JoAnne L Flynn: Influence Statistics

JoAnne L Flynn

JoAnne L Flynn

Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA | Center for Vaccine ...

JoAnne L Flynn: Expert Impact

Concepts for which JoAnne L Flynn has direct influence: Mycobacterium tuberculosis , Tuberculosis infection , Cynomolgus macaques , Latent tuberculosis , Lymph nodes , Lung granulomas , Mycobacterium tuberculosis infection .

JoAnne L Flynn: KOL impact

Concepts related to the work of other authors for which for which JoAnne L Flynn has influence: Mycobacterium tuberculosis , Immune response , Dendritic cells , Nitric oxide , Mycobacterial infection , Necrosis factor , Animal models .

KOL Resume for JoAnne L Flynn

Year
2022

Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Lead contact

2021

Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, 15260, United States

2020

Department of Microbiology & Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA

Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

2019

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;

2018

School of Medicine University of Pittsburgh, 3501 5th Avenue, 15261 Pittsburgh, United States of America

2017

Department of Microbiology and Molecular Genetics, 450 Technology Drive

University of Pittsburgh School of Medicine, 15261, Pittsburgh, Pennsylvania, USA

2016

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219.

2015

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.

2014

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA

2013

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261;

2012

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; and

2011

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, W1144 Biomedical Science Tower, 15261, Pittsburgh, PA, USA

2010

JoAnne Flynn is at the Department of Molecular Genetics and Biochemistry, Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

Fleming Professor of Medical Microbiology, Imperial College, and Division of Mycobacterial Research, MRC National Institute for Medical Research, London, United Kingdom

Departments of Microbiology and Molecular Genetics and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

2009

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, USA

2008

Molecular Genetics and Biochemistry

2007

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA, USA

University of Pittsburgh School of Medicine, W1157 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261

2006

Department of Immunology, University of Pittsburgh, 200 Lothrop Street, BST E1048, 15261, Pittsburgh, PA

2005

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Division of Allergy, Immunology and Infectious Diseases, Children's Hospital of Pittsburgh, USA

