David Jayne

David Jayne

Department Of Clinical Neurosciences, University Of Cambridge, Cambridge, United Kingdom.

Direct Impact

Concepts for which David Jayne has direct influence:

mycophenolate mofetil
conventional therapy
remission induction
systemic lupus
vasculitis resistant
cyclophosphamide anca
autoimmune conditions

External impact

Concepts related to the work of other authors for which David Jayne has influence:

systemic lupus erythematosus
polymyalgia rheumatica
damage accrual
literature search
cholesterol embolism
rheumatoid arthritis
bacterial proteins

Prominent publications by David Jayne

KOL-Index: 72 This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and diagnostic value of ANCA detection in patients with connective tissue diseases, idiopathic interstitial pneumonia, autoimmune liver diseases, inflammatory bowel diseases, ...
Known for
Bowel Anti | Gbm Idiopathic | Anca Tested | Liver Inflammatory
KOL-Index: 27 OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS). BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final ...
Known for
Suitably Chosen Sets | Caregiver | Doris Task | Evaluators
KOL-Index: 26 Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) recommendations for the management of PMR. We used the Grading of Recommendations, Assessment, Development and Evaluation ...
Known for
Direction | Basic Follow-Up Investigations | Subsequent Tapering Regimens | Non-Steroidal Anti-Rheumatic Drugs
KOL-Index: 14 OBJECTIVES: The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus ...
Known for
Sle | 94 | Hispanic | 100
KOL-Index: 13 Abstract Background and Aims Rituximab is an effective therapy for induction of remission in ANCA-associated vasculitis (AAV). However, the effect of rituximab is not sustained, and subsequent relapse rates are high, especially in patients with a history of relapse. The RITAZAREM trial (ClinicalTrials.gov identifier: NCT01697267) is an international, ...
Known for
5 Level | Therapy Rituximab | Time Relapse | Pre-Specified Higher Glucocorticoid Induction
KOL-Index: 13 BACKGROUND: Surgical site infection (SSI) is the most common postoperative complication worldwide. WHO guidelines to prevent SSI recommend alcoholic chlorhexidine skin preparation and fascial closure using triclosan-coated sutures, but called for assessment of both interventions in low-resource settings. This study aimed to test both interventions in low-income and middle-income countries. ...
Known for
Ssi Alcoholic | Non-Coated Sutures | Clean Contaminated | Triclosan-Coated Suture
KOL-Index: 12 The respiratory manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) have not been studied in detail.In this retrospective multicentre study, EGPA was defined by asthma, eosinophilia and at least one new onset extra-bronchopulmonary organ manifestation of disease.The study population included 157 patients (mean±sd age 49.4±14.1 years), with a mean±sd blood eosinophil count ...
Known for
Inhaled Oral Corticosteroid | Persistent Airflow Obstruction | 46 | Diagnosis Mean±sd
KOL-Index: 11 OBJECTIVE: To guide nosology and classification of patients with eosinophilic granulomatosis with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. METHODS: Organ manifestations and ANCA status were retrospectively analyzed based on the presence or not of predefined definite vasculitis features or surrogates of vasculitis in patients asthma, eosinophilia, and at least ...
Known for
Systemic Organ Manifestation | 53 | 41 | Vasculitis Presence
KOL-Index: 11 OBJECTIVE: To develop and validate classification criteria for microscopic polyangiitis (MPA). METHODS: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate items using consensus methodology, 2) prospective collection of candidate items present at the time of diagnosis, 3) data-driven ...
Known for
10 Items | Anti-Myeloperoxidase-Anca Positivity | International | Comparators Set

Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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