Neil P SMITH: Influence Statistics

Neil P SMITH

Neil P SMITH

Skin Tumour Unit, St. John's Institute of Dermatology, St. Thomas' Hospital, London, UK | Depts of Dermatology, St John's Institute of Dermatology, St Thomas's Hospital, ...

Neil P SMITH: Expert Impact

Concepts for which Neil P SMITH has direct influence: Mycosis fungoides , Chronic actinic dermatitis , Desmoplastic malignant melanoma , Sézary syndrome , Cutaneous lymphoma , Sezary syndrome , P53 immunoreactivity .

Neil P SMITH: KOL impact

Concepts related to the work of other authors for which for which Neil P SMITH has influence: Mycosis fungoides , Eosinophilic cellulitis , Sézary syndrome , Dermatofibrosarcoma protuberans , Lymphomatoid papulosis , Cell lymphoma , Erythema elevatum diutinum .

KOL Resume for Neil P SMITH

Year
1997

Skin Tumour Unit, St. John's Institute of Dermatology, St. Thomas' Hospital, London, UK

1996

Dermatopathology Unit, St John's Institute of Dermatology. St Thomas' Hospital. Lumbeth Palace Road. London SE1 7EH, U.K.

St John's Dermatology Centre, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH UK

1995

St Thomas' Campus, London, U.K.

1994

From the Skin Tumour Unit, St. John’s Institute of Dermatology, St. Thomas’ Hospital, London, United Kingdom

St John's Dermatology Centre, St Thomas' Hospital, London, U.K.

1993

St John's Dermatology Centre, St Thomas' Hospital, Lambeth Palace Road SEI 7EH, U.K

London, United Kingdom

1992

St John's Dermatology Centre, St Thomas' Hospital, London

1991

Laboratory of Molecular Genetics, Department of Haematology, Hammersmith Hospital and St Johns Hospital for Diseases of Skin, London, U.K.

London, England

1990

St. John's Hospital for Diseases of the Skin, London

1989

St John's Hospital for Diseases of the Skin, London WC2H 7BJ, UK

1986

Unit of Dermatology, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.

The Institute of Dermatology, Lisle Street, London

1985

St John's Hospital for Diseases of the Skin, London

1981

Department of Histopathology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ

1980

Department of Histopathology, St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2

1979

St Thomas' Hospital, Lambeth Palace Road, London SE17EH and St John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London WC2H 7BJ

Prominent publications by Neil P SMITH

KOL-Index: 13986 . The authors have analyzed the configuration of immunoglobulin (Ig) and beta, gamma and delta T-cell receptor (TCR) genes in DNA extracted from skin, lymph nodes, and peripheral blood mononuclear cells obtained from 41 patients with mycosis fungoides (MF), 14 patients with Sezary syndrome, and 13 patients with benign inflammatory dermatoses. No discrete rearranged bands (DRB) were detected ...
Known for Cell Receptor | Mycosis Fungoides | Sezary Syndrome | Patients Mf
KOL-Index: 10384 . Using a panel of seven cell markers, we studied the value of immunocytochemical labelling in the histological diagnosis of desmoplastic malignant melanoma. Sections from routine formalin-fixed tissue of 45 surgical specimens were obtained from 25 cases of malignant melanoma that showed well-marked desmoplastic or neurotropic features. Routinely stained sections (Haematoxylin- and -eosin ...
Known for Malignant Melanoma | 25 Cases | Neoplasm Antigens | S100 Proteins
KOL-Index: 7568 . To investigate the histogenesis of lymphomatoid papulosis (LYP), we have analyzed the configuration of the beta, gamma, and delta T-cell receptor (TCR) and Ig genes in DNA from 31 biopsies of 18 patients with this condition and also from peripheral blood mononuclear cells of eight of these patients. Immunoglobulin genes were in a germ-line configuration in all patients, and TCR genes were ...
Known for Lymphomatoid Papulosis | Patients Lyp | Tcr Genes | Germline Configuration
KOL-Index: 7035 . Three patients with cutaneous T-cell lymphoma (CTCL) are reported who had concurrent B-cell chronic lymphocytic leukaemia (B-CLL). The separate lineage and clonal nature of the individual lymphoid malignancies were confirmed by gene-rearrangement analysis. The chronology of the illnesses did not support the hypothesis that CTCL predisposes to the development of B-cell proliferative ...
Known for Cell Lymphoma | Chronic Lymphocytic | Cutaneous Male Neoplasms | Gene Rearrangement
KOL-Index: 6589 . Histological interpretation of frozen sections made during Mohs' micrographic surgery may be difficult, depending on the morphological and staining characteristics of the tumour and on the nature of the associated inflammatory infiltrate. We have employed an adaptation of micrographic surgery in which horizontal, formalin-fixed, paraffin-embedded sections were used to improve histological ...
Known for Micrographic Surgery | Frozen Sections | Merkel Cell Carcinoma | Horizontal Paraffin
KOL-Index: 5719 . Sezary syndrome is an uncommon variant of cutaneous T-cell lymphoma (CTCL) characterized by erythroderma, pruritus, adenopathy, and circulating atypical T-lymphocytes with cerebriform nuclei. The definition of Sezary syndrome can be further refined by including only patients with a circulating peripheral blood population of clonal T-cells. We have evaluated 79 skin biopsies from such a ...
Known for Sézary Syndrome | Cell Clone | Skin Biopsies | Erythrodermic Patients
KOL-Index: 5557 . Peripheral blood mononuclear cells from two well-defined groups of patients with the Sézary syndrome have been studied employing indirect immunofluorescent and indirect immunogold techniques in light and electron microscopy, using monoclonal antibodies against T-cell subpopulations. Four patients had chronic actinic dermatitis (CAD) of the actinic reticuloid variant, with erythroderma. ...
Known for Sézary Syndrome | Chronic Actinic Dermatitis | Cutaneous Tcell Lymphoma | Suppressor Cells
KOL-Index: 5316 . Expression of the p53 tumor suppressor gene product was determined in keratoses and skin cancers associated with psoralen photochemotherapy (PUVA). An immunocytochemical study was employed using CM-1 (polyclonal) and Do-1 (monoclonal) antibodies to human wild-type p53. Thirty-two cutaneous lesions and 20 perilesional PUVA-irradiated skin biopsies were examined from 7 patients, all of whom ...
Known for P53 Immunoreactivity | Skin Neoplasms | Puva Therapy | Immunocytochemical Study
KOL-Index: 5182 . Expression of the lymphocyte homing receptor CD44 and its splice variants have been linked to tumour dissemination and poor prognosis in non-Hodgkin's lymphoma. Specifically, the in vitro expression of variant exon V6 confers metastatic potential in rat pancreatic carcinoma cell lines. In this study, we investigated the expression of CD44 splice variants in cutaneous T-cell lymphomas, ...
Known for Cell Lymphoma | Cd44 Variant | Lichen Planus | Expression Cutaneous
KOL-Index: 5165 . The role of locally released cytokines in inducing lymphocyte activation and infiltration in the skin lesions of mycosis fungoides has been investigated. The levels of selected cytokines were measured in chamber fluid samples from lesional and control skin. Biologically active interleukin 6 was significantly elevated in lesional samples and a recombinant form of this cytokine was shown to ...
Known for Mycosis Fungoides | Transudates Female Humans | Interleukin 6 | Skin Lesions
KOL-Index: 4837 . Cellular neurothekeoma is a recently recognized benign cutaneous neoplasm, which is currently regarded as being of nerve sheath origin and is thought to represent a variant of conventional neurothekeoma (dermal nerve sheath myxoma). Nine new cases presenting predominantly in adolescents or young adults are described. Morphologically they were characterized by short fascicles or small nests ...
Known for Cellular Neurothekeoma | Epithelioid Variant | S100 Protein | Immunohistochemical Analysis
KOL-Index: 4637 . p53 gene mutation appears to play an important role in the development of systemic lymphoma, and may be associated with tumour progression. Its role in cutaneous lymphoma is currently unknown. We examined p53 expression in 55 biopsies of cutaneous lymphoma, including patch-, plaque- and tumour-stage mycosis fungoides (MF), T- and B-cell lymphoma and lymphomatoid papulosis. Strong, ...
Known for Cutaneous Lymphoma | P53 Expression | Mycosis Fungoides | Gene Mutation
KOL-Index: 4231 . Multinucleate cell angiohistocytoma is a newly described benign vascular condition that usually arises on the extremities of women over the age of 40 as discrete grouped violaceous erythematous papules, often mimicking Kaposi's sarcoma. Of 10 patients, nine were women aged between 37-66 (average 51.5) years at the onset of their condition. The legs, and in particular the calves and thighs, ...
Known for Multinucleate Cell | Kaposis Sarcoma | Differential Female Histiocytoma | Kaposi Skin
KOL-Index: 4096 . The clinicopathological features of eight patients with cutaneous disease associated with HTLV-1 infection are reviewed. All were U.K. residents of West Indian extraction, and two are currently alive. Disease remained confined to the skin in two patients. Five patients with a cutaneous prodromal phase developed leukaemia after a median duration of 124 months (3 months-21 years), and in one ...
Known for Leukemia Lymphoma | Southern Dna | Skin Lesions | Cutaneous Cell
KOL-Index: 3849 . We have studied four patients from two families and obtained the clinical data from four other affected family members who demonstrated the coexistence of multiple cylindromas and trichoepitheliomas. An autosomal dominant pattern of inheritance with variable penetrance was exhibited in both families, with a female to male ratio of 3:1. The clinical and pathological features of this rare ...
Known for Brooke‐spiegler Syndrome | Multiple Cylindromas Trichoepitheliomas | Aged Neoplasms | Female Male

Key People For Mycosis Fungoides

Top KOLs in the world
#1
Rein Willemze
mycosis fungoides cell lymphoma sézary syndrome
#2
Eric C Vonderheid
mycosis fungoides sézary syndrome cell lymphoma
#3
Sean J Whittaker
mycosis fungoides sézary syndrome cell lymphoma
#4
Lorenzo Cerroni
mycosis fungoides cell lymphoma skin neoplasms
#5
Günter Burg
cutaneous lymphomas mycosis fungoides cell lymphoma
#6
Robert Martin Knobler
extracorporeal photopheresis host disease mycosis fungoides

Skin Tumour Unit, St. John's Institute of Dermatology, St. Thomas' Hospital, London, UK | Depts of Dermatology, St John's Institute of Dermatology, St Thomas's Hospital, London, UK | Dermatopathology Unit, St John's Institute of Dermatology. St Thoma