• Multiple Sclerosis
    • Mario Zappia
    • Mario Zappia: Influence Statistics

      Mario Zappia

      Mario Zappia

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      Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy | Department “G.F. ...

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      Mario Zappia:Expert Impact

      Concepts for whichMario Zappiahas direct influence:Multiple sclerosis,Parkinson disease,Essential tremor,Motor fluctuations,Parkinsons disease,Cognitive impairment,Parkin gene,Mount etna.

      Mario Zappia:KOL impact

      Concepts related to the work of other authors for whichfor which Mario Zappia has influence:Multiple sclerosis,Parkinson disease,Mitochondrial dynamics,Cognitive impairment,Essential tremor,Movement disorders,Motor symptoms.

      KOL Resume for Mario Zappia


      Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy


      Department GF Ingrassia, University of Catania, Catania, Italy.

      Clinica Neurologica, A.O.U. Policlinico “G. Rodolico”, Via S. Sofia 78, 95123, Catania, Italy


      Section of Neurosciences, Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Catania, Italy


      Clinica Neurologica, AOU Policlinico Vittorio Emanuele, Via S. Sofia, 78, 95125, Catania, Italy


      Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Via Santa Sofia 79, 95123, Catania, Italy

      Dip. di Ingegneria Elettrica Elettronica ed Informatica, University of Catania, Viale A. Doria 6, 95125, Catania, ITALY


      Clinica Neurologica, AOU Policlinico Vittorio Emanuele of Catania, Catania, Italy

      Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie, Avanzate, G.F., Ingrassia

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      Sample of concepts for which Mario Zappia is among the top experts in the world.
      Concept World rank
      prevalence isolated rbd #1
      environmental factors toxocariasis #1
      phone rbd #1
      water bodies measure #1
      pdw pdsmc #1
      prbd prevalence #1
      case pull test #1
      mri morphometric features #1
      illness aged alpha #1
      populations eastern flank #1
      eacs rural area #1
      definite rbd italy #1
      atypical parkinsonisms introduction #1
      new drugs order #1
      shortterm ldopa test #1
      sleep specialist stage #1
      nonamnestic singledomain #1
      drugresistant spasticity improvement #1
      clinical tetrad #1
      gps low level #1
      isolated rbd #1
      ldopa therapy pulsatile #1
      normality cutoff values #1
      developing cancer patients #1
      typical instability dynamics #1
      delta psd pdmci #1
      8 6 women #1
      parkinsons disease fragamp #1
      motor progression 95 #1
      mdsupdrs sensitivity #1
      global score subscores #1
      pdnc mci #1
      risk cyanobacteria humans #1
      ldr ldopa #1
      52210 inhabitants #1
      introductionthe approval #1
      literature clinical sign #1
      followup impairment #1
      511±140 years seroprevalence #1
      cns pervasive child #1
      acute levodopa test #1
      response ldr #1
      mount etna province #1
      stage positive participants #1
      disease 31 december #1
      lid impairment #1
      sclerosis volcanic #1
      tests pull test #1
      longduration response ldr #1
      differentiate parkinson #1
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      Prominent publications by Mario Zappia

      KOL-Index: 15885

      PURPOSE: To prospectively assess sensitivity and specificity of magnetic resonance (MR) imaging measurements of midbrain, pons, middle cerebellar peduncles (MCPs), and superior cerebellar peduncles (SCPs) for differentiating progressive supranuclear palsy (PSP) from Parkinson disease (PD) and Parkinson variant of multiple system atrophy (MSA-P), with established consensus criteria as reference standard.

      MATERIALS AND METHODS: All study participants provided informed consent; study was ...

      Known for Patients Psp | Parkinson Variant | Supranuclear Palsy | Mcp Scp | Control Participants
      KOL-Index: 14490

      Clinical differentiation of parkinsonian syndromes such as the Parkinson variant of multiple system atrophy (MSA-P) and progressive supranuclear palsy (PSP) from Parkinson's disease is difficult in the early stage of the disease. In order to identify objective markers for differential diagnosis, we studied these three groups of patients with diffusion-weighted MRI (DWI). Sixteen MSA-P patients, 16 with PSP, 16 with Parkinson's disease and 15 healthy volunteers were studied. Regional ...

      Known for Parkinson Variant | Progressive Supranuclear | Apparent Diffusion | Middle Cerebellar | Basal Ganglia
      KOL-Index: 14108

      Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological ...

      Known for Cognitive Impairment | Pdd Pdmci | Patients Mci | Parkinson Disease | Baseline Follow
      KOL-Index: 12783

      INTRODUCTION: Epilepsy represents around 0.7% of the overall global burden of diseases and is particularly prevalent and associated with significant disability in low- and middle-income countries (LMIC) in Latin American Countries (LAC). A community-based epilepsy awareness program was carried out by our group in the rural areas of the Chaco region, Plurinational state of Bolivia, to improve the knowledge about epilepsy, with a first part directed toward general practitioners and a ...

      Known for Quality Life | Knowledge Epilepsy | Rural Communities | Chaco Region | Attitudes Practices
      KOL-Index: 12700

      The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA-P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we ...

