Department of Neurology, Brigham and Women's Hospital, Boston, MA; Department of Neurology, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. | ...
KOL Resume for Patrick Chen
Department of Neurology, Brigham and Women's Hospital, Boston, MA; Department of Neurology, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.
Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
UC San Diego Med Cntr, San Diego, CA
Department of Biological Chemistry and Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Department of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USA.
MoSys, Inc., Santa Clara, CA, USA
RTI International, Research Triangle Park, USA
Vancouver General Hospital Department of Psychiatry Clinical Practice Unit Vancouver BC Canada
Business Development Center, KISmart Corporation, Taiwan
Student, Faculty of Medicine, University of British Columbia
From the Department of Orthodontics and the Center for Craniofacial Research and Diagnosis, Baylor College of Dentistry, Texas A&M University System, Dallas
BASF Bioresearch Corporation, Worcester, MA 01605, USA.
Patrick Chen: Influence Statistics
|time referring hospital||#5|
|3 posterior teeth||#12|
|unilateral posterior crossbites||#19|
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Prominent publications by Patrick Chen
Morphological and positional asymmetries of young children with functional unilateral posterior crossbite
[ PUBLICATION ]
This prospective clinical study evaluated the morphological and positional mandibular asymmetry of young patients with functional unilateral posterior crossbite. The sample included 9 girls and 6 boys (8.8 +/- 1.0 years of age), evaluated at the initiation of treatment and approximately 6 months after the retention phase (1.1 +/- 0.2 years after initiation of treatment). Each patient had a complete unilateral posterior crossbite involving 3 or more posterior teeth, a functional shift ...
|Known for Young Children | Posterior Crossbite | Asymmetry Mandible | Functional Shift | Temporomandibular Disorder|
The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1 beta converting enzyme (ICE) and three of its homologs in enzymatic assays. Coexpression of p35 prevented the autoproteolytic activation of ICE from its precursor form and blocked ICE-induced apoptosis. Inhibition of enzymatic activity correlated with the cleavage of p35 and the formation of a stable ICE-p35 complex. The ability of p35 to block apoptosis in different pathways and in ...
|Known for P35 Apoptosis | Antiapoptotic Protein | Ice Proteases | Enzymatic Activity | Enzyme Activation|
Effect of transport team interventions on stabilization time in neonatal and pediatric interfacility transports
[ PUBLICATION ]
INTRODUCTION: During interfacility transport, the length of time taken by the transport team to prepare the patient for transport is often perceived as a problem by referring hospital staff. The purpose of this study was to examine the effects on time at the referring hospital of the number and complexity of interventions performed by the transport team to stabilize the patient prior to transfer.
SETTING: Interfacility transfers by the provincial infant transport team (ITT) to British ...
|Known for Stabilization Time | Interfacility Transport | Referring Hospital | Pediatric Humans Infant | Patient Transfer|
Neural Circuit Mechanisms of Social Behavior
[ PUBLICATION ]
We live in a world that is largely socially constructed, and we are constantly involved in and fundamentally influenced by a broad array of complex social interactions. Social behaviors among conspecifics, either conflictive or cooperative, are exhibited by all sexually reproducing animal species and are essential for the health, survival, and reproduction of animals. Conversely, impairment in social function is a prominent feature of several neuropsychiatric disorders, such as autism ...
|Known for Social Behavior | Neural Circuit Mechanisms | Brain Regions | Animal Species | Autism Spectrum Disorders|
Heterogeneous transcriptional start site usage by HIV-1 produces 5'-capped RNAs beginning with one, two, or three 5'-guanosines (Cap1G, Cap2G, or Cap3G, respectively) that are either selected for packaging as genomes (Cap1G) or retained in cells as translatable messenger RNAs (mRNAs) (Cap2G and Cap3G). To understand how 5'-guanosine number influences fate, we probed the structures of capped HIV-1 leader RNAs by deuterium-edited nuclear magnetic resonance. The Cap1G transcript adopts a ...
|Known for Messenger Rna | Structural Basis | Start Site | Nuclear Magnetic | Hiv1 Humans|
Using level‐of‐effort paradata in non‐response adjustments with application to field surveys
[ PUBLICATION ]
Summary. The paper considers the use of level-of-effort (LOE) paradata to model the non-response mechanism in surveys and to adjust for non-response bias, particularly bias that is missing not at random or non-ignorable. Our approach is based on an unconditional maximum likelihood estimation (call-back) model that adapts and extends the prior work to handle the complexities that are encountered for large-scale field surveys. A test of the ‘missingness at random’ assumption is also ...
|Known for Field Surveys | National Survey | Nonresponse Bias | Ignorable Response | Paradata Model|
Overview of psychiatric scales used in Nepal: Their reliability, validity and cultural appropriateness
[ PUBLICATION ]
A review of the Western mental health scales that have been utilized in Nepal was conducted. Academic search engines (PubMed, MEDLINE, PsychLIT, Social Sciences Citation Index, and Anthropology Plus) were searched using relevant terms for the years 1990-2011. Search results indicated a limited number of mental health scales had been used and/or developed in Nepal with mixed emphasis on reliability and validity, as well as cultural considerations. These scales, methods and limitations are ...
|Known for Sensitivity Specificity|
A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia
[ PUBLICATION ]
Importance. As Rivaroxaban has increased in popularity, it has been accompanied with a growing body of evidence displaying its ability to cause drug induced liver injury (DILI). Observation. A 74-year-old Caucasian female developed Rivaroxaban DILI two weeks after finishing a 14-day course. The patient was symptomatic and jaundiced with elevated transaminases and hyperbilirubinemia with normal lab values two months priorly. Liver biopsies showed mixed inflammatory infiltrate of ...
|Known for Liver Injury | Drug Induced|
We propose improving system availability by performing in-field repair at the chip level. This enables margining and detection of degrading memory cells before the user observes any errors. A 576 Mb embedded DRAM at 1.5 GHz in a 40nm CMOS technology achieves improved resilience to both aging memory cells and cells with variable retention time (VRT). Un-interrupted user access of 6 billion 72-bit read and write operations per second is maintained during background repair.
How genetic variation arises and persists over evolutionary time despite the depleting effects of natural selection remains a long-standing question. Here, we investigate the impacts of two extreme forms of population regulation-at the level of the total, mixed population (hard selection) and at the level of local, spatially distinct patches (soft selection)-on the emergence and fate of diversity under strong divergent selection. We find that while the form of population regulation has ...
|Known for Natural Selection|
Key People For Neural Circuit Mechanisms
Patrick Chen:Expert Impact
Concepts for whichPatrick Chenhas direct influence:Neural circuit mechanisms, Stabilization time, Social behavior, Interfacility transport, Field surveys, Posterior crossbite, Flat lighting, Crossbite treatment.
Patrick Chen:KOL impact
Concepts related to the work of other authors for whichfor which Patrick Chen has influence:Cell death, Apoptosis proteins, Caspase inhibitors, Social behavior, Unilateral posterior crossbite, Baculovirus p35, Cysteine proteases.
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