• Disease
  • Murine
  • Murine Schistosomiasis
  • Joel V Weinstock

    Prominent publications by Joel V Weinstock

    KOL Index score: 13063

    BACKGROUND: The hygiene hypothesis suggests an inverse relationship between the incidence of parasitic infections and chronic inflammatory bowel diseases (IBD). We investigated the therapeutic potential of Schistosoma mansoni and Ancylostoma caninum soluble proteins on experimental colitis in mice.

    METHODS: Colitis was induced by intrarectal administration of 10 mg trinitrobenzene sulfonic acid (TNBS) in 30% ethanol. Six hours after TNBS injection, mice were treated intraperitoneally ...

    Also Ranks for: Therapeutic Potential |  mice colitis |  mansoni proteins |  regulatory cytokines |  treatment ibd
    KOL Index score: 12784

    BACKGROUND AND AIMS: Total parenteral nutrition (TPN) is typically delivered through catheters inserted into the superior vena cava (SVC) via a subclavian or internal jugular vein approach. A peripherally-inserted central venous catheter (PICC), utilizing a cephalic or basilic venous approach, may provide a safe alternative to the standard catheter approach and, because non-physician providers can insert the PICC, may introduce a potential cost-savings to health care institutions. We ...

    Also Ranks for: Hospitalized Patients |  central catheters |  parenteral nutrition |  picc lines |  insertion maintenance
    KOL Index score: 12271

    BACKGROUND & AIMS: Interleukin (IL)-10 is an anti-inflammatory and immune regulatory cytokine. IL-10-deficient mice (IL-10(-/-)) develop chronic inflammatory bowel disease (IBD), indicating that endogenous IL-10 is a central regulator of the mucosal immune response. Prostaglandins are lipid mediators that may be important mediators of intestinal inflammation. In this study we assessed the role of prostaglandins in the regulation of mucosal inflammation in the IL-10(-/-) mouse model of ...

    Also Ranks for: Il10 Mice |  nsaid treatment |  intestinal inflammation |  cytokine production |  anti inflammatory
    KOL Index score: 11946

    Helminthic infections protect mice from colitis in murine models of inflammatory bowel disease and also may protect people. Helminths like Heligmosomoides polygyrus bakeri can induce regulatory T cells (Treg). Experiments explored whether H. polygyrus bakeri infection could protect mice from colitis through activation of colonic Treg and examined mechanisms of action. We showed that H. polygyrus bakeri infection increased the number of T cells expressing Foxp3 in the colon. More ...

    Also Ranks for: Polygyrus Bakeri |  mice colitis |  intestinal diseases |  regulatory cells |  inflammatory bowel disease
    KOL Index score: 11342

    We studied the effects of an anti-interleukin (IL)-5 monoclonal antibody (TRFK-5) or dexamethasone (DEX) to reverse already established airway hyperresponsiveness (AHR) and tissue eosinophilia in a Schistosoma mansoni antigen-sensitized and airway-challenged mouse model of chronic asthma. In this model at 4 d after antigen challenge there is dramatic bronchoalveolar lavage fluid (BAL) eosinophilia, AHR to intravenous methacholine (MCh), and histologic evidence of peribronchial ...

    Also Ranks for: Airway Eosinophilia |  chronic asthma |  murine model |  antigen challenge |  bal fluid
    KOL Index score: 11271

    Angiotensin I converting enzyme activity is detectable in serum and isolated liver granulomas of mice infected with Schistosoma mansoni. At the chronic phase of the infection (20 wk) the intensity of the granulomatous response spontaneously diminishes. Concomitantly, an increase in angiotensin I converting enzyme activity is observed. The objective of this investigation was to determine the source of this elevated angiotensin I converting enzyme activity. In chronically infected mice, ...

    Also Ranks for: Converting Enzyme |  schistosoma mansoni |  granuloma macrophages |  infected mice |  culture medium
    KOL Index score: 11189

    Previous studies have shown that the pan CD28/cytotoxic T lymphocyte antigen (CTL)A-4 antagonist CTLA4 immunoglobulin (Ig) inhibits eosinophilic airway inflammation in Schistosoma mansoni-sensitized and airway-challenged mice. In the present study, the importance of CD28 as well as the individual roles of CD80 and CD86 were examined in this system using wild-type and CD28 knockout (KO) mice. Unlike wild-type controls, CD28KO mice did not produce systemic IgE or eosinophilic airway ...

    Also Ranks for: Cd80 Cd86 |  monoclonal antigens |  airway inflammation |  cd28 b7 |  inbred c57bl mice
    KOL Index score: 11047

    Complete T-cell activation requires two distinct signals, one delivered via the T-cell receptor, and the second "co-stimulatory" signal through CD28/B7 ligation. Previous studies showed that the blockade of CD28/B7 ligation alters differentiation of Th1/Th2 lymphocyte subsets in vitro and in vivo. The present study was designed to determine the effect of a CD28/B7 antagonist (CTLA4Ig) on Th1/Th2 development in Schistosoma mansoni-sensitized and airway-challenged mice. Treatment of mice ...

    Also Ranks for: Murine Model |  airway eosinophilia |  bal fluid |  lung lymphocytes |  th1 th2
    KOL Index score: 10724

    A novel costimulatory molecule expressed on activated T cells, inducible costimulator (ICOS), and its ligand, B7-related protein-1 (B7RP-1), were recently identified. ICOS costimulation leads to the induction of Th2 cytokines without augmentation of IL-2 production, suggesting a role for ICOS in Th2 cell differentiation and expansion. In the present study, a soluble form of murine ICOS, ICOS-Ig, was used to block ICOS/B7RP-1 interactions in a Th2 model of allergic airway disease. In this ...