2004

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, and

Prominent publications by JoAnne L Flynn

KOL-Index: 16653 . It is estimated that one-third of the world's population is infected with Mycobacterium tuberculosis. Infection typically remains latent, but it can reactivate to cause clinical disease. The only vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG), is largely ineffective, and ways to enhance its efficacy are being developed. Of note, the candidate booster vaccines currently under ...
Known for Tuberculosis Infection | Multistage Vaccine | Bcg H56 | Cynomolgus Macaques
KOL-Index: 15204 . IFN-γ is necessary in both humans and mice for control of Mycobacterium tuberculosis. CD4 T cells are a significant source of IFN-γ during acute infection in mice and are required for control of bacterial growth and host survival. However, several other types of cells can and do produce IFN-γ during the course of the infection. We sought to determine whether IFN-γ from sources other than ...
Known for Tuberculosis Infection | Cd4 Cells | Ifn Γ | Knockout Mice
KOL-Index: 14616 . Several lines of evidence suggest that CD8 T cells are important in protection against tuberculosis. To understand the function of this cell population in the immune response against Mycobacterium tuberculosis, T cells from lungs of M. tuberculosis-infected mice were examined by flow cytometry. The kinetics of the appearance of CD8 T cells in lungs of infected mice closely paralleled that ...
Known for Cd8 Cells | Infected Mice | Mycobacterium Tuberculosis | Gamma Interferon Ifngamma
KOL-Index: 13042 . The control of acute and chronic Mycobacterium tuberculosis infection is dependent on CD4(+) T cells. In a variety of systems CD8(+) T cell effector responses are dependent on CD4(+) T cell help. The development of CD8(+) T cell-mediated immune responses in the absence of CD4(+) T cells was investigated in a murine model of acute tuberculosis. In vitro and in vivo, priming of ...
Known for Cd4 Cells | Mycobacterium Tuberculosis | Wildtype Mice | Lymphocytes Cytotoxic
KOL-Index: 12913 . The contribution of CD8(+) T cells to the control of tuberculosis has been studied primarily during acute infection in mouse models. Memory or recall responses in tuberculosis are less well characterized, particularly with respect to the CD8 T-cell subset. In fact, there are published reports that CD8(+) T cells do not participate in the memory immune response to Mycobacterium ...
Known for Cd8 Cells | Memory Immune Response | Mycobacterium Tuberculosis Tuberculosis | Immune Mice
KOL-Index: 12690 . OBJECTIVE: An increased risk of tuberculosis has been documented in humans treated with tumor necrosis factor alpha (TNFalpha)-neutralizing agents. In murine models, impaired signaling by TNF causes exacerbation of both acute and chronic infection associated with aberrant granuloma formation and maintenance. This study was undertaken to investigate immune modulation in the setting of TNF ...
Known for Tuberculosis Infection | Necrosis Factor | Monoclonal Antibodies | Latent Mycobacterium
KOL-Index: 12422 . Granulomas, focal accumulations of immune cells, form in the lung during Mycobacterium tuberculosis infection. Chemokines, chemotactic cytokines, are logical candidates for inducing migration of T lymphocytes and monocytes to and within the lung. TNF influences chemokine expression in some models. TNF-deficient mice infected with M. tuberculosis are highly susceptible to disease, and ...
Known for Mycobacterium Tuberculosis Infection | Chemokine Expression | Granuloma Formation | Immune Cells
KOL-Index: 12375 . The development of a portfolio of COVID-19 vaccines to vaccinate the global population remains an urgent public health imperative1. Here we demonstrate the capacity of a subunit vaccine, comprising the SARS-CoV-2 spike protein receptor-binding domain displayed on an I53-50 protein nanoparticle scaffold (hereafter designated RBD–NP), to stimulate robust and durable neutralizing-antibody ...
Known for Protective Immunity | Neutralizing Antibodies | Spike Glycoprotein | Protection Sarscov2
KOL-Index: 12359 . Tuberculosis is a major cause of death in much of the world. Current estimates are that one-third of the world's population is infected with Mycobacterium tuberculosis. Most infected persons control the infection but in many cases may not eliminate the organism. Reactivation of this clinically latent infection is responsible for a large proportion of active tuberculosis cases. A major risk ...
Known for Nitric Oxide | Interferon Γ | Cd4 Cells | Latent Tuberculosis
KOL-Index: 12321 . CD8+ T lymphocytes have been implicated in the protective immune response against human and murine tuberculosis. However, the functional role that this cell subset plays during the resolution of infection remains controversial. In this study, we demonstrate the presence of Mycobacterium tuberculosis-specific CD8+ CTL in the lungs and lung-draining lymph nodes of mice infected with M. ...
Known for Infected Macrophages | Cytotoxic Tuberculosis | Cd8 Ctl | Inbred C57bl Mice
KOL-Index: 11933 . The chemokine receptor CXCR3 plays a significant role in regulating the migration of Th1 cells. Given the importance of Th1 immunity in the control of tuberculous infection, the results of the present study demonstrating that CXCR3-deficient BALB/c mice are more resistant to Mycobacterium tuberculosis, compared with wild-type mice, is surprising. This enhanced resistance manifests in the ...
Known for Tuberculosis Infection | Chemokine Receptor | Cxcr3 Mice | Chronic Phase
KOL-Index: 11903 . In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is an effective treatment for TB. However, extended LZD use can lead to LZD-associated host toxicities, most commonly bone marrow suppression. ...
Known for Linezolid Therapy | Lzd Macaques | Tuberculosis Infection Il1 | Early Immunity
KOL-Index: 11612 . Macrophages in granulomas are both antimycobacterial effector and host cell for Mycobacterium tuberculosis, yet basic aspects of macrophage diversity and function within the complex structures of granulomas remain poorly understood. To address this, we examined myeloid cell phenotypes and expression of enzymes correlated with host defense in macaque and human granulomas. Macaque granulomas ...
Known for Nitric Oxide | Tuberculous Granulomas | Macrophage Subsets | Host Cell
KOL-Index: 11570 . Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major cellular component of TB lung granulomas and are known to play an important role in containment of Mycobacterium tuberculosis (Mtb) infection. We used cynomolgus macaques, a non-human primate model that recapitulates human TB with clinically active disease, latent infection or early infection, to ...
Known for Tuberculosis Granuloma | Cell Responses | Bacterial Burden | Inflammatory Cytokines

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Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA | Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States o