinary Centre of Excellence, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary. |

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