    Also Ranks for: Allergic Airway Disease |  inducible costimulator |  th2 differentiation |  airway inflammation |  mice icos
    KOL Index score: 10181

    Less developed countries have a low incidence of immunological diseases like inflammatory bowel disease (IBD), perhaps prevented by the high prevalence of helminth infections in their populations. In the Rag IL-10(-/-) T cell transfer model of colitis, Heligmosomoides polygyrus, an intestinal helminth, prevents and reverses intestinal inflammation. This model of colitis was used to explore the importance of innate immunity in H. polygyrus protection from IBD. Rag mice briefly exposed to ...

    Also Ranks for: Heligmosomoides Polygyrus |  innate immunity |  knockout mice |  intestinal inflammation |  ot2 cells
    KOL Index score: 10001

    The intestinal epithelium forms an essential barrier between a host and its microbiota. Protozoa and helminths are members of the gut microbiota of mammals, including humans, yet the many ways that gut epithelial cells orchestrate responses to these eukaryotes remain unclear. Here we show that tuft cells, which are taste-chemosensory epithelial cells, accumulate during parasite colonization and infection. Disruption of chemosensory signaling through the loss of TRMP5 abrogates the ...

    Also Ranks for: Tuft Cells |  type 2 |  intestinal diseases |  gut microbiota |  primary source
    KOL Index score: 9938

    Immunological diseases such as inflammatory bowel disease (IBD) are infrequent in less developed countries, possibly because helminths provide protection by modulating host immunity. In IBD murine models, the helminth Heligmosomoides polygyrus bakeri prevents colitis. It was determined whether H. polygyrus bakeri mediated IBD protection by altering dendritic cell (DC) function. We used a Rag IBD model where animals were reconstituted with IL10⁻/⁻ T cells, making them susceptible to IBD ...

    Also Ranks for: Polygyrus Bakeri |  block colitis |  dendritic cells |  cell responses |  host immunity
    KOL Index score: 9872

    Murine schistosomiasis is a granulomatous disease associated with high serum and granuloma angiotensin I-converting enzyme (ACE) activity. SQ 14225, a specific competitive inhibitor of ACE, was administered to normal mice and mice infected with Schistosoma mansoni to determine whether this compound could inhibit granuloma ACE activity and modify the size of the granulomatous response to schistosome eggs. Peroral administration of SQ 14225 for 5 wk to infected mice with peak granulomatous ...

    Also Ranks for: Granulomatous Response |  schistosoma mansoni |  converting enzyme |  normal mice |  schistosome eggs


    Joel V Weinstock: Influence Statistics

    Sample of concepts for which Joel V Weinstock is among the top experts in the world.
    Concept World rank
    mif activity lyt #1
    eosinophils plaques #1
    th2suppressing th1 responses #1
    inhibits established #1
    splenocytes granuloma cells #1
    colitis normal controls #1
    il12 spr #1
    environmental engenders #1
    helminthcolonized mice #1
    improving knowledge aspect #1
    granulomas infected #1
    generic products viruses #1
    ifngamma granuloma cells #1
    isolated granuloma macrophages #1
    schistosome ova #1
    colonic mucosal levels #1
    asthmathic lung #1
    suis americanus #1
    splenic vip production #1
    ifngamma il5 production #1
    somatostatin immunoregulatory properties #1
    induced rag #1
    schistosoma mansoni induces #1
    outcome trichuris #1
    vipmediated effects #1
    nk1r hemokinin #1
    thymidine captopril #1
    srif murine schistosomiasis #1
    mucosal response th2 #1
    schistosomeinfected mice #1
    humans immunoglobulin interleukin3 #1
    lp mononuclear cells #1
    stimulation granuloma #1
    mansoni mycobacterium #1
    dying parasites #1
    necator crohn #1
    lyt granuloma cells #1
    bowel diseases therapy #1
    vpac2 vpac2 mrna #1
    granulomasize #1
    worm joel weinstock #1
    granulomatous response neuropeptides #1
    nk1r inhibitor #1
    protective lesions role #1
    abrogates antigen‐specific #1
    dex trfk5 #1
    hemokinin #1
    component host response #1
    captopril aii iii #1
    il6 mutant mice #1

    Key People For Murine Schistosomiasis

    Top KOLs in the world
    Dov L Boros
    schistosoma mansoni granulomatous response murine schistosomiasis
    Allen W Cheever
    schistosoma mansoni hepatic fibrosis inbred balb mice
    Edward J Pearce
    schistosoma mansoni dendritic cells th2 responses
    Kenneth S Warren
    schistosoma mansoni granuloma formation delayed hypersensitivity
    Alan Sher
    schistosoma mansoni dendritic cells toxoplasma gondii
    Daniel G Colley
    schistosoma mansoni human schistosomiasis immune responses

    Joel V Weinstock:Expert Impact

    Concepts for whichJoel V Weinstockhas direct influence:Murine schistosomiasis,  Granuloma macrophages,  Murine schistosomiasis mansoni,  Granulomatous response,  Granuloma cells,  Schistosoma mansoni,  Inflammatory bowel disease,  Liver granulomas.

    Joel V Weinstock:KOL impact

    Concepts related to the work of other authors for whichfor which Joel V Weinstock has influence:Inflammatory bowel disease,  Dendritic cells,  Ulcerative colitis,  Immune response,  Gut microbiota,  Hygiene hypothesis,  Multiple sclerosis.



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    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tufts Medical Center, Boston, MA, USA | Tufts Medical Center, Boston, MA, USA | Division of Gastroenterology-Hepatology, Department of Internal Medicine, Tufts Medical Cent