Prominent publications by Colin E Sullivan

KOL Index score: 13241

Although obstructive sleep apnea (OSA) occurs commonly in acromegaly, we have recently reported an unexpectedly high prevalence of central sleep apnea (CSA) in these patients. Acromegalic patients with CSA have increased growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels compared with their counterparts with OSA. Studies in animals, normal humans, and patients with sleep apnea have suggested that CSA is associated with increased gain of the respiratory control system. To ...

Also Ranks for: Sleep Apnea |  growth hormone |  patients acromegaly |  carbon dioxide |  osa csa
KOL Index score: 12317

There are no reports concerning the regulation of end-expiratory lung volume (EELV) and flow-volume relationships during upper limb exercise in health and disease. We studied EELV during such exercise in 22 adults with cystic fibrosis (CF) and nine age-matched healthy control subjects. Subjects with CF were grouped according to the severity of their lung disease, as follows: mild = FEV1 > 80% predicted; moderate = FEV1 40 to 80% predicted, and severe = FEV1 < 40% predicted. EELV was ...

Also Ranks for: Leg Exercise |  cystic fibrosis |  lung volume |  normal subjects |  dynamic hyperinflation
KOL Index score: 11637

STUDY OBJECTIVES: Nasal continuous positive airway pressure (nCPAP) is the most common treatment for obstructive sleep apnea (OSA) in adults, and it has been effective in the treatment of OSA in children. We wanted to determine the effectiveness of long-term nCPAP therapy for OSA in infants.

PATIENTS: Twenty-four infants who had OSA were treated with nCPAP via nose mask. These infants had clinical histories that included a family history of sudden infant death syndrome, an apparent ...

Also Ranks for: Obstructive Sleep Apnea |  osa infants |  positive airway |  nasal continuous |  pressure cpap
KOL Index score: 11593

OBJECTIVE: To assess the frequency of obstructive sleep apnoea among women with and without hypertensive disorders of pregnancy.

DESIGN: Cohort study.

SETTING: Obstetric clinics at an academic medical centre.

POPULATION: Pregnant women with hypertensive disorders (chronic hypertension, gestational hypertension, or pre-eclampsia) and women who were normotensive.

METHODS: Women completed a questionnaire about habitual snoring and underwent overnight ambulatory polysomnography.


Also Ranks for: Obstructive Sleep |  hypertensive disorders |  women hypertension |  habitual snoring |  apnoea pregnancy
KOL Index score: 11053

BACKGROUND: Marfan's syndrome is associated with a high prevalence of obstructive sleep apnea (OSA). As this syndrome is associated with a characteristic constricted maxilla and high-arched palate, we reasoned that nasal airway constriction and resultant high nasal airway resistance (NAR) may contribute to the development of OSA. Therefore, the aim of this study was to measure NAR in patients with Marfan's syndrome. In addition, we aimed to examine the influence of maxillary morphology ...

Also Ranks for: Maxillary Constriction |  sleep apnea |  marfans syndrome |  nar marfan |  airway resistance
KOL Index score: 10743

We analyzed the polysomnographic records of 15 children and 20 infants with obstructive sleep apnea (OSA) to examine the interaction between central and obstructive breathing abnormalities and arousal from sleep. Each patient was matched for age with an infant or child who had no OSA. We found that the majority of respiratory events in infants and children was not terminated with arousal. In children, arousals terminated 39.3 +/- 7.2% of respiratory events during quiet sleep and 37.8 +/- ...

Also Ranks for: Children Osa |  respiratory events |  infants arousals |  active sleep |  arousal child
KOL Index score: 10337

PURPOSE: There is a high incidence of sleep apnea in patients with untreated hypothyroidism. Thyroxine treatment is said to significantly reduce the apnea index and length and sleep apnea symptoms. We undertook a review of 10 consecutive hypothyroid patients with sleep apnea to investigate mechanisms and management of these two disorders.

PATIENTS AND METHODS: Polysomnograms were obtained in 10 consecutive hypothyroid patients referred to our sleep disorders unit. All patients were ...

