• Disease
  • Mast
  • Mast Cells
  • Stephen T Holgate

    Prominent publications by Stephen T Holgate

    KOL Index score: 16649

    We have shown that viruses are associated with 80 to 85% of asthma exacerbations in school-age children in the community. We hypothesize that viral infections are also associated with severe attacks of asthma precipitating hospital admissions. To investigate this, we conducted a time-trend analysis, comparing the seasonal patterns of respiratory infections and hospital admissions for asthma in adults and children. During a 1-yr study in the Southampton area of the United Kingdom, 108 ...

    Also Ranks for: Hospital Admissions |  respiratory infections |  asthma children |  united kingdom |  seasonal patterns
    KOL Index score: 16110

    We describe the effects of the antiallergic drug cromolyn sodium and the beta 2-selective adrenoceptor agonist albuterol against early and late phase changes in specific airways conductance (sGaw) and leukocyte infiltration into the airways after allergen challenge of nonanesthetized guinea pigs. Inhalation of ovalbumin by sensitized guinea pigs induced three phases of airways obstruction: an early asthmatic response (EAR) peaking at 2 h, a late response (LAR) peaking at 17 h, and a ...

    Also Ranks for: Allergen Challenge |  cromolyn sodium |  guinea pigs |  leukocyte infiltration |  ear lar
    KOL Index score: 15492

    OBJECTIVES: To assess the effect of montelukast versus salmeterol added to inhaled fluticasone propionate on asthma exacerbation in patients whose symptoms are inadequately controlled with fluticasone alone. Design and setting A 52 week, two period, double blind, multicentre trial during which patients whose symptoms remained uncontrolled by inhaled corticosteroids were randomised to add montelukast or salmeterol.

    PARTICIPANTS: Patients (15-72 years; n = 1490) had a clinical history of ...

    Also Ranks for: Asthma Exacerbation |  montelukast salmeterol |  patients symptoms |  beta agonist |  1 year
    KOL Index score: 15078

    Recurrent lower respiratory tract symptoms are common and disabling in childhood, but little is known of their natural history and relationship to asthma. We report a 12-month longitudinal study designed to determine the influence of atopy on respiratory symptoms and bronchial responsiveness in 7- and 8-yr-old children. A postal questionnaire inquiring into the presence of respiratory symptoms was sent to 3,698 children aged 7 and 8 yr. Those reporting either current wheeze (14.8%) or ...

    Also Ranks for: Bronchial Responsiveness |  respiratory symptoms |  cough wheeze |  expiratory flow |  atopy natural
    KOL Index score: 14955

    BACKGROUND: Childhood wheezing illnesses are characterized into different phenotypes. However, severity of the disease associated with these phenotypes has not been extensively studied.

    OBJECTIVES: To determine characteristics of childhood wheezing phenotypes in the first decade of life using health outcomes plus measurements of atopy, lung function and bronchial hyper-responsiveness.

    METHODS: A whole population birth cohort (n = 1456) was prospectively studied to examine the natural ...

    Also Ranks for: 10 Years |  wheezing phenotypes |  persistent wheezers |  decade life |  onset age
    KOL Index score: 14919

    BACKGROUND: Increased production of IL-4 and IL-5 and decreased production of IFN-gamma by CD4+ T cells has been implicated in asthma pathogenesis. However, CD8+ T cells also produce type 1 and type 2 cytokines and the relative roles of CD4+ and CD8+ T cell cytokine production in asthma have not been previously studied.

    OBJECTIVE: To determine the production of the type 1 and type 2 cytokines by CD4+ and CD8+ T cell subsets in asthmatic and normal subjects.

    METHODS: Intracellular ...

    Also Ranks for: Cytokine Production |  normal subjects |  cd8 cells |  type 2 |  peripheral blood
    KOL Index score: 14784

    BACKGROUND: Airway smooth muscle infiltration by mast cells is a feature of asthma and not eosinophilic bronchitis. In asthma, Th2 cytokines have been implicated as playing a critical role in the development of airway inflammation and hyper-responsiveness. Whether inflammatory cells within the airway smooth muscle release these cytokines is unknown.

    METHODS: We have undertaken a comparative immunohistochemical study in bronchial biopsies from 14 subjects with asthma, 10 with eosinophilic ...

    Also Ranks for: Airway Smooth Muscle |  mast cells |  eosinophilic bronchitis |  subjects asthma |  th2 cytokines
    KOL Index score: 14545

    Omalizumab is a humanized monoclonal anti-IgE antibody developed for the treatment of allergic disease, with established efficacy in patients with moderate-to-severe allergic asthma and in patients with intermittent (seasonal) and persistent (perennial) allergic rhinitis (AR). Omalizumab is known to result in a marked reduction in serum levels of free IgE and down-regulation of IgE receptors on circulating basophils. Recent work has shed further light on its mechanism of action, showing ...

    Also Ranks for: Allergic Diseases |  monoclonal antibodies |  patients omalizumab |  perennial rhinitis |  ige receptors
    KOL Index score: 14410

    The epidermal growth factor receptor (EGFR, c-erbB1) plays a pivotal role in maintenance and repair of epithelial tissues; however, little is known about coexpression of c-erbB receptors and their ligands in human bronchial epithelium. We therefore analyzed the expression of these molecules in cultured bronchial epithelial cells and normal bronchial mucosa, using reverse transcription-polymerase chain reaction (RT- PCR), flow cytometry, and immunohistochemistry. Messenger RNA (mRNA) ...

