 | Steven C LeClerq |
Prominent publications by Steven C LeClerq
Year-round influenza immunisation during pregnancy in Nepal: a phase 4, randomised, placebo-controlled trial
[ PUBLICATION ]
BACKGROUND: Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year.
METHODS: In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal. We randomised ...
| Also Ranks for: Influenza Immunisation | vaccine placebo | women infants | controlled trial | infant low |
Iron deficiency is one of the main causes of anemia during pregnancy, although other micronutrient deficiencies may play a role. We examined the effects of daily antenatal and postnatal supplementation with four combinations of micronutrients on maternal hematologic indicators in a double-masked randomized controlled community trial. Communities, called sectors, were randomly assigned to supplementation with folic acid (400 microg), folic acid plus iron (60 mg), folic acid plus iron and ...
| Also Ranks for: Folic Acid | iron zinc | hematologic status | pregnant women | rural nepal |
Background:Classification of infants into low birth weight (LBW, <2500 g) or very low birth weight (VLBW, <2000 g) categories is a crucial step in targeting interventions to high-risk infants.Objective:To compare the validity of chest circumference and foot length as surrogate anthropometric measures for the identification of LBW and VLBW infants.Subjects and setting:Newborn infants (n=1640) born between March and June 2004 in 30 Village Development Committees of Sarlahi district, ...
| Also Ranks for: Foot Length | chest circumference | birth weight | anthropometric measures | newborn infant |
INTRODUCTION: Iron deficiency is widespread in the developing world and is especially common in young children who live on the Indian subcontinent. Supplementation with iron and folic acid alleviates severe anaemia and enhances neurodevelopment in deficient populations, but little is known about the risks of mortality and morbidity associated with supplementation.
METHODS: We did a community-based, cluster-randomised, double-masked, placebo-controlled, 2x2 factorial trial in children ...
| Also Ranks for: Southern Nepal | folic acid | child mortality | zinc iron | controlled trial |
OBJECTIVE: To assess the impact on mortality related to pregnancy of supplementing women of reproductive age each week with a recommended dietary allowance of vitamin A, either preformed or as beta carotene.
DESIGN: Double blind, cluster randomised, placebo controlled field trial.
SETTING: Rural southeast central plains of Nepal (Sarlahi district).
SUBJECTS: 44 646 married women, of whom 20 119 became pregnant 22 189 times.
INTERVENTION: 270 wards randomised to 3 groups of 90 each for ...
| Also Ranks for: Mortality Pregnancy | beta carotene | women vitamin | cluster randomised | dietary supplements |
Prenatal Micronutrient Supplementation and Intellectual and Motor Function in Early School-aged Children in Nepal
[ PUBLICATION ]
CONTEXT: Iron and zinc are important for the development of both intellectual and motor skills. Few studies have examined whether iron and zinc supplementation during gestation, a critical period of central nervous system development, affects children's later functioning.
OBJECTIVE: To examine intellectual and motor functioning of children whose mothers received micronutrient supplementation during pregnancy.
DESIGN, SETTING, AND PARTICIPANTS: Cohort follow-up of 676 children aged 7 to 9 ...
| Also Ranks for: Micronutrient Supplementation | motor function | iron folic acid | aged children | adjusted difference |
BACKGROUND: We previously reported that a randomized controlled trial of antenatal micronutrient supplements in rural Nepal decreased the risk of low birth weight by approximately 15%.
OBJECTIVE: The objective was to examine the effects of micronutrient supplementation on growth and body composition in children of supplemented mothers through school age.
DESIGN: Mothers received 1 of 5 micronutrient supplements daily: folic acid, folic acid + iron, folic acid + iron + zinc, multiple ...
| Also Ranks for: Folic Acid | rural nepal | linear growth | weight age | micronutrient supplementation |
BACKGROUND: Among the most important causes of illness and death in both pregnant women and their newborn infants are respiratory infections including influenza. Pregnant women in North America have a 4 to 5 fold excess rate of hospitalization compared to non-pregnant women. Rates of infant hospitalization associated with influenza are much higher than in their mothers. Fully half of children hospitalized for influenza in the US are in the age group 0-5 months, a group where no vaccine ...
| Also Ranks for: Influenza Immunization | rural nepal | pregnant women | respiratory illness | mothers infants |
Antenatal supplementation with micronutrients and biochemical indicators of status and subclinical infection in rural Nepal.
[ PUBLICATION ]
BACKGROUND: Previously we showed that women in rural Nepal experience multiple micronutrient deficiencies in early pregnancy.
OBJECTIVE: This study examined the effects of daily antenatal micronutrient supplementation on changes in the biochemical status of several micronutrients during pregnancy.
DESIGN: In Nepal, we conducted a randomized controlled trial in which 4 combinations of micronutrients (folic acid, folic acid + iron, folic acid + iron + zinc, and a multiple micronutrient ...
| Also Ranks for: Rural Nepal | antenatal supplementation | iron zinc | folic acid | micronutrients pregnancy |
BACKGROUND: Zinc supplementation can reduce subsequent morbidity in children recovering from diarrhoea and respiratory illness in developing countries. However, whether routine supplementation would decrease morbidity and mortality in populations with zinc deficiency is unclear. We assessed the effect of daily zinc supplementation on children in southern Nepal.
METHODS: We did a community-based, cluster-randomised, double-masked, placebo-controlled, 2x2 factorial trial in children aged ...
| Also Ranks for: Child Mortality | southern nepal | zinc supplementation | placebo iron | controlled trial |
Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trial
[ PUBLICATION ]
OBJECTIVE: To assess the impact on birth size and risk of low birth weight of alternative combinations of micronutrients given to pregnant women.