      Known for Progressive Supranuclear | Patients Psp | Superior Cerebellar Peduncle | Apparent Diffusion Coefficient | Parkinsons Disease
      KOL-Index: 12667

      PURPOSE: To evaluate the natural history and mortality of chronic epilepsy in an untreated prevalence cohort of people with epilepsy (PWE) in a rural area of Bolivia.

      METHODS: During 1994-1996 we carried out an epidemiologic survey in a sample of 9,995 subjects in the Cordillera province. At the end of the survey we identified 130 PWE, of whom 118 were classified as having "active epilepsy." We revisited this cohort 10 years after the prevalence survey.

      RESULTS: We were able to trace 103 ...

      Known for Chronic Epilepsy | Rural Bolivia | 10 Years | Untreated Population | Natural Mortality
      KOL-Index: 12118

      INTRODUCTION: Epilepsy represents a major global healthcare issue, particularly in low- and middle-income countries (LMIC), where nonmedical health workers play a key role in providing care to people with epilepsy (PWE). Over the last 20 years, many projects have been carried out by our group in the Chaco region, Plurinational State of Bolivia, with the aim of enhancing knowledge about epilepsy. However, the level of knowledge of epilepsy that nonmedical health workers have reached has ...

      Known for Knowledge Epilepsy | Rural Bolivia | Chaco Region | Health Workers | Plurinational State
      KOL-Index: 11653

      BACKGROUND: Trace elements have been hypothesised to be involved in the pathogenesis of Multiple Sclerosis and volcanic degassing is the major natural sources of trace elements. Both incidence of Multiple Sclerosis in Catania and volcanic activity of Mount Etna have been significantly increased during the last 30 years. Due to prevailing trade winds direction, volcanic gases from Etna summit craters are mostly blown towards the eastern and southern sectors of the volcano.

      OBJECTIVE: To ...

      Known for Multiple Sclerosis | Mount Etna | Trace Elements | Eastern Flank | Prevalence Incidence
      KOL-Index: 11203

      BACKGROUND: The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition. Two polymorphic sites in these genes (MPO-G/A and A2M-Ile/Val) have been associated with Alzheimer disease (AD), but conflicting findings have been reported in populations with different ethnic backgrounds.

      OBJECTIVES: To study the association of MPO-G/A and A2M-Ile/Val polymorphisms with sporadic AD and to investigate the ...

      Known for Alzheimer Disease | A2m Polymorphisms | Southern Italy | Genetic Risk | Molecular Pathways
      KOL-Index: 10816

      OBJECTIVE: To assess in a noninterventional setting the prevalence and severity of fatigue in patients with Parkinson disease (PD).

      METHODS: This was a cross-sectional study conducted in Italian patients with PD. Objectives included the evaluation of the current prevalence and severity of fatigue in patients with PD measured using the 16-item Parkinson Fatigue Scale (PFS-16), distressing fatigue (defined as a PFS-16 mean score ≥3.3), and assessment of its clinical correlates.

      RESULTS: A ...

      Known for Parkinson Disease | Distressing Fatigue | Sleep Disorders | Clinical Correlates | Patients Pfs16
      KOL-Index: 10749

      BACKGROUND: Chronic cerebrospinal venous insufficiency (CCSVI) has been associated to multiple sclerosis (MS).

      OBJECTIVE: To evaluate the possible association between CCSVI and MS, using a population-based control design.

      METHODS: A random cohort of 148 incident MS patients were enrolled in the study. We have also studied 20 patients with clinically isolated syndrome (CIS), 40 patients with other neurological diseases (OND), and 172 healthy controls. Transcranial (TCC) and Echo Color ...

      Known for Multiple Sclerosis | Ccsvi Patients | Color Ultrasonography | Case Control | Venous Insufficiency
      KOL-Index: 10684

      BACKGROUND: Impulse control disorders and dyskinesia are common and disabling complications of dopaminergic treatment in Parkinson's disease. They may coexist and are possibly related. The objectives of this study were to assess the frequency and severity of impulse control disorders in Parkinson's disease patients with dyskinesia.

      METHODS: The ALTHEA study enrolled 251 Parkinson's disease patients with various degrees of dyskinesia severity from 11 movement disorders centers in Italy. ...

      Known for Impulse Control Disorders | Parkinson Disease | Positive Patients | Dyskinesia Drug | Dopaminergic Treatment
      KOL-Index: 10652

      INTRODUCTION: Epilepsy represents a major health problem in low- and middle-income countries where treatment gap (TG) levels are high. The reduction of epilepsy TG in the rural area of the Chaco region, Plurinational State of Bolivia, has been the aim of many projects based on the reinforcement of the primary care setting. To plan educational campaigns directed to the healthcare professionals, it is necessary to establish their baseline knowledge level. The objective of our study was to ...

      Known for Rural Bolivia | Attitudes Practices | Chaco Region | General Practitioners | Kap Epilepsy

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      Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy | Department “G.F. Ingrassia”, Section of Neurosciences, Neurology Clinic, University of Catania, Via S

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