• Disease
  • Psoriatic
  • Psoriatic Arthritis
  • David John Kane

    Prominent publications by David John Kane

    KOL Index score: 12744

    OBJECTIVE: To compare ultrasonography with bone scintigraphy in the diagnosis of plantar fasciitis and to compare ultrasound-guided injection with palpation-guided injection in the management of idiopathic plantar fasciitis.

    METHODS: Twenty-three patients with a clinical diagnosis of idiopathic plantar fasciitis in 28 heels underwent ultrasonography and bone scintigraphy of both heels at baseline. The patients were randomized to ultrasound- or palpation-guided injection of triamcinolone ...

    Also Ranks for: Plantar Fasciitis |  palpationguided injection |  diagnosis management |  bone scintigraphy |  ultrasound guided
    KOL Index score: 12704

    Expression of the orphan nuclear receptor NR4A2 is controlled by pro-inflammatory mediators, suggesting that NR4A2 may contribute to pathological processes in the inflammatory lesion. This study identifies the chemoattractant protein, interleukin 8 (IL-8/CXCL8), as a molecular target of NR4A2 in human inflammatory arthritis and examines the mechanism through which NR4A2 modulates IL-8 expression. In TNF-alpha-activated human synoviocyte cells, enhanced expression of IL-8 mRNA and protein ...

    Also Ranks for: Expression Nr4a2 |  inflammatory arthritis |  nuclear receptor |  cell nucleus |  dna binding
    KOL Index score: 12651

    Modulation by proinflammatory mediators indicate that NURR1 induction represents a point of convergence of distinct signaling pathways, suggesting an important common role for this transcription factor in mediating multiple inflammatory signals. The present study identifies NURR1 as a molecular target of methotrexate (MTX) action in human inflammatory joint disease and examines the mechanism through which MTX modulates NURR1 expression. MTX significantly suppresses expression of NURR1 in ...

    Also Ranks for: Nurr1 Expression |  nuclear receptor |  human inflammatory |  adenosine a2a |  joint disease
    KOL Index score: 11702

    OBJECTIVE: To compare ultrasonography (US) with clinical examination in the detection of entheseal abnormality of the lower limb in patients with spondyloarthropathy (SpA).

    METHODS: 35 patients with SpA (ankylosing spondylitis 27; psoriatic arthritis 7; reactive arthritis 1) underwent independent clinical and ultrasonographic examination of both lower limbs at five entheseal sites-superior pole and inferior pole of patella, tibial tuberosity, Achilles tendon, and plantar aponeurosis. US ...

    Also Ranks for: Lower Limb |  clinical examination |  entheseal insertions |  psoriatic arthritis |  spondyloarthropathy spa
    KOL Index score: 11671

    OBJECTIVE: To conduct a robust, double-blind, placebo-controlled study examining the effects of tumor necrosis factor (TNF) modulation on concentrations of traditional and novel cardiovascular disease risk factors in patients with an inflammatory condition.

    METHODS: In this double-blind study, 127 patients with psoriatic arthritis (PsA) and active psoriasis were randomized to 1 of 3 treatment arms (placebo, onercept 50 mg, or onercept 100 mg for 12 weeks). Traditional and novel ...

    Also Ranks for: Tumor Necrosis Factor |  psoriatic arthritis |  cardiovascular risk |  homocysteine levels |  binding globulin
    KOL Index score: 11332

    OBJECTIVE: To document the current state of musculoskeletal US (MSUS) training and extent of implementation among rheumatologists in the member countries of EULAR.

    METHODS: An English-language questionnaire, divided into five sections (demographics, clinical use of MSUS, overall MSUS training for rheumatologists, MSUS education in the rheumatology training curriculum and education in MSUS offered by the national rheumatology society) was sent by e-mail to three different groups: (i) all ...

    Also Ranks for: Scientific Societies |  msus training |  musculoskeletal ultrasound |  member countries |  national rheumatology
    KOL Index score: 11320

    OBJECTIVE: Methotrexate is one of the most commonly used disease-modifying antirheumatic drugs in the management of psoriatic arthritis (PsA). Despite the differences between the inflammation in PsA and rheumatoid arthritis (RA), the effects of methotrexate on the synovium have been described solely in RA. In this study, we sought to determine the effects of methotrexate on the inflammatory infiltrate and on cytokine and metalloproteinase gene expression in the synovium of PsA ...

    Also Ranks for: Psoriatic Arthritis |  patients psa |  cytokine expression |  inflammatory infiltrate |  effects methotrexate
    KOL Index score: 11270

    OBJECTIVE: To analyze S-100 protein expression, in the form of myeloid-related protein 8 (MRP8), MRP14, and the heterodimer MRP8/MRP14, in psoriatic arthritis (PsA) patients compared with rheumatoid arthritis (RA) and spondylarthropathy (SpA) patients, and to determine the effect of methotrexate (MTX) on the MRP antigen expression in PsA patients.

    METHODS: Serum, synovial fluid (SF), and synovium (taken at arthroscopy) samples were obtained from PsA (before and after MTX treatment), RA, ...