    Also Ranks for: Erbb Receptors |  bronchial epithelium |  egfr egf |  reverse transcriptase |  messenger rna
    KOL Index score: 14371

    Airway neutrophilia is a prominent feature of chronic obstructive pulmonary disease. As cigarette smoke (CS) and epidermal growth factor (EGF) both cause release of interleukin-8 (IL-8) from epithelial cells in vitro, we investigated whether autocrine ligands for the EGF receptor (EGFR) are involved in this proinflammatory response to CS. NCI-H292 or primary bronchial epithelial cells were cultured with or without cigarette smoke extract (CSE) or EGF for 6-48 h. We then tested culture ...

    Also Ranks for: Growth Factor |  autocrine ligands |  bronchial epithelial cells |  peptides proteins |  response cse
    KOL Index score: 14192

    Increased Th2 cytokine production in asthma is widely accepted, but excess production by asthmatic human airway CD4(+) T cells has not been demonstrated, nor has a relationship with disease severity. The importance of airway CD8(+) T cell type 1 and type 2 cytokine production in asthma is unknown. We investigated frequencies of IFN-gamma, interleukin (IL)-4 and IL-5 producing CD4(+) and CD8(+) blood and sputum T cells from normal subjects and subjects with asthma and compared between ...

    Also Ranks for: Atopic Asthma |  cd4 cells |  lymphocytes cd8 |  vitro stimulation |  cytokine production
    KOL Index score: 13885

    BACKGROUND: Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed to assess the effects of monoclonal antibody to IL-5 on blood and sputum eosinophils, airway hyper-responsiveness, and the late asthmatic reaction to inhaled allergen in patients with mild asthma.

    METHODS: We did a double-blind randomised placebo-controlled trial, in which a single intravenous infusion ...

    Also Ranks for: Monoclonal Antibody |  late asthmatic response |  airway hyper |  sputum eosinophils |  effects treatment
    KOL Index score: 13444

    BACKGROUND: Rhinovirus infections cause exacerbations of asthma. We postulated that people with asthma are more susceptible to rhinovirus infection than people without the disease and compared the susceptibility of these groups.

    METHODS: We recruited 76 cohabiting couples. One person in every couple had atopic asthma and one was healthy. Participants completed daily diary cards of upper-respiratory-tract (URT) and lower-respiratory-tract (LRT) symptoms and measured peak expiratory flow ...

    Also Ranks for: Rhinovirus Infection |  people asthma |  healthy individuals |  frequency severity |  lrt symptoms


    Stephen T Holgate: Influence Statistics

    Sample of concepts for which Stephen T Holgate is among the top experts in the world.
    Concept World rank
    eosinophils scd48 #1
    rhinoviruses rhinovirus infection #1
    brussels declaration asthma #1
    bronchoconstriction asthma #1
    increased numbers eosinophils #1
    wheezing groups #1
    adolescent wheeze #1
    absence bronchial responsiveness #1
    placebo flurbiprofen #1
    nedocromil sodium challenge #1
    airways lability #1
    adam33 #1
    asthma allergy susceptibility #1
    asthma tgfβ2 #1
    bulbar substantia propria #1
    sensitized asthmatic airways #1
    vehicle bradykinin #1
    abc mast cells #1
    terfenadine combination #1
    airways healthy subjects #1
    bronchial provocation 90 #1
    scg gastrointestinal tract #1
    inhaled nebulised interferon #1
    il13ralpha2 il4ralpha #1
    terfenadine flurbiprofen #1
    cfs diagnostic test #1
    infection normal subjects #1
    adam33 polymorphism #1
    asthma il13 receptor #1
    shil4ralpha #1
    salbutamol lar #1
    fcεri‐α #1
    persistent wheezing adolescence #1
    non‐bronchoconstrictor #1
    histamine bradykinin #1
    montelukast leukotriene antagonist #1
    common gene #1
    allergen‐induced inflammation #1
    icam1 desloratadine #1
    control study day #1
    nedocromil sodium scg #1
    response deps #1
    baseline airway caliber #1
    q029 #1
    histamine nar #1
    bronchial biopsy evidence #1
    polylysine a23187 #1
    asthmatics antigen challenge #1
    smooth statistics #1

    Key People For Mast Cells

    Top KOLs in the world
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    mast cells stem cell factor inbred balb mice
    Dean Darrel Metcalfe
    mast cells bone marrow stem cell factor
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    mast cells leukotriene c4 chondroitin sulfate
    Lawrence B Schwartz
    mast cells tryptase levels hypereosinophilic syndrome
    Theoharis Constantin Theoharides
    mast cells interstitial cystitis acute stress

    Stephen T Holgate:Expert Impact

    Concepts for whichStephen T Holgatehas direct influence:Mast cells,  Mast cell,  Nedocromil sodium,  Bronchial epithelium,  Asthmatic subjects,  Allergen challenge,  Severe asthma,  Epithelial cells.

    Stephen T Holgate:KOL impact

    Concepts related to the work of other authors for whichfor which Stephen T Holgate has influence:Mast cells,  Air pollution,  Severe asthma,  Allergic rhinitis,  Lung function,  Nitric oxide,  Inhaled corticosteroids.



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    MRC Clinical, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK | NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine,