Lei Lei Lin

Recent evidence has identified disrupted in schizophrenia-1 (DISC1) as an important genetic risk factor for the development of many psychiatric disorders, including major depressive disorders. In addition, studies using animal models have demonstrated that chronic stress affects hippocampal structure and function. However, the functional effects of chronic stress on DISC1 remain unknown. Using a chronic mild stress (CMS) paradigm, we investigated the effects of CMS on depressive-like ...

In this paper, we propose a novel approach for the compression of multichannel electroencephalograph (EEG) signals. The method assumes that EEG signals are the linear mixture of several independent components (ICs). To retain the ICs, the proposed scheme first applies an independent component analysis (ICA) with a preprocessing step of principal component analysis (PCA) to EEG signals. Then the compression scheme is composed of two parts: the ICs compression part and the residue ...

In recent years, the rapid increase in natural gas consumption and huge dependency on foreign gas have forced China to speed up the process of natural gas pricing reform. The price-gap approach is applied to estimate China’s natural gas subsidies, and the results indicate that China's natural gas subsidies increased from CNY 93.341 billion in 2010 to CNY 188.537 billion in 2012. We also apply the input-output model and find that a natural gas price increase of 10–15 percent has less ...

OBJECTIVE: To explore the prospective correlation between serum metals before 24 weeks' gestation and gestational diabetes mellitus (GDM) or glucose in the late second trimester among southern Chinese pregnant women.

METHODS: A total of 8169 pregnant women were included in our retrospective cohort study. Logistic regression was used to investigate the relationships between metals (Manganese [Mn], copper [Cu], lead [Pb], calcium [Ca], zinc [Zn], magnesium [Mg]) and GDM. Quantile ...

BACKGROUND: Type XI collagen (COL11A1) was reported to associate with malignancy in several cancer types, whereas its role in lung cancer is not fully understood. Therefore, the present study aimed to explore the expression level and biological role of COL11A1 in lung cancer cells.

METHODS: Gene Expression Omnibus (GEO) database containing 6 lung cancer tissues and normal lung tissues was used to identify potential aberrantly expressed genes. The expression of COL11A1, apoptosis related ...

Advancements in 3D-Flash memory-layer-stacking technology has enabled density scaling that circumvents the lithography limitations which have prevented 2D-NAND Flash memory from scaling [1]. Bit densities as high as 5.95Gb/mm2 on a single die were recently reported [2], where a 512Gb NAND Flash was built on 96 layers of memory. As memory density increases, with memory layers increasing from 96 layers to 128 layers, higher bit density can be achieved by adopting larger capacity die; ...

BACKGROUND: Subthreshold depression (StD) is a prevalent condition that may increase the risk of incident major depressive disorder (MDD). However, the relationship between StD and MDD remains unclear.

METHODS: A total of 153 adult subjects, including 53 drug-naive MDD, 50 StD and 50 healthy control (HC) subjects, underwent a T1-weighted magnetic resonance imaging scan, and the gray matter volume (GMV) alterations among the three groups were quantitatively analyzed using voxel-based ...

The Bohai Sea is a large, semi-enclosed bay of China with a transport timescale of more than 1 year. Residence time (RT) is an important indicator used to determine the water exchange rate of coastal oceans, and it has a significant influence on coastal ecosystems and the environment. In this study, the RT and its seasonal variability within the Bohai Sea were investigated using a 3-D hydrodynamic model and the adjoint method of the RT. The model results show that the annual mean RT in ...

Intrusive complexes with compositional diversity commonly document magma mixing processes and provide insights into regional magmatism and tectonics. Here, we present an integrated study involving detailed field investigations, petrography, mineral chemistry, whole-rock geochemistry, SrNd isotopic compositions, and zircon U–Pb–Hf isotopes for the Quxu intrusive complex in southern Tibet, with the aim of constraining the origin of the complex and gaining insights into the early Eocene ...

Layered tin diselenide (SnSe2) is of high interest to material scientists because it is an n-type semiconductor with a narrow bandgap. In this letter, we prepared single-phase SnSe2 films and investigated the lateral photovoltaic effect (LPE) in SnSe2/p-Si junctions. The XRD, XPS, and Raman spectra confirm that the SnSe2 film is of high quality. The LPE shows a linear dependence on the position of the laser spot. The observed position sensitivity is as high as 364.5 mV mm−1. The optical ...

Objective To investigate the effect of Naoxintong capsule on clinical efficacy and inflammatory factors in patients with ischemic stroke. Methods 81 patients with ischemic stroke were divided into two groups according to random number table method.40 patients in the control group were treated with treatment guidelines, and the observation group was treated with another Naoxintong capsule.The serum interleukin-10(IL-10), tumor necrosis factor-a(TNF-α), high sensitivity C reactive ...

The durability and safety of cement-treated foundation in marine environment has been drawn close attention because many offshore, coastal and marine engineering are under construction in these years. Effect of compound nano-CaCO3 addition on strength development and microstructure of cement-stabilized soil in marine environment was studied in this paper by uniaxial compressive test and micro-structure analysis methods including X-ray Diffraction Analysis (XRD), Scanning Electron ...

The 4H-SiC NPN structure with a 3-step junction termination extension (JTE), which shows a great capability for control of both the peak surface and bulk electric fields at breakdown, has been investigated and optimized using Synopsys Sentaurus, a two-dimensional (2-D) device simulator. The experimental results show that the NPN structure with an optimized 3-step JTE can accomplish a high breakdown voltage of 7630V, reaching more than 90% of the ideal parallel plane junction breakdown ...