DESIGN: Double blind cluster randomised controlled trial.
SETTING: Rural community in south eastern Nepal.
PARTICIPANTS: 4926 pregnant women and 4130 live born infants.
INTERVENTIONS: 426 communities were randomised to five regimens in which pregnant women received daily supplements of folic acid, folic acid-iron, folic acid-iron-zinc, or ...
| Also Ranks for: Low Birth Weight | rural nepal | birth size | acid folic | multiple micronutrients |
BACKGROUND: Omphalitis contributes to neonatal morbidity and mortality in developing countries. Umbilical cord cleansing with antiseptics might reduce infection and mortality risk, but has not been rigorously investigated.
METHODS: In our community-based, cluster-randomised trial, 413 communities in Sarlahi, Nepal, were randomly assigned to one of three cord-care regimens. 4934 infants were assigned to 4.0% chlorhexidine, 5107 to cleansing with soap and water, and 5082 to dry cord care. ...
| Also Ranks for: Neonatal Mortality | umbilical cord | southern nepal | incidence omphalitis | randomised trial |
Hookworms, malaria and vitamin A deficiency contribute to anemia and iron deficiency among pregnant women in the plains of Nepal.
[ PUBLICATION ]
Anemia and iron deficiency during pregnancy are prevalent in developing countries, but their causes are not always known. We assessed the prevalence and severity of anemia and iron deficiency and their association with helminths, malaria and vitamin A deficiency in a community-based sample of 336 pregnant women in the plains of Nepal. Hemoglobin, erythrocyte protoporphyrin (EP) and serum ferritin were assessed in venous blood samples. Overall, 72.6% of women were anemic (hemoglobin < 110 ...
| Also Ranks for: Anemia Iron Deficiency | pregnant women | serum ferritin | plains nepal | malaria hookworm |
BACKGROUND: Vitamin A is important in regulating early lung development and alveolar formation. Maternal vitamin A status may be an important determinant of embryonic alveolar formation, and vitamin A deficiency in a mother during pregnancy could have lasting adverse effects on the lung health of her offspring. We tested this hypothesis by examining the long-term effects of supplementation with vitamin A or beta carotene in women before, during, and after pregnancy on the lung function ...
| Also Ranks for: Lung Function | maternal vitamin | beta carotene | pregnancy offspring | children mothers |
Vitamin A or beta-carotene supplementation reduces but does not eliminate maternal night blindness in Nepal.
[ PUBLICATION ]
We investigated the effect of supplementing women weekly with 7000 microg retinol equivalents as preformed vitamin A or beta-carotene vs. a placebo, on the incidence of night blindness during pregnancy and the postpartum period in the rural plains of Nepal. Over a period of approximately 3 y, approximately 29,000 women of child-bearing age, living in 171 wards that were randomized to one of the three supplements, contributed 9932 first pregnancies. A prospective, weekly surveillance ...
| Also Ranks for: Blindness Pregnancy | carotene supplementation | vitamin beta | postpartum period | childbearing age |
Steven C LeClerq: Influence Statistics
| Concept | World rank |
|---|---|
| supplementation preschool | #1 |
| nepal pregnant | #2 |
| inflammation nepal | #2 |
| nepal maternal | #2 |
| ironfolic acid zinc | #2 |
| nepal obstetric | #2 |
| rural nepal | #2 |
| groups iron | #2 |
| control anemia | #2 |
| nepal design | #2 |
| district sarlahi | #2 |
| nepal objective | #2 |
| zinc placebo | #2 |
| pregnant women nepal | #2 |
| blind pregnant | #2 |
| nepal sarlahi | #2 |
| blind cases | #2 |
| pahadi | #2 |
| nepal iron | #2 |
| rural sarlahi | #2 |
| setting sarlahi | #2 |
| nnips | #2 |
| cifazn | #3 |
| female humans nepal | #3 |
| infants nepal | #3 |
| cortisol adult anemia | #3 |
| acidironzinc multiple | #3 |
| practices food intake | #3 |
| female study workers | #3 |
| 9 post partum | #3 |
| 95 muacaz | #3 |
| bmiaz female follow | #3 |
| iron folic | #3 |
| 10000 keystrokes | #3 |
| effects micronutrient supplementation | #3 |
| nepal pregnancy | #3 |
| rural sarlahi district | #3 |
| women compliance | #3 |
| sarlahi | #3 |
| delivery puerperal morbidity | #3 |
| antenatal micronutrient | #3 |
| tablets sideeffects | #3 |
| field worker performance | #3 |
| preprimary school attendance | #3 |
| age bmiaz | #3 |
| acid zinc | #3 |
| xerophthalmia nepal | #3 |
| nepal randomised | #3 |
| pregnancy low compliance | #3 |
| micronutrients nepal | #3 |
Key People For Rural Nepal
Steven C LeClerq:Expert Impact
Concepts for whichSteven C LeClerqhas direct influence:Rural nepal, Neonatal mortality, Southern nepal, Folic acid, Pregnant women, Sarlahi district, Birth asphyxia, Maternal reports.
Steven C LeClerq:KOL impact
Concepts related to the work of other authors for whichfor which Steven C LeClerq has influence:Pregnant women, Neonatal mortality, Birth weight, Iron deficiency, Folic acid, Developing countries, Zinc supplementation.
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