    Also Ranks for: Psoriatic Arthritis |  psa patients |  mrp8 mrp14 |  synovial membrane |  illness spondylitis
    KOL Index score: 10992

    OBJECTIVE: To evaluate microscopic measures of inflammation in rheumatoid arthritis synovial tissue samples selected at arthroscopy compared with those obtained blindly by needle biopsy from the suprapatellar pouch (SPP) of the same joint.

    METHODS: Samples were selected at knee arthroscopy from the SPP and the lateral and medial gutters. Immediately following arthroscopy, a biopsy needle was inserted through the same portal into the SPP by a second investigator, and 3 further samples ...

    Also Ranks for: Needle Biopsy |  synovial membrane |  rheumatoid arthritis |  macrophage infiltration |  lining layer
    KOL Index score: 10735

    OBJECTIVES: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA.

    METHODS: A total of 15 single nucleotide polymorphisms were selected ...

    Also Ranks for: Psoriatic Arthritis |  psa psoriasis |  evidence association |  ptpn22 susceptibility |  genetic loci
    KOL Index score: 10296

    OBJECTIVE: A common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of psoriasis vulgaris (PsV). One previous report found no association of the deletion with psoriatic arthritis (PsA), suggesting it may be a specific risk factor for PsV. Given the genetic overlap between PsA and PsV, a study was undertaken to investigate whether single ...

    Also Ranks for: Psoriatic Arthritis |  psa psv |  cornified envelope |  linkage disequilibrium |  snps rs4112788
    KOL Index score: 10132

    OBJECTIVE: To assess the intra- and interobserver reproducibility of musculoskeletal ultrasonography (US) in detecting inflammatory shoulder changes in patients with rheumatoid arthritis, and to determine the agreement between US and the Shoulder Pain and Disability Index (SPADI) and the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, using magnetic resonance imaging (MRI) as a gold standard.

    METHODS: Eleven rheumatologists investigated 10 patients in 2 rounds ...

    Also Ranks for: Rheumatoid Arthritis |  shoulder synovitis |  magnetic resonance imaging |  gold standard |  musculoskeletal ultrasonography
    KOL Index score: 9906

    OBJECTIVE: Rigorously ascertained cases of psoriatic arthritis in subjects presenting to a rheumatology unit were compared with cases of psoriasis in subjects presenting to a dermatology unit, where subjects with musculoskeletal features were excluded, to address 1) the extent to which the contribution of the major histocompatibility complex (MHC) to psoriatic arthritis susceptibility resembles that in psoriasis, and 2) whether MHC genes determine quantitative traits within the psoriatic ...

    Also Ranks for: Psoriatic Arthritis |  patients psoriasis |  hla associations |  genetic heterogeneity |  alleles haplotypes


    David John Kane: Influence Statistics

    Sample of concepts for which David John Kane is among the top experts in the world.
    Concept World rank
    msus modular #1
    basic training msus #1
    shoulders palpation #1
    diagnosis enthesitis #1
    diagnosis hip effusion #1
    pdus vegf #1
    studies longerterm outcome #1
    substantial examination #1
    msus imaging #1
    c19gra #1
    performed msus #1
    mortality outcomes people #1
    msus rheumatologist #1
    clinicbased msus #1
    c19gra provider registry #1
    msus practices rheumatologist #1
    60 standard views #1
    guided injection #1
    rheumatologist requested #1
    studies early psa #1
    rheumatologist stethoscope #1
    msusguided 6 weeks #1
    accuracy joint injection #1
    efficacy ultrasound guidance #1
    compare ultrasonography #1
    requested rheumatologists #1
    vegf membrane ultrasonography #1
    northern ireland msus #1
    radiologist msus #1
    enthesitis msus #1
    steroid arm week #1
    early stages psa #1
    rheumatologist msus #1
    basic scanning #1
    radiologist requested #1
    range gsus score #1
    total 3600 images #1
    case bursae #1
    total pdus score #1
    training musculoskeletal ultrasound #1

    Key People For Psoriatic Arthritis

    Top KOLs in the world
    D Gladman Gladman
    psoriatic arthritis systemic lupus erythematosus patients psa
    Philip J Mease
    psoriatic arthritis eli lilly novartis pfizer
    Philip S Helliwell
    psoriatic arthritis tight control axial involvement
    Oliver M FitzGerald
    psoriatic arthritis synovial tissue patients psa
    Christopher T Ritchlin
    psoriatic arthritis radiographic progression janssen development
    Paul Emery
    rheumatoid arthritis ankylosing spondylitis radiographic progression

    David John Kane:Expert Impact

    Concepts for whichDavid John Kanehas direct influence:Psoriatic arthritis,  Musculoskeletal ultrasound,  Rheumatoid arthritis,  Rheumatic disease,  Psoriatic arthritis psa,  Elementary lesions,  Plantar fasciitis,  Inflammatory arthritis.

    David John Kane:KOL impact

    Concepts related to the work of other authors for whichfor which David John Kane has influence:Psoriatic arthritis,  Plantar fasciitis,  Musculoskeletal ultrasound,  Synovial tissue,  Clinical remission,  Patients psa,  Ankylosing spondylitis.



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    Clinical Medicine, Trinity College Dublin, Dublin, Ireland | Department of Rheumatology, Tallaght University Hospital | Department of Rheumatology, Tallaght University Hospital, Dublin, Ireland | Trinity College Dublin, Dublin, Ireland | Trinity Coll