Also Ranks for: Sleep Apnea |  patients hypothyroidism |  upper airway |  positive pressure |  respiration respiratory
KOL Index score: 10326

This is a retrospective review of children 15 years of age or younger, who underwent overnight sleep studies between 1980 and 1993. All were diagnosed and treated for obstructive sleep apnea (OSA). Overnight studies were performed for OSA in 413 children. One hundred seventy-five (42.4%) children were treated with adenotonsillectomy and 80 (19.4%) with nasal mask continuous positive airway pressure (nCPAP). The proportion of male children was greater than expected in both the entire ...

Also Ranks for: Children Osa |  obstructive sleep apnea |  nasal cpap |  sleep studies |  retrospective review
KOL Index score: 10084

Although nasal continuous positive airway pressure (CPAP) is effective in the treatment of most patients with obstructive sleep apnea (OSA), there is a small group of such patients in whom rapid eye movement (REM) hypoventilation and CO2 retention persist despite the use of CPAP and supplemental oxygen. In this report we describe our experience with nocturnal nasal ventilation (nocturnal nasal positive pressure ventilation [NIPPV] in such patients and its effectiveness in reversing ...

Also Ranks for: Sleep Apnea |  positive pressure |  cpap nippv |  severe osa |  nasal ventilation
KOL Index score: 10001

Cheyne-Stokes respiration (CSR) during sleep is common in patients with congestive heart failure (CHF). This pattern of breathing fragments sleep, leading to daytime symptoms of sleepiness and fatigue. It was hypothesized that by controlling CSR with noninvasive pressure preset ventilation (NPPV), there would be a decrease in sleep fragmentation and an improvement in sleep quality. Nine patients (eight males, one female; mean +/- SD 65 +/- 11 yrs) with symptomatic CSR diagnosed on ...

Also Ranks for: Cheynestokes Respiration |  nppv patients |  congestive heart failure |  csr sleep |  airway pressure
KOL Index score: 9982

Marfan's syndrome is a hereditary disorder characterized by a defect in connective tissue, resulting in tissue laxity. It is associated with a high prevalence of obstructive sleep apnea (OSA). The aim of this study was to determine whether excessive upper airway collapsibility during sleep is an important pathophysiologic factor predisposing these individuals to OSA. We measured upper airway closing pressures (UACP) during sleep in 12 patients with Marfan's syndrome and 6 age-, and ...

Also Ranks for: Sleep Apnea |  upper airway |  patients osa |  marfans syndrome |  connective tissue
KOL Index score: 9973

Based on the theory that obstructive (OSA) and central (CSA) sleep apneas share common pathophysiologic mechanisms, we attempted to treat eight patients with predominantly CSA by continuous positive airway pressure (CPAP). All patients exhibited repetitive episodes of CSA and mixed sleep apneas (MSA) in the supine position with a mean duration of 23.7 +/- 0.7 s and 34.5 +/- 1.3 s, respectively. The pattern of apnea changed when the subject lay in the lateral position. Five patients were ...

Also Ranks for: Nasal Cpap |  csa patients |  sleep apnea |  lateral position |  aged airway

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Colin E Sullivan:Expert Impact

Concepts for whichColin E Sullivanhas direct influence:Sleep apnea,  Nasal cpap,  Obstructive sleep apnea,  Rem sleep,  Obstructive sleep,  Upper airway,  Cystic fibrosis,  Obstructive sleep apnoea.

Colin E Sullivan:KOL impact

Concepts related to the work of other authors for whichfor which Colin E Sullivan has influence:Sleep apnea,  Cystic fibrosis,  Blood pressure,  Noninvasive ventilation,  Positive airway,  Metabolic syndrome,  Heart failure.



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David Reid Laboratory, University of Sydney, NSW, Australia | Professor Emeritus, University of Sydney, Sydney, Australia | Professor Discipline of Child and Adolescent Health, The Children's Hospital at Westmead, The University of Sydney, Sydney